Navigation Links
Insights into micromillimeters

"TIGA," the new high-tech imaging center at the University of Heidelberg founded in cooperation with the Japanese company Hamamatsu, provides deep insights: a high-tech robot makes it possible for the first time to automatically reproduce and evaluate tissue slices only micromillimeters thick an important aid for researchers in understanding cancer or in following in detail the effect of treatment on cells and tissue.

The Hamamatsu Tissue Imaging and Analysis (TIGA) Center is a cooperative effort between the Institutes of Pathology and of Medical Biometry and Informatics at the University of Heidelberg and the Japanese company Hamamatsu Photonics. In addition, it belongs to BIOQUANT, the research center for quantitative biology at the University of Heidelberg. At its core is the imaging robot "NanoZoomer" from Hamamatsu Photonics: the robot scans the tissue slices and displays them on the monitor for researchers at ultra high resolution and in various planes.

"Technically, this has brought the fully automatic evaluation of tissue changes and approaches for new therapy within our grasp," states Professor Dr. Peter Schirmacher, Director of the Institute for Pathology at Heidelberg University Hospital. This would represent a new milestone in pathology.

Detailed images help understand diseases

Which proteins are formed to a greater degree in cancer cells? How is tumor tissue changed during radiation treatment? Thanks to the NanoZoomer's high-resolution images and special evaluation programs, researchers in the future will be able to evaluate tissue and cell samples more quickly and accurately and gain important new insights for therapy tailored to the individual patient, for example for breast cancer.

In the future, the robot will be able to determine changes in cells and tissue fully automatically. "The NanoZoomer represents a quantum leap in tissue research," says Dr. Niels Grabe of the Institute for Medical Biometry and Informatics and research director at the TIGA Center.

Virtual Tissue is modeled from data

The medical IT specialists use the NanoZoomer to evaluate huge quantities of data from tissues for their research. For example, Dr. Niels Grabe and his team used data to model virtual skin tissue. "On a computer model of human skin tissue we can test whether certain substances are toxic, for example," explains Dr. Grabe. "In the future, this could make it easier to develop potential new drugs."

Hamamatsu recognized the many possible applications early on, so that new technological markets have now been opened up for them. "We are happy to have found two partners in the Heidelberg Institute of Pathology and the Institute of Medical Biometry and Informatics with whom we can develop concrete clinical uses and new applications for research," said Hideo Hiruma, Managing Director of Hamamatsu Photonics, Japan.


Contact: Dr. Annette Tuffs
University Hospital Heidelberg

Related biology news :

1. Study of marine snail leads to new insights into long-term memory
2. Researchers reveal insights into hidden world of protein folding
3. Metagenomics of skin reveals insights into the human microbiome
4. First study hints at insights to come from genes unique to humans
5. New insights into the diversity of Creutzfeldt-Jakob disease agents
6. New chemical tool kit manipulates mitochondria, reveals insights into drug toxicity
7. New dinosaur from Mexico offers insights into ancient life on West America
8. Antarctic expedition provides new insights into the role of the Southern Ocean for global climate
9. New mechanical insights into wound healing and scar tissue formation
10. Hinode: new insights on the origin of solar wind
11. New insights into the fate of antiparasitics in manure and manured soils
Post Your Comments:
Related Image:
Insights into micromillimeters
(Date:5/9/2016)... , UAE, May 9, 2016 ... it comes to expanding freedom for high net worth ... Even in today,s globally connected world, there is still ... system could ever duplicate sealing your deal with a ... second passports by taking advantage of citizenship via investment ...
(Date:4/28/2016)... , April 28, 2016 First quarter 2016: ... up 966% compared with the first quarter of 2015 ... SEK 589.1 M (loss: 18.8) and the operating margin was 40% ... 0.32) Cash flow from operations was SEK 249.9 M ... revenue guidance is unchanged, SEK 7,000-8,500 M. The operating ...
(Date:4/19/2016)... , UAE, April 20, 2016 ... implemented as a compact web-based "all-in-one" system solution for ... biometric fingerprint reader or the door interface with integration ... modern access control systems. The minimal dimensions of the ... readers into the building installations offer considerable freedom of ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of commercial spectrophotometers and ... and the 6000i models are higher end machines that use the more unconventional z-dimension ... light beam from the bottom of the cuvette holder. , FireflySci has developed ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... release of its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering ... retention in this eBook by providing practical tips, tools, and strategies for clinical ...
(Date:6/23/2016)...   Boston Biomedical , an industry leader ... target cancer stemness pathways, announced that its lead ... Designation from the U.S. Food and Drug Administration ... gastroesophageal junction (GEJ) cancer. Napabucasin is an orally ... stemness pathways by targeting STAT3, and is currently ...
(Date:6/23/2016)... 23, 2016 A person commits a crime, and ... to track the criminal down. An outbreak of ... Drug Administration (FDA) uses DNA evidence to track down the ... Sound far-fetched? It,s not. The FDA has increasingly used a ... of foodborne illnesses. Put as simply as possible, whole genome ...
Breaking Biology Technology: