Navigation Links
International deal to screen potential cancer drugs using DNA 'barcodes'
Date:1/21/2014

An innovative screening technology that tags compounds with unique strands of DNA like barcodes will be used to assess up to a billion prototype drug molecules for anti-cancer activity, under a collaboration announced today (Tuesday) between The Institute of Cancer Research, London, Cancer Research Technology (CRT) and Denmark-based drug discovery company Nuevolution A/S.

Researchers will use Nuevolution's novel screening technology, Chemetics, to screen libraries of DNA-tagged compounds to identify those that act on a key protein in the stress response pathway, which has an important role in cancer cell survival and resistance to cancer treatments.

The collaboration will give scientists at The Institute of Cancer Research (ICR) access to data from screens of Nuevolution's proprietary library of small-molecule compounds, each of which is tagged with a unique strand of DNA marking it like a barcode. Up to a billion compounds will be assessed, with the successful hit compounds identifiable through their DNA tag. This state-of the-art screening technology allows potent drug leads to be identified quickly, accurately and from very large and complex compound mixtures.

The three-way deal between the ICR, Nuevolution and CRT, the commercial arm of Cancer Research UK, builds on a previous collaboration between CRT and Nuevolution, which aimed to identify drug leads that block the activity of several challenging cancer targets of therapeutic interest.

Under the new deal the Cancer Research UK Cancer Therapeutics Unit at the ICR and Nuevolution will collaborate to screen a key target within the stress response pathway using Nuevolution's Chemetics technology. Researchers from the Cancer Research UK Cancer Therapeutics Unit at the ICR will provide detailed insights and scientific expertise on the specific stress pathway target as well as their extensive experience in cancer drug discovery and development. In addition, they will use
'/>"/>

Contact: Graham Shaw
Graham.Shaw@icr.ac.uk
44-020-715-35380
Institute of Cancer Research
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. The International Society for Stem Cell Research announces its 2014 award recipients
2. Story of human regeneration wins international physics journalism prize
3. CROS NT Ltd Announces Acquisition of MDSL International Ltd.
4. EcoHealth Alliance and Bat Conservation International forge partnership to work on global bat conservation and public health issues
5. International team completes systematic, genomic study of cervical cancer
6. World e-waste map reveals national volumes, international flows
7. First International Bioenergy Conference brings together world-leading experts
8. International gene therapy trial for bubble boy disease shows promising early results
9. 20th International AIDS Conference (AIDS 2014) plenary speakers announced
10. Antibiotic resistance is a international issue that better education can address
11. NSF, with interagency and international partners, makes first round of grants to understand Arctic sustainability
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/6/2015)... and TELTOW, Germany , August ... Siggraph Conference, SensoMotoric Instruments (SMI) shows the ... , based on Epson,s Moverio BT-200 see-through ... platform. With this new solution, unprecedented quality and efficiency ... interaction with context-sensitive displays. For the first time, professionals ...
(Date:8/5/2015)... According to a new market ... Services, Vertical (BFSI, Airport, IT & Telecom, Utilities, Education, ... to 2020", published by MarketsandMarkets, defines and segments the ... segments. The global PIAM Market is estimated to grow ... 2019, at a CAGR of 14.9 % from 2014 ...
(Date:8/5/2015)... , Aug. 5, 2015 The biosensors ... growth in applications, penetration into newer sectors, and development ... The global biosensors space has seen the entry of ... market so far. (Photo - http://photos.prnewswire.com/prnh/20150805/255570 ... Sullivan, Analysis of the Global Biosensors Market ...
Breaking Biology News(10 mins):SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 2SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 3Physical Identity and Access Management Market Worth $546.2 Million by 2019 2Physical Identity and Access Management Market Worth $546.2 Million by 2019 3Physical Identity and Access Management Market Worth $546.2 Million by 2019 4Innovative Biosensors Incite Use in Non-Traditional Applications 2Innovative Biosensors Incite Use in Non-Traditional Applications 3Innovative Biosensors Incite Use in Non-Traditional Applications 4
... NY, February 20, 2014A new era of manufacturing is upon ... are set to usher in the next generation of industrial ... groundbreaking new technology, Mary Ann Liebert, Inc., publishers has released ... journal 3D Printing and Additive Manufacturing ( 3DP ...
... NY, February 20, 2014A new era of manufacturing is upon ... are set to usher in the next generation of industrial ... groundbreaking new technology, Mary Ann Liebert, Inc., publishers has released ... journal 3D Printing and Additive Manufacturing ( 3DP ...
... highly sexed mouse-like marsupial in Queensland,s Springbrook National Park., ... of the World Heritage Area.,It,s the third new species ... research team has discovered in the past two years, ... the rare, Black-tailed Antechinus was a separate species when ...
Cached Biology News:3-D Printing and Additive Manufacturing: Preview issue of groundbreaking peer-reviewed journal now available 23D Printing and Additive Manufacturing 2Newly discovered marsupial the victim of fatal attraction 2
(Date:9/3/2015)... 3, 2015 According to a ... (LC (HPLC, UHPLC, Flash), GC, Other Components (Autosamplers, Detectors, ... Vials) - Analysis & Global Forecasts to 2020", published ... reach around 9.223 Billion by 2020 from USD 7.062 ... Browse 141 tables and 36 figures spread through ...
(Date:9/3/2015)... ... September 03, 2015 , ... Michigan-based technology startup ... 2016. , The device, called the Halo H1, is a wearable that ... technology. These sensors track trending interstitial fluid levels in the body, in addition ...
(Date:9/2/2015)... Bermuda , Sept. 2, 2015 Axovant Sciences ... the treatment of dementia, today announced upcoming presentations at three ... PM at the Baird 2015 Healthcare Conference in ... , Thursday, September 10 at 2:00 PM at the ... at the Millennium Broadway Hotel & Conference Center , ...
(Date:9/2/2015)... (PRWEB) , ... September 02, ... ... provider of regulatory compliance, quality systems, analytical testing, education and consulting services ... with expertise in medical device products/processes development, design control, validation, quality assurance ...
Breaking Biology Technology:Chromatography Instruments Market Worth $ 9.223 Billion by 2020 2Chromatography Instruments Market Worth $ 9.223 Billion by 2020 3Chromatography Instruments Market Worth $ 9.223 Billion by 2020 4Technology Startup Halo Wearables to Unveil Non-Invasive Hydration Monitoring Device Early 2016 2Axovant Sciences To Present At Upcoming Investor Conferences 2Axovant Sciences To Present At Upcoming Investor Conferences 3NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 2NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 3NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 4NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 5NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 6NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 7
... Childhood obesity is a widespread global epidemic [1] ... [2] is now the leading cause of liver disease ... Congress™ 2012 furthers this concern by showing that childhood obesity ... most common form of liver cancer [3] - in ...
... brain and muscles can restore complex hand movements in ... the National Institutes of Health. In a report ... they combined two pieces of technology to create a ... nervous system function. One piece is a multi-electrode array ...
... Hendrik Casimir calculated that two mirrors placed facing each ... arises from the energy of virtual particles flitting into ... Now Norio Inui, a scientist from the University of ... a reversal in the direction of the so-called Casimir ...
Cached Biology Technology:Childhood Obesity Linked to Increased Risk of Hepatocellular Carcinoma in Adulthood 2Childhood Obesity Linked to Increased Risk of Hepatocellular Carcinoma in Adulthood 3Childhood Obesity Linked to Increased Risk of Hepatocellular Carcinoma in Adulthood 4Brain-activated muscle stimulation restores monkeys' hand movement after paralysis 2Brain-activated muscle stimulation restores monkeys' hand movement after paralysis 3
Rabbit polyclonal to Vitronectin ( Abpromise for all tested applications). Antigen: Full length native Vitronectin (Cow) Entrez Gene ID: 7448 Swiss Protein ID: P04004...
McCoy's 5A Medium. Without Tryptose or Phosphate Broth. Contains Sodium Bicarbonate....
... fast and specific detection of chromosomal sequences ... hybridisation time ( Works ... Multiplex capability Available with different tags ... available with different labels. Related Content: ...
... a K-12 strain ideally suited as an ... transformation efficiency, blue/white screening capability (with appropriate ... in high yields of excellent quality plasmid ... potentially useful as a stringent host due ...
Biology Products: