Navigation Links
International Rett Syndrome Foundation awards $2M for cutting-edge Rett syndrome research
Date:10/1/2009

mRNA is an ideal target for drug discovery because it is a key regulatory molecule in the cell.

Annamaria Lilienkampf PhD, University of Illinois at Chicago (Mentor Alan Kozikowski, PhD)
The Role of Histone Lysine Methylation Marks in Rett Syndrome Identification of Novel Histone Lysine Methyltransferase Modulating Agents

Dr. Lilienkampf will conduct a novel drug discovery project based on interactions between MeCP2 and key enzymes called histone lysine methyltransferases (HKMTs) which are known to regulate transcription. Small molecules that can manipulate this interaction called HKMT inhibitors will be studied to better understand if they alter the developmental course and rescue the pathology of Rett syndrome. The first series of HKMT inhibitors could eventually be tested as new drugs for intervention in Rett syndrome but they could also help guide the process of identifying new therapeutic agents within the same lead series.

Additional Grants Awarded in 2009

Omar Khwaja, MD, PhD Children's Hospital Boston - ANGEL AWARD RECIPIENT
Pharmacological Treatment of Rett Syndrome by Stimulation of Synaptic Maturation with IGF1

The study will test an experimental treatment based on the administration of insulin like growth factor 1 (IGF1) in a pilot clinical study in 30 patients with Rett syndrome. The trial is based on preliminary findings in mice which suggest that targeting the IGF1 signaling axis may partially reverse Rett symptoms by boosting synaptic maturation of neurons in the brain. The treatment to be used in the study is an FDA approved drug called Increlex, a bioengineered form of the IGF1 protein. The study drug has previously been used to treat growth and has a known safety and tolerability profile in a pediatric population. Although this is a pilot clinical trial in 30 patients, if successful the study will have significant impact on the field and may lead to a new diseas
'/>"/>

Contact: Dr. Antony Horton
212-459-2608
International Rett Syndrome Foundation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9 10 11 12

Related biology news :

1. International conference on endothelin
2. International event brings worlds top cancer doctors to Queens
3. Forest Service to host 2nd International Conference on Forests and Water in a Changing Environment
4. EMBO pioneers pension plan for internationally mobile postdoctoral researchers
5. International conference on CO2 sequestration processes
6. International research team seeks to unravel flatworm regeneration
7. Fujitsu PalmSecure Certified Under International Common Criteria Evaluation Assurance Level 2
8. Journal of Vascular and Interventional Radiology increases impact, international reach
9. International team of students and scientists on month-long field course in Siberian Arctic
10. ESHRE launches international study of polar body screening
11. International collaboration by scientists culminates in novel ion channels database
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/17/2014)... . To date, ... overdoses, doctors are often limited to supportive therapy such as ... combination of drugs involved. So what can be done if ... ETH professor Jean-Christophe Leroux from the Institute of Pharmaceutical Sciences ... question. "The task was to develop an agent that could ...
(Date:10/16/2014)... can be cultivated efficiently, they are anything but ... by monoculture cultivation is becoming increasingly evident. Despite ... form and are regarded as the sole possibility ... quite wrongfully, finds Bernhard Schmid, an ecology professor ... novel form of agriculture and forestry. After all, ...
(Date:10/15/2014)... As our ability to assess the pandemic risk from ... developments, we must not allow ourselves to become complacent ... an international consortium of scientists. , Influenza pandemics arise ... have yet to develop widespread immunity – spreads in ... in the past 100 years, the worst of which ...
Breaking Biology News(10 mins):Emergency aid for overdoses 2Emergency aid for overdoses 3Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2
... to perfumes is the most common contact allergy in ... that even natural aromatic oils, which many deem harmless ... Roughly one in five adults in northern Europe ... or more chemicals. The most common is nickel allergy, ...
... of Bioinformatics and the Swiss National Center of Competence ... a new test to predict how breast cancer patients ... is delivered in the future. In an article, ,A ... breast cancer, i, published in Nature Medicine , ...
... are abdominal obesity and high levels of a type of ... a person,s risk for stroke. The potential complications are serious: ... kidney disease and stroke. Preserving the ... a type of poly-unsaturated fat thought to play an important ...
Cached Biology News:Even natural perfumes may cause allergies 2Stroma genomic signature predicts resistance to anthracyclin-based chemotherapy in breast cancer 2Stroma genomic signature predicts resistance to anthracyclin-based chemotherapy in breast cancer 3Fighting obesity and illness with a novel approach to nutrition 2Fighting obesity and illness with a novel approach to nutrition 3
(Date:10/19/2014)... NextCODE Health, which enables clinicians and researchers to ... today announced the launch of its new genomic data analysis ... American Society of Human Genetics (ASHG) annual meeting in ... and apply for free beta access, visit www.nextcode.com . ... be viewed here . The Exchange: ...
(Date:10/19/2014)... Orthopedic braces and support systems report defines and segments the ... The Orthopedic braces and support systems market in Asia is ... a developing CAGR of 4.4% from 2013 to 2018. , ... support systems market, to get an idea of the in-depth ... of orthopedic braces and support systems market in the same ...
(Date:10/18/2014)... The report "1,6-Hexanediol Market by Application and ... analyzes the global market on the basis of ... details such as the key drivers, current trends ... Browse 81 Market Data Tables and 29 Figures ... “1,6-Hexanediol Market by Application and by Geography - ...
(Date:10/18/2014)... The Biomass Power industry ... years to 2014. The industry's expansion has been propelled ... that encouraged the use of biomass power. Furthermore, the ... which require local utilities to generate electricity from renewable ... Increased campaigning for green technology also influenced industry performance ...
Breaking Biology Technology:The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 2The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 3The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 2The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 3The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 41,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 21,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 31,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 41,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 5Biomass Power in the US Industry Market Research Report from IBISWorld Has Been Updated 2Biomass Power in the US Industry Market Research Report from IBISWorld Has Been Updated 3
... 9, 2011) The brain is a black box. ... much like the inner workings of a computer chip. ... economy of an assembly line, neural circuits are impenetrable ... Department of Neurobiology have developed a technique for unraveling ...
... of Standards and Technology (NIST),have demonstrated an ... mechanical component 1,000 times,more vigorously than ever ... a new tool for processing,information and potentially ... object at the,smallest possible, or quantum, scale. ...
... NEW YORK, March 9, 2011 Reportlinker.com ... is available in its catalogue: ... and Market Forecasts to 2017 ... Retinopathy Therapeutics - Pipeline Assessment and Market ...
Cached Biology Technology:Web-crawling the brain 2Web-crawling the brain 3NIST electromechanical circuit sets record beating microscopic 'drum' 2NIST electromechanical circuit sets record beating microscopic 'drum' 3Reportlinker Adds Diabetic Retinopathy Therapeutics - Pipeline Assessment and Market Forecasts to 2017 2Reportlinker Adds Diabetic Retinopathy Therapeutics - Pipeline Assessment and Market Forecasts to 2017 3
Practical tool for easy, effective sealing of 0.2ml PCR tubes and plates using cap strips....
... BioLegend, the Quansys Biosciences Q-Plex Array is ... cytokines/chemokines for human, mouse, and rat research. ... fully quantitative ELISA-based test where 4 distinct ... well of a 96-well plate in a ...
The strip cap tool is a used for properly seating 8- and 12-cap strips in microplates or strip tubes. A grooved channel on one side is designed to seat domed caps, while the flat edge on the opposite...
... The expertise that made the original Gene Pulser ... system available has been applied in the Gene ... The modular design of the Gene Pulser II ... accessory that has the widest range of settings ...
Biology Products: