Navigation Links
Improving the development of new cancer models using an advanced biomedical imaging method
Date:12/17/2012

Scientists at the University of Arizona Cancer Center and the Moffitt Cancer Center, led by Dr. Robert Gillies, have demonstrated that an advanced magnetic resonance imaging (MRI) method can non-invasively evaluate the cellular proliferation of tumor models of breast cancer. This quantitative imaging method evaluates the diffusion of water in tumor tissue, which correlates with the growth rates of the tumor models. The results, which appear in the November 2012 issue of Experimental Biology and Medicine, can contribute to the development of new tumor models for cancer research.

"In the absence of imaging such as we describe here, developers of tumor models are flying blind" says Dr. Gillies. "In this study, we show that the behavior of water in tissues can provide important information about tumor development. More specifically, the mobility of water is inhibited by biological barriers such as cell membranes, so that decreased mobility can be used as a measure of cell density and proliferation in tumor models."

The development of new tumor models is a high priority for current cancer research. Yet creating new pre-clinical tumor models from cancer cells obtained from patients is a laborious process with a low potential for success. Dr. Marty Pagel, co-investigator on the study states that "noninvasive, quantitative imaging techniques have potential to accelerate and improve the success of establishing new tumor models for innovative cancer studies."

Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine said "This exciting study by Gillies and colleagues demonstrates that a Diffusion Weighted MRI technique provides a quantitative measure of tumor development in models of breast cancer. Such a non-invasive method will allow for the development of new tumor models that can be used for the development of improved therapies for breast cancer".


'/>"/>
Contact: Dr. Robert J. Gillies
robert.gillies@moffitt.org
Society for Experimental Biology and Medicine
Source:Eurekalert

Page: 1

Related biology news :

1. Genetic research develops tools for studying diseases, improving regenerative treatment
2. Interventional radiology: Mitigating symptoms, improving quality of life of MS patients
3. Improving equine health: Research studies vaccinations to protect newborn foals
4. Global Surgical Devices Market Growth Driven by Improving Standards of Living and Longer Life Expectancies, Research Shows
5. Validity CTO to Present Natural ID Solutions for Improving Mobile Risk Management and User Experience at NFC Solutions Summit 2012
6. Waste to watts: Improving microbial fuel cells
7. Improving water quality can help save coral reefs
8. GOCEs second mission improving gravity map
9. U of Minn. receives $1.8 million grant for improving efficiencies in fuel and plastics production
10. Artificial womb unlocks secrets of early embryo development
11. REST is crucial for the timing of brain development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/9/2017)... The biomass boiler market report by Transparency Market Research ... in terms of revenue (US$ Mn) based on the ... boilers has been segmented on the basis of feedstock ... based on feedstock type, has been segmented into woody ... urban residues, and others. On the basis of product ...
(Date:2/8/2017)... BEDFORD, Mass., Feb. 7, 2017  Aware, Inc. (NASDAQ: ... services, today reported financial results for its quarter and year ... fourth quarter of 2016 was $3.9 million compared to $6.9 ... the fourth quarter of 2016 was $0.6 million compared to ... in the fourth quarter of 2016 was $0.5 million, or ...
(Date:2/8/2017)... YORK , Feb. 7, 2017 ... Driven largely by the confluence of organizations, desires ... distaste for knowledge-based systems (password and challenge questions), ... industrial, and government systems. The market is driven ... a demarcation between consumer and enterprise uses cases, ...
Breaking Biology News(10 mins):
(Date:2/23/2017)... Madison, Wisconsin (PRWEB) , ... February 23, 2017 ... ... their Drug Discovery Services portfolio to include an array of biochemical ... clients with reliable data to drive their hit-to-lead and SAR programs, including inhibitor ...
(Date:2/23/2017)... ROCHESTER, Minn. , Feb. 23, 2017 /PRNewswire/ ... a new product line of oncolytic vaccinia viruses ... Genelux Corporation as part of Genelux,s proprietary, vaccinia ... "We are excited to enter into a partnership ... time, selected oncolytic vaccinia viruses for use in ...
(Date:2/23/2017)... ... February 23, 2017 , ... The Greater Gift Initiative, Inc , (GGI) ... Compass Research . GGI's mission is to advance global health and highlight the greater ... in honor of each clinical trial volunteer. The vision of GGI is to serve ...
(Date:2/22/2017)... Therapeutics, Inc. (NASDAQ: PETX), a pet therapeutics company focused on ... companion animals, will host a live conference call on Tuesday, ... results from the fourth quarter and full year ended December ... access the audio webcast or use the conference ... ...
Breaking Biology Technology: