Navigation Links
In lab studies, hydroxyethyl starch has direct harmful effects on kidney cells
Date:7/11/2014

July 11, 2014 The increased risk of kidney injury related to the use of hydroxyethyl starch (HES) in resuscitation fluids reflects the mass of HES molecules, according to a report in Anesthesia & Analgesia, official journal of the International Anesthesia Research Society (IARS).

The "total mass of HES molecules" explains the harmful effect of HES on cultured human renal proximal tubule cells (PTCs), concludes the laboratory study by Dr Christian Wunder and colleagues of University Hospital Wrzburg, Austria. Other factorssuch as differences in the origin or molecular weight of HES solutionsappear to play little or no role in cellular-level toxicity of HES.

What Factors Affect Toxic Effects of HES on Kidney Cells?

Hydroxyethyl starch is a starch derivative that has been widely used for fluid resuscitation with volume expansion for critically ill or injured patients in shock. A growing body of evidence suggests that HES solutions may have harmful effects, including an increased risk of kidney injury and death.

In previous studies, Dr Wunder and colleagues found that HES caused impaired kidney function in animals with sepsis (severe infection). Those studies showed that HES was localized mainly in the kidney PTCs. The researchers performed a series of in-depth follow-up experiments to look at factors influencing the toxic effects of HES on cultured human PTCs.

Most of the factors assessed had no major influence on reductions in cell viability caused by HES. Cellular toxicity was unrelated to the type of "carrier" solution used in the cell cultures, the use of HES made from different origins (potato versus corn starch), or the time cells spent in culture with HES.

The toxic effects were also similar for HES solutions of different molecular weights. That's an important finding, as newer low-molecular weight HES solutions were thought to be safer than previous products. There was also no evidence
'/>"/>

Contact: Connie Hughes
Connie.Hughes@wolterskluwer.com
646-674-6348
Wolters Kluwer Health
Source:Eurekalert

Page: 1 2

Related biology news :

1. Are enough women included in medical device studies, as required by the FDA?
2. Resistant starch content of potatoes varies significantly by preparation and service method
3. Study shows that diet of resistant starch helps the body resist colorectal cancer
4. Study documents eating of soil, raw starch in Madagascar
5. Inexpensive, abundant starch fibers could lead to ouchless bandages
6. Avery Biomedical Devices, Inc. announces the appointment of Mark E Ginsburg, M.D. to its Board of Directors
7. CNIO scientists develop technology to redirect proteins towards specific areas of the genome
8. Wyss Institute founding director Don Ingber to deliver 2014 Graeme Clark Oration
9. Turtle migration directly influenced by ocean drift experiences as hatchlings
10. Galectins direct immunity against bacteria that employ camouflage
11. Ground breaking technique offers DNA Sat Nav direct to your ancestors home 1,000 years ago
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2015)... May 5, 2015, NXT-ID, Inc. (NASDAQ: NXTD ... on the growing mobile commerce market, reminds investors and media ... Officer, is presenting  at CARTES SECURE CONNEXIONS AMERICA 2015, held ... The three-day conference is organized into a ... in is themed Global Fraud: Where is the Trust ...
(Date:4/20/2015)... , April 20, 2015 Huntington Memorial ... Valley to implant a new miniaturized, wireless monitoring sensor ... is the first and only FDA-approved heart failure monitoring ... admissions when used by physicians to manage heart failure. ... that is implanted in the pulmonary artery (PA) during ...
(Date:4/13/2015)... According to a recently ... & Opportunities, 2020", the global biometrics market is ... till 2020. The biometrics market is garnering attention ... review of biometric management systems. The constant development ... greater efficiency, are resulting in increasing installation of ...
Breaking Biology News(10 mins):NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 2NXT-ID, Inc.'s CTO, David Tunnell, Presents at CARTES SECURE CONNEXIONS AMERICA 2015 Today in Washington DC. 3Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2
... under attack by toxic seaweed do what anyone might do when ... in the journal Science shows that threatened corals send ... noxious alga which can kill the coral if not promptly ... evidence that these "mutualistic" fish respond to chemical signals from the ...
... This press release is available in German . ... in multicellular organisms. Because of their potent effects, the production ... That is the key finding of a new study performed ... Biology. They identified a new component that modulates the production ...
... 126,000 sites across the U.S. have contaminated groundwater that requires ... "complex," meaning restoration is unlikely to be achieved in the ... a new report from the National Research Council. The ... these sites ranges from $110 billion to $127 billion, but ...
Cached Biology News:Corals attacked by toxic seaweed use chemical 911 signals to summon help 2Corals attacked by toxic seaweed use chemical 911 signals to summon help 3Corals attacked by toxic seaweed use chemical 911 signals to summon help 4MicroRNAs in plants: Regulation of the regulator 2MicroRNAs in plants: Regulation of the regulator 3Report: Cleanup of some contaminated groundwater sites unlikely for decades 2Report: Cleanup of some contaminated groundwater sites unlikely for decades 3
(Date:5/26/2015)... REDWOOD CITY, California and HILDEN, ... -- QIAGEN N.V. (NASDAQ: QGEN ... commercial launch of its QIAGEN Clinical Insight ® ... clinical testing labs to interpret and report on ... first two supported applications for the bioinformatics platform ...
(Date:5/26/2015)... 2015 Tianyin Pharmaceutical Inc. (NYSE Amex: ... patented biopharmaceutical, modernized traditional Chinese medicine (mTCM), branded generics ... Annual Meeting of Shareholders for fiscal year ended June ... the Company,s office located in Chengdu, China ... (local time in Chengdu, China ) ...
(Date:5/26/2015)...  A simple blood test developed at the University ... Alzheimer,s disease is a step closer to being used ... that are needed before a blood test could be ... & Dementia . The guidelines establish protocols and reflect ... includes UNT Health Science Center. "If we ...
(Date:5/26/2015)... Mr. Kevin Xu , President of MEBO ... Obama and President Bill Clinton for their ... Dr. Rongxiang Xu , Kevin,s father. ... his time, Dr. Xu,s commitment to the advancement of science ... will not be forgotten. As a renowned life scientist, Dr. ...
Breaking Biology Technology:QIAGEN Launches Clinical Bioinformatics Platform for Next-Generation Sequencing 2QIAGEN Launches Clinical Bioinformatics Platform for Next-Generation Sequencing 3QIAGEN Launches Clinical Bioinformatics Platform for Next-Generation Sequencing 4QIAGEN Launches Clinical Bioinformatics Platform for Next-Generation Sequencing 5TPI Adjourned Its 2014 Annual Shareholder Meeting and Received Notice of Non-Compliance with NYSE MKT Continued Listing Requirements 2TPI Adjourned Its 2014 Annual Shareholder Meeting and Received Notice of Non-Compliance with NYSE MKT Continued Listing Requirements 3Guidelines bring UNT Health Science Center's blood test for Alzheimer's one step closer 2Dr. Rongxiang Xu, Beyond A Legend 2
... Growth Rates Under 1 Percent Since 2000,Partnership Will Target Acceleration and ... ... Banos, Philippines (vocus) March 3, 2009 -- DuPont and ... partnership to boost rice yields. The Scientific Know-How and Exchange ...
... 3 Zymetis Inc., a biotechnology company focused on ... today announces it was named a 2009 GoingGreen East ... "greentech" companies in the Eastern U.S. and Canada. ... given to emerging companies creating new green technology businesses. ...
... Informed Medical Communications (IMC), a leading provider of ... announced the appointment of Kerry Crawford to the ... this critical role, Kerry will lead operations and ... relationship management systems. This key addition is ...
Cached Biology Technology:DuPont and International Rice Research Institute Partner to Boost Rice Yields 2DuPont and International Rice Research Institute Partner to Boost Rice Yields 3Zymetis Inc. Named Top 50 'Cleantech/Greentech' Company 2Informed Medical Communications Appoints New Senior Manager, Strategic Operations 2
Recombinant Rat Leptin, CF...
Rat whole blood (Sprague-Dawley, averaging 7-8 weeks of age, either sex) is collected at the time of slaughter and refrigerated within 6 hours, and processed and frozen within 24 hours. The serum is ...
Polaroid black & white positive, 3 x 4 inch pack film, ISO 3000/ 36 ASA DIN (20 expsures). For use in the Polaroid Direct Copy Camera (PHC34)....
Applications: (+) Immunocytochemistry and immunohistochemistry...
Biology Products: