e-modifying treatment for Rett syndrome.
Alan Kozikowski PhD, University of Illinois, Chicago
Synthesis and preliminary (ADME) testing of selective HDAC inhibitors for treatment of a mouse model of Rett Syndrome
Histone deacetylase (HDAC) enzymes are proteins that regulate gene expression and are involved in brain cell degeneration in neurodegenerative diseases. HDAC inhibitors are drugs which block the action of HDAC enzymes and have shown promise as potential treatments for neurodegenerative diseases such as Parkinson's, Motor Neuron and Huntington's diseases. These drugs have also recently been suggested as potential treatments for neurodevelopmental disorders such as Fragile X, RubinsteinTaybi syndrome and Rett syndrome. Dr. Kozikowski was awarded a short-term contract to fund preliminary predictive tests to select the best candidate drug from a lead series for testing in a Rett mouse model.
IRSF conducts thorough due diligence on all research grants and for clinical studies involving patients with Rett syndrome, since safety is of paramount importance. We accomplish this through a rigorous peer-review process, drawing on the external advice and expertise of leading experts and specialists in the fields of Rett syndrome, neuroscience, autism, drug discovery and development and other relevant disciplines as appropriate.
IRSF will shortly announce additional detail on the two new funding mechanisms and will solicit research programs through an online grants submission process. Dr. Horton commented "With the launch of these new award mechanisms, we will have greater power and flexibility to accelerate drug discovery and to develop and test new treatments. These awards will bring us another step closer to finding a cure through the pharmacological reversal of Rett syndrome."
According to Stephen Bajardi, Executive Director of IRSF, "It is through the combined efforts of our parent volunteers, generous con
'/>"/>
| Contact: Dr. Antony Horton 212-459-2608 International Rett Syndrome Foundation Source:Eurekalert |
Related biology news :
1. International conference on endothelin
2. International event brings worlds top cancer doctors to Queens
3. Forest Service to host 2nd International Conference on Forests and Water in a Changing Environment
4. EMBO pioneers pension plan for internationally mobile postdoctoral researchers
5. International conference on CO2 sequestration processes
6. International research team seeks to unravel flatworm regeneration
7. Fujitsu PalmSecure Certified Under International Common Criteria Evaluation Assurance Level 2
8. Journal of Vascular and Interventional Radiology increases impact, international reach
9. International team of students and scientists on month-long field course in Siberian Arctic
10. ESHRE launches international study of polar body screening
11. International collaboration by scientists culminates in novel ion channels database
| Copyright © 2003-2012 Bio-Medicine. All rights reserved. ABOUT | CONTACT US | DISCLAIMER | PRIVACY POLICY | TERMS AND CONDITIONS |  |