Navigation Links
La Jolla Institute discovers new player critical to unleashing T cells against disease
Date:6/23/2013

. Sharma, who was recently appointed to a faculty position, and now leads her own independent laboratory at the La Jolla Institute, in addition to serving as scientific director of the newly established RNAi screening center.

Dr. Hogan says the discovery took the research team by surprise. "We knew septins existed in the cellular plasma (surface) membrane, but we didn't know they had anything to do with calcium signaling," he says. Septins are known to build scaffolding to provide structural support during cell division.

This finding builds on Dr. Rao and Dr. Hogan's groundbreaking discovery in 2006 showing that the protein ORAI1 forms the pore of the calcium channel. The channel's entryway had been one of the most sought after mysteries in biomedical science because it is the gateway to T cell functioning and, consequently, to better understanding how the body uses these cells to fight disease.

To the research team's surprise, the septins were forming a ring around the calcium channel. "We aren't sure why, but we theorize that the septins are rearranging the cellular membrane's structure to "corral" the key proteins STIM and ORAI1, and maybe other factors needed for the calcium channel to operate," says Dr. Hogan.

Dr. Sharma adds that, "essentially we believe the septins are choreographing the interaction of these two proteins that are important in instigating the immune response." Without the septins' involvement, T cell activation does not occur.

In the study, the researchers devised a simple visual readout of activity in a main pathway responsible for activation of T cells the same pathway that is targeted by the immunosuppressive drug cyclosporin A that is used clinically and looked for impairment of the activity when individual genes were, in effect, deleted. After sorting through the roughly 20,000 human genes, they turned up 887 gene "hits," says Dr. Hogan.

With further experiments, they should
'/>"/>

Contact: Bonnie Ward
contact@liai.org
619-991-0868
La Jolla Institute for Allergy and Immunology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. La Jolla Institute identifies molecular switch enabling immune cells to better fight disease
2. La Jolla institute identifies critical cell in fighting E. coli infection
3. La Jolla Institute scientist discovers key step in immune system-fueled inflammation
4. La Jolla Institute discovery could lead to new way to screen drugs for adverse reactions
5. National Institutes of Health to fund research probing proteins linked to cancer, diabetes
6. Roy J. Carver Charitable Trust funds new research focus at Institute for Genomic Biology
7. The DOE Joint Genome Institute expands capabilities via new partnerships
8. St. Jude scientist named Howard Hughes Medical Institute investigator
9. Feinstein Institute collaborates with GSK, UPenn, MIT to research bodys electrical impulses
10. DOE Joint Genome Institute 8th Annual Meeting on March 26-28, 2013
11. Forsyth Institute receives $4.1 million grant for new center
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/19/2015)...  NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... mobile commerce market, announces its biometric payment technology, the Wocket® ... this week on Washington DC,s Fox ... segment "The Next Great Thing", host Laura Evans ... and ,a really big breakthrough in mobile payment.,  ...
(Date:3/16/2015)... 2015 Between 16 and ... groundbreaking innovations in biometric identification at the CeBIT ...      (Photo: http://photos.prnewswire.com/prnh/20150316/735333 ) ... well at the forefront: the company,s all new ... Germany . BiometricGate is the ...
(Date:3/11/2015)... Mar. 11, 2015 Research and Markets ... "Access Control Market by Product, Application & By ... report to their offering. , This report ... reach $10.4 billion by 2020, with an estimated CAGR ... covers the products types such as contact cards & ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 2NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 3DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 2DERMALOG Presents its Latest Biometric Innovations at the Hannover CeBIT Exhibition, 16 - 20 March 2015 3Global Access Control (Cards & Readers, Biometrics, Controllers, Management Software) Market 2015-2020 - Analysis of the $10 Billion Market 2
... Molecular biologists, developmental biologists and computer scientists at the ... cracking the code for how gene expression is controlled. ... in January 2006. , A genome milestone was reached ... completed. This has been followed by complete chemical read-outs ...
... cluster of 45 genes coding for antibacterial drug ... cause of hospital-acquired infections worldwide. The study ... , "We expected to find resistance genes," said ... and Genomic Information Laboratory at France's National Center ...
... Thanks to this flexibility--the arm is said to ... freedom"--the octopus is able to generate a vast ... human arm. Nonetheless, despite the huge evolutionary gap ... the octopus arm acts much like a three-jointed ...
Cached Biology News:Cracking the genetic code for control of gene expression 2Supersized 'island' of resistance genes discovered in an infectious bacterium 2How the octopus forms an elbow 2
(Date:3/26/2015)... 26, 2015 PRC Clinical, a Silicon-Valley ... several management and executive appointments effective immediately. , Mike ... (CFO) and member of the Board of Directors. Daniel ... and Sue Dowden will assume the position of Senior ... Chief Operations Officer (COO), has been appointed to the ...
(Date:3/26/2015)... 26, 2015 Neogen Corporation (NASDAQ: NEOG ... third quarter of fiscal 2015, which ended Feb. 28, ... year,s $6,575,000. Earnings per share in the current quarter ... year-to-date net income increased 17% over prior year to ... $0.56 per share, for the same period a year ...
(Date:3/26/2015)... 26, 2015 WriteResult, a premier provider ... from Yale University’s School of Public Health and New ... during a 4 month-long project. The goal of the ... income families with free access to fresh produce and ... health concerns like high blood pressure, diabetes and weight ...
(Date:3/25/2015)... UK (PRWEB) March 25, 2015 ... uptake of smartphones have fuelled social media growth, ... being currently engaged in social networking. Insurance companies ... to communicate with clients and promote a diversity ... globe over are increasingly exploiting social networking services ...
Breaking Biology Technology:PRC Clinical Announces Key Management Appointments and Launches East Coast Operations 2PRC Clinical Announces Key Management Appointments and Launches East Coast Operations 3Neogen reports 13% increase in net income 2Neogen reports 13% increase in net income 3Neogen reports 13% increase in net income 4Neogen reports 13% increase in net income 5Neogen reports 13% increase in net income 6Neogen reports 13% increase in net income 7Neogen reports 13% increase in net income 8Yale and New Haven Farms Improving Patient Health with WriteResult's myPROpad™ 2Yale and New Haven Farms Improving Patient Health with WriteResult's myPROpad™ 3Social Media Role in Global Insurance Industry Examined by Timetric in New Market Research Report Published at MarketPublishers.com 2Social Media Role in Global Insurance Industry Examined by Timetric in New Market Research Report Published at MarketPublishers.com 3
... , ANNAPOLIS, Md., Dec. 8 ... company specializing in the development and commercialization of medical countermeasures ... hold a conference call at 9:00 a.m. Eastern Time, on ... recombinant protective antigen (rPA) anthrax vaccine program. The dial-in ...
... , CORALVILLE, Iowa, Dec. 8 Vivakor, ... how shareholders of record on December 1, 2009 will receive ... that was previously approved by Vivakor,s Board of Directors. HealthAmerica ... 84% of the outstanding common shares on the record date. ...
... , SAN DIEGO, Dec. 8 ... announced today they have licensed their Target Informatics Platform (TIP) ... Toxicological Research (NCTR). , Under the terms of the license, ... TIP structural knowledgebase via onlineTIP as well ...
Cached Biology Technology:PharmAthene Announces Updated Time for Conference Call to Review BARDA rPA Decision 2Vivakor Announces Mechanics of Dividend Distribution 2Vivakor Announces Mechanics of Dividend Distribution 3Eidogen-Sertanty Licenses TIP to the FDA 2
... containing Vaginal Keratinocyte Progenitors, Rabbit, and media. ... and 10% DMSO at passage 25 (approx), ... medium.This cell culture is supplied as a ... an additional 6 months of continuous growth ...
... use spatulas have been designed to save ... for those interested in eliminating the recycling ... spatula is individually packaged, RNase/DNase free, non-pyrogenic ... a new product number, created to easily ...
... high-density functional protein microarray is the first ... proteinprotein interactions on a proteome scale. The ... reading frames (ORFs) expressed as 5'-GST fusions, ... 1 inch x 3 inch nitrocellulose-coated slide. ...
... is a compact, versatile system that simultaneously ... or 24-well microplates into a solid filter ... scintillation and gamma counter. The FilterMate is ... applications such as cell proliferation, receptor binding, ...
Biology Products: