Navigation Links
In the war against diseases, nerve cells need their armor
Date:11/12/2008

In a new study, researchers at the Montreal Neurological Institute (MNI), McGill University, and the Universit de Montral have discovered an essential mechanism for the maintenance of the normal structure of myelin, the protective covering that insulates and supports nerve cells (neurons). Up until now, very little was known about myelin maintenance. This new information provides vital insight into diseases such as Multiple Sclerosis (MS) and other progressive demyelinating diseases in which myelin is destroyed, causing irreversible damage and disrupting the nerve cells' ability to transmit messages. The research, published recently in the Journal of Neuroscience, is the first to identify a role for the protein netrin-1, previously characterized only in the developing nervous system, with this critical function in the adult nervous system. This research was funded by the MS Society of Canada and the Canadian Institutes of Health Research.

Netrin-1, a protein deriving its name from the ancient Indian language, Sanskrit, word for 'one who guides,' is known to guide and direct nerve cell axons to their targets. In the molecular biological studies conducted by the team, they found that blocking the function of netrin-1 and one of its receptors in adult neural tissue causes the disruption of myelin. "We've known for just over 10 years that netrin is essential for normal development of the nervous system, and we also knew that netrin was present in the adult brain, but we didn't know why. It is fascinating that netrin-1 has such a vital role in maintaining the structure of myelin in the adult nervous system," says Dr. Tim Kennedy, a neuroscientist at the MNI and the senior investigator of this study, "continuing to pursue the implications of that are incredibly exciting." "Our mission is to find a cure as quickly as possible and enhance quality of life," says Karen Lee, assistant vice-president of research programs for the MS Society of Canada. "We
'/>"/>

Contact: Anita Kar
anita.kar@mcgill.ca
514-398-3376
Montreal Neurological Institute and Hospital
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. A new weapon in the fight against obesity and diabetes
2. Severe gestational hypertension may protect against testicular cancer
3. Gene against bacterial attack unravelled
4. Purple tomatoes: The richness of antioxidants against tumors
5. Research identifies type of vaccine that holds promise in protecting against TB
6. Wielding microbe against microbe, beetle defends its food source
7. Vitiligo skin disorder could yield clues in fight against melanoma
8. Friendly bacteria protect against type 1 diabetes, Yale researchers find
9. Bats pick up rustling sounds against highway background noise
10. Vaccine against HER2-positive breast cancer offers complete protection in lab
11. Tuberculosis drug shows promise against latent bacteria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2014)... . Wind ... large amount of electricity is to be produced with renewable ... be stored during productive periods so that these fluctuations can ... adequate for the purpose. Science and industry are therefore working ... systems that used to be too expensive or unsophisticated to ...
(Date:8/19/2014)... not a monkey. It,s not a lemur. It,s not an ... Philippine tarsier: a tiny, adorable and downright "cool" primate from ... Americans are familiar with," said Rafe Brown, curator-in-charge at the ... and ears; an extremely cute, furry body; a long tail ... fingers and toe tips that look a bit like the ...
(Date:8/19/2014)... retail seafood counters in 10 different states show ... to unexpectedly high levels of mercury, a harmful ... fish of the same species, but from a ... according to new research by University of Hawai,i ... is essential to allow consumers to choose sustainable ...
Breaking Biology News(10 mins):Asian inventions dominate energy storage systems 2Asian inventions dominate energy storage systems 3Philippine tarsier gets boost from Kansas research, and genetic proof of a new variety 2Philippine tarsier gets boost from Kansas research, and genetic proof of a new variety 3Seafood substitutions can expose consumers to unexpectedly high mercury 2Seafood substitutions can expose consumers to unexpectedly high mercury 3
... as 25 percent of hospital nurses go without sleep for ... on the night shift, which is the least effective strategy ... That is one of the results of the first study ... between day and night sleep cycles. The study was based ...
... hydrogen in a sustainable way is a challenge and production ... Xile Hu has discovered that a molybdenum based catalyst is ... the research are published online in Chemical Science ... this discovery has just been filled. Existing in large quantities ...
... Ceelox, Inc. (OTCBB: CELO) announced today that the ... cloud applications using biometrics. Ceelox ID Online® utilizes a ... Internet server-based biometric software application. This enables users to ... i.e. user name and password, compromised or stolen by ...
Cached Biology News:A sleep strategy commonly used by night nurses throws off their circadian clocks 2A sleep strategy commonly used by night nurses throws off their circadian clocks 3Ceelox Provides Biometric Identity Access to Cloud Applications 2Ceelox Provides Biometric Identity Access to Cloud Applications 3
(Date:8/16/2014)... 2014 Dr. Carl Peck, ... today that Agnes Westelinck, PharmD, has joined the ... Premier Experts are top tier consultants whose expertise ... value to the company’s clients. Premier Experts collaborate ... clients successfully develop their medical products, pursue optimal ...
(Date:8/15/2014)... 15, 2014 Actor Robin Williams’ suicide ... As NBC’s Today Show reports, someone commits suicide every ... symptoms of depression from the outside in, I contend ... the underlying cause from the inside out,” says neuroscientist ... Virginia. , “Some of the accounts of Williams’ suicide ...
(Date:8/15/2014)...  Two 5-foot-5 superbug-slaying machines were deployed from ... to JFK Hospital and ELWA Hospital in ... , where they will aid in the fight against ... - http://photos.prnewswire.com/prnh/20140814/136426 The devices, ... environments where Ebola patients are being treated. TRU-D is ...
(Date:8/14/2014)... experiments, researchers at Johns Hopkins have learned why people ... third and subsequent time around. The reason: They are ... the task, but also by memories of the errors ... new motor task, there appear to be two processes ... in the Department of Biomedical Engineering at the Johns ...
Breaking Biology Technology:Former GlaxoSmithKline Senior Executive Agnes Westelinck Joins NDA Partners as a Premier Expert Consultant 2Neurofeedback Helps Alleviate the Underlying Causes of Depression 2Neurofeedback Helps Alleviate the Underlying Causes of Depression 3Germ-Killing Robots Deployed to the Republic of Liberia To Aid in Battle Against Ebola Virus 2Germ-Killing Robots Deployed to the Republic of Liberia To Aid in Battle Against Ebola Virus 3Memories of errors foster faster learning 2
... billions of clot-forming platelets every day, but there are ... with certain diseases or during invasive surgery. Now, University ... can induce bone marrow cells called megakaryocytes to quadruple ... a graduate student of pharmacology in Penn,s Perelman School ...
... Tiny chemical particles emitted by diesel exhaust fumes could raise ... have found that ultrafine particles produced when diesel burns are ... blood clots forming in arteries, leading to a heart attack ... measured the impact of diesel exhaust fumes on healthy volunteers ...
... Mass. -- A novel application of carbon nanotubes, developed by ... solar energy for use whenever it,s needed. Storing the ... to electricity or storing the heat itself in a heavily ... chemical material can be stored for long periods of time ...
Cached Biology Technology:Penn researchers show single drug and soft environment can increase platelet production 2Penn researchers show single drug and soft environment can increase platelet production 3Diesel fumes pose risk to heart as well as lungs, study shows 2MIT research update: New way to store sun's heat 2MIT research update: New way to store sun's heat 3
Mouse monoclonal [DJR3] to DcR1 (Phycoerythrin) ( Abpromise for all tested applications). entrezGeneID: 8794 SwissProtID: O14798...
Applications: Beadlyte® assay Stability: 2 years at 4°C (lyophilized) or 6 months at -20°C (rehydrated) ...
Dnase and Rnase free...
... Quality 96 Well BAC Prep; ... preparation from 1.5ml 2xYT cultures; ... automated fluorescent sequencing for small ... ProPrep strategy which minimizes shearing ...
Biology Products: