Navigation Links
Key to future medical breakthroughs is systems biology, say leading European scientists
Date:1/13/2009

Crucial breakthroughs in the treatment of many common diseases such as diabetes and Parkinson's could be achieved by harnessing a powerful scientific approach called systems biology, according to leading scientists from across Europe. In a Science Policy Briefing released today by the European Science Foundation, the scientists provide a detailed strategy for the application of systems biology to medical research over the coming years.

Systems biology is a rapidly advancing field that combines empirical, mathematical and computational techniques to gain understanding of complex biological and physiological phenomena. For example, dozens, or even hundreds, of proteins can be involved in signalling processes that ensure the proper functioning of a cell. If such a signalling network is disturbed in any way, diseases such as cancer and diabetes can result.

Conventional approaches of biology do not have the capacity to unravel these elaborate webs of interactions, which is why drug design often fails. Simply knocking out one target molecule in a biochemical pathway is turning out to be a flawed strategy for drug design, because cells are able to find alternative routes. It is a similar scenario to setting up a roadblock: traffic will grind to a standstill for a short time, but soon motorists will start turning around and using side-roads to get to their destination. Just as the network of roads allows alternative routes to be used, the network of biochemical pathways can enable a disease to by-pass a drug.

Systems biology is now shedding light on these complex phenomena by producing detailed route maps of the subcellular networks. These will make it possible for scientists to develop smarter therapeutic strategies for example by disrupting two or three key intersections on a biochemical network. This could lead to significant advances in the treatment of disease and help with the shrinking pipeline of pharmaceutical companies using tradi
'/>"/>

Contact: Olaf Wolkenhauer
Olaf.Wolkenhauer@uni-rostock.de
49-038-149-87570
European Science Foundation
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Great Plains historical stability vulnerable to future changes
2. Gene may hold key to future cancer hope
3. DOE publishes update of plan: Facilities for the Future of Science: A 20-Year Outlook
4. NASA technology helps predict and prevent future pandemic outbreaks
5. Sunbathing tree frogs future under a cloud
6. Methane from microbes: a fuel for the future
7. Setting a course for the future of tissue engineering
8. Air quality forecasts see future in space
9. Oceans Past: A Guide to Oceans Future
10. Building the future -- 21st century nano tools to repair the nervous system
11. Climate change in the Baltic Sea basin -- past, present and future
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2014)... river turtle in North America, weighing in at up ... researchers from Florida and the University of Vermont have ... three. , Examining museum specimens and wild turtles, the ... , Once heavily hunted for turtle meat alligator ... in the 1960s the riverine populations have been ...
(Date:4/23/2014)... shows Africa,s Congo rainforest, the second-largest tropical rainforest in ... over the past decade. , The study, led by ... New York, shows between 2000 and 2012 the decline ... The research, published Wednesday in Nature , is ... the effects of long-term drought on the Congo rainforest ...
(Date:4/23/2014)... domestic heating may contribute to early fetal death according ... Research Institute of Children,s Hospital Los Angeles and Ulaanbaatar, ... , In a paper published today in the journal ... strong statistical correlations" between seasonal ambient air pollutants and ... has one of the highest levels of air pollution ...
Breaking Biology News(10 mins):Two new US turtle species described 2Two new US turtle species described 3NASA satellites show drought may take toll on Congo rainforest 2NASA satellites show drought may take toll on Congo rainforest 3Pollutants from coal-burning stoves strongly associated with miscarriages in Mongolia 2
... scientific results from an ambitious voyage led by a group ... San Diego offer a stark view of human pollution and ... been labeled as the "Great Pacific Garbage Patch." Two ... or SEAPLEX, found evidence of plastic waste in more than ...
... continuing partnership with Smithsonian Institution Scholarly Press, has converted ... to digital formats for use on Kindles, Nooks and ... unprecedented access to a vast research collection. These scholarly ... take up valuable physical space or face the threat ...
... Conservation Biology Institute and George Mason University broke ... that embodies the concept of the living classroom. ... Program has trained future conservationists with an interdisciplinary ... National Zoological Park,s 3,200-acre facility in Front Royal, ...
Cached Biology News:Scripps study finds plastic in 9 percent of 'garbage patch' fishes 2Scripps study finds plastic in 9 percent of 'garbage patch' fishes 3Smithsonian Conservation Biology Institute and George Mason University expand partnership 2
(Date:1/15/2014)... NC (PRWEB) January 15, 2014 DTS ... to its Online Web Portal for Life Science organizations who ... to specify the subject matter of their documents in advance ... will help reduce time-to-delivery of translations, often a critical factor ...
(Date:1/14/2014)... Date: Friday, April 11, 2014 , Time: 6 p.m. ... Road, Warrington, Pa. , Details: The Hepatitis B ... a cure for hepatitis B and improving the quality of ... Ball on Friday, April 11 at Warrington Country Club in ...
(Date:1/14/2014)... 2014 EquitiesIQ, a leading informational research ... Alliqua is an emerging biomedical company acquiring, developing, manufacturing, ... market. , Free report download: http://equitiesiq.com/reports/alliqua/ , ... management team and Board, which launched the company’s new ...
(Date:1/14/2014)...  RXi Pharmaceuticals Corporation (OTCQX: RXII), a biotechnology company ... addressing major unmet medical needs using RNA-targeted technologies, ... Allowance from the United States Patent and Trademark ... for the treatment of fibrosis. The patent covers ...
Breaking Biology Technology:DTS Improves Efficiency for Life Science Document Translations 2Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3
... DIEGO and PHILADELPHIA, March 19, 2012 Toby Odenheim, director ... contract research organization (CRO), is slated to present on ... at the Outsourcing in Clinical Trials, East Coast ... Odenheim will speak at 11 a.m. EDT, Wed., March 28, ...
... the ,Scotch tape technique," researchers first extracted graphene with a ... of carbon atoms arranged in a honeycomb, hexagonal pattern. It ... material. It is one-hundred-times better at conducting electricity than silicon. ... thick, it is so thin as to be essentially a ...
...  Foundation for Health Improvement and Technology (FHIT), ... nonprofit, with the mission to rid the world ... educational programs promoting early detection and aggressive medical ... have made it entirely possible to detect many ...
Cached Biology Technology:Synteract Director of IT Services Toby Odenheim Speaking at March 2012 Outsourcing in Clinical Trials East Coast Conference 2Synteract Director of IT Services Toby Odenheim Speaking at March 2012 Outsourcing in Clinical Trials East Coast Conference 3Straintronics: Engineers create piezoelectric graphene 2Straintronics: Engineers create piezoelectric graphene 3Straintronics: Engineers create piezoelectric graphene 4Foundation for Health Improvement and Technology (FHIT) Launched to Beat Cardiovascular Disease 2
Request Info...
... blotted protein on PVDF membrane or with ... N-terminal sequence of proteins (5-20 residues) can ... HPLC or mono-and bidimensional SDS-PAGE, followed by ... the well known EDMAN degradation method. Pre-treatment ...
Mycoplasma Removal Agent (MRA) has been developed for cell culture, to combat the widespread problems caused by contamination of cell cultures with mycoplasma....
... 5 ml Dynabeads® (4.5 ... BerEP4 against the human epithelial ... molecule). Also available in ... 10e7 MNC in 1 ml ...
Biology Products: