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La Jolla Institute discovers new player critical to unleashing T cells against disease
Date:6/23/2013

be able to classify those hits into genes that affect the calcium channel itself and genes that act later in the pathway. "We are hopeful that one or more of these genes can be used as a clinical target for new drugs to treat transplant rejection and immune diseases, some of the same indications now treated with cyclosporine A," adds Dr. Hogan. He believes that a medication aimed at an early step of calcium entry through the ORAI channel could be more effective and have fewer side effects than cyclosporin A, which targets a later step in the pathway and can cause complications such as kidney disease.


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Contact: Bonnie Ward
contact@liai.org
619-991-0868
La Jolla Institute for Allergy and Immunology
Source:Eurekalert

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