Date:3/15/2013

start of treatment and then retransplanted following remission; however, there is a potential risk of reintroducing malignant material during transplantation. To overcome this hurdle, Serena Dovey and colleagues at the University of Pittsburgh characterized the cell surface markers of human spermatogonia in testicular tissue from organ donors. In this issue of the Journal of Clinical Investigation, Dovey and colleagues report the development of a multi-parameter sorting approach to separate SSCs from cancerous cells. Sorted SSCs exhibited were able to function properly when transplanted into mice, but did not form tumors. These results suggest that SSC transplantation could be a viable method to preserve fertility in male childhood cancer survivors.

TITLE:
Eliminating malignant contamination from therapeutic human spermatogonial stem cells

AUTHOR CONTACT:
Kyle Orwig
University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Phone: 412-641-2460; Fax: 412-641-3899; E-mail: orwigke@upmc.edu

View this article at: http://www.jci.org/articles/view/65822?key=92403084007f62aaa983

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ALSO IN THIS ISSUE

TITLE:
Autocrine production of IL-11 mediates tumorigenicity in hypoxic cancer cells

AUTHOR CONTACT:
Giovanni Melillo
Bristol-Myers Squibb, Princeton, NJ, USA
Phone: 609-2526975; Fax: 609-252-7821; E-mail: Giovanni.Melillo@bms.com

View this article at: http://www.jci.org/articles/view/59623?key=09427167d2ca471d63fb

TITLE:
Myeloid cell-specific serine palmitoyltransferase subunit 2 haploinsufficiency reduces murine atherosclerosis

AUTHOR CONTACT:
Xian-Cheng J
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Contact: Jillian Hurst press_releases@the-jci.org Journal of Clinical Investigation Source:Eurekalert

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