Navigation Links
International Rett Syndrome Foundation awards $2M for cutting-edge Rett syndrome research
Date:10/1/2009

P2.

Steven Gray PhD, University of North Carolina at Chapel Hill
rAAV-Mediated Replacement of the MeCP2 Gene in a Rett Syndrome Mouse Model

Gene-replacement therapy of MeCP2 is a potential future treatment option for Rett syndrome patients. The proposed study focuses on overcoming two critical issues that are likely to impede clinical translation of MeCP2 gene-replacement therapy using viral vectors. These are; transferring enough of the gene into the brain to make a difference and limiting the likely adverse impact of MeCP2 over-expression. Dr. Gray is a talented young investigator who has clearly demonstrated his ability to perform the proposed work and is associated with an excellent team in the area of virus-mediated gene transfer for CNS diseases.

Heekyung Hong PhD, Northwestern University
Genetic Dissection of of Rett Syndrome: a Screen for Modifiers of MeCP2 in the mouse

This proposal seeks to discover potential genes that could modify the course and/or severity of Rett syndrome in a Mecp2-null mouse model. The project will examine novel signaling elements that may alter MeCP2-dependent transcriptional regulation. This is a project that has a potentially high-impact since it may yield novel therapeutic targets for the treatment of Rett Syndrome.

Daniel Kilpatrick PhD, University of Massachusetts Medical School
Transcriptional Dys-Regulation in Rett Syndrome

This proposal will investigate a gene which is involved in regulating the downstream targets of MeCP2. Previous work has shown that the gene, called Rest, is upregulated in Rett syndrome and is thought to contribute to the spectrum of down-regulated genes in the CNS of Rett patients and in Mecp2-deficient mice. Dr. Kilpatrick will generate new 'knock-out' mouse models targeting the Rest gene and will use other techniques to decrease levels of the gene, with the goal of rescuing features of Rett syndrome in MeCP2
'/>"/>

Contact: Dr. Antony Horton
212-459-2608
International Rett Syndrome Foundation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9 10 11 12

Related biology news :

1. International conference on endothelin
2. International event brings worlds top cancer doctors to Queens
3. Forest Service to host 2nd International Conference on Forests and Water in a Changing Environment
4. EMBO pioneers pension plan for internationally mobile postdoctoral researchers
5. International conference on CO2 sequestration processes
6. International research team seeks to unravel flatworm regeneration
7. Fujitsu PalmSecure Certified Under International Common Criteria Evaluation Assurance Level 2
8. Journal of Vascular and Interventional Radiology increases impact, international reach
9. International team of students and scientists on month-long field course in Siberian Arctic
10. ESHRE launches international study of polar body screening
11. International collaboration by scientists culminates in novel ion channels database
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/3/2014)... 2, 2014   Marvin Test Solutions , ... solutions for military, aerospace, and manufacturing organizations, today ... successful TS-900 PXI semiconductor test platform . ... high-end systems to customers at a fraction of ... traditional ATE. "Our semiconductor customers ...
(Date:11/21/2014)... NEW YORK , Nov. 19, 2014  Earlier ... Board at New York College, and one of the ... for biosensor signals that are transmitted from Smartphones to ... there were Smartphones and has one of the earliest ... are discussing its usage in the military, child care, ...
(Date:11/21/2014)... Nov. 20, 2014   Atmel® Corporation (NASDAQ: ... (MCU) and touch technology solutions, today launched the industry,s ... with the widest V cc range from 1.7V ... and faster I 2 C bus communication speeds, and ... memory making them ideal for consumer, industrial, computer, and ...
Breaking Biology News(10 mins):Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4
... the nature of crowds playing Foldit called some strategies ... methods already used by protein scientists., Gamers made headlines ... central to research on AIDS. Today, in a ... National Academy of Sciences, University of Washington researchers ...
... 2011 AVT, Inc. (formerly Automated Vending Technologies) (Ticker: ... provide a new line of Secure Automated Retailing Systems ... This new system provides extra security for automated ... customer is critical. AVT worked with ...
... characterize the genes involved in wood formation in poplar trees ... wood as a feedstock for biofuels production. "This ... work of other biofuels researchers who develop better and more ... Beers, professor of horticulture and the lead investigator on the ...
Cached Biology News:Paper uncovers power of Foldit gamers' strategies 2Paper uncovers power of Foldit gamers' strategies 3AVT Partners with MedBox to Provide New Biometric Fingerprint Recognition for Secure Automated Retailing 2Genomics of wood for biofuels production investigated 2
(Date:12/19/2014)... 2014 Research and Markets ( ... "Technology Innovations in Smart Fabrics (Technical Insights)" ... http://photos.prnewswire.com/prnh/20130307/600769 The Research ... a detailed assessment on technological advancements and market ... 1. The Smart Fabrics market is ...
(Date:12/19/2014)... December 18, 2014 Today, ... its pilot production facility and future company headquarters ... produce innovative new materials that safely and effectively ... only because of its historic, strong support for ... to attract leading edge, technology-based companies such as ...
(Date:12/19/2014)... Ed Bilsky, Ph.D., vice president for Research ... in the Neurosciences (CEN), and professor of pharmacology at ... a member of the prestigious Dana Alliance for Brain ... to receive this honor. , The Dana Alliance ... Dana Foundation. Its mission is to advance public ...
(Date:12/19/2014)... Boston, MA (PRWEB) December 18, 2014 ... software, announced the appointment of Siri Bryant as the ... the new Director of Core Implementations. These two new ... provide outstanding customer service by ensuring that iLab continues ... , “In the last four years, iLab has been ...
Breaking Biology Technology:Technology Innovations in Smart Fabrics (Technical Insights) 2Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 2Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 3Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 4UNE's Ed Bilsky Named Member of Dana Alliance for Brain Initiatives 2UNE's Ed Bilsky Named Member of Dana Alliance for Brain Initiatives 3iLab Solutions Announces Two New Leadership Positions to Meet the Needs of Its Growing Customer Base 2
... ... Expertise, OMAHA, ... that it has appointed David P.,Pauluzzi to its Board of Directors. ... Chicago-based private equity firm,specializing in the healthcare sector., Prior to ...
... Inc.,(Nasdaq: NXXI ), a growing developer and ... and Iceland Health(R) brands,that help consumers manage blood ... chronic joint pain, will report,financial results for the ... 2007 on Monday, February 11, 2008, after market ...
... Feb. 5 Perrigo Company,(Nasdaq: PRGO ; ... CEO will present at the Merrill Lynch Global ... 6, at,11:40 a.m. (ET) at the Grand Hyatt ... a leading global healthcare supplier that develops,manufactures and ...
Cached Biology Technology:Transgenomic Appoints David Pauluzzi to Board of Directors 2Transgenomic Appoints David Pauluzzi to Board of Directors 3Nutrition 21 to Report Second Quarter Fiscal 2008 Financial Results Monday, February 11, 2008 2
...
...
... the Quansys Biosciences Q-Plex Array is a ... for human, mouse, and rat research. The ... quantitative ELISA-based test where 4 distinct capture ... of a 96-well plate in a defined ...
Caliper offers a wide array of standard LabChip products designed to be used in combination with our AMS 90 and LabChip 3000 microfluidic platforms....
Biology Products: