Navigation Links
Impaired cell division leads to neuronal disorder
Date:1/31/2014

Prof. Erich Nigg and his research group at the Biozentrum of the University of Basel have discovered an amino acid signal essential for error-free cell division. This signal regulates the number of centrosomes in the cell, and its absence results in the development of pathologically altered cells. Remarkably, such altered cells are found in people with a neurodevelopmental disorder, called autosomal recessive primary microcephaly. The results of these investigations have been published in the current issue of the US journal Current Biology.

Cell division is the basis of all life. Of central importance is the error-free segregation of genetic material, the chromosomes. A flawless division process is a prerequisite for the development of healthy, new cells, whilst errors in cell division can cause illnesses such as cancer. The centrosome, a tiny cell organelle, plays a decisive role in this process.

Prof. Erich Nigg's research group at the Biozentrum of the University of Basel has investigated an important step in cell division: the duplication of the centrosome and its role in the correct segregation of the chromosomes into two daughter cells. The protein STIL has an essential function in this process. It ensures that centrosome duplicate before one half of the genetic material is transported into each of the two daughter cells.

KEN-Box important for protein breakdown

During cell division, the protein STIL is degraded. If this does not occur, the protein accumulates in the cell, which then causes an overproduction of centrosomes. As a consequence, mis-segregated chromosomes are incorporated into the daughter cells, which then represent cells with faulty genetic material. The scientists discovered an amino acid signal on the STIL protein, a so-called KEN-Box, and showed that this is critical for the breakdown of the protein: "The Ken-Box is the signal that orders the protein degradation machinery to break down the ST
'/>"/>

Contact: Heike Sacher
heike.sacher@unibas.ch
University of Basel
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Research breakthrough: Impaired autophagy associated with age-related macular degeneration
2. People with impaired glucose tolerance can show cognitive dysfunction
3. Psychopaths have an impaired sense of smell
4. Impaired recovery of Atlantic cod -- forage fish or other factors?
5. Researchers identify key components linking circadian rhythms and cell division cycles
6. High-resolution 3-D imaging draws new picture of Golgis whereabouts during cell division
7. SourceMedical Announces Hiring of Clinical Expert for ASC Division
8. Division of labor in the test tube
9. Discovery of cell division master controller may improve understanding and treatment of cancer
10. New insight into double-protected dance of cell division
11. Molecular forces are key to proper cell division
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Impaired cell division leads to neuronal disorder
(Date:3/31/2015)... , March 31, 2015   Guidepoint , a ... of the Post-Surgical Pain Management TRACKER, part of the ... usage trends in the medical device and therapeutics markets. ... data including treatment volumes, market share, and adoption rates ... associated with joint surgery. The Post-Surgical Pain ...
(Date:3/24/2015)... 24, 2015 Research and Markets ( http://www.researchandmarkets.com/research/kvdtcw/face_and_voice ) ... - Global Strategic Business Report" report to their offering. ... Biometrics in US$ Thousands by the following Segments: Face Biometrics, and ... Canada , Japan , ... Middle East & Africa , and ...
(Date:3/23/2015)... 23, 2015   HOYOS Labs , a leading ... announced that the Company will demonstrate multiple biometrics-based technologies ... consumers at Connect:ID on March 23 through 25, 2015, ... will highlight the IEEE Biometric Open Protocol Standard; free ... enterprise access control system. BOPS was invented by HOYOS ...
Breaking Biology News(10 mins):Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3
... how one of the most common household painkillers works, ... medications to be developed in the future. Paracetamol, ... a widely-used analgesic (painkiller) and the main ingredient in everyday ... in the 1890s and marketed as a painkiller since the ...
... advantage of a new genetics test -- one of the ... States -- that can help determine the best treatment for ... School of Medicine in St. Louis (GPS@WUSTL) is now offering ... The genes in the test affect a variety of different ...
... a century, the use of X-rays has been a prime ... turns out, X-rays also are a crucial component for studying ... by researchers at the University of Georgia -- may dramatically ... of the primary ways scientists can understand molecules is to ...
Cached Biology News:First study to reveal how paracetamol works could lead to less harmful pain relief medicines 2First study to reveal how paracetamol works could lead to less harmful pain relief medicines 3New service brings power of genomics to patient care 2New service brings power of genomics to patient care 3New strategy could lead to dose reduction in X-ray imaging 2New strategy could lead to dose reduction in X-ray imaging 3
(Date:4/1/2015)... Goldman Small Cap Research, a stock market ... sectors, announced today that it has issued a new ... publicly traded clinical stage biotechnology company focused on developing ... the sponsored research article, along with disclosures and disclaimers, ... www.GoldmanResearch.com .  In the article ...
(Date:4/1/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/8dzk58/blood_screening ) ... Screening Market by Technology (Nucleic Acid Amplification Test, ... Western Blotting), Product (Instrument, Reagent) & End User ... report to their offering. The ... billion by 2019 from $1.5 billion in 2014, ...
(Date:4/1/2015)... , Mar. 30, 2015 Research and Markets ... addition of the "Forensic Technologies and Services ... their offering. This report analyzes the ... US$ Million by the following Segments: Forensic Databases, ... and Others. Annual estimates and forecasts ...
(Date:4/1/2015)... , April 1, 2015  Spherix Incorporated (Nasdaq: ... to the fostering and monetization of intellectual property, ... privately held full service global investment bank specializing ... an industry note featuring Spherix. The ... a Senior Analyst at Chardan, was published on ...
Breaking Biology Technology:Flurry of Biotech Mergers and Acquisitions Bodes Well for PharmaCyte Biotech 2Flurry of Biotech Mergers and Acquisitions Bodes Well for PharmaCyte Biotech 3Flurry of Biotech Mergers and Acquisitions Bodes Well for PharmaCyte Biotech 4Global Blood Screening (Nucleic Acid Amplification Test, ELISA, Rapid Test, Chemiluminescence Immunoassay, Next Generation Sequencing, Western Blotting) Market 2015-2019 2Global Blood Screening (Nucleic Acid Amplification Test, ELISA, Rapid Test, Chemiluminescence Immunoassay, Next Generation Sequencing, Western Blotting) Market 2015-2019 3Forensic Technologies and Services - Global Strategic Business Report 2015-2020: Rise in Terrorist Bombings Sharpens the Business Case for Explosives Forensics 2Forensic Technologies and Services - Global Strategic Business Report 2015-2020: Rise in Terrorist Bombings Sharpens the Business Case for Explosives Forensics 3Forensic Technologies and Services - Global Strategic Business Report 2015-2020: Rise in Terrorist Bombings Sharpens the Business Case for Explosives Forensics 4Forensic Technologies and Services - Global Strategic Business Report 2015-2020: Rise in Terrorist Bombings Sharpens the Business Case for Explosives Forensics 5Forensic Technologies and Services - Global Strategic Business Report 2015-2020: Rise in Terrorist Bombings Sharpens the Business Case for Explosives Forensics 6Forensic Technologies and Services - Global Strategic Business Report 2015-2020: Rise in Terrorist Bombings Sharpens the Business Case for Explosives Forensics 7Chardan Capital Issues Industry Note Covering Spherix 2Chardan Capital Issues Industry Note Covering Spherix 3
... more convenient security to residences and private offices with their state-of-the-art ... businesses, hospitals, schools and the military is now accessible to the ... ... same innovative biometric technology used to enhance Hollywood films like Mission ...
... 27 MichBio, the association for,Michigan,s biosciences industry, ... to its program on day one of its ... Rock Financial ShowPlace Novi, MI. The,event will provide ... bioscience technologies and emerging companies to an audience ...
... Alexza,Pharmaceuticals, Inc. (Nasdaq: ALXA ) announced today the company,s,participation and ... investor conferences in September., Conference: NewsMakers ... Millennium Broadway Hotel & Conference Center ... West 44th Street, New York Presentation Date: Thursday, September ...
Cached Biology Technology:BIOLOCK(TM) USA Launches Affordable Fingerprint door Locks for Homes and Offices 2Start-Up and Emerging Biotech Companies Will Tell Their Stories at Biosciences Showcase Planned for MichBio Expo 2Alexza Pharmaceuticals Announces Upcoming Webcasts and Conference Participation 2Alexza Pharmaceuticals Announces Upcoming Webcasts and Conference Participation 3
Mouse monoclonal [SPM302] to BCAR1, prediluted ( Abpromise for all tested applications). entrezGeneID: 9564 SwissProtID: P56945...
... are predominantly used for labeling proteins, the ... peptides and nucleotides because they give better ... required in the conjugation processes. 5-TAMRA is ... peptides and proteins. 6-TAMRA is predominately used ...
6-keto Prostaglandin F1α EIA Antiserum 6-keto-PGF1alpha EIAs prostaglandins antisera enzyme immunoassays reagents 6-keto-PGF1.alpha....
Anti-Human Factor XI Purified (Polyclonal) (sheep IgG)...
Biology Products: