Navigation Links
La Jolla Institute discovers new player critical to unleashing T cells against disease
Date:6/23/2013

. Sharma, who was recently appointed to a faculty position, and now leads her own independent laboratory at the La Jolla Institute, in addition to serving as scientific director of the newly established RNAi screening center.

Dr. Hogan says the discovery took the research team by surprise. "We knew septins existed in the cellular plasma (surface) membrane, but we didn't know they had anything to do with calcium signaling," he says. Septins are known to build scaffolding to provide structural support during cell division.

This finding builds on Dr. Rao and Dr. Hogan's groundbreaking discovery in 2006 showing that the protein ORAI1 forms the pore of the calcium channel. The channel's entryway had been one of the most sought after mysteries in biomedical science because it is the gateway to T cell functioning and, consequently, to better understanding how the body uses these cells to fight disease.

To the research team's surprise, the septins were forming a ring around the calcium channel. "We aren't sure why, but we theorize that the septins are rearranging the cellular membrane's structure to "corral" the key proteins STIM and ORAI1, and maybe other factors needed for the calcium channel to operate," says Dr. Hogan.

Dr. Sharma adds that, "essentially we believe the septins are choreographing the interaction of these two proteins that are important in instigating the immune response." Without the septins' involvement, T cell activation does not occur.

In the study, the researchers devised a simple visual readout of activity in a main pathway responsible for activation of T cells the same pathway that is targeted by the immunosuppressive drug cyclosporin A that is used clinically and looked for impairment of the activity when individual genes were, in effect, deleted. After sorting through the roughly 20,000 human genes, they turned up 887 gene "hits," says Dr. Hogan.

With further experiments, they should
'/>"/>

Contact: Bonnie Ward
contact@liai.org
619-991-0868
La Jolla Institute for Allergy and Immunology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. La Jolla Institute identifies molecular switch enabling immune cells to better fight disease
2. La Jolla institute identifies critical cell in fighting E. coli infection
3. La Jolla Institute scientist discovers key step in immune system-fueled inflammation
4. La Jolla Institute discovery could lead to new way to screen drugs for adverse reactions
5. National Institutes of Health to fund research probing proteins linked to cancer, diabetes
6. Roy J. Carver Charitable Trust funds new research focus at Institute for Genomic Biology
7. The DOE Joint Genome Institute expands capabilities via new partnerships
8. St. Jude scientist named Howard Hughes Medical Institute investigator
9. Feinstein Institute collaborates with GSK, UPenn, MIT to research bodys electrical impulses
10. DOE Joint Genome Institute 8th Annual Meeting on March 26-28, 2013
11. Forsyth Institute receives $4.1 million grant for new center
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... Becoming invisible is probably the ultimate form of camouflage: ... you. And this strategy is not as uncommon as ... Maryland Baltimore County, USA, explains that the larval life ... is one part of the anatomy that most creatures ... compound eyes have to shield each individual eye unit ...
(Date:9/17/2014)... accessible and affordable health care to reproductive technologies, ... on the ability of people to identify key ... and respectfully, and find the most defensible ways ... to support these societal conversations?, The Hastings Center ... Bioethical Issues have teamed up to publish a ...
(Date:9/17/2014)... professor and his doctoral student have designed a device ... collected from fog and dew., The device could provide ... around the globe., Cheng Luo, professor in the Mechanical ... in the same College of Engineering department, published "Bioinspired ... ACS, (American Chemical Society) Applied Materials & ...
Breaking Biology News(10 mins):Transparent larvae hide opaque eyes behind reflections 2Why bioethics literacy matters 2Why bioethics literacy matters 3Shorebird's beak inspires UT Arlington research on water collection 2
... Abroad ReportedWALL, N.J., Jan. 19 BIO-key International, ... finger-based biometric identification and wireless public safety solutions, ... the media on its fingerprint biometrics identification solutions ... 8th edition of This Week in Consumer ...
... latest American Chemical Society (ACS) Weekly PressPac from the Office ... journals and Chemical & Engineering News . Please credit ... source for this information. ARTICLE #1 FOR IMMEDIATE RELEASE ... , Analytical Chemistry In a macabre discovery ...
... SHORES, Calif., Jan. 14 Communication Intelligence Corporation ... leading supplier of electronic signature solutions for business ... recognized leader** in biometric signature verification will be ... an independent technology and market research company that ...
Cached Biology News:BIO-key(R) Fingerprint Biometrics Media Spotlights 2BIO-key(R) Fingerprint Biometrics Media Spotlights 3American Chemical Society's weekly PressPac -- Jan. 14, 2009 2American Chemical Society's weekly PressPac -- Jan. 14, 2009 3American Chemical Society's weekly PressPac -- Jan. 14, 2009 4American Chemical Society's weekly PressPac -- Jan. 14, 2009 5American Chemical Society's weekly PressPac -- Jan. 14, 2009 6CIC to Host Webinar Featuring Independent Research Firm: 'Enabling Straight Through Processing - Why the Insurance Industry Needs Electronic Signature Technology' 2CIC to Host Webinar Featuring Independent Research Firm: 'Enabling Straight Through Processing - Why the Insurance Industry Needs Electronic Signature Technology' 3CIC to Host Webinar Featuring Independent Research Firm: 'Enabling Straight Through Processing - Why the Insurance Industry Needs Electronic Signature Technology' 4
(Date:9/19/2014)... 2014  An entire month is dedicated to one ... Charcot-Marie-Tooth disease (CMT) – a debilitating neuromuscular disease affecting ... atrophy, weakness, and foot and hand deformities. CMT affects ... CMT is a progressive disease, and over time patients ... devices such as leg braces, wheelchairs and scooters to ...
(Date:9/19/2014)... , September 19, 2014 BioTech ... developments, patents and results of studies and trials.  Companies ... and Company (NYSE: LLY ), Gilead Sciences ... CELG ) and Arena Pharmaceuticals Inc. (NASDAQ: ... in developing prodrug therapeutics for the treatment of cancer, ...
(Date:9/19/2014)... 2014 , The first grants ... Paediatric Endocrinology (ESPE) Meeting  Investment supports innovative ... in the field of growth  , EMD ... Germany , today announced the first recipients of ... awards were announced during a Satellite Symposium organized by ...
(Date:9/18/2014)... , Sept. 18, 2014 About ... testing, is performed outside a clinical laboratory. It ... in administrating appropriate treatments and medication. POCT is ... prevalence of lifestyle diseases such as diabetes, heart ... user-friendly. POCT devices are standardized to minimize errors ...
Breaking Biology Technology:September is Charcot-Marie-Tooth (CMT) Awareness Month - Scheduled events, activities and important partnerships announced throughout the month! 2Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 2Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 3Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 4Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 5Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 6Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 7EMD Serono Awards Grant for Growth Innovation (GGI) for the First Time 2EMD Serono Awards Grant for Growth Innovation (GGI) for the First Time 3POCT Market in China 2014-2018 2
... (Nasdaq: NKTR ) announced today that Bharatt ... Operating Officer and Head of the,PEGylation Business Unit. ... the PEGylation Business Unit, including research,and manufacturing, as ... also,serve as Chairman of Nektar India Pvt., Ltd. ...
... 22 Edwards Lifesciences,Corporation (NYSE: EW ... of heart valves,today announced the opening of ... North Crescent, Singapore. The state-of-the-art facility produces,Edwards, ... also serves as the headquarters for Edwards, ...
... Celldex,Therapeutics (a wholly-owned subsidiary of AVANT,Immunotherapeutics)(Nasdaq: ... CDX-110, being developed for the treatment of Glioblastoma,Multiforme ... presentation at the 44th,Annual Meeting of the American ... be held at McCormick Place in Chicago from ...
Cached Biology Technology:Bharatt Chowrira Joins Nektar Therapeutics as Chief Operating Officer and Head of PEGylation Business Unit 2Bharatt Chowrira Joins Nektar Therapeutics as Chief Operating Officer and Head of PEGylation Business Unit 3Edwards Lifesciences Opens New Singapore Heart Valve Facility 2AVANT Immunotherapeutics Announces Oral Presentation of CDX-110 at ASCO Annual Meeting 2AVANT Immunotherapeutics Announces Oral Presentation of CDX-110 at ASCO Annual Meeting 3
...
... deuterium atoms at the 9, 10, 12, and ... an internal standard for the quantification of 13(S)-HODE ... by incubation of linoleic acid with plant and ... the adhesion of tumor cells to the endothelium ...
... Cells and TriEx Insect Cell Medium are ... constructs. This cell/medium combination has been selected ... high protein expression levels observed specifically with ... note that our Ready-Plaque Sf9 Cells and ...
...
Biology Products: