Navigation Links
Key to future medical breakthroughs is systems biology, say leading European scientists
Date:1/13/2009

Crucial breakthroughs in the treatment of many common diseases such as diabetes and Parkinson's could be achieved by harnessing a powerful scientific approach called systems biology, according to leading scientists from across Europe. In a Science Policy Briefing released today by the European Science Foundation, the scientists provide a detailed strategy for the application of systems biology to medical research over the coming years.

Systems biology is a rapidly advancing field that combines empirical, mathematical and computational techniques to gain understanding of complex biological and physiological phenomena. For example, dozens, or even hundreds, of proteins can be involved in signalling processes that ensure the proper functioning of a cell. If such a signalling network is disturbed in any way, diseases such as cancer and diabetes can result.

Conventional approaches of biology do not have the capacity to unravel these elaborate webs of interactions, which is why drug design often fails. Simply knocking out one target molecule in a biochemical pathway is turning out to be a flawed strategy for drug design, because cells are able to find alternative routes. It is a similar scenario to setting up a roadblock: traffic will grind to a standstill for a short time, but soon motorists will start turning around and using side-roads to get to their destination. Just as the network of roads allows alternative routes to be used, the network of biochemical pathways can enable a disease to by-pass a drug.

Systems biology is now shedding light on these complex phenomena by producing detailed route maps of the subcellular networks. These will make it possible for scientists to develop smarter therapeutic strategies for example by disrupting two or three key intersections on a biochemical network. This could lead to significant advances in the treatment of disease and help with the shrinking pipeline of pharmaceutical companies using tradi
'/>"/>

Contact: Olaf Wolkenhauer
Olaf.Wolkenhauer@uni-rostock.de
49-038-149-87570
European Science Foundation
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Great Plains historical stability vulnerable to future changes
2. Gene may hold key to future cancer hope
3. DOE publishes update of plan: Facilities for the Future of Science: A 20-Year Outlook
4. NASA technology helps predict and prevent future pandemic outbreaks
5. Sunbathing tree frogs future under a cloud
6. Methane from microbes: a fuel for the future
7. Setting a course for the future of tissue engineering
8. Air quality forecasts see future in space
9. Oceans Past: A Guide to Oceans Future
10. Building the future -- 21st century nano tools to repair the nervous system
11. Climate change in the Baltic Sea basin -- past, present and future
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/5/2014)... career to understanding the Earth,s climate and communicating ... deputy director and regional climatologist for the Western ... Redmond has more than three decades of experience ... data to the general public. , At its ... December 15-19, 2014 the American Geophysical Union (AGU) ...
(Date:11/4/2014)... School of Medicine announced today that it is ... by the Bill & Melinda Gates Foundation. ... and Reproductive Sciences; and Vice Chair of Research ... Medicine will pursue an innovative global health and ... Assess Fetal Neurodevelopment.", Grand Challenges Explorations (GCE) funds ...
(Date:11/4/2014)... (Nov. 4, 2014) – A majority of Madagascar,s 101 ... could have serious consequences for the rainforests they call ... the positive impacts lemurs can have on rainforest tree ... disappearance could have on the region,s rich biodiversity. , ... fruits eaten by lemurs. Lemurs in turn disperse ...
Breaking Biology News(10 mins):Nevada climatologist to be honored at AGU Fall Meeting for lifetime of public outreach 2Temple University School of Medicine receives Grand Challenges Explorations grant 2Gardeners of Madagascar rainforest at risk 2Gardeners of Madagascar rainforest at risk 3
... Amgen TM Oncology Assistance (AOA), a comprehensive, ... "cap" on out-of-pocket co-payments for cancer patients receiving ... who are uninsured, underinsured, or unable to afford ... support for Amgen's cancer medicines. , "We recognize ...
... small segment of DNA in the genome of a primeval ... animals from sea to land, or to later key evolutionary ... copied DNA elements known as retroposons could be an important ... Howard Hughes Medical Institute investigator David Haussler. , "The ...
... of G&D, Dr. Marie-Louise Hammarskjold (UVA) and colleagues lend ... 1 tumor suppressor. The Wilms' Tumor 1 (WT1) protein ... with known roles in kidney and urogenital formation as ... and colleagues reveal that WT1 works not only at ...
Cached Biology News:Amgen introduces comprehensive financial assistance programs for cancer patients 2Mobile DNA part of evolution's toolbox 2Mobile DNA part of evolution's toolbox 3Mobile DNA part of evolution's toolbox 4
(Date:11/24/2014)... Belgium , Nov. 24, 2014 ... focused on developing diagnostic tests for cancer and other conditions, ... will be presented at the Science for Business BioWin Day ... Belgium . The data come from VolitionRx,s lung cancer ... Pneumology department of the Centre Hospitalier Universitaire (CHU) de Liege ...
(Date:11/24/2014)... (PRWEB) November 23, 2014 One of the ... of optics and photonics is now available to high school ... low cost. SPIE, the international society for optics and ... the complete SPIE Digital Library available to high ... , “Light-based technologies are integral to all areas of life ...
(Date:11/24/2014)... November 24, 2014 The new ... from METTLER TOLEDO demonstrates how to reduce the ... analytics and sample panel design can be complicated, ... and protect against corrosion and deposition. Dedicated single ... significant amount of panel space. Additionally, installing and ...
(Date:11/23/2014)... 2014 Apiscent Labs, a privately ... chemical ingredients to the global pharmaceutical and flavor ... new website, Apiscent.com. , The Apiscent.com homepage welcomes ... design, easy navigation, rotating images and content focused ... out. , The company’s work in ...
Breaking Biology Technology:VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 2VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 3VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 4VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 5VolitionRx to Present Positive Data from Pilot Lung Cancer Study at BioWin Day 2014 6SPIE Digital Library Now Available to High Schools, Two-Year Colleges at No or Low Cost 2New Video Shows How to Simplify Cycle Chemistry Sample Panels to Save Time and Costs 2
... , Compatible with GeneChip , ... little as 100 , ng RNA in a single round ... ArrayScript engineered M-MLV RT, engineered to maximize , ... cRNA synthesis powered by , ...
... More thermostable than AMV RT and M-MLV RT , ... Highly sensitive enzyme for RT-PCR applications , ... G/C content , ... AMV RT, Ambion's HIV RT synthesizes cDNA from single-stranded , ...
... Probe & Marker Kit , ... , small RNAs , Prepare high specific activity RNA ... small RNA probes , , Contains ... DNA and RNA positive controls , The new <A , ...
Cached Biology Technology:RNA Amplification Just Got Better: MessageAmp II 2RNA Amplification Just Got Better: MessageAmp II 3RNA Amplification Just Got Better: MessageAmp II 4RNA Amplification Just Got Better: MessageAmp II 5Recombinant HIV Reverse Transcriptase 2Rapidly Prepare Probes and Markers for Small RNA Analysis 2Rapidly Prepare Probes and Markers for Small RNA Analysis 3Rapidly Prepare Probes and Markers for Small RNA Analysis 4
Chicken polyclonal to Thaumatin 2 ( Abpromise for all tested applications). Antigen: Full length Thaumatin 2...
Proteinase K Buffer 3.9 ml...
Rabbit polyclonal to VEGF Receptor 2 (phospho Y1214) ( Abpromise for all tested applications). entrezGeneID: 3791 SwissProtID: P35968...
Glutathione Agarose Beads 10 ml...
Biology Products: