Navigation Links
Improving the development of new cancer models using an advanced biomedical imaging method
Date:12/17/2012

Scientists at the University of Arizona Cancer Center and the Moffitt Cancer Center, led by Dr. Robert Gillies, have demonstrated that an advanced magnetic resonance imaging (MRI) method can non-invasively evaluate the cellular proliferation of tumor models of breast cancer. This quantitative imaging method evaluates the diffusion of water in tumor tissue, which correlates with the growth rates of the tumor models. The results, which appear in the November 2012 issue of Experimental Biology and Medicine, can contribute to the development of new tumor models for cancer research.

"In the absence of imaging such as we describe here, developers of tumor models are flying blind" says Dr. Gillies. "In this study, we show that the behavior of water in tissues can provide important information about tumor development. More specifically, the mobility of water is inhibited by biological barriers such as cell membranes, so that decreased mobility can be used as a measure of cell density and proliferation in tumor models."

The development of new tumor models is a high priority for current cancer research. Yet creating new pre-clinical tumor models from cancer cells obtained from patients is a laborious process with a low potential for success. Dr. Marty Pagel, co-investigator on the study states that "noninvasive, quantitative imaging techniques have potential to accelerate and improve the success of establishing new tumor models for innovative cancer studies."

Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine said "This exciting study by Gillies and colleagues demonstrates that a Diffusion Weighted MRI technique provides a quantitative measure of tumor development in models of breast cancer. Such a non-invasive method will allow for the development of new tumor models that can be used for the development of improved therapies for breast cancer".


'/>"/>
Contact: Dr. Robert J. Gillies
robert.gillies@moffitt.org
Society for Experimental Biology and Medicine
Source:Eurekalert

Page: 1

Related biology news :

1. Genetic research develops tools for studying diseases, improving regenerative treatment
2. Interventional radiology: Mitigating symptoms, improving quality of life of MS patients
3. Improving equine health: Research studies vaccinations to protect newborn foals
4. Global Surgical Devices Market Growth Driven by Improving Standards of Living and Longer Life Expectancies, Research Shows
5. Validity CTO to Present Natural ID Solutions for Improving Mobile Risk Management and User Experience at NFC Solutions Summit 2012
6. Waste to watts: Improving microbial fuel cells
7. Improving water quality can help save coral reefs
8. GOCEs second mission improving gravity map
9. U of Minn. receives $1.8 million grant for improving efficiencies in fuel and plastics production
10. Artificial womb unlocks secrets of early embryo development
11. REST is crucial for the timing of brain development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/4/2014)... research study examining only marketing directed at children ... restaurants has found that the majority of black, ... such marketing tactics. , Authored by Arizona State ... study is the first to examine the use ... of fast food restaurants and its relationship to ...
(Date:11/3/2014)... , Nov. 3, 2014 Research and ... "Cell Therapy - Technologies, Markets and Companies" to ... cell therapy technologies and methods, which have already started to ... stem cell transplantation is replacing the old fashioned bone marrow ... Cell therapy is bound to become a part of medical ...
(Date:11/2/2014)... Physics World , James Dacey explores the ways in ... take their innovations from the lab into the commercial ... all start-up companies as they move from prototype to ... main factors: physics-based inventions are usually far from market-ready ... be a lot more complicated than had been originally ...
Breaking Biology News(10 mins):Fast food marketing for children disproportionately affects certain communities 2Fast food marketing for children disproportionately affects certain communities 3Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 2Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 3The 'valley of death' facing physics start-ups 2
... the genetic identity of human immunodeficiency virus (HIV), the ... The finding provides important clues in the ongoing search ... University of Alabama at Birmingham (UAB). The UAB team ... few lead to sexual transmission. Earlier studies have ...
... of experts in biomechanics and physiology from six ... Massachusetts Institute of Technologys Media Lab, refute scientific ... a 21-year-old South African bilateral amputee track athlete, ... 400-meter race. Their conclusions were based on data ...
... Evolution is supposed to inch forward over eons, but ... called the threespine stickleback, the process can go in relative ... Fred Hutchinson Cancer Research Center and published online ahead of ... Press). , There are not many documented examples of reverse ...
Cached Biology News:HIV infection stems from few viruses 2Breaking news: Study revives Olympic prospects for amputee sprinter 2Breaking news: Study revives Olympic prospects for amputee sprinter 3Researchers document rapid, dramatic 'reverse evolution' in the threespine stickleback fish 2Researchers document rapid, dramatic 'reverse evolution' in the threespine stickleback fish 3
(Date:11/22/2014)... (PRWEB) November 21, 2014 Prominent ... investors will gather on December 3rd at Genetic ... Conferences series. GeneticRx will take place at the ... School and will discuss the present and future ... exon skipping, and gene editing—as well as the ...
(Date:11/22/2014)... November 22, 2014 Respiratory therapy ... the proper management of life-like respiratory ailments using ... devices . Grand Rapids-based, Michigan Instruments Inc. developers ... two of the respiratory simulation units to the ... Grand Valley and Muskegon Community College are collaborating ...
(Date:11/21/2014)... 2014 The science of light and ... with more than 200 primary students in a traveling ... University of Otago Physics Department and funded by an ... members of the university’s OSA/SPIE Student Chapter visited six ... giving children from small, rural schools hands-on lessons in ...
(Date:11/21/2014)... November 20, 2014 The November 2014 ... as an open access journal featuring the following articles:, ... proteins to preserve photoresponsiveness in the retina , ... in situ hybridization using chromogenic substrates in zebrafish , ... RNA, and protein electrophoresis , Nuclear LC3-positive ...
Breaking Biology Technology:Pioneering Academics and Key Industry Leaders to Discuss Rare Diseases and the Emergence of New Genetic Medicines at Genetic Rx on December 3rd 2Michigan Instruments Donates Two Respiratory Simulation Training and Test Lung (TTL) Devices to Grand Valley State University 2Michigan Instruments Donates Two Respiratory Simulation Training and Test Lung (TTL) Devices to Grand Valley State University 3Optics and photonics outreach programs share science, spark fascination with light 2Optics and photonics outreach programs share science, spark fascination with light 3BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 2BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 3
... be the nation,s next "Strontium Valley"? The University of Pittsburgh ... the National Science Foundation and the Nanoelectronics Research Initiative (NRI) ... kind of computer out of the lab and into the ... Levy, a professor of physics and astronomy in Pitt,s School ...
... 19, 2011 Reportlinker.com announces that a ... its catalogue: Established and ... http://www.reportlinker.com/p0618133/Established-and-Emerging-Biotech-Clusters.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Biotechnology There has ... clusters of biotechnology companies and related organizations. ...
... HAYWARD, Calif., Sept. 19, 2011 OptiScan Biomedical ... systems for use in intensive care units (ICU), ... Glucose Monitoring System has received CE Mark certification ... Mark certifies that the OptiScanner has met all ...
Cached Biology Technology:Post-silicon computing 2Post-silicon computing 3Post-silicon computing 4Established and Emerging Biotech Clusters 2Established and Emerging Biotech Clusters 3Established and Emerging Biotech Clusters 4Established and Emerging Biotech Clusters 5Established and Emerging Biotech Clusters 6Established and Emerging Biotech Clusters 7Established and Emerging Biotech Clusters 8OptiScan Biomedical Receives CE Mark for OptiScanner Automatic Bedside Glucose Monitoring System 2OptiScan Biomedical Receives CE Mark for OptiScanner Automatic Bedside Glucose Monitoring System 3OptiScan Biomedical Receives CE Mark for OptiScanner Automatic Bedside Glucose Monitoring System 4
... Pulser Xcell microbial system, 100 to ... for electroporation of bacterial and fungal ... unit, PC module for exponential decay ... cuvettes (5 each of 0.1 and ...
... solution. In PBS containing ... other proprietary stabilizers; 0.2 ... to stabilize activity of ... at high conjugate dilutions ...
... Pulser Xcell eukaryotic system, 100 ... is used for electroporation of ... the main unit, CE module ... or square-wave pulses, ShockPod shocking ...
... on Macintosh operating systems to predict ... sequence up to 3,200 bases, which ... and GC clamps for mutation detection ... constant denaturing gel electrophoresis (CDGE), and ...
Biology Products: