Navigation Links
International Rett Syndrome Foundation awards $2M for cutting-edge Rett syndrome research
Date:10/1/2009

e-modifying treatment for Rett syndrome.

Alan Kozikowski PhD, University of Illinois, Chicago
Synthesis and preliminary (ADME) testing of selective HDAC inhibitors for treatment of a mouse model of Rett Syndrome

Histone deacetylase (HDAC) enzymes are proteins that regulate gene expression and are involved in brain cell degeneration in neurodegenerative diseases. HDAC inhibitors are drugs which block the action of HDAC enzymes and have shown promise as potential treatments for neurodegenerative diseases such as Parkinson's, Motor Neuron and Huntington's diseases. These drugs have also recently been suggested as potential treatments for neurodevelopmental disorders such as Fragile X, RubinsteinTaybi syndrome and Rett syndrome. Dr. Kozikowski was awarded a short-term contract to fund preliminary predictive tests to select the best candidate drug from a lead series for testing in a Rett mouse model.

IRSF conducts thorough due diligence on all research grants and for clinical studies involving patients with Rett syndrome, since safety is of paramount importance. We accomplish this through a rigorous peer-review process, drawing on the external advice and expertise of leading experts and specialists in the fields of Rett syndrome, neuroscience, autism, drug discovery and development and other relevant disciplines as appropriate.

IRSF will shortly announce additional detail on the two new funding mechanisms and will solicit research programs through an online grants submission process. Dr. Horton commented "With the launch of these new award mechanisms, we will have greater power and flexibility to accelerate drug discovery and to develop and test new treatments. These awards will bring us another step closer to finding a cure through the pharmacological reversal of Rett syndrome."

According to Stephen Bajardi, Executive Director of IRSF, "It is through the combined efforts of our parent volunteers, generous con
'/>"/>

Contact: Dr. Antony Horton
212-459-2608
International Rett Syndrome Foundation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9 10 11 12

Related biology news :

1. International conference on endothelin
2. International event brings worlds top cancer doctors to Queens
3. Forest Service to host 2nd International Conference on Forests and Water in a Changing Environment
4. EMBO pioneers pension plan for internationally mobile postdoctoral researchers
5. International conference on CO2 sequestration processes
6. International research team seeks to unravel flatworm regeneration
7. Fujitsu PalmSecure Certified Under International Common Criteria Evaluation Assurance Level 2
8. Journal of Vascular and Interventional Radiology increases impact, international reach
9. International team of students and scientists on month-long field course in Siberian Arctic
10. ESHRE launches international study of polar body screening
11. International collaboration by scientists culminates in novel ion channels database
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/18/2014)... Nov. 18, 2014   EyeLock Inc. , ... and MorphoTrust USA (Safran), a leading ... announced a strategic partnership to offer comprehensive biometric ... administration (MVA), airport screening and financial services markets. ... MorphoTrust serves consumers through a nationwide network of ...
(Date:11/7/2014)... Auguste, associate professor, biomedical engineering, in the Grove ... New York, have identified a molecule that could ... most aggressive forms of breast cancer. , Triple ... rate owing to aggressive proliferation and metastasis and ... Auguste,s team, discovered the overexpression of intercellular adhesion ...
(Date:11/6/2014)... for a predator. Except when that predator runs so fast ... to its size, is the fastest creature on Earth. Some ... second (at about five miles per hour). The fastest human ... gold from the tiger beetle, a person would have to ... has a problem. At peak speeds, everything becomes a blur. ...
Breaking Biology News(10 mins):EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 2EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 3The tiger beetle: Too fast to see 2
... as earth -- and amylophagy, eating raw starches -- are ... 180 species of animals are also known to engage in ... appearing Oct. 17 in the online journal Public Library of ... Madagascar. It is one of only a few studies to ...
... of scientists searching for genes that determine the susceptibility and ... a five-year renewal grant of $4.3 million from the National ... John Reveille, M.D., of The University of Texas Health Science ... to this arthritic condition known as ankylosing spondylitis and hopes ...
... of Washington scientists have succeeded in removing the extra ... a person with Down,s syndrome. In Down syndrome, ... rather than the usual pair. A triplicate of ... trisomy. Trisomies account for almost one-quarter of pregnancy loss ...
Cached Biology News:Study documents eating of soil, raw starch in Madagascar 2Renewal grant supports genetic research into arthritis of the spine 2Extra chromosome 21 removed from Down syndrome cell line 2Extra chromosome 21 removed from Down syndrome cell line 3
(Date:11/26/2014)... PA (PRWEB) November 25, 2014 The ... of its official conference and exposition mobile app, ... for free download in the App Store for iOS ... a valuable resource tool before, during and after the ... containing details on exhibiting companies, technical sessions, Conferee Networking ...
(Date:11/26/2014)... and WILMINGTON, DE (PRWEB) November 26, 2014 ... Annual MPN Heroes recognition reception on December 5, 2014, ... Hematology’s annual meeting. The MPN Heroes event will honor ... in the field of myeloproliferative neoplasms (MPNs). , ... "Nashville," will discuss his family's cancer journey at the ...
(Date:11/26/2014)... , 25 novembre 2014 /PRNewswrie/ -- Theravalues Corporation annuncia ... mercato europeo in occasione di Hi Europe 2014 (dal ... Si tratta della curcumina con la maggiore ... (senza cristalli) e ingredienti approvati dalle norme europee. ... spezia della pianta curcumina ( Curcuma longa ) che ...
(Date:11/24/2014)... , Nov. 24, 2014  Last week, ... G.K. Butterfield (D-NC) took a bold bipartisan ... by introducing the OPEN Act. Original co-sponsors of ... (D-FL). The Act will incentivize drug makers and ... rare diseases and pediatric cancers, which opens the ...
Breaking Biology Technology:Pittcon Releases 2015 Mobile App 2CURE Magazine and Incyte to Honor MPN Heroes 2CURE Magazine and Incyte to Honor MPN Heroes 3CURE Magazine and Incyte to Honor MPN Heroes 4La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 2La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 3OPEN Act Introduced to Repurpose Drugs for Rare Diseases 2
... like Jack Welch and Larry Bossidy have been lionized ... attitude, relentless focus on bottom line performance and stellar ... run offer many valuable lessons, the management philosophies they ... for every company. Super Jacks rank and yank approach ...
... Engineering and Testing Services and Underwriters Laboratories have ... equipment building systems (NEBS) tests for telecommunications suppliers. ... such as seismic and transportation vibration, heat, humidity, ... not-for-profit product testing company, will provide customers of ...
... to be fooled by first impressions. And I have to admit ... Confoti in the January 2002 issue of DEMOletter, I was rather ... over the Internet. Dot-com businesses were imploding left and right ... site wouldn't be around for long. , ,I couldn't have been ...
Cached Biology Technology:Seven leadership lessons of Next Generation Companies 2Seven leadership lessons of Next Generation Companies 3Confoti: Revisiting a dotcom business model 2Confoti: Revisiting a dotcom business model 3Confoti: Revisiting a dotcom business model 4Confoti: Revisiting a dotcom business model 5
... The Universal Vacuum System UVS400 is ... system. The UVS400 combines a refrigerated vapor ... in a single integrated unit. The easy-to-use, ... recovered solvent into single jar for easy ...
... FastPrep System combines 2 products into 1:, ... A molecular isolation kit , ,The ... machine and Qbiogene/BIO101 System Matrix and Isolation ... individual micro tubes eliminating the use of ...
... X-Gal (5-bromo-4-chloro-3-indoyl-beta-D-galactopyranoside) is a ... identify recombinant plasmids. In ... and IPTG, lac ... blue, whereas recombinant colonies ...
... is a fully flexible quadrupole MS detector ... high-speed HPLC, 1-D and 2-D LC, as ... It incorporates a drying gas system to ... sensitivity, especially for low-to-medium polarity compounds, while ...
Biology Products: