Post Doctoral Fellowships
Cassiano Carromeu, PhD University of California San Diego (Mentor Alysson Muotri PhD)
Modeling Rett Syndrome with human pluripotent stem cells
Dr. Carromeu's project will be carried out in the laboratory of Dr. Alysson Muotri who has recently developed induced pluripotent stem cells (iPSCs) from Rett patients'skin cells. These iSPCs have been derived from patients with different MeCP2 mutations, and with different clinical phenotypes. The reprogrammed cells can generate a virtually unlimited supply of human neurons and other neural cell types of interest. In preliminary work, Dr. Carromeu showed that neurons generated this way displayed reduced synaptic contacts which are consistent with neuronal alterations seen in Rett syndrome. This model system will now be used for testing drugs to rescue these cellular alterations and to investigate developmental changes seen in Rett syndrome. Dr. Carromeu's mentor is the recent recipient of an NIH "New Innovator award." Dr. Muotri's research program seeks to use Rett syndrome as a model for other autism-spectrum disorders, this may reveal common molecular and cellular mechanisms present in different types of autism.
Jun Ren PhD, University of Alberta (Mentor John Greer PhD)
Investigation of Respiratory Dysfunction in a Mouse Model of Rett Syndrome
|Contact: Dr. Antony Horton|
International Rett Syndrome Foundation