Navigation Links
Influenza study: Meet virus' new enemy
Date:2/21/2013

Simon Fraser University virologist Masahiro Niikura and his doctoral student Nicole Bance are among an international group of scientists that has discovered a new class of molecular compounds capable of killing the influenza virus.

Working on the premise that too much of a good thing can be a killer, the scientists have advanced previous researchers' methods of manipulating an enzyme that is key to how influenza replicates and spreads.

Their new compounds will lead to a new generation of anti-influenza drugs that the virus' strains can't adapt to, and resist, as easily as they do Tamiful. It's an anti-influenza drug that is becoming less effective against the constantly mutating flu virus.

These increasingly less adequate anti-influenza drugs are currently doctors' best weapons against influenza. They helped the world beat H1N1, swine flu, into submission four years ago.

The journal Science Express has just published online the scientists' study, revealing how to use their newly discovered compounds to interrupt the enzyme neuraminidase's facilitation of influenza's spread.

Tamiful and another anti-influenza drug, Relenza, focus on interrupting neuraminidase's ability to help influenza detach from an infected cell's surface by digesting sialic acid, a sugar on the surface of the cell. The flu virus uses the same sugar to stick to the cell while invading it. Once attached, influenza can invade the cell and replicate. v

This is where the newly discovered compounds come to the still-healthy cells' rescue. They clog up neuraminidase, stopping the enzyme from dissolving the sialic acid, which prevents the virus from escaping the infected cell and spreading.

The new compounds are also more effective because they're water-soluble. "They reach the patient's throat where the flu virus is replicating after being taken orally," says Niikura, a Faculty of Health Sciences associate professor.

"Influe
'/>"/>

Contact: Carol Thorbes
cthorbes@sfu.ca
Simon Fraser University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Target for potent first-strike influenza drugs identified
2. Climate change could increase levels of avian influenza in wild birds
3. Harnessing anticancer drugs for the future fight against influenza
4. Influenza research: Can dynamic mapping reveal clues about seasonality?
5. Pandemic controversies: The global response to pandemic influenza must change
6. BYU study: Using a gun in bear encounters doesnt make you safer
7. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
8. Study: Exercise can lead to female orgasm, sexual pleasure
9. U of I study: Lose body weight before gaining baby weight
10. Study: Men who do load-bearing exercise in early 20s may be shielded from osteoporosis
11. USF study: Common fungicide wreaks havoc on freshwater ecosystems
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... been known about what genetic changes transform wild animals ... of whom is a University of Montana assistant professor, ... the development of the brain and the nervous system ... published Aug. 28 in Science and gives ... http://www.sciencemag.org/ ., The domestication of animals and plants, ...
(Date:8/29/2014)... This news release is available in German . ... of chemical signals between organisms is considered the oldest ... social interactions between conspecifics, for example, the sexual attraction ... trigger social responses and to coordinate reproductive behavior in ... at the University of the Algarve in Faro, Portugal, ...
(Date:8/28/2014)... app called TX Invasives is now available from the ... Texas at Austin for identifying harmful non-native plant, insect ... in the United States cause about $137 billion in ... crops, clog waterways, kill native plants and more. , ... for reporting where invasive species occur, we,re more likely ...
Breaking Biology News(10 mins):New research reveals how wild rabbits were genetically transformed into tame rabbits 2New research reveals how wild rabbits were genetically transformed into tame rabbits 3Ready for mating at the right time 2Ready for mating at the right time 3Mobile app makes ID of harmful plants, insects in Texas a snap 2
... below are the selected highlights for the July 2012 issue ... The July issue is available online at www.genetics.org/content/current ... 2012, Copyright 2012. ISSUE HIGHLIGHTS , ... studies through the use of meta-analysis for structured populations , ...
... Researchers at the Translational Genomics Research Institute (TGen) have developed ... less costly, less invasive and more accurate way of diagnosing ... complication of diabetes, high blood pressure and a form of ... progressive deterioration of the kidney,s ability to filter waste from ...
... satellite imagery have been limited by weather. Clouds, in ... However, University of Iowa scientists have created a ... better estimate the concentration of pollutants, such as soot. ... block remote-sensing satellites, ability to detect, and thus calculate, ...
Cached Biology News:Genetics Society of America's Genetics journal highlights for July 2012 2Genetics Society of America's Genetics journal highlights for July 2012 3TGen method isolates biospecimens for treatment of kidney disease 2UI researchers develop technique to help pollution forecasters see past clouds 2
(Date:8/28/2014)... “This kit has an improved extraction efficiency and provides ... ppb,” said Mark Tess, PhD, Mycotoxin Product Manager for Charm ... and USDA-GIPSA inspection agencies that have a need to detect ... in a matter of minutes with nothing but our equipment ... and grain before accepting it, but they no longer have ...
(Date:8/28/2014)... The ability for organizations to attract top ... individuals to perform at the highest of levels, are ... to compete in this post–recession era. The pharmaceutical ... the sector increasingly focuses on the importance of employee-fit ... real results on the organization's development and the innovation ...
(Date:8/28/2014)... MENLO PARK, Calif. , Aug. 28, 2014 ... company focused on developing novel mid- to late-stage ... raised $7.0 million in its first round of ... AshHill Biomedical Investments and Hercules Bioventures with participation ... biotech entrepreneur and pharmaceutical executive, Dr. Larry ...
(Date:8/28/2014)... 2014 Earlier this month, a ... partnership with the U.S. Air Force on the performance ... indicated that this type of fuel made from mustard ... be important to America’s Eco friendly future. In fact, ... mandate to become independent of foreign oil over the ...
Breaking Biology Technology:Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 2Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 3Armetheon Completes $7.0 Million Series A Financing 2Armetheon Completes $7.0 Million Series A Financing 3Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 2Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 3Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 4Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 5
... 24, 2011 Amgen (Nasdaq: AMGN ) today ... full year financial results on Monday, Jan. 24, 2011 after ... followed by a conference call with the investment community at ... will be Kevin Sharer, chairman and chief executive officer, and ...
... (Nasdaq: CEPH ) will hold a public memorial service ... and CEO on February 1, 2011, at 6:00 p.m. at The ... Dr. Baldino founded Cephalon in 1987 and led the ... ten biotechnology companies in the world. He was a recognized pioneer ...
... a strategy-driven biotech and pharmaceutical product development company, announced ... the National Institutes of Health (NIH) Therapeutics for Rare ... and development partner. The RRD and ... development projects: Hereditary Inclusion Body Myopathy (HIBM), a rare ...
Cached Biology Technology:Amgen Announces Webcast of 2010 Fourth Quarter and Full Year Financial Results 2Cephalon to Hold Public Memorial Service to Celebrate the Life of Company Founder, Frank Baldino, Jr., Ph.D. 2RRD Selected as Development Partner for NIH Therapeutics for Rare and Neglected Diseases Program 2RRD Selected as Development Partner for NIH Therapeutics for Rare and Neglected Diseases Program 3
... Mouse anti-Yersinia pestis F1 antigen, Monoclonal ... ELISA: Use at an ... an assay dependent dilution. WB: Use ... molecular weight: 18 kDa. Not tested ...
Anti-Phospho-JKK/SEK1/MKK4 pAb Description: 100 g rabbit polyclonal antibody. Reacts with human/mouse/rat. Tested in WB. Research Focus: signal transduction Storage: -20C Shipping Tem...
... A - Fixation medium Reagent B - ... for fixing cells in suspension with Reagent ... Reagent B. This procedure gives antibodies access ... scatter characteristics of the cells intact. Specific ...
... formulated for covering tissue sections and cell preparations immunohistochemically stained ... , ... Application: Vision Mount ... that require an aqueous mounting medium, or those that do ...
Biology Products: