Navigation Links
Intentional variation increases result validity in mouse testing
Date:3/9/2010

WEST LAFAYETTE, Ind. - For decades, the traditional practice in animal testing has been standardization, but a study involving Purdue University has shown that adding as few as two controlled environmental variables to preclinical mice tests can greatly reduce costly false positives, the number of animals needed for testing and the cost of pharmaceutical trials.

Joseph Garner, a Purdue assistant professor of animal sciences, said the finding challenges the assumption in drug discovery and related fields that animal experiments should eliminate all variables. He said that despite standardization efforts, two experiments in different labs could never truly be exactly the same because of uncontrollable variables such as the scent of the researchers or background noises.

"Human drug trials get around this problem by deliberately including variability in the experiment in a controlled manner so that the effect of a drug can be tested across a variable human population," Garner said.

Garner and his co-authors compared results from multiple mice experiments set up in a standardized manner against multiple experiments set up with controlled variables as if the mice were people.

"Overall, the differences between experiments are much, much greater in the standardized setups than in the ones where we deliberately varied the environment as if the experiment was a human drug trial," said Garner, whose results were published in the current issue of the journal Nature Methods. "In fact, the traditional standardized experiments generally disagreed with each other, while the experiments designed like a human drug trial generally agreed with each other."

The study is a follow-up of another published last year in Nature Methods in which Garner, Hanno Wrbel, a co-author on the papers and professor at the University of Giessen in Germany, and Helene Richter, Wrbel's graduate student, suggested that adding controlled
'/>"/>

Contact: Brian Wallheimer
bwallhei@purdue.edu
765-496-2050
Purdue University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. New book presents successful strategies for probing genetic variation
2. Physician-scientists seek solutions to reproductive problems related to chromosomal variations
3. Copy number variation may stem from replication misstep
4. Gene variation may elevate risk of liver tumor in patients with cirrhosis
5. DNA variations signal lupus risk
6. U-M researchers release most detailed global study of genetic variation
7. Michigan Tech researchers link 11 genetic variations to type 2 diabetes
8. Mental stress reduces blood flow to the heart in patients with gene variation
9. Genetic variation linked to sugary food
10. Statistical tool could explain gene study variations
11. Why do people vote? Genetic variation in political participation
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Intentional variation increases result validity in mouse testing
(Date:8/3/2015)... , Aug. 3, 2015 Synaptics, Inc. (Nasdaq: ... solutions, today announced that members of the executive management ... Pacific Crest Global Technology Leadership Forum on Tuesday, August ... will be held at the Sonnenalp Resort in ... presentation may include forward-looking information. An audio webcast of ...
(Date:7/31/2015)... julho de 2015 A 10 a. ... realizada pela BGI de 22-25 de outubro de 2015, em ... A conferência está celebrando seu 10 o. aniversário este ... tornou uma das reuniões mais influentes do mundo no ... dinâmicos, entusiastas e prazerosos. A ICG-10 ...
(Date:7/31/2015)... , 31. Juli 2015 Die 10. internationale Konferenz ... BGI veranstaltet und findet vom 22. bis 25. ... , statt. Die Konferenz feiert ... Start 2006 ist die ICG weltweit zu einem ... Sie ist eines der dynamischsten, enthusiastischsten und angenehmsten ...
Breaking Biology News(10 mins):A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 2Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 3
... PROVIDENCE, R.I. [Brown University] -- Bisphenol A (BPA), a ... recently become infamous -- and banned in some places -- ... new study by Brown University toxicologists, however, finds that male ... BPA while pregnant developed no signs of harm to their ...
... A complex of proteins in the bacterium E.coli ... viruses and other invaders has been discovered to have the ... of Energy,s Lawrence Berkeley National Laboratory (Berkeley Lab). This discovery ... might think. In its never-ending battle to protect you ...
... (Bronx, NY) -- Researchers at Albert Einstein College ... a novel type of antibody works against pneumococcal bacteria. ... in the September/October issue of mBio , the ... Until recently, scientists thought that antibodies work against pneumococcal ...
Cached Biology News:No harm to mice testes from BPA in utero 2Close up look at a microbial vaccination program 2Close up look at a microbial vaccination program 3Close up look at a microbial vaccination program 4Newly identified antibodies may improve pneumonia vaccine design 2
(Date:7/31/2015)... KONG , July 31, 2015 China ... China,s leading provider of cord ... stem cell storage services, today announced that the Company ... the U.S. Securities and Exchange Commission. The filed Form ... ended March 31, 2015. The Form 20-F can be ...
(Date:7/30/2015)... ... July 31, 2015 , ... Ralco is honored to ... the Lyon County Fair to be held August 5-9 in Marshall. The Ralco Enrichment ... meals come from and how agriculture impacts their daily lives. This unique exhibit also ...
(Date:7/30/2015)... July 30, 2015   GenoSpace , a ... interpretation and analysis of genomic and other biomedical ... has joined the company as Vice President of ... http://photos.prnewswire.com/prnh/20150730/250931 "GenoSpace partners with ... interpret, analyze and explore complex sets of genomic, ...
(Date:7/30/2015)... ... ... The 2015 Market Research Report on the Global Propanol Industry is ... with a focus on the Chinese situation. Major companies included in the propanol market ... Royal Dutch Shell, LG Chem and Zhejiang Xinhua Chemical. , The report provides a ...
Breaking Biology Technology:China Cord Blood Corporation Files Its Annual Report on Form 20-F 2Ralco Announces Primary Sponsorship of Ralco Enrichment Center at Lyon County Fair 2GenoSpace Introduces Matthew Fischer as Vice President of Sales and Marketing 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 2Global Propanol Market Technical Data and Manufacturing Analysis 2020 3
... Holdings, Inc. (OTC,Bulletin Board: HTWO) announced today that ... Mirant Energy Trading LLC, a subsidiary of Mirant ... biofuel technology in utility,scale power generation applications., ... biofuel for a gas,turbine test program that will ...
... Considered Largest Hurdle in Adoption of Incisionless ... Surgery (NOTES), SAN CLEMENTE, Calif., Dec. 19 ... Incisionless Surgery, today announced that,its EndoSurgical Operating System(TM) (EOS) ... (an incision in the stomach wall) during,a NOTES procedure ...
... Calif., Dec. 19 AMDL, Inc., (Amex:,ADL), today ... manufacturer, and marketer of pharmaceutical, nutraceutical,diagnostic, consumer healthcare ... first large-scale JPGreen Health and Personal Care Center ... Jade to be converted,into a flagship JPGreen Health ...
Cached Biology Technology:H2Diesel Holdings Announces Test Burn Agreement With Mirant Corp. 2H2Diesel Holdings Announces Test Burn Agreement With Mirant Corp. 3USGI Medical Demonstrates First System for Gastrotomy Closure in NOTES 2AMDL's First Full Service JPGreen Health and Personal Care Center Set to Open in Hangzhou, China 2
... DASGIP Overhead Drive for individual and parallel ... flexible agitation of DASGIP vessels, featuring range ... ,Up to 16 overhead drives can ... Cultivation Systems fedbatch-pro® and cellferm-pro® for microbiology ...
... your Ion Chromatography requirements, IonQuest will ... The newly developed conductivity detector has ... . In addition to the standard ... with other detectors, such as electrochemical, refractive ...
This pump accomodates StemSep ; pump feed columns of the following sizes : 0.3in., 0.5in., 0.6in., and 1.0in.....
...
Biology Products: