Navigation Links
LSUHSC contributes to work identifying new DNA regions associated with schizophrenia
Date:7/22/2014

New Orleans, LA -- Nancy Buccola, MSN, APRN, PMHCNS-BC, CNE, Assistant Professor of Clinical Nursing at LSU Health Sciences Center New Orleans School of Nursing, contributed samples used in a study reporting new locations of genetic material associated with schizophrenia and also suggesting a possible link between the immune system and schizophrenia. The study, Biological insights from 108 schizophrenia-associated genetic loci, was published online July 22, 2014 in Nature, available at http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13595.html.

Buccola collected samples as part of the Molecular Genetics of Schizophrenia (MGS) study. A large international collaboration, called the Schizophrenia Working Group of the Psychiatric Genomics Consortium, combined these previously collected samples with published or unpublished genome-wide association study genotypes into a single, systematic analysis. To the Consortiums knowledge this is the largest molecular genetic study of schizophrenia ever conducted.

The researchers not only identified previously unknown areas associated with schizophrenia, but also show that the associations are not random; rather they converge upon genes active in certain tissues and cell types, including those that play important roles in immune function. They report 128 independent associations spanning 108 regions of DNA, 83 of which have not been previously reported. The findings provoke the question of whether or not treatments for autoimmune disorders might also be helpful in treating schizophrenia, or at least provide new targets for drug development.

According to the National Institute of Mental Health, which funded the research, approximately 2.4 million American adults, or about 1.1 percent of the population age 18 and older in a given year, have schizophrenia. Schizophrenia is a chronic, severe, and disabling brain disorder. People with the disorder may hear voices other people don't hear. They may believe other people are reading their minds, controlling their thoughts, or plotting to harm them. This can terrify people with the illness and make them withdrawn or extremely agitated.

While treatments are available, they are not effective for many patients. All of the currently used antipsychotic drugs work by a mechanism discovered more than 60 years ago. No new effective drugs have been developed since partly due to lack of knowledge about how the disease develops.

Buccola, Principal Investigator at LSU Health Sciences Center New Orleans for the MGS study, says The lead authors have done a tremendous job of coordinating the analysis of a vast amount of data. This study brings us closer to understanding the cause of schizophrenia as well as potential treatments.


'/>"/>
Contact: Leslie Capo
lcapo@lsuhsc.edu
504-568-4806
Louisiana State University Health Sciences Center
Source:Eurekalert  

Related biology news :

1. LSUHSCS Sothern pens new book on safe exercise for overweight kids
2. LSUHSC research reveals structure of master regulator and new drug target for autism, cervical cancer
3. LSUHSC research finds inflammation linked to obesity in adults may be protective in young children
4. LSUHSC research finds combo of plant nutrients kills breast cancer cells
5. LSUHSCS OCHOA 1 of 10 chosen by NIH director for Transformative Research Award
6. LSUHSC researchers develop new system to better study behavior, cell function
7. LSUHSC researcher awarded NCI grant to study link between chronic inflammation and cancer
8. LSUHSC research identifies new risk factors for parasitic infection
9. LSUHSC research discovers new drug target for metastatic breast cancer
10. LSUHSC research identifies co-factors critical to PTSD development
11. LSUHSC scientist awarded nearly $2 million to determine role of biofilms in common fungal infection
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
LSUHSC contributes to work identifying new DNA regions associated with schizophrenia
(Date:4/26/2016)... and LONDON , ... Finacle, part of EdgeVerve Systems, a product subsidiary ... Onegini today announced a partnership to integrate the ...      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ) ... provide their customers enhanced security to access and ...
(Date:4/15/2016)... 15, 2016 Research and ... Biometrics Market 2016-2020,"  report to their offering.  , ... , ,The global gait biometrics market is expected ... the period 2016-2020. Gait analysis generates ... be used to compute factors that are not ...
(Date:3/31/2016)... R.I. , March 31, 2016  Genomics firm ... of founding CEO, Barrett Bready , M.D., who ... members of the original technical leadership team, including Chief ... President of Product Development, Steve Nurnberg and Vice President ... returned to the company. Dr. Bready served ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016 /PRNewswire/ - FACIT ... Ontario biotechnology company, Propellon Therapeutics ... development and commercialization of a portfolio of first-in-class ... Epigenetic targets such as WDR5 represent an exciting ... significantly in precision medicine for cancer patients. Substantial ...
(Date:6/23/2016)... Prostate Cancer Foundation (PCF) is pleased to announce 24 new Young ... cancer. Members of the Class of 2016 were selected from a pool of ... More About the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... ... June 23, 2016 , ... STACS DNA Inc., the sample tracking software company, ... Crime Laboratory, has joined STACS DNA as a Field Application Specialist. , “I ... President and COO of STACS DNA. “In further expanding our capacity as a scientific ...
(Date:6/23/2016)... , June 23, 2016 ... Review, 2016;12(1):22-8 http://doi.org/10.17925/OHR.2016.12.01.22 Published ... the peer-reviewed journal from touchONCOLOGY, Andrew D ... cost of cancer care is placing an increasing ... of expensive biologic therapies. With the patents on ...
Breaking Biology Technology: