Navigation Links
Is DNA from mom or dad?
Date:11/3/2013

November 3, 2013, New York, NY and San Diego, Calif. A new technique successfully takes on a longstanding challenge in DNA sequencing determining whether a particular genetic sequence comes from an individual's mother or father. The method, described in a Ludwig Cancer Research study in Nature Biotechnology, promises to accelerate studies of how genes contribute to disease, improve the process of matching donors with organs and help scientists better understand human migration patterns.

"The technique will enable clinicians to better assess a person's individual risk for disease. It is potentially transformative for personalized medicine," says Bing Ren, Ludwig scientist at the University of California, San Diego School of Medicine, who led the research on the new technique, called "HaploSeq."

"Current sequencing technologies are fast and rapidly getting cheaper an individual's genome can now be sequenced in about a week for $5,000," says Ren. "In the not too distant future, everyone's genome will be sequenced. That will become the standard of care." But, he explains, "There has been a problem with this scenario." Except for the sex chromosomes, everyone has two copies of each chromosome. One copy comes from mom, and the other from dad. Current techniques cannot distinguish between the two copies of each gene and, therefore, are not very good at determining whether particular genetic differences, such as a single-letter change in the DNA, originate with an individual's mother or father muddying genetic analyses.

Ren's new technique, a mixture of molecular biology and computational biology approaches, bypasses this problem. The method enables researchers to quickly determine which genetic variants occur together on the same stretch of chromosome and, therefore, came from the same parent. "This advance has direct implications for the utility of genomics in clinical practice and will also have profound effects on genetic research
'/>"/>

Contact: Rachel Steinhardt
rsteinhardt@licr.org
212-450-1582
Ludwig Institute for Cancer Research
Source:Eurekalert

Page: 1 2 3

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2014)... 50 years ago, electron microscopy revealed the presence of ... and disappear. But scientists still don,t know what they ... proteins are believed to be crucial to the life ... approach to disease treatment., In the Journal of ... to investigators from various backgrounds, from biophysics to cell ...
(Date:8/31/2014)... of Warwick have discovered that ,good, cholesterol is turned ... methylglyoxal - MG, was found to damage ,good, HDL ... the body. , Low levels of HDL, High ... increased levels of MG being common in the elderly ... Supported by funding from the British Heart Foundation (BHF) ...
(Date:8/31/2014)... is developing drugs that are highly effective against a ... patient. Such properties are directly related to the 3D ... have a shape that is perfectly complementary to a ... specificity. Publishing in Nature Chemistry , EPFL scientists ... the 3D structure of bioactive peptides and enhance their ...
Breaking Biology News(10 mins):Scientists call for investigation of mysterious cloud-like collections in cells 2Sugar substance 'kills' good HDL cholesterol, new research finds 2A new synthetic amino acid for an emerging class of drugs 2A new synthetic amino acid for an emerging class of drugs 3
... director of Syracuse Biomaterials Institute (SBI) and Milton and ... Syracuse University,s L.C. Smith College of Engineering and Computer ... functionally graded materials (FGMs) to shape memory polymers (SMPs). ... switch between two shapes, from a fixed (temporary) shape ...
... SPRING HARBOR, N.Y. (Jan. 5, 2011) Auxin is a ... aspects of plant development and physiology. A new book, ... overview of auxin and its many roles in plant biology. ... plant research," write the editors, Mark Estelle, Dolf Weijers, Karin Ljung, ...
... Treating fractures in children requires special knowledge of ... and adolescent patients is less often caused by technical ... in this age group. Using the example of treating ... Marburg-Gieen University Medical Center, and Lucas Wessel, University Medical ...
Cached Biology News:Syracuse University team develops functionally graded shape memory polymers 2
(Date:8/28/2014)... Best Sanitizers, Inc., the first company ... sanitizer, asks food processors and food handling professionals to ... they’re currently using to Best Sanitizers’ Alpet® E3 ... to fighting cross-contamination and the spread of pathogens in ... are key criteria that make a hand sanitizer most ...
(Date:8/28/2014)... The ability for organizations to attract ... allow individuals to perform at the highest of levels, ... looking to compete in this post–recession era. The ... as the sector increasingly focuses on the importance of ... have real results on the organization's development and the ...
(Date:8/28/2014)... Exciting new work by a Florida State University ... that can take your temperature, emit white light, and ... the molecule looks like a butterfly. , Biwu Ma, ... Engineering in the FAMU-FSU College of Engineering, created the ... has continued to discover that his creation has many ...
(Date:8/28/2014)... CA (PRWEB) August 28, 2014 ... is offering a promotion for Eppendorf Safe ... customers to purchase the highest quality tubes at ... are ideal for customers doing chemical, medical, pharmaceutical, ... technicians who are not regularly able to afford ...
Breaking Biology Technology:Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 2Food Processors and Food Handlers are Encouraged to Prepare for Fall Harvest by Evaluating Their Current Hand Sanitizer Using Nine Key Criteria 3Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 2Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 3Novel 'butterfly' molecule could build new sensors, photoenergy conversion devices 2Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 2Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 3
... CITY, China, Feb. 11 /PRNewswire-Asia-FirstCall/ -- ... CBPO) (,China Biologic, or the,Company,), one ... in the,People,s Republic of China (,PRC,), ... subsidiary, Shandong Taibang Biological Products Co.,Ltd. ...
... -- Tianyin,Pharmaceutical, Co., Inc., (NYSE: TPI ), ... based in Chengdu, China, today,announced that management will hold ... at 8:45 a.m. EST on Wednesday, February 18, 2009.,Financial ... the market,closes. , Interested parties ...
... China, Feb. 11 /PRNewswire-Asia-FirstCall/ -- China Pharma,Holdings, Inc. ... and markets specialty pharmaceutical products in China,announced today ... the generic,version of the leading hypertension drug Candesartan. ... for this product are anticipated to require,approximately 18 ...
Cached Biology Technology:China Biologic Products Receives High-Technology Enterprise Certification to Qualify for Preferential Income Tax Rate 2China Biologic Products Receives High-Technology Enterprise Certification to Qualify for Preferential Income Tax Rate 3Tianyin Pharmaceutical Co., Inc. to Host Fiscal Year 2009 Second Quarter Earnings Conference Call on Wednesday, February 18, 2009 at 8:45 a.m. EST 2China Pharma Holdings, Inc. Announces Clinical Trials Already Underway for Candesartan 2China Pharma Holdings, Inc. Announces Clinical Trials Already Underway for Candesartan 3
... The Rapid-Screen cDNA Library Panels were ... just three sets of PCRs to identify ... analysis is performed in a 96-well "Master ... from 5,000 clones. Having identified the positive ...
... Library Panels were designed for full-length gene ... PCRs to identify the desired cDNA clone. ... a 96-well "Master Plate," where each well ... identified the positive well(s) by gel electrophoresis ...
... is an affordable, compact benchtop imager ... providing a broad array of automated ... high-resolution images with high-performance laser autofocus, ... and emission filter changers, and a ...
... Contents include: Microarray hybridization chamber ... chamber top, clamp, thumbscrew) Microarray chamber user ... and are intended to be cleaned and ... with Agilents Catalog Oligo Microarray kits and ...
Biology Products: