Navigation Links
Kidney stone mystery solved
Date:4/18/2012

Kidney stones strike an estimated 1 million Americans each year, and those who have experienced the excruciating pain say it is among the worst known to man (or woman).

Now, new research by scientists at Washington University School of Medicine in St. Louis provides evidence to explain why some people are more prone to develop the condition than others. Their discovery opens the door to finding effective drug treatments and a test that could assess a person's risk of kidney stones.

"Now, we finally have a more complete picture detailing why some people develop kidney stones and others do not," says senior author Jianghui Hou, PhD, assistant professor of medicine. "With this information, we can begin to think about better treatments and ways to determine a person's risk of the condition, which typically increases with age."

The research, in mice, is now available online in the EMBO Journal, published by the European Molecular Biology Organization.

Because kidneys function the same way in mice as in humans, the new findings can help scientists understand the root causes of kidney stones in patients. The mouse model used in the study can also serve as a platform for the preclinical testing of novel treatments for the condition, the researchers say.

Most kidney stones form when the urine becomes too concentrated, allowing minerals like calcium to crystallize and stick together. Diet plays a role in the condition not drinking enough water or eating too much salt (which binds to calcium) also increases the risk of stones.

But genes are partly to blame. A common genetic variation in a gene called claudin-14 recently has been linked to a substantial increase in risk roughly 65 percent of getting kidney stones. In the new study, the researchers have shown how alterations in the gene's activity influence the development of stones.

Typically, the claudin-14 gene is not active in the kidney. The
'/>"/>

Contact: Caroline Arbanas
arbanasc@wustl.edu
314-286-0109
Washington University School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Scientists identify cell changes leading to impaired artificial kidney function
2. Kidney function discovery sheds light on genetic complexity of disease
3. UC San Diego researchers use metagene portraits to reveal distinct stages of kidney formation
4. UC Davis discovery offers hope for treating kidney cancer
5. Gene mutation increases drug toxicity, rejection risk in pediatric kidney transplants
6. Shorter wait means longer life for kidney transplant candidates
7. Updated formula measures kidney function more accurately
8. Freezing kidney cancer: Hot treatment should be new gold standard for destroying small tumors
9. Is it really only our kidneys that control blood pressure?
10. UT Southwestern researchers probe kidney damage, protection in lupus
11. Drinking diet soda may reduce the risk of forming kidney stones
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Kidney stone mystery solved
(Date:4/15/2014)... have previously shown that a genetic pre-disposition to be ... new study, Frank Booth, a professor in the MU ... between the genetic pre-disposition for high levels of exercise ... , For his study, Booth selectively bred rats that ... Booth then put the rats in cages with running ...
(Date:4/15/2014)... ITHACA, N.Y. If an insect drew a line ... would be a tangled mess. But there,s method to ... of mechanical engineering and physics, who tries to find ... Photo: https://cornell.box.com/tbeetle , It turns out the ... an optimal reorientation dance as it chases its prey ...
(Date:4/15/2014)... how social behavior has developed over the course of ... have gained new insights from the study of earwigs. ... the siblings share what is available amongst themselves, especially ... of the Evolutionary Biology section of the Institute of ... team of biologists from Mainz University and the University ...
Breaking Biology News(10 mins):Genetic pre-disposition toward exercise and mental development may be linked 2Photo: Tiger beetle's chase highlights mechanical law 2Sibling cooperation in earwig families gives clues to early evolution of social behavior 2
... BATON ROUGE, LAKeeping with the global "green" trend, ... lessons to enhance students, science knowledge. Studies have ... raises not just science scoresenvironmental-based lessons can also ... Naturally, educators are interested in developing new ways ...
... Scientists studying how bacteria under stress collectively weigh and ... insights into how humans make strategic decisions that affect ... society. Their study, published this week in the ... the National Academy of Sciences , was accomplished when ...
... available in French . , Montreal, December ... mechanism that prevents cancer. In the December 11 edition of ... Universit de Montral and the Universit de Sherbrooke explain how ... of cytokines, hormones that are culprits in cancer-prone chronic inflammation ...
Cached Biology News:Students learn environmental stewardship, improve science scores 2Bacteria provide new insights into human decision making 2Bacteria provide new insights into human decision making 3Bacteria provide new insights into human decision making 4Bacteria provide new insights into human decision making 5Scientists identify natural anti-cancer defenses 2
(Date:1/15/2014)... -- TaiGen Biotechnology Company, Limited ("TaiGen") today announced ... R-Pharm, a leading Russian pharmaceutical company, to develop ... Russian Federation , ... Commonwealth Independent States (CIS). Nemonoxacin is a novel antibiotic ... caused by drug-resistant bacteria. Under the terms of ...
(Date:1/14/2014)... January 14, 2014 Carahsoft and ... for Thursday, January 23, 2014 at 2pm EST ... into Actionable Knowledge.” The topic focuses on how ... knowledge to drive mission critical decisions for government ... hour. , Synopsis: Big Data has become an ...
(Date:1/14/2014)... 2014  3D Communications, a leading provider of strategic communications ... business, and media events in the United States ... its former associate Virginia Cox , JD, is returning ... Virginia Cox re-joins 3D after more ... Office of External Affairs at the U.S. Food and Drug ...
(Date:1/14/2014)... New York, NY (PRWEB) January 14, 2014 ... has initiated coverage of Alliqua, Inc. (OTCQB: ALQA). ... manufacturing, and marketing proprietary products to serve the ... http://equitiesiq.com/reports/alliqua/ , In late 2012, Alliqua was ... which launched the company’s new strategy to become ...
Breaking Biology Technology:TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2Former FDA Associate Commissioner Returns To 3D Communications 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... , , , , for one-step RT-PCR ... 016 338 50 reactions , Cat. No. 2 016 346 250 reactions ... Description , , , The system contains a unique ... , Note: C. therm. Polymerase provided ...
... , , , Mark R. Kagan 1 , Julian Phillips 2 , , ... 1Thermo Finnigan, Piscataway, NJ; , 2Thermo Finnigan, San Jose, CA; , ... Chemical Structure Validation , The data presented here can be acquired using ... , Introduction , ...
... , , , Jack Cunniff, Philip Tiller, Michael Harvey, , ... , , , , ... Finnigan LCQ , Series of ion trap mass spectrometers. , ... For more than five thousand years tea has been used in China as an ...
Cached Biology Technology:C. therm. Polymerase One-Step RT-PCR System 2C. therm. Polymerase One-Step RT-PCR System 3Analyzing Trace-Level Impurities of a Pharmaceutical Intermediate Using , an LCQ Deca Ion Trap Mass Spectrometer and the Mass Frontier , Software Package 2Analyzing Trace-Level Impurities of a Pharmaceutical Intermediate Using , an LCQ Deca Ion Trap Mass Spectrometer and the Mass Frontier , Software Package 3Analyzing Trace-Level Impurities of a Pharmaceutical Intermediate Using , an LCQ Deca Ion Trap Mass Spectrometer and the Mass Frontier , Software Package 4Analyzing Trace-Level Impurities of a Pharmaceutical Intermediate Using , an LCQ Deca Ion Trap Mass Spectrometer and the Mass Frontier , Software Package 5Analyzing Trace-Level Impurities of a Pharmaceutical Intermediate Using , an LCQ Deca Ion Trap Mass Spectrometer and the Mass Frontier , Software Package 6Analyzing Trace-Level Impurities of a Pharmaceutical Intermediate Using , an LCQ Deca Ion Trap Mass Spectrometer and the Mass Frontier , Software Package 7Analyzing Trace-Level Impurities of a Pharmaceutical Intermediate Using , an LCQ Deca Ion Trap Mass Spectrometer and the Mass Frontier , Software Package 8Analyzing Trace-Level Impurities of a Pharmaceutical Intermediate Using , an LCQ Deca Ion Trap Mass Spectrometer and the Mass Frontier , Software Package 9Structural Determination of Flavonoids Using MSn 2Structural Determination of Flavonoids Using MSn 3Structural Determination of Flavonoids Using MSn 4
... GeneBLAzer cell-based assays utilize the ... of the negatively charged fluorescent beta-lactamase ... esters readily enter the cell, where ... converts them into their negatively charged ...
... GeneBLAzer cell-based assays utilize the membrane-permeant ... the negatively charged fluorescent beta-lactamase substrates, ... readily enter the cell, where cleavage ... them into their negatively charged forms, ...
1M stock solution (238mg/ml)...
Request Info...
Biology Products: