Navigation Links
Important role for the cerebellum
Date:3/18/2011

The team of Prof. Dr. Stefan Herlitze, the Chair of the Department of Zoology and Neurobiology at RUB, showed that the diseases broke out in mice if, a week after birth, they eliminated a particular protein in the cerebellum which regulates the influx of ions into nerve cells. "It's the first time that we have gained an insight into the origin of these diseases" said Prof. Herlitze. "We can now start conducting research to develop new therapeutic approaches."

Defective calcium channels as a cause of disease

Various forms of epilepsy, coordination disturbances (ataxias) and migraines are caused by mutations in the so-called P/Q-type calcium channel that controls the influx of calcium ions into the nerve cells of the brain. Dr. Melanie Mark from Prof. Herlitze's team developed an animal model in which this calcium channel could be deactivated at any time in a brain region of choice. The researchers focused on specific cells in the cerebellum (Purkinje cells) that coordinate the movements of the body. "The calcium channel is actually present throughout the entire brain", explains Dr. Mark. "It is the first time that we have been able to show that the diseases can be triggered by dysfunctional signal processing originating in the cerebellum."

Through cooperation to a new therapy

With the aid of the new mouse model, the so-called Purky mouse, Prof. Herlitze's team is now investigating the molecular basis of the diseases caused by changes in the P/Q-type calcium channel, in order to develop new therapeutic approaches. In cooperation with Prof. Dr. Timmann-Braun of the University Clinic in Essen and Prof. Dr. Klockgether of the University Clinic in Bonn, Bochum's neuroscientists want to compare their studies in the mouse model with results from patient studies. "We especially hope to help children suffering from absence epilepsy, i.e. epilepsy associated with a disturbance of consciousness", says Prof. Herlitze.


'/>"/>

Contact: Dr. Stefan Herlitze
stefan.herlitze@rub.de
49-023-432-24363
Ruhr-University Bochum
Source:Eurekalert

Related biology news :

1. Scripps Research team discovers new details about medically important protein family
2. Notre Dame research offers important clues about grasshopper population explosions
3. Uterine health more important than egg quality
4. An important breakthrough by IRCM researchers in hematopoiesis and the development of B cells
5. Process leading to protein diversity in cells important for proper neuron firing
6. A discovery could be important for the therapy of lymphoma and leukemia
7. Is the shape of a genome as important as its content?
8. Scientists reveal important clues to how bacteria and viruses are identified as enemies
9. ‘Scientific leaders of the future’ gear up for important talks on Capitol Hill
10. U of Alberta researchers discover important mechanism in fighting infection
11. Sensor important to understanding root, seedling development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2017)... According to a new market research report "Consumer IAM Market by ... Service, Authentication Type, Deployment Mode, Vertical, and Region - Global Forecast to ... USD 14.30 Billion in 2017 to USD 31.75 Billion by 2022, at ... ... MarketsandMarkets Logo ...
(Date:4/11/2017)... 11, 2017 Research and Markets has announced ... report to their offering. ... global eye tracking market to grow at a CAGR of 30.37% ... Tracking Market 2017-2021, has been prepared based on an in-depth market ... landscape and its growth prospects over the coming years. The report ...
(Date:4/11/2017)... NXT-ID, Inc. (NASDAQ:   NXTD ) ("NXT-ID" or ... independent Directors Mr. Robin D. Richards and Mr. ... the company,s corporate governance and expertise. ... Gino Pereira , Chief Executive Officer said," ... and benefiting from their considerable expertise as we move forward ...
Breaking Biology News(10 mins):
(Date:10/9/2017)... (PRWEB) , ... October 09, 2017 , ... ... a four-tiered line of medical marijuana products targeting the needs of consumers who ... packaging of Kindred takes place in Phoenix, Arizona. , As operators of two ...
(Date:10/7/2017)... Phoenix, Arizona (PRWEB) , ... ... ... than 15 years’ experience providing advanced instruments and applications consulting for microscopy ... the in-house expertise in application consulting, Nanoscience Analytical offers a broad range ...
(Date:10/7/2017)...  The 2017 Nobel Prize in Chemistry recognizes ... Joachim Frank and Richard Henderson ... (cryo-EM) have helped to broaden the use ... The winners worked with systems manufactured by Thermo ... resolved, three-dimensional images of protein structures that lead ...
(Date:10/6/2017)... ... October 06, 2017 , ... ... lunch discussion and webinar on INSIGhT, the first-ever adaptive clinical trial for glioblastoma ... Cancer Institute. The event is free and open to the public, but registration ...
Breaking Biology Technology: