Navigation Links
Kidney stone mystery solved

new research shows that its expression is dampened by two snippets of RNA, a sister molecule of DNA, that essentially silence the gene.

When claudin-14 is idled, the kidney's filtering system works like it's supposed to. Essential minerals in the blood like calcium and magnesium pass through the kidneys and are reabsorbed back into the blood, where they are transported to cells to carry out basic functions of life.

But when people eat a diet high in calcium or salt and don't drink enough water, the small RNA molecules release their hold on claudin 14. An increase in the gene's activity prevents calcium from re-entering the blood, the study shows.

Hou and his team have found that claudin-14 blocks calcium from entering passageways called tight junctions in cells that line the kidney and separate blood from urine.

Without a way back to the bloodstream, excess calcium goes into the urine. Too much calcium in the urine can lead to stones in the kidneys or bladder. Intense pain develops when a large stone gets stuck in the bladder, ureter or urethra and blocks the flow of urine.

Hou's research supports the theory that people with a common variation in claudin-14 lose the ability to regulate the gene's activity, increasing the risk of kidney stones.

He is optimistic, however, that drugs could be developed to target the short stretches of RNA that are intimately linked to claudin 14. Drugs that mimic these so-called microRNAs could keep the activity of claudin-14 in check and reduce the likelihood that stones would form.

Also, it may one day be possible to develop a diagnostic test to measure levels of the claudin-14 protein excreted in urine. Elevated levels would indicate an increased risk of stones, and people could take steps to prevent stones by modifying their diet.

"Many genes likely play a role in the formation of kidney stones," Hou says. "But this study gives us a better idea of the way one

Contact: Caroline Arbanas
Washington University School of Medicine

Page: 1 2 3

Related biology news :

1. Scientists identify cell changes leading to impaired artificial kidney function
2. Kidney function discovery sheds light on genetic complexity of disease
3. UC San Diego researchers use metagene portraits to reveal distinct stages of kidney formation
4. UC Davis discovery offers hope for treating kidney cancer
5. Gene mutation increases drug toxicity, rejection risk in pediatric kidney transplants
6. Shorter wait means longer life for kidney transplant candidates
7. Updated formula measures kidney function more accurately
8. Freezing kidney cancer: Hot treatment should be new gold standard for destroying small tumors
9. Is it really only our kidneys that control blood pressure?
10. UT Southwestern researchers probe kidney damage, protection in lupus
11. Drinking diet soda may reduce the risk of forming kidney stones
Post Your Comments:
Related Image:
Kidney stone mystery solved
(Date:5/21/2015)... DALLAS , May 21, 2015 ... report, "Thermal Imaging Market by Solutions (Hardware, Software, Services), ... Veterinary, Automotive & others), by End-Users (Military & ... published by MarketsandMarkets, Thermal Imaging Market is expected ... $9998.9 Million by 2020, at a Compound Annual ...
(Date:5/19/2015)... 19, 2015  Technology is rapidly advancing, outpacing enterprises, ... the cloud. Passwords and their management are soon to ... standards-based specifications such as those developed by the FIDO ... passwords presents for BYOD, COPE, IoT, and mobile payments, ... protocol. In response to the call ...
(Date:5/11/2015)... JOSE, Calif. , May 11, 2015 /PRNewswire/ ... developer of human interface solutions, today announced the ... Vice President and Chief Financial Officer, reporting to ... Ali replaces Synaptics, current Chief Financial Officer, ... December 2014. Mr. Ali brings ...
Breaking Biology News(10 mins):Thermal Imaging Market Worth $9,998.9 Million by 2020 2Thermal Imaging Market Worth $9,998.9 Million by 2020 3Thermal Imaging Market Worth $9,998.9 Million by 2020 4HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 2HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 3Synaptics Appoints Wajid Ali as Senior Vice President and Chief Financial Officer 2
... National biobanks play a vital role in modern health research ... data, but they are expensive to run. Can we make ... borders on a larger scale? This is the theme of ... How can we maximize the value and use of ...
... the Johns Hopkins Bloomberg School of Public Health have ... triggers an immune response in multiple mosquito species capable ... parasite that causes malaria in humans. By silencing ... the development of the malaria-causing parasite in Anopheles ...
... Software, a company with an outstanding track record ... high throughput technologies, announced today that it was ... "Identification and assignment of functionally corresponding regulatory sequences ... European Patent Office. The Patent relates to ...
Cached Biology News:Harmonizing biobank research: An achievable world-wide goal 2Malaria immunity trigger found for multiple mosquito species 2Genomatix gets patent for comparative genomics method 2
(Date:6/2/2015)... -- Research and Markets ( ) has announced ... Product , Test, Application & End User - Forecast ... The bioburden testing market is expected to reach $565.6 ... at a CAGR of 9.8% from 2014 to 2019 ... testing market is segmented into consumables and instruments. The ...
(Date:6/2/2015)... June 2, 2015 Meet ARGUS, ... Scanner. Scan & Read People. Analyze emotions and predict ... Concepts, including the very first Responsive-RPG: "The Eye: Genesis". ... , , , , ... truly affect your inner feelings - and those of ...
(Date:6/2/2015)... Pa. , June 2, 2015   ... be attending the BIO Exhibition 2015 in ... Exhibition, the world,s largest biotechnology gathering, allows influential ... high-level executives, where they can evaluate emerging technologies ... significant eClinical expertise in the design, implementation and ...
(Date:6/2/2015)... 2015   Sigma-Aldrich Corporation (NASDAQ: SIAL ... announced today it has entered into an agreement ... engineered human neural differentiated cells and accompanying culture ... diseases. These new products, in combination with Sigma-Aldrich,s ... for the study of central nervous system (CNS) ...
Breaking Biology Technology:Bioburden Testing Market 2015 - Global Forecasts to 2019 2ARGUS - The World's First Inner Emotion Scanner Launches on KickStarter 2ARGUS - The World's First Inner Emotion Scanner Launches on KickStarter 3YPrime at BIO Exhibition in Philadelphia and DIA in Washington DC during the month of June 2Sigma-Aldrich to Launch XCell Science Genetically Engineered iPSC-Derived Neural Disease Cells 2Sigma-Aldrich to Launch XCell Science Genetically Engineered iPSC-Derived Neural Disease Cells 3
... 19, 2012 Separate Study ... Two studies presented at the International ... disease has across Europe. One highlights the financial cost ... highlights the high mortality rates associated with cirrhosis. ...
... selective hearing works how people can tune in to ... is solved this week in the journal Nature ... Francisco (UCSF). Psychologists have known for decades about the ... Men era in which it was coined. It is the ...
... More than half-a-century ago, the Dutch theoretical physicist Hendrik ... in a vacuum would attract. The mysterious force arises ... out of existence, as described by quantum theory. Now ... in Japan, has predicted that in certain circumstances a ...
Cached Biology Technology:Chronic Hepatic Diseases Generate High Costs to Europe 2Chronic Hepatic Diseases Generate High Costs to Europe 3Chronic Hepatic Diseases Generate High Costs to Europe 4How selective hearing works in the brain 2How selective hearing works in the brain 3
... 15(S)-15-methyl PGF2α is a metabolically ... is a potent uterine stimulant ... administered intramuscularly to induce labor. ... serum progesterone concentrations when given ...
... S-X media are neutral, porous ... exclusion chromatography of lipophilic polymers ... organic eluents. The beads are ... carbon tetrachloride, dimethylformamide, ketones, aromatics, ...
... Epitope: A BALB/c mouse was ... Recommended Storage: Store vial at -20 C ... at -20 C or below for extended storage. ... Centrifuge product if not completely clear after standing ...
Mouse monoclonal [HYB 232-02] to Protein S ( Abpromise for all tested applications). entrezGeneID: 5627 SwissProtID: P07225...
Biology Products: