Navigation Links
International team sheds new light on biology underlying schizophrenia
Date:7/21/2014

July 21, 2014 (Toronto) As part of a multinational, collaborative effort, researchers from Canada's Centre for Addiction and Mental Health (CAMH) have helped identify over 100 locations in the human genome associated with the risk of developing schizophrenia, in what is the largest genomic study published on any psychiatric disorder to date. The findings, published online in Nature, point to biological mechanisms and pathways that may underlie schizophrenia, and could lead to new approaches to treating the disorder, which has seen little innovation in drug development in more than 60 years.

The research was led by senior author Michael O'Donovan at Cardiff University School of Medicine, and CAMH was the only Canadian site in the collaboration.

Schizophrenia, a debilitating mental illness that affects approximately one out of every 100 people worldwide, is characterized by hallucinations, delusions, and disordered thinking, and often emerges in the teens and early 20s. Its lifetime impact on individuals and society is high, both in terms of direct health-care and other costs, as well as lost productivity and unemployment, which costs an estimated $6.85 billion a year in Canada.

Medications currently on the market treat only one of the symptoms of the illness (psychosis), and there are no effective treatments for the debilitating cognitive symptoms of schizophrenia. In part, treatment options are limited because the biological mechanisms underlying schizophrenia have not been understood.

Recent research focusing on the genetic underpinnings of schizophrenia has revealed the complexity of the illness. Evidence suggests that it is caused by the combined effects of many genes, and roughly two dozen genomic regions have been found to be associated with schizophrenia. The new study confirms those earlier findings, and expands our understanding of the genetic basis of schizophrenia and its underlying biology.

In
'/>"/>

Contact: Kate Richards
kate.richards@camh.ca
416-535-8501 x36015
Centre for Addiction and Mental Health
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UC Riverside entomologist receives international honor for chemical ecology contributions
2. Louisiana Tech University professor presents at International Bioprinting Congress
3. Montreal hosts International Union of Microbiology Societies congresses
4. International Space Station researcher guides aim to maximize science
5. Registration is now open for the HFES 2014 International Annual Meeting
6. Largest International Meeting for the Study of Reproductive Biology Attracts Researchers from 36 Countries in Grand Rapids, Michigan
7. International Biometrics Technology Market - Industry Analysis Size Share Growth Trends and Forecast to 2019
8. Marshall University to partner with international company in drug development venture
9. The ICIST-KAIST International Conference 2014 from August 4-8, 2014 in Korea
10. International Tree Nut Council study results may help people with type 2 diabetes
11. 10th International Symposium on Earthworm Ecology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/29/2014)... decompose, their types and numbers of bugs and ... mean the difference between a closed case and ... using a more than $866,000 U.S. Department of ... these changing populations. The microbial communities may provide ... gender, race, socioeconomic relations and more, said Eric ...
(Date:10/29/2014)... research potential of the Barcode of Life Data ... Biodiversity Data Journal (BDJ) used ... imported these into a human-readable text developed in manuscript ... were used to study the species distributions of ten ... , BOLD is originally designed to support the generation ...
(Date:10/29/2014)... Ghrelin is a hormone released by the stomach and ... viewed as a psychoactive substance that primarily affects brain ... , This knowledge, combined with findings from animal ... the potential to stimulate alcohol craving. , Dr. Lorenzo ... found that, as they had anticipated, alcohol craving was ...
Breaking Biology News(10 mins):MSU partners with Detroit to investigate death scenes 2Go straight and publish: From Barcode of Life Data Systems to scholarly publishing systems 2Ghrelin stimulates an appetite for drinking alcohol 2
... CA) Researchers at the Burnham Institute for Medical Research ... intestinal protein leakage in mice, allowing the team to ... in an in vivo setting. Protein-losing enteropathy (PLE) encompasses ... into the digestive tract. One type of PLE ...
... the Hinode mission have shed new light on the Sun,s ... disrupt power grids, satellites and communications on Earth. The ... journal Science. , Data from Hinode, a Japanese (JAXA) mission ... role in driving the solar wind into space. The solar ...
... new and compelling argument for reducing fish harvests the ... short-term pain of lower catches for the long-term gain of ... ground-breaking study on fisheries over-exploitation. They say their findings, ... a key cause of over-fishing industry opposition to lower ...
Cached Biology News:Safe and effective therapy discovered for patients with protein-losing enteropathy 2Hinode: new insights on the origin of solar wind 2Economists: Reduce fish catch now for bigger net profits later 2Economists: Reduce fish catch now for bigger net profits later 3
(Date:10/27/2014)... MILAN , October 27, 2014 ... the right to produce, exhibit and sell its ... sought to impeach their patent.      ... After four years of fighting, the definitive judgement ... designs and produces innovative and accessible hi-tech prostheses ...
(Date:10/27/2014)... 2014 Called the NOAH Protocol, ... several types of pediatric brain cancer. The implications ... over 30 years of research and development. Amber ... that one mom's determination can make a difference. ... trick-or-treating, and it’s only fitting that we’ve received ...
(Date:10/26/2014)... 26, 2014 The report "Data ... Network Security Equipment, WAN Optimization Appliances]: Global Advancements, ... the data center networking market into various segments ... The report also identifies the factors driving this ... it along with the future roadmaps. , Browse ...
(Date:10/25/2014)... According to new market research ... Types (Colocation, Enterprise, Telecom), by Design Types (Electrical, ... 2, Tier 3, Tier 4) - Global Forecast ... the Data Center Construction Market into various segments ... This research report also identifies the factors driving ...
Breaking Biology Technology:Italian Lower Limb Prosthesis Company Wins Lawsuit Against German Giant Ottobock 2FDA Approves Breakthrough in Pediatric Brain Cancer - First in 30 Years 2FDA Approves Breakthrough in Pediatric Brain Cancer - First in 30 Years 3Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 2Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 3Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 4Data Center Construction Market Worth $22.73 Billion by 2019 - New Report by MarketsandMarkets 2Data Center Construction Market Worth $22.73 Billion by 2019 - New Report by MarketsandMarkets 3Data Center Construction Market Worth $22.73 Billion by 2019 - New Report by MarketsandMarkets 4
... Calif., July 26, 2011 Synterra Energy, Inc. ... and assets for waste biomass conversion from Pacific ... Lion Bio-Energy (Toledo, Ohio).  With the merger, Synterra ... bio-refineries for the economic production of renewable fuels, ...
... 26, 2011   At the ... Center for Devices and Radiologic Health of the United States ... Thursday July 21 in Gaithersburg, Maryland to review the results ... charge of the panel was to review the clinical data ...
... Neogen Corporation (NASDAQ: NEOG ) announced today that ... 31, increased 30% from the previous year to $22,839,000. Net ... compared to the prior year,s $0.76 per share. ... up from $140,509,000 in the company,s previous fiscal year. Both ...
Cached Biology Technology:Synterra Energy Merges Key Technologies to Commercialize Next Generation Integrated Bio-refinery 2FDA Advisory Panel Unanimously Recommends Approval of EXCOR(R) Pediatric Ventricular Assist Device for Use in the United States 2FDA Advisory Panel Unanimously Recommends Approval of EXCOR(R) Pediatric Ventricular Assist Device for Use in the United States 3FDA Advisory Panel Unanimously Recommends Approval of EXCOR(R) Pediatric Ventricular Assist Device for Use in the United States 4Neogen Reports 30% Increase in Net Income 2Neogen Reports 30% Increase in Net Income 3Neogen Reports 30% Increase in Net Income 4Neogen Reports 30% Increase in Net Income 5
... DNase is a preparation of deoxyribonuclease ... DNA to produce 3-hydroxyl oligonucleotides. This ... applications where maintaining the integrity of ... qualified for use with the Core ...
... Type Liquid. In 100 mM KCl, ... EDTA, 20% glycerol, pH 7.9. AVOID FREEZE/THAW CYCLES. ... monomeric protein of 765 amino acids encoded by ... both positive and negative supercoiled DNAs without the ...
Request Info...
... III digests duplex DNA in a 3'-> ... or nick, producing stretches of single-stranded DNA. ... Exonuclease III proceeds at a uniform rate ... rate of exonucleolytic excision of deoxyribonucleotides by ...
Biology Products: