Navigation Links
Kidney gene implicated in increased heart failure risk
Date:1/17/2011

Scientists have identified the first DNA sequence variant common in the population that is not only associated with an increased risk of heart failure, but appears to play a role in causing it.

The variant, a change in a single letter of the DNA sequence, impairs channels that control kidney function.

"It's not a heart gene," says Gerald W. Dorn II, MD, the Philip and Sima K. Needleman Professor of Medicine at Washington University School of Medicine in St. Louis and a lead investigator on the study. "It's a kidney gene. This protein is not even expressed in the heart. Nobody has previously considered that kidney-specific gene defects might predispose you to heart failure."

Heart failure is diagnosed when the heart can no longer provide sufficient blood to the body. It can have a number of causes, including high blood pressure, cancer therapy, viral infections of the heart or heart attack.

"It's a syndrome," Dorn says. "You've had sufficient damage to your heart that it doesn't work very well. You collect fluid in your lungs, you swell up, and you have trouble breathing."

The unexpected results highlight the advantage of performing genome-wide studies to find DNA sequence variants associated with disease.

"I was surprised by the finding," says Thomas P. Cappola, MD, assistant professor of medicine at the University of Pennsylvania School of Medicine, also a lead investigator on the study. "This is a good example of how taking unbiased approaches to study human disease can lead you to unexpected targets."

The study, a collaboration between Washington University School of Medicine, the University of Pennsylvania and other institutions, appears Jan. 17 in The Proceedings of the National Academy of Sciences.

In previous work, Dorn and colleagues used a partial genome-wide search technique to define the region of DNA in which sequence changes were associated with heart failure. But mo
'/>"/>

Contact: Joni Westerhouse
westerhousej@wustl.edu
314-286-0120
Washington University School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Blood pressure control system found in kidneys structural units
2. Researchers discover genetic predisposition for breast, kidney cancers
3. Scientists learn more about how kidneys fail and how new drugs may intervene
4. Common diabetes drug may halt growth of cysts in polycystic kidney disease
5. UCSF unveils model for implantable artificial kidney to replace dialysis
6. TGen-led studies identify genetic links to kidney disease, kidney failure
7. Genetically modified cell procedure may prove useful in treating kidney failure
8. Study finds epigenetic similarities between Wilms tumor cells and normal kidney stem cells
9. International research team discovers novel genes influencing kidney disease risk
10. Promising results shown for kidney cancer drug
11. Australian study sheds light on kidney repair and disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Kidney gene implicated in increased heart failure risk
(Date:9/17/2014)... creation of the Santa Ana Wildfire Threat Index ... of the powerful, hot, dry Santa Ana wind, which ... was introduced Sept. 17 by the U.S. Forest Service, ... Electric. , The index includes four classification levels ranging ... help fire agencies and other emergency responders, the media ...
(Date:9/17/2014)... an EC-FP5 four-year project, delivering its first release in ... participations in several EC projects, as a part of ... (EU BON), to increase the general awareness of the ... general dissemination of the Fauna Europaea results, the ... novel e-Publishing tools to prepare data papers for all ...
(Date:9/17/2014)... plastic shopping bags and their environmental impact recently scored ... first statewide ban on the bags, and Governor Jerry ... bag industry is not yielding without a fight, according ... , the weekly newsmagazine of the American Chemical Society. ... that the anti-bag campaign logged its first small victory ...
Breaking Biology News(10 mins):UCLA scientists play key role in developing new Santa Ana Wildfire Threat Index 2Contributions on Fauna Europaea: Data papers as innovative model on expert involvement 2
... is also available in Spanish . , ... the University of Granada and the Spanish Institute ... Spanish Ministry of Education and Science ) has studied the ... has been found that, contrary to popular belief, rivers do ...
... been found in male cichlid fish that evolved to lure ... the females mouths. A study in the online open access ... egg-like markings on the fins of cichlid fishes and uncovers ... the success of the fishes, exotic oral mating behaviour. ...
... lakes, reservoirs and groundwater as well as snow fields ... support terrestrial life and human livelihoods. Continuous observations ... benefit of mankind and the environment and also to ... as floods and droughts. These tasks are routinely undertaken ...
Cached Biology News:Scientists from the UGR prove that rivers do not act as barriers for groundwater flow 2Space technology put into service for global water resources observations 2
(Date:9/18/2014)... 18, 2014 Leatherwood Plastics has ... material, to stay competitive in the semiconductor, clean ... materials ultimately impact product quality and productivity, according ... , Established in 1980 in Lewisville, TX, ... fabricators have left the business. Much of Leatherwood’s ...
(Date:9/18/2014)... Sept. 18, 2014  Neogen Corporation (Nasdaq: ... a strategic agreement with Merck Animal Health to market ... The Igenity Dairy Heifer Program consists of genomic ... the genetic potential of replacement dairy heifers. The genomic ... born, and is an excellent tool in the decision-making ...
(Date:9/18/2014)... LOUIS , Sept. 18, 2014   ... announced today it has entered into a new ... (U-M) Medical School,s Vector Core. Under the partnership, ... CRISPR technology, experimental design consultation, and dedicated gene ... to accelerate gene editing-based research at the U-M ...
(Date:9/18/2014)... dysplasia is a group of rare diseases that ... cartilage. Its onset hits at the fetal stage ... in the gene encoding fibroblast growth factor receptor ... of skeletal dysplasia, thanatophoric dysplasia (TD), a skeletal ... and is often lethal, and achondroplasia (ACH), which ...
Breaking Biology Technology:Leatherwood Plastics Selects Vycom’s Flametec PVC-C Material to Stay Competitive in Semiconductor and Lab Equipment Industries 2Merck Animal Health to market Neogen's dairy genomic program 2Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 2Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 3Sigma-Aldrich, University of Michigan Medical School Establish CRISPR Core Lab Partnership 4Researchers use iPS cells to show statin effects on diseased bone 2Researchers use iPS cells to show statin effects on diseased bone 3
... Technologies, a global leader in scientific asset management, ... its third in a series of four Global ... 4th annual Biorepositories Conference on Sept. 19, 2011 ... of multidisciplinary professionals and experts within the biobanking ...
... 2011 Cellectis (Alternext: ALCLS), the French ... nuclease production capacity has increased ten-fold in ... the nuclease manufacturing gives Cellectis bioresearch, the ... Cellectis, the potential to supply the technology ...
... 7, 2011 CMC Biologics and Oxford BioTherapeutics (OBT) ... license agreement providing OBT with access to CMC Biologics, ... have not been disclosed, covers the research, development, and ... CHEF1 cell line development platform promotes high level expression ...
Cached Biology Technology:BioStorage Technologies, Inc. to Hold Global Sample Management Benchmarking Symposium in Conjunction With 2011 IIR Biorepositories Conference 2BioStorage Technologies, Inc. to Hold Global Sample Management Benchmarking Symposium in Conjunction With 2011 IIR Biorepositories Conference 3Cellectis Announces a Ten-Fold Increase in Nuclease Production Capacity in 2011 2CMC Biologics Licenses Its CHEF1® Expression System to Oxford BioTherapeutics 2CMC Biologics Licenses Its CHEF1® Expression System to Oxford BioTherapeutics 3CMC Biologics Licenses Its CHEF1® Expression System to Oxford BioTherapeutics 4
Request Info...
Goat polyclonal to Factor VIII, prediluted ( Abpromise for all tested applications). Antigen: Full length native protein (purified) (Human): Factor VIII from blood. Entrez GeneID: 2157 Sw...
Anti-Bcl-G (CT) Host: rabbit polyclonal Species Reactivity: human, mouse, rat Applications: WB, IHC Storage: 4C...
Affinity Purified Rabbit Anti-mouse sRANKL Biotinylated Polyclonal Antibody...
Biology Products: