Navigation Links
Important role for the cerebellum
Date:3/18/2011

The team of Prof. Dr. Stefan Herlitze, the Chair of the Department of Zoology and Neurobiology at RUB, showed that the diseases broke out in mice if, a week after birth, they eliminated a particular protein in the cerebellum which regulates the influx of ions into nerve cells. "It's the first time that we have gained an insight into the origin of these diseases" said Prof. Herlitze. "We can now start conducting research to develop new therapeutic approaches."

Defective calcium channels as a cause of disease

Various forms of epilepsy, coordination disturbances (ataxias) and migraines are caused by mutations in the so-called P/Q-type calcium channel that controls the influx of calcium ions into the nerve cells of the brain. Dr. Melanie Mark from Prof. Herlitze's team developed an animal model in which this calcium channel could be deactivated at any time in a brain region of choice. The researchers focused on specific cells in the cerebellum (Purkinje cells) that coordinate the movements of the body. "The calcium channel is actually present throughout the entire brain", explains Dr. Mark. "It is the first time that we have been able to show that the diseases can be triggered by dysfunctional signal processing originating in the cerebellum."

Through cooperation to a new therapy

With the aid of the new mouse model, the so-called Purky mouse, Prof. Herlitze's team is now investigating the molecular basis of the diseases caused by changes in the P/Q-type calcium channel, in order to develop new therapeutic approaches. In cooperation with Prof. Dr. Timmann-Braun of the University Clinic in Essen and Prof. Dr. Klockgether of the University Clinic in Bonn, Bochum's neuroscientists want to compare their studies in the mouse model with results from patient studies. "We especially hope to help children suffering from absence epilepsy, i.e. epilepsy associated with a disturbance of consciousness", says Prof. Herlitze.


'/>"/>

Contact: Dr. Stefan Herlitze
stefan.herlitze@rub.de
49-023-432-24363
Ruhr-University Bochum
Source:Eurekalert

Related biology news :

1. Scripps Research team discovers new details about medically important protein family
2. Notre Dame research offers important clues about grasshopper population explosions
3. Uterine health more important than egg quality
4. An important breakthrough by IRCM researchers in hematopoiesis and the development of B cells
5. Process leading to protein diversity in cells important for proper neuron firing
6. A discovery could be important for the therapy of lymphoma and leukemia
7. Is the shape of a genome as important as its content?
8. Scientists reveal important clues to how bacteria and viruses are identified as enemies
9. ‘Scientific leaders of the future’ gear up for important talks on Capitol Hill
10. U of Alberta researchers discover important mechanism in fighting infection
11. Sensor important to understanding root, seedling development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/9/2016)... , June 9, 2016 ... Police deploy Teleste,s video security solution to ensure the safety ... France during the major tournament Teleste, ... communications systems and services, announced today that its video security ... to back up public safety across the country. ...
(Date:6/2/2016)... Perimeter Surveillance & Detection Systems, Biometrics & ... & Other Service  The latest report from ... of the global Border Security market . Visiongain ... billion in 2016. Now: In November 2015 ... and hardware technologies for advanced video surveillance. ...
(Date:5/12/2016)... WearablesResearch.com , a brand of Troubadour ... from the Q1 wave of its quarterly wearables survey. ... receptivity to a program where they would receive discounts ... company. "We were surprised to see that ... LaColla , CEO of Troubadour Research, "primarily because there ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... ClinCapture, the only free ... and will showcase its product’s latest features from June 26 to June 30, ... poster on Disrupting Clinical Trials in The Cloud during the conference. DIA ...
(Date:6/23/2016)... ... June 23, 2016 , ... Velocity Products, a ... designed, tuned and optimized exclusively for Okuma CNC machining centers at The International ... a collaboration among several companies with expertise in toolholding, cutting tools, machining dynamics ...
(Date:6/23/2016)... , June 23, 2016 ... market research report to its pharmaceuticals section with ... product details and much more. Complete ... across 151 pages, profiling 15 companies and supported ... at http://www.reportsnreports.com/reports/601420-global-cell-culture-media-industry-2016-market-research-report.html . The ...
(Date:6/22/2016)... DUBLIN , June 22, 2016 Research ... and Global Markets" report to their offering. ... $39.4 billion in 2014 from $29.3 billion in 2013. The market ... (CAGR) of 13.8% from 2015 to 2020, increasing from $50.6 billion ... and projected product forecasts during the forecast period (2015 to 2020) ...
Breaking Biology Technology: