Navigation Links
Keck Foundation funds study of biological interactions with nanomaterials

The University of Oregon has received a $1.6 million grant from the W.M. Keck Foundation to explore the biological effects of exposure to precisely engineered nanoparticles that are being designed for diagnostic and therapeutic uses.

The three-year grant from the Keck Foundations medical research program will involve six researchers: Mark Lonergan, Jim Hutchison and Andy Berglund, all UO professors of chemistry; UO biology professors Karen Guillemin and Eric Johnson; and Robert Tanguay, a professor of environmental and molecular toxicology at Oregon State University.

All are members of the Safer Nanomaterials and Nanomanufacturing Initiative (SNNI), directed by Hutchison and part of the Oregon Nanoscience and Microtechnologies Institute (ONAMI).

This award from the Keck Foundation puts us at the forefront of this quickly developing and promising field of nanotechnology, said UO President Dave Frohnmayer. Nanotechnology has been described as being in its discovery phase. This newly funded project means the University of Oregon, Oregon State University and the state, through ONAMI Oregons first Signature Research Center can help build a green roadmap for the field.

The interdisciplinary project is designed to help researchers understand potential biological interactions of engineered nanomaterials and develop design rules for the development of nanoparticles with enhanced biological properties. The researchers will produce specific structures of nanomaterials, investigate their interactions with biological systems and then design new materials and nanoparticle libraries that have specific biological responses.

The biological testing will involve laboratory experiments using zebrafish, an invertebrate animal model system that was first developed for research at the University of Oregon. With zebrafish, researchers can monitor tissue-specific interactions with nanoparticles, developmental and acute toxicity, and the impacts of exposure on gene regulation.

The researchers will address existing gaps in the field, from the basic construction of nanoparticles to how they interface with biological cells. As the foundation for the project, the group will build upon the library of gold nanoparticles created by Hutchison using his patented green-chemistry approach.

Our goal is to define the important interactions at the bio-nano interface, as well as the ground rules for producing nanoparticles that have very fine-tuned objectives, Hutchison said. The end results could lead to a variety of future therapeutics that specifically seek out and destroy cancer cells or promote desired cell growth for tissue regeneration.

The Keck Foundation funds will cover just under $1 million in graduate and faculty research, with the remainder going toward the purchase of equipment and space for housing it. The instruments will go into the Lorry I. Lokey Laboratories, the underground portion of the Integrated Science Complex, where some of the projects research will be conducted.


Contact: Jim Barlow
University of Oregon

Related biology news :

1. W.M. Keck Foundation funds study of friendly microbes
2. Digging in the dirt for lifes biochemical foundations
3. Protein folding: Building a strong foundation
4. WHO suspends Marburg work, appeals for new funds
5. Grand Challenges in Global Health initiative funds Yale project
6. European Commission funds EBI to do new research on synergies between bioinformatics and medical informatics
7. Federal grant funds research on novel HIV therapy
8. Bioartificial kidney under study at MCG
9. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
10. Yellowstone microbes fueled by hydrogen, according to U. of Colorado study
11. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
Post Your Comments:
(Date:11/4/2015)... York , November 4, 2015 ... a new market report published by Transparency Market Research "Home ... Growth, Trends and Forecast 2015 - 2022", the global home ... US$ 30.3 bn by 2022. The market is estimated ... forecast period from 2015 to 2022. Rising security needs ...
(Date:10/29/2015)... RESTON, Va. , Oct. 29, 2015 ... announced today that it has released a new version ... Daon customers in North America ... gains. IdentityX v4.0 also includes a FIDO UAF ... customers are already preparing to activate FIDO features. These ...
(Date:10/29/2015)... , Oct. 29, 2015 Today, ... a partnership with 2XU, a global leader in ... a smart hat with advanced bio-sensing technology. The ... athletes to monitor key biometrics to improve overall ... partnership, the two companies will bring together the most ...
Breaking Biology News(10 mins):
(Date:11/30/2015)... 30, 2015 /PRNewswire/ - Zenith Epigenetics Corp. ("Zenith" or the ... C.W. Wong to its Board of Directors to replace ... with a wealth of experience as co-founder of Resverlogix, with ... --> --> Dr. Wong remarked, ... of directors. Zenith,s long standing expertise in epigenetics and the ...
(Date:11/30/2015)... -- TapImmune, Inc. (TPIV), a clinical-stage ... and gene-based immunotherapeutics and vaccines for the treatment of ... presenting at the 8 th Annual LD Micro ... PT. Dr. John N. Bonfiglio a TapImmune ... presentation and will join TapImmune management in meeting with ...
(Date:11/30/2015)... 2015  Northwest Biotherapeutics (NASDAQ: NWBO ) ("NW ... therapies for solid tumor cancers, announced today that the ... and the Company welcomes Neil Woodford,s call ... anonymous internet report on NW Bio.  The Company,s Board ... Powers stated, "We agree with Mr. Woodford that, ...
(Date:11/27/2015)... , ... November 27, 2015 , ... ... that includes over 2,000 technical presentations offered in symposia, oral sessions, workshops, ... applied spectroscopy, covers a wide range of applications such as, but not limited ...
Breaking Biology Technology: