Navigation Links
JCI early table of contents for Mar. 15, 2013
Date:3/15/2013

Cytoskeletal dysregulation underlies Buruli ulcer formation

Mycobacterium ulcerans infects the skin and subcutaneous tissues and secretes a lipid toxin, mycolactone, which causes open skin lesions, known as Buruli ulcers. In this issue of the Journal of Clinical Investigation, researchers led by Caroline Demangel at the Pasteur Institue in Paris investigated the molecular actions of mycolactone and found that it dysregulates the cellular skeleton (cytoskeleton) through activation of a protein known as N-WASP. They found that excessive N-WASP activity caused defects in cell adhesion and migration that impaired the integrity of the skin. Demangel and colleagues demonstrated that they could block the degradation process by administration of the N-WASP inhibitor wiskostatin. These results reveal the molecular pathogenesis of M. ulcerans and suggest that drugs that disrupt mycolactone/N-WASP interaction could be used to treat Buruli ulcers.

TITLE:
Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation

AUTHOR CONTACT:
Caroline Demangel
Institut Pasteur, Paris Cedex 15, FRA
Phone: 33 1 40 61 30 66; E-mail: demangel@pasteur.fr

View this article at: http://www.jci.org/articles/view/66576?key=27d03cca761796d4a69e


Sorting out fertility after childhood cancer

As success rates in treating childhood cancers have improved, greater emphasis is being placed on quality of life issues following successful treatment. Many cancer treatments can lead to infertility, but there are few methods to preserve the fertility of children who have not entered puberty. Spermatogonial stem cells (SSCs), which produce sperm cells, are present prior to the start of puberty. In theory, SSCs could be removed via biopsy prior to the
'/>"/>

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Artificial womb unlocks secrets of early embryo development
2. Mid-Atlantic suburbs can expect an early spring thanks to the heat of the big city
3. An early spring drives butterfly population declines
4. Hazy shades of life on early Earth
5. American Society of Plant Biologists honors early career women scientists
6. Early warning system for seizures could cut false alarms
7. A new gene thought to be the cause in early-onset forms of Alzheimers disease
8. Promising developments in early diagnosis and treatment of mesothelioma
9. Early detection techniques offer hope for improved outcomes in lung cancer patients
10. New study links air pollution and early death in the UK
11. Attendees Save Up To $800 on Boston-area Pharmaceutical and Healthcare Conferences, Early Bird Discounts Expiring April 27
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/18/2015)... Fingerprint Cards (FPC) has received an ... and FPC1035 from one if its module partners. Deliveries are ... 2015 and the sensors will be used by smartphone manufacturers ... 2015 hereby amount to 740 MSEK to date. In addition ... and a number of smaller orders not separately communicated amounting ...
(Date:5/11/2015)... , May 11, 2015  Synaptics Incorporated (NASDAQ: ... interface solutions, today announced the appointment of ... Chief Financial Officer, reporting to Rick Bergman ... current Chief Financial Officer, Kathleen Bayless , ... Mr. Ali brings extensive financial management ...
(Date:5/10/2015)... , May 11, 2015 Fingerprint Cards ... FPC1025 and FPC1155 from the distributor World Peace Industrial Group ... distributors in Asia . Deliveries are planned ... be used by smartphone manufacturers in China ... the communicated revenue guidance of + 1 000 MSEK for 2015. ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Synaptics Appoints Wajid Ali as Senior Vice President and Chief Financial Officer 2Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 235 Million 2
... A new analysis has found that the presence of ... papillary thyroid cancer tumors suggests a likelihood of recurrence ... early online in CANCER , a peer-reviewed journal ... blood levels of the genetic material after surgery may ...
... to attribute two types of tumour almost entirely to specific ... are found in nearly 100 per cent of patients suffering ... of the bone. Chondroblastoma and giant cell tumour of ... young adults, respectively. They can be extremely debilitating tumours and ...
... A new study that decoded the DNA sequence of ... similarities between its 39,040 genes and other plant species, including ... evolutionary events that occurred millions of years ago in the ... fruit crop. It has long been called ,the king of ...
Cached Biology News:Measuring segments of genetic material may help predict and monitor recurrence after thyroid cancer 2Novel mutations define 2 types of bone tumor 2Surprises discovered in decoded kiwifruit genome 2
(Date:5/28/2015)... , May 28, 2015 ... has announced the addition of Jain PharmaBiotech,s ... Markets and Companies"  to their offering.  ... disease remains a challenge in management. With ... in the seven major markets of the ...
(Date:5/28/2015)... DUBLIN , May 27, 2015 /PRNewswire/ ... announced the addition of Jain PharmaBiotech,s new ... to their offering. An ... and biotechnology industries is anticipated. Nanotechnology will ... development - from formulations for optimal delivery ...
(Date:5/28/2015)... The Academy of Model Aeronautics Foundation will ... August 15, 2015. National Model Aviation Day was created to ... model flying to the general public. , The AMA has ... in the celebration by hosting events in their own communities. ... Aviation Day events. View our online event map to ...
(Date:5/28/2015)... May 28, 2015 BioNorth Texas ... and representing the life sciences industry in northern ... Directors meeting at The Foundry in Dallas on ... organization brought together a broad spectrum of biotech ... the organization's early successes in partnering with key ...
Breaking Biology Technology:Global Alzheimer Disease Report 2015-2024 - New Drugs, Markets and Companies 2Global Alzheimer Disease Report 2015-2024 - New Drugs, Markets and Companies 3Global Nanobiotechnology Market 2015-2024 - Applications, Markets and Companies 2Global Nanobiotechnology Market 2015-2024 - Applications, Markets and Companies 3Model flying pilots celebrate the Academy of Model Aeronautics Foundation’s Third Annual National Model Aviation Day 2BioNorthTX Holds Inaugural Board of Directors Meeting 2BioNorthTX Holds Inaugural Board of Directors Meeting 3
... Feb. 4 Diplomat Specialty Pharmacy is,pleased to ... As of January 2009, DSP launched both a ... Reed has joined Diplomat as National,Sales Manager for ... Indiana University and,has over 18 years of ...
... GAITHERSBURG, Md. and ATLANTA, Feb 4 Lentigen ... and manufacture of lentiviral gene delivery technologies, and ... VIII-based therapeutics, today announced a collaborative agreement to ... A.Hemophilia A is an inherited blood clotting disorder ...
... (NYSE: APD ) and Alter NRG Corp. ... Development Agreement (JDA) to pursue renewable energy opportunities in ... Air Products the right to license and incorporate Alter ... renewable energy projects. Air Products will initially focus ...
Cached Biology Technology:Diplomat Specialty Pharmacy Expands National Hemophilia & IVIG Program 2Lentigen and Expression Therapeutics Sign Hemophilia Co-Development Agreement 2Lentigen and Expression Therapeutics Sign Hemophilia Co-Development Agreement 3Air Products and Alter NRG Sign JDA on Renewable Energy Projects 2Air Products and Alter NRG Sign JDA on Renewable Energy Projects 3Air Products and Alter NRG Sign JDA on Renewable Energy Projects 4
... Rotor for use in the ... and Centra-MP4/MP4R. Perfect for ... and other difficult to separate ... containment. Complete with rotor and ...
Buckets for 2 racks of 5 tubes, type Stago/Hitachi...
Buckets for tube holder inserts...
Rotor for four tube-loaded buckets; ma RCF 2550g; sold without buckets...
Biology Products: