Navigation Links
JCI early table of contents for Mar. 15, 2013
Date:3/15/2013

Cytoskeletal dysregulation underlies Buruli ulcer formation

Mycobacterium ulcerans infects the skin and subcutaneous tissues and secretes a lipid toxin, mycolactone, which causes open skin lesions, known as Buruli ulcers. In this issue of the Journal of Clinical Investigation, researchers led by Caroline Demangel at the Pasteur Institue in Paris investigated the molecular actions of mycolactone and found that it dysregulates the cellular skeleton (cytoskeleton) through activation of a protein known as N-WASP. They found that excessive N-WASP activity caused defects in cell adhesion and migration that impaired the integrity of the skin. Demangel and colleagues demonstrated that they could block the degradation process by administration of the N-WASP inhibitor wiskostatin. These results reveal the molecular pathogenesis of M. ulcerans and suggest that drugs that disrupt mycolactone/N-WASP interaction could be used to treat Buruli ulcers.

TITLE:
Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation

AUTHOR CONTACT:
Caroline Demangel
Institut Pasteur, Paris Cedex 15, FRA
Phone: 33 1 40 61 30 66; E-mail: demangel@pasteur.fr

View this article at: http://www.jci.org/articles/view/66576?key=27d03cca761796d4a69e


Sorting out fertility after childhood cancer

As success rates in treating childhood cancers have improved, greater emphasis is being placed on quality of life issues following successful treatment. Many cancer treatments can lead to infertility, but there are few methods to preserve the fertility of children who have not entered puberty. Spermatogonial stem cells (SSCs), which produce sperm cells, are present prior to the start of puberty. In theory, SSCs could be removed via biopsy prior to the
'/>"/>

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Artificial womb unlocks secrets of early embryo development
2. Mid-Atlantic suburbs can expect an early spring thanks to the heat of the big city
3. An early spring drives butterfly population declines
4. Hazy shades of life on early Earth
5. American Society of Plant Biologists honors early career women scientists
6. Early warning system for seizures could cut false alarms
7. A new gene thought to be the cause in early-onset forms of Alzheimers disease
8. Promising developments in early diagnosis and treatment of mesothelioma
9. Early detection techniques offer hope for improved outcomes in lung cancer patients
10. New study links air pollution and early death in the UK
11. Attendees Save Up To $800 on Boston-area Pharmaceutical and Healthcare Conferences, Early Bird Discounts Expiring April 27
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/15/2014)... , Nov. 13, 2014  While we may still be ... McCoy used in "Star Trek" to gain instant access to ... to work with smartphones and tablets for monitoring and measuring ... healthcare world. This may seem a tad Orwellian to some, ... adopt some of these technological opportunities into their healthcare regime. ...
(Date:11/7/2014)... 7, 2014  In conjunction with the Glendale ... The Community Foundation of the Verdugos has announced the " ... PROJECT," a $250,000 initiative to keep the Verdugo Regional Crime ... first six months of existence, the Lab has processed more ... local law enforcement. "Because our number one priority ...
(Date:11/6/2014)... 6, 2014 - Insilico Medicine, Inc, a Baltimore-based ... age related diseases announced a research collaboration with ... Champions Oncology, Inc (OTC: CSBR). , "There are ... medicine, but Champions Oncology,s TumorGraft technology is unique ... chemotherapy regimen experimentally generating vast amounts of valuable ...
Breaking Biology News(10 mins):Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4Community Foundation Of The Verdugos Unveils Campaign To Fund Glendale-Burbank DNA Justice Project 2Insilico Medicine, Inc announces research collaboration with Champions Oncology, Inc 2
... shady pursuit of endangered bird eggs made international headlines ... most notorious illegal egg collector, died after falling from ... The Royal Society for the Protection of Birds estimates ... are targeted by collectors. Classical economics theory predicts that ...
... world's oceans to land about 415 million years ago, then ... record contains few examples of animals with backbones for the ... again, this time for good. , The mysterious lull in ... for the Yale University paleontologist, Alfred Romer, who first recognized ...
... games this holiday season because the fun of playing ... , Psychologists at the University of Rochester, in collaboration ... 1,000 gamers what motivates them to keep playing. The ... month suggest that people enjoy video games because they ...
Cached Biology News:A human taste for rarity spells disaster for endangered species 2A human taste for rarity spells disaster for endangered species 3Steep oxygen decline halted first land colonization by Earth's sea creatures 2A reason why video games are hard to give up 2
(Date:11/26/2014)... NJ (PRWEB) November 25, 2014 ... has officially joined the Morris County (New Jersey) ... which is a leading business organization in the ... opportunity to further engage some key clients in ... operations in the geographic area. Membership enables Whitehouse ...
(Date:11/26/2014)... The Pittcon marketing department is pleased to announce ... app, Pittcon 2015 . The ... for iOS and Android devices and the Kindle Fire, ... after the event. It acts as an all-inclusive real-time ... Conferee Networking sessions and short courses. , The Pittcon ...
(Date:11/26/2014)... and WILMINGTON, DE (PRWEB) November 26, 2014 ... Annual MPN Heroes recognition reception on December 5, 2014, ... Hematology’s annual meeting. The MPN Heroes event will honor ... in the field of myeloproliferative neoplasms (MPNs). , ... "Nashville," will discuss his family's cancer journey at the ...
(Date:11/26/2014)... TOKYO , 25 novembre 2014 /PRNewswrie/ -- Theravalues ... per il mercato europeo in occasione di Hi Europe ... ). Si tratta della curcumina con ... tecnologia amorfa (senza cristalli) e ingredienti approvati dalle norme ... presente nella spezia della pianta curcumina ( Curcuma longa ...
Breaking Biology Technology:Whitehouse Laboratories Joins Morris County Chamber of Commerce 2Whitehouse Laboratories Joins Morris County Chamber of Commerce 3Pittcon Releases 2015 Mobile App 2CURE Magazine and Incyte to Honor MPN Heroes 2CURE Magazine and Incyte to Honor MPN Heroes 3CURE Magazine and Incyte to Honor MPN Heroes 4La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 2La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 3
... October 20 Speaking in Rome, Italy today ... Foundation,(IOF) CEO Patrice McKenney called for individuals and ... osteoporosis. "Osteoporosis is a common but,devastating disease which ... taken to reduce the burden of osteoporotic fractures ...
... Air Force-funded researcher, Dr. scar Custance from the National Institute ... 2009 Feynman Prize for Experimental Work in Nanotechnology for his ... research could someday lead to more effective catalysts for the ... experimental work will be awarded in January 2010 near Palo ...
... Neurobiological Technologies, Inc. (Nasdaq: NTII ) ("NTI") announced ... Market LLC ("NASDAQ") that NTI intends to file a Form ... about October 28, 2009 to effect the voluntary delisting of ... dissolution of the company pursuant to a Plan of Complete ...
Cached Biology Technology:World Osteoporosis Day Call for Immediate Action to Prevent Fractures 2Researcher honored for experimental work in nanotechnology 2
... a DNA sequencing service. We can sequence ... products, BACs, etc. Our DNA sequencing service ... plasmids or purified PCR products. We use ... automated reaction setup and dye terminator removal. ...
... The BD FACSAria cell sorter sets ... cytometry. Based on a revolutionary new ... delivers high-speed sorting and multicolor analysis. The ... sorter that incorporates a fixed-alignment cuvette flow ...
Mouse polyclonal antibody raised against a partial recombinant AGTRAP. NCBI Entrez Gene ID = 57085...
...
Biology Products: