Navigation Links
International Rett Syndrome Foundation awards $2M for cutting-edge Rett syndrome research
Date:10/1/2009

mice. This project could therefore present a novel therapeutic target for Rett syndrome treatments.

Jeffrey Neul MD, PhD, Baylor College of Medicine
Characterization of cardiac abnormalities in Rett syndrome

This project will thoroughly investigate cardiac conduction abnormalities previously identified by Dr. Neul's team in Rett syndrome mice, which accurately model defects in Rett syndrome patients. The studies involve long-term, periodic heart monitoring coupled with a correlative analysis of potential MECP2 target genes. These studies may explain the long QT syndrome seen as a consequence of Rett syndrome. Dr. Neul will further this work by developing a conditional knock-out mouse to better determine if MeCP2 loss in neuronal vs. cardiomyocyte cell types is the origin of the observed conduction defects. The innovative aspect of the study is its focus on evaluating the effects of Mecp2 dysfunction outside the CNS, in particular in the heart, an aspect that has not yet been thoroughly explored. In addition, it could help to understand the basis for the proposed autonomic dysfunction that may be the cause for sudden unexplained death in this population.

N. Carolyn Schanen, MD, PhD
Alfred I. DuPont Hospital for Children/Nemours Children's Clinic at the University of Delaware Suppression of Rett Nonsense Mutations by Pharmacological Agents

Dr. Schanen will conduct a study that seeks to better understand the pharmacological properties of drugs which suppress nonsense mutations. A nonsense mutation is an alteration in the genetic code that prematurely halts the synthesis of an essential protein. The study will examine a lead series of "read-through" compounds, and will provide valuable information on their mechanism of action within cells. These read-through compounds hold great promise for the treatment of individuals who possess nonsense mutations in the MECP2 gene.

N. Carolyn Schanen, MD
'/>"/>

Contact: Dr. Antony Horton
212-459-2608
International Rett Syndrome Foundation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9 10 11 12

Related biology news :

1. International conference on endothelin
2. International event brings worlds top cancer doctors to Queens
3. Forest Service to host 2nd International Conference on Forests and Water in a Changing Environment
4. EMBO pioneers pension plan for internationally mobile postdoctoral researchers
5. International conference on CO2 sequestration processes
6. International research team seeks to unravel flatworm regeneration
7. Fujitsu PalmSecure Certified Under International Common Criteria Evaluation Assurance Level 2
8. Journal of Vascular and Interventional Radiology increases impact, international reach
9. International team of students and scientists on month-long field course in Siberian Arctic
10. ESHRE launches international study of polar body screening
11. International collaboration by scientists culminates in novel ion channels database
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2014)... decade-long effort by members of the International Glossina Genome ... of the tsetse fly, Glossina morsitans . The ... a potentially deadly disease endemic in sub-Saharan Africa. The ... new ways to prevent the disease and provide insights ... fly is quite unique in the insect world: it ...
(Date:4/24/2014)... New Rochelle, NY, April 24, 2014D-ribose is a ... nutritional supplement, and as a starting compound for ... of Escherichia coli to increase the ... step toward achieving more efficient industrial-scale production of ... in Industrial Biotechnology , a peer-reviewed journal ...
(Date:4/24/2014)... have identified the structural features that enable the ... endogenous RNAs in living cells. , When viruses ... and hijack cellular resources for the production of ... RNA molecules that are delivered directly to (in ... in the host cell, and provide the blueprints ...
Breaking Biology News(10 mins):Genetic code of the deadly tsetse fly unraveled 2Viral infections: Identifying the tell-tale patterns 2Viral infections: Identifying the tell-tale patterns 3
... have discovered that mimecan and Thioredoxin Domain-Containing Protein ... The research article describing this work entitled Differential ... in Colorectal Adenoma and Cancer: A Proteomic Study ... of Experimental Biology and Medicine., Adenoma is the ...
... other fish in the rivers of Californias Central Valley ... researchers at Duke University and the National Oceanic and ... may serve as a cautionary tale to policymakers, scientists ... the construction of new dams in the region. ...
... of males than females are born worldwide every year. In ... than girls, there has been an apparent decline in the ... including Canada, Denmark, England, Germany, Japan and the United States. ... that can influence the probability of giving birth to a ...
Cached Biology News:A search for biomarkers for early detection of colorectal cancer 2New paper examines dams' effects on California salmon 2Weight gain between first and second pregnancies associated with increased odds of male second child 2
(Date:1/15/2014)... 15, 2014 ­ RedBrick Health , a fast-growing ... today announces that EmblemHealth , the ... is now providing the RedBrick Compass health assessment, combined ... all of its members. EmblemHealth is among the first ...
(Date:1/15/2014)... , January 15, 2014 A study has ... on the Formula 1 track could help to tackle the ... Technologies (MAT), Stowhealth (a GP surgery based in Stowmarket) and ... provider Simplyhealth. Telemetry technology, which is inspired by ...
(Date:1/15/2014)... January 15, 2014 Two champions of ... their sponsorship of an annual competition for middle and ... access to, innovative STEM study. The competition presents students ... Tests of Engineering Aptitude, Mathematics, and Sciences is ...
(Date:1/15/2014)... DTS Language Services, Inc . is pleased ... Life Science organizations who need document translations. Clients will ... their documents in advance with a selection of nearly 50 ... often a critical factor in clinical and scientific fields, and ...
Breaking Biology Technology:EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5DTS Improves Efficiency for Life Science Document Translations 2
... ... the FBRM® C35 particle size distribution technology in the particle characterization and material sciences ... 26-29 in Nuremberg, Germany. , ... (PRWEB) May 18, 2010 -- The Powtech/TechnoPharm jury awarded METTLER TOLEDO the ...
... Caliper Life Sciences, Inc. (Nasdaq: CALP ), a leading ... today announced that it reached an agreement to sell its RapidTrace ® ... Biotage AB for $16.5 million in cash.   , ... "Divesting these product lines is a ...
... (Nasdaq: SIAL ) will be presenting at the Baird,s 2010 Growth Stock ... ( 2:15 PM EDT ) in Chicago, IL.  Interested parties may ...  Users can click the "Webcast" icon to access this file.   , ... About Sigma-Aldrich: Sigma- Aldrich ...
Cached Biology Technology:FBRM C35 In-Process Particle Characterization Technology Receives Powtech/TechnoPharm Innovation Award 2010 2FBRM C35 In-Process Particle Characterization Technology Receives Powtech/TechnoPharm Innovation Award 2010 3Caliper Enhances Strategic Focus and Increases Growth Capital with Sale of Product Lines to Biotage 2Caliper Enhances Strategic Focus and Increases Growth Capital with Sale of Product Lines to Biotage 3Caliper Enhances Strategic Focus and Increases Growth Capital with Sale of Product Lines to Biotage 4Sigma-Aldrich Corporation to Present at the Baird's 2010 Growth Stock Conference on Thursday, May 20, 2010 2
... Clear amber to slightly ... Contains 10 vials per set, each ... adjuvant homogenized in the following proportions ... Arlacel A (mannide monooleate emulsifier), and ...
... Although there have been many modifications to the ... media, salt solutions still play an important role ... maintain the pH and osmotic balance in the ... and essential inorganic ions, is as valuable today ...
Request Info...
... LXQ linear ion trap mass spectrometer enables ... laboratory., The LXQ linear ion trap mass ... proteomic applications, delivering the fast cycle time ... ion trap at an attractive price. ...
Biology Products: