Navigation Links
JCI online ahead of print table of contents for April 17, 2014

Double-stapled peptide inhibits RSV infection

Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections, generating life-threating illness in very young and elderly populations. Despite great effort, preventive therapies are limited. RSV enters host cells through the fusion protein RSV F, which forms a six-helix fusogenic bundle. Small interfering peptides that prevent bundle formation limit RSV infection in vitro; however, these peptides are highly susceptible to degradation. In this issue of the Journal of Clinical Investigation, Loren Walensky and colleagues at the Dana-Farber Cancer Institute applied hydrocarbon stapling to stabilize the α-helical structure of an RSV F peptide (SAH-RSV). Pretreatment with SAH-RSV prevented infection in both cell culture and murine models of RSV. Intranasal delivery prevented viral infection within the nares, while intratracheal delivery of a nanoparticle preparation of SAH-RSV prevented RSV infection in the lung. In the companion Commentary, Sarah Katen and Terrence Dermody of Vanderbilt University discuss the implications of this study for RSV prevention.

TITLE: Mucosal delivery of a double-stapled RSV peptide prevents nasopulmonary infection

AUTHOR CONTACT: Loren Walensky
Dana-Farber Cancer Institute, Boston, MA, USA
Phone: 617-632-6307; Fax: 617-582-8240; E-mail:

View this article at:

ACCOMPANYING COMMENTARY TITLE: Repurposing staples for viruses: applying peptide design to RSV prophylaxis

AUTHOR CONTACT: Terence S. Dermody
Vanderbilt University School of Medicine, Nashville, TN, USA
Phone: 615-343-9943; Fax: 615-343-9723; E-mail:

View this article at:

Fibroblast-derived exosomes mediate caridiomyocyte hypertrophy via microRNA delivery

Cardiovascular disease promotes a progressive, pathological heart remodeling that is characterized by fibrosis, and cardiomyocyte hypertrophy. Gene expression patterns associated with heart disease are linked alterations in microRNAs (miRNAs), which in addition to regulating intracellular target gene expression can affect gene expression in neighboring cells. In this issue of the Journal of Clinical Investigation, Thomas Thum and colleagues at Hanover Medical School provide evindence that cardiac fibroblasts release miRNA-enriched that are taken up by neighboring cardiomyocytes and promote hypertrophy. Surprisingly, many of the miRNAs enriched in fibroblast-derived exosomes were miRNA passenger strands (miRNA*), which are typically degraded in the cytoplasm. In particular, miR-21* was required for altering cardiomyocyte-associated protein profiles, and pharmacological inhibition of miR-21* reduced angiotensin II-induced cardiac hypertrophy in a murine model. In the accompanying Commentary, Ciro Indolfi of Magna Graecia University discusses the clinical implications of targeting exosome-mediated communication between cardiac fibroblasts and myocytes.

TITLE: Cardiac fibroblastderived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy

Hannover Medical School, Hannover, DEU
Phone: +495115325272; Fax: +495115325274; E-mail:

View this article at:

ACCOMPANYING COMMENTARY TITLE: Stargazing microRNA maps a new miR-21 star for cardiac hypertrophy

Magna Graecia University, Catanzaro, , ITA
Phone: +3909613697067; E-mail:

View this article at:

Patient response to cryptococcosis is dependent on fungal-specific factors

Cryptococcal meningitis is a serious secondary complication of HIV infection that results in substantial patient mortality. Patient fungal burden in the cerebrospinal fluid (CSF) at time of diagnosis and response to antifungal therapy are predictive of disease outcome; however, cryptococcal-specific phenotypes have not been associated with clinical presentation. In this issue of the Journal of Clinical Investigation, Robin May and colleagues at the University of Birmingham evaluated 65 clinical Cryptococcus neoformans isolates collected from HIV+ individuals enrolled in clinical trials to evaluate the strain-specific impact on long-term patient survival. C. neoformans isolates that exhibited enhanced uptake by macrophages in vitro and increased laccase activity were associated with increased fungal burden, response to antifungal treatment, and increased patient mortality. In a companion Commentary, John Perfect of Duke University notes that understanding both pathogen and host-specific factors in disease etiology will enhance therapeutic strategies for treating cryptococcosis.

TITLE: Efficient phagocytosis and laccase activity affect the outcome of HIV-associated cryptococcosis

University of Birmingham, Birmingham, United Kingdom
Phone; Fax: 44.0.1214145925; E-mail:

View this article at:

ACCOMPANYING COMMENTARY TITLE: Cryptococcosis: a model for the understanding of infectious diseases

Duke University, Durham, NC, USA
Phone: 919 684 4016; Fax: 919 684 8902; E-mail:

View this article at:

The coinhibitory receptor PD-1H suppresses T cell responses

The balance between coinhibitory and costimulatory molecules on antigen presenting cells (APCs) are crucial for proper regulation of T cell responses and inflammation. Programmed death 1 homologue (PD-1H) on APCs suppresses T cell responses, and agonist and blocking antibodies targeting this ligand have been shown to exacerbate and ameliorate inflammatory conditions, respectively. In this issue of the Journal of Clinical Investigation, Leiping Chen and colleagues at Yale University examined the T cell responses in mice lacking PD-1H and found that these animals exhibit an enhanced immune response to antigen stimulation. Compared to controls animals lacking PD-1H were resistant to tumor induction in a transplant model of brain glioma. This resistance required the presence of CD4+ T cells. Administration of an agonist PD-1H antibody to mice with experimental acute hepatitis reduced disease through suppression of CD4+ T cells. In an accompanying Commentary, Yang Liu of Children's National Medical Center remarks that this study provides further evidence that targeting PD-1H has potential for treating inflammatory disease and cancers.

TITLE: Coinhibitory receptor PD-1H preferentially suppresses CD4+ T cellmediated immunity

Yale University School of Medicine, New Haven, CT, USA
Phone: 203-737-1819; E-mail:

Yale Cancer Center, New Haven, CT, USA
Phone: 203-785-7001; Email:

View this article at:


Children's National Medical Center, Washington, D.C., DC, USA
Phone: 202-476-5849; E-mail:

View this article at:


TITLE: Type-1 angiotensin receptors on macrophages ameliorate IL-1 receptor-mediated kidney fibrosis

AUTHOR CONTACT: Steven Crowley
Duke University Medical Center, Durham, NC, USA
Phone: 919-684-9788; E-mail:

View this article at:

TITLE: Monocytes expressing CX3CR1 orchestrate the development of vincristine-induced pain

AUTHOR CONTACT: Marzia Malcangio
King's College London, London, GBR
Phone: 004420-7848 6092; E-mail:

View this article at:

TITLE: Multifactorial ERβ and NOTCH1 control of squamous differentiation and cancer

AUTHOR CONTACT: Gian Paolo Dotto
University of Lausanne, Epalinges, CHE
Phone: +41/21 692 57 20; Fax: +41/21 692 57 05; E-mail:

View this article at:

TITLE: Apolipoprotein O is mitochondrial and promotes lipotoxicity in heart

INSERMU1048, Toulouse, FRA
Phone: 33 685 561 529; E-mail:

View this article at:


Contact: Corinne Williams
Journal of Clinical Investigation

Related biology news :

1. JCI online ahead of print table of contents for April 8, 2014
2. JCI online ahead of print table of contents for March 25, 2014
3. Online tool aids clinicians efforts to treat injured workers
4. Opens Its Online Store for Holiday Shopping: Personal and Corporate Gifts Available
5. Missouri Botanical Garden aims to improve access to digital texts through online gaming
6. 2 online science video pioneers combine to form new
7. Geosphere, GSAs dynamic online-only journal posts 9 new articles in Sept.
8. Online citizen scientists: Classify plankton images
9. ACLS Online Renewal Course from United Medical Education Now Features Newly-Updated Course Materials
10. Reproductive BioMedicine Online publishes study on assisted reproduction
11. 7 new GSA Bulletin articles posted online ahead of print
Post Your Comments:
(Date:1/27/2020)... ... January 27, 2020 , ... On Thursday, February 20, 2020 ... Sciences, Reed Tech and Richard Castle, Global Account Manager Medical Device at ... procedure, other topics include EU MDR timing deadlines, best practices in creating and submitting ...
(Date:1/24/2020)... ... ... Worldwide Business with kathy ireland® has announced an exclusive interview with ... and Marketing Jeff Maier to discuss their innovative technology, High-Speed Vibration Therapy. The segment ... at 5:30 p.m. EST and internationally on Bloomberg Television on Saturday, Jan. 25, 2020 ...
(Date:1/22/2020)... ... January 21, 2020 , ... Astro Pak’s president ... Business Development Department. The move, which is part of the company’s structural reorganization, ... the company’s Senior Vice President where he oversaw its Cleanroom Division as well ...
Breaking Biology News(10 mins):
(Date:2/3/2020)... ... February 03, 2020 , ... Global molecular diagnostics company ... the 11-locus, single tube multiplex successor to Holotype HLA is available through an ... and short library preparation, for HLA genotyping from sample to answer in less ...
(Date:1/27/2020)... (PRWEB) , ... January 27, 2020 , ... ... announced it has secured financing from strategic investors led by Halma plc ... from existing investors Sonion, TDF Ventures, GII LLC, and WSJ Joshua Fund. A ...
(Date:1/22/2020)... SAN MATEO, Calif. (PRWEB) , ... January 20, ... ... Home System, today announced a partnership with WAVE Electronics, the largest independent electronics ... their installer partners to purchase Brilliant Smart Home Systems with leading smart home ...
(Date:1/10/2020)... ... January 09, 2020 , ... ... today announced the acquisition of Cunesoft, a move that expands the company’s portfolio ... of life sciences companies. , Based in Munich, Germany, Cunesoft provides intelligent software ...
Breaking Biology Technology: