Navigation Links
Key to future medical breakthroughs is systems biology, say leading European scientists
Date:1/13/2009

Crucial breakthroughs in the treatment of many common diseases such as diabetes and Parkinson's could be achieved by harnessing a powerful scientific approach called systems biology, according to leading scientists from across Europe. In a Science Policy Briefing released today by the European Science Foundation, the scientists provide a detailed strategy for the application of systems biology to medical research over the coming years.

Systems biology is a rapidly advancing field that combines empirical, mathematical and computational techniques to gain understanding of complex biological and physiological phenomena. For example, dozens, or even hundreds, of proteins can be involved in signalling processes that ensure the proper functioning of a cell. If such a signalling network is disturbed in any way, diseases such as cancer and diabetes can result.

Conventional approaches of biology do not have the capacity to unravel these elaborate webs of interactions, which is why drug design often fails. Simply knocking out one target molecule in a biochemical pathway is turning out to be a flawed strategy for drug design, because cells are able to find alternative routes. It is a similar scenario to setting up a roadblock: traffic will grind to a standstill for a short time, but soon motorists will start turning around and using side-roads to get to their destination. Just as the network of roads allows alternative routes to be used, the network of biochemical pathways can enable a disease to by-pass a drug.

Systems biology is now shedding light on these complex phenomena by producing detailed route maps of the subcellular networks. These will make it possible for scientists to develop smarter therapeutic strategies for example by disrupting two or three key intersections on a biochemical network. This could lead to significant advances in the treatment of disease and help with the shrinking pipeline of pharmaceutical companies using tradi
'/>"/>

Contact: Olaf Wolkenhauer
Olaf.Wolkenhauer@uni-rostock.de
49-038-149-87570
European Science Foundation
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Great Plains historical stability vulnerable to future changes
2. Gene may hold key to future cancer hope
3. DOE publishes update of plan: Facilities for the Future of Science: A 20-Year Outlook
4. NASA technology helps predict and prevent future pandemic outbreaks
5. Sunbathing tree frogs future under a cloud
6. Methane from microbes: a fuel for the future
7. Setting a course for the future of tissue engineering
8. Air quality forecasts see future in space
9. Oceans Past: A Guide to Oceans Future
10. Building the future -- 21st century nano tools to repair the nervous system
11. Climate change in the Baltic Sea basin -- past, present and future
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... , Dec. 16, 2014 Research and ... the addition of the "Global Chemical Sensor ... http://photos.prnewswire.com/prnh/20130307/600769 ... the increasing demand for medical sensors in biomedical ... data for quick and correct diagnosis during surgical ...
(Date:12/15/2014)... , Dec. 12, 2014 Research and ... the addition of the "Global Facial Recognition ... http://photos.prnewswire.com/prnh/20130307/600769 ... identification of individuals. Facial recognition system measures the ... nose, jaw edges, mouth, and the distance between ...
(Date:12/11/2014)... 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced the addition of ... report to their offering. One ... adoption of multimodal biometric systems. Multimodal biometric systems ... for verification and identification purposes. This helps to ...
Breaking Biology News(10 mins):Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... down of their woody material, could be the key to ... researchers who add that the approach could also help turn ... major component of woody plant material, is woven in with ... gusts of wind and microbial attack. However, this protective barrier ...
... socioeconomic status and children,s educational environment. Nevertheless, some ... of high parental education and support for learning ... psychologists Angela Friend, John C. DeFries and Richard ... on reading disability, the most commonly identified learning ...
... 22, 2008, Cambridge, UK A new report demonstrates ... hand in seeking out bacteria in chronic infections. ... that can cause severe illness and death. Listeria ... infection is the third most common cause of bacterial ...
Cached Biology News:Modified plants may yield more biofuel 2The effect of parental education on the heritability of children's reading disability 2New research lights up chronic bacterial infection inside bone 2
(Date:12/19/2014)...  Decision Resources Group finds that the ... moderately through 2023 as the aging population, increasing adoption ... biomaterials all spur procedure volumes. Growth will be particularly ... and India , where ... for a larger proportion of the population. ...
(Date:12/19/2014)... -- Relmada Therapeutics, Inc. (OTCQB: RLMD), a clinical-stage company ... announced the results of its annual general meeting of ... year in Relmada,s history and it set the stage ... Sergio Traversa , chief executive officer of Relmada. "Over ... human resource and clinical development objectives that position Relmada ...
(Date:12/17/2014)... “Never say, ‘I cannot do ... Department of Physics, advises young women pursuing careers ... SPIE Women in Optics 18-month planner ... ask questions.” , In the annual planner, women ... ranging from university professor and laboratory researcher to ...
(Date:12/17/2014)... 2014 Once more, EMAAR has ... packaged waste water treatment plant to phase one of ... (KAEC). Two years ago Bioshaft successfully supplied and operated ... two residential towers with an occupancy of 900 residences. ... million gallons per day and was signed on September ...
Breaking Biology Technology:Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 2Asia Pacific Dental Biomaterial Market Will Grow Strongly Through 2023 3Relmada Therapeutics Announces Results of Annual Shareholders Meeting 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 2Network, Multitask, Persevere: SPIE Women in Optics Planner Subjects Share from Experience 3
... ACCESS PHARMACEUTICALS, INC. (OTC Bulletin Board: ... proprietary polymer-based oral mucositis product has been launched ... countries by its European commercial partner, SpePharm, a ... of high medical value medicines in supportive and ...
... Micromet, Inc. (Nasdaq: MITI ), a ... of cancer, inflammation and autoimmune diseases, yesterday presented data ... Cancer Research (AACR) in Denver, Colorado, showing that its ... Cancer stem cells are thought to be responsible for ...
... Research and Manufacturers of America (PhRMA) and the national ... to promote three key policies designed to help achieve ... Families USA will work together and will reach out ... incorporated in the healthcare reform proposals to be considered ...
Cached Biology Technology:Access Pharmaceuticals Announces the European Launch of MuGard(TM) by its European Partner, SpePharm 2Access Pharmaceuticals Announces the European Launch of MuGard(TM) by its European Partner, SpePharm 3Micromet Presents Data at AACR Meeting Showing Elimination of Colorectal Cancer Stem Cells by BiTE Antibody MT110 2Micromet Presents Data at AACR Meeting Showing Elimination of Colorectal Cancer Stem Cells by BiTE Antibody MT110 3Micromet Presents Data at AACR Meeting Showing Elimination of Colorectal Cancer Stem Cells by BiTE Antibody MT110 4PhRMA, Families USA Jointly Promote Measures to Ensure Quality, Affordable Healthcare Coverage 2PhRMA, Families USA Jointly Promote Measures to Ensure Quality, Affordable Healthcare Coverage 3
...
...
... Mouse A-20 cells were cultured in RPMI ... the log phase of growth. In order ... cells were fixed in acetone-methanol. The cells ... coated slide, with each wells surface specifically treated ...
... proteases/caspases initiates apoptosis in mammalian cells. ... provides a simple and convenient means for ... in intact cells. The assay utilizes ... linked to rhodamine 110 (D2R), a reported ...
Biology Products: