Navigation Links
Immunotherapy in high-risk pediatric sarcomas shows promising response
Date:7/31/2008

PHILADELPHIA Based on a pilot study in children with sarcoma, researchers at the National Institutes of Health (NIH) believe that immunotherapy could prove beneficial in treating high-risk forms of this cancer.

The researchers tested a novel dendritic vaccine as well as a standard flu vaccine to potentially strengthen the immune system post chemotherapy. Their findings, published in the August 1 issue of Clinical Cancer Research, a journal of the American Association for Cancer Research, show that although the dendritic vaccine they tested did not perform as well as hoped, children participating in the study responded well to the standard flu vaccine suggesting that a strategy to bolster immune function in these patients holds promise for fighting their cancer.

Researchers also found that survival in these patients was at the higher end of what is generally seen with recurrent and/or metastatic Ewing's sarcoma (ESFT) or alveolar rhabdomyosarcoma (AR) the two sarcomas tested in this single arm study. The 22 enrolled patients who did not receive immunotherapy had a 31 percent five-year overall survival, compared to 43 percent five-year survival in 30 patients who ultimately received the novel immunotherapy.

Although the study is small, these early findings are promising, says the study's senior investigator, Crystal Mackall, M.D., of the National Cancer Institute's (NCI) Pediatric Oncology Branch. "We need new therapies. While outcomes overall for these tumors have improved during the past 40 years, there has not been substantial improvement for patients with metastatic or recurrent disease. This study shows that immunotherapy is safe and well tolerated, and could ultimately be beneficial for this high risk population. Mackall calls the study a rational approach to improving treatment of ESFT and AR. "We now know that the immune system of patients recovering from chemotherapy is malleable, so we just need to find the best
'/>"/>

Contact: Jeremy Moore
Jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Cancer immunotherapy shows long-term promise in lung cancer
2. Leading pediatrician addresses the future of childrens health
3. Pediatricians alerted to the developmental nature of underage drinking in special journal supplement
4. Research shows skeleton to be endocrine organ
5. Clones on task serve greater good, evolutionary study shows
6. Study shows link between alcohol consumption and hiv disease progression
7. Novel 3-D cell culture model shows selective tumor uptake of nanoparticles
8. New study shows greenback cutthroat trout involved in recovery effort misidentified
9. DNA analysis shows true dispersal of protozoa
10. New genetic research into nicotine addiction shows promise for personalized treatment
11. International team shows mercury concentrations in fish respond quickly to increased deposition
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Washington , January 20, 2015 Investorideas.com, ... tech stocks, releases video from the CES 2015 (Consumer Electronics ... Apollo Robbins . Apollo shows how easily ... smart wallet, a product of NXT-ID, Inc. (NASDAQ: ...
(Date:1/22/2015)... 22, 2015 Research and Markets ( ... "Global Wearable Technologies Market and Applications, Opportunities, ... and Forecast 2014-2020" report to their offering. ... devices that can be worn on the user,s ...
(Date:12/24/2014)... , Dec. 23, 2014  Since its launch in December 2014, the ... eliminate the pain of trying to remember their usernames and ... fused to their smartphones. To assist people who have struggled ... company that created 1U and focuses on redefining identity, announced ...
Breaking Biology News(10 mins):Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 3Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3
... CA February 4, 2013 A team led by ... cellular events that appear key to lupus, a debilitating autoimmune ... findings suggest that blocking this pathway in lupus-triggering cells could ... new study, described in an online Early Edition of the ...
... of activity at the back of the brain ... would respond to an experimental rapid-acting antidepressant, a ... "We have discovered a potential neuroimaging ... selection by revealing brain-based differences between patients," explained ...
... of American Societies for Experimental Biology (FASEB) announces ... Conference (SRC): TGF-β Superfamily: Signaling in Development and ... Development and Disease" is an important and unique ... family members in developmental and homeostatic processes is ...
Cached Biology News:Scientists find a key element of lupus, suggesting better drug targets 2Scientists find a key element of lupus, suggesting better drug targets 3Scientists find a key element of lupus, suggesting better drug targets 4Imaging biomarker predicts response to rapid antidepressant 2Imaging biomarker predicts response to rapid antidepressant 3
(Date:2/26/2015)... On behalf of biotech client GenScript ... Goldman & Spitzer, P.A. (Wilentz) secured a significant ... Inc. in excess of $10 million. The jury determined ... and that it improperly hired one or more of ... motions for judgment notwithstanding the verdict, a new trial, ...
(Date:2/26/2015)... , Feb. 26, 2015 The healthcare landscape ... ever-changing arena, Frost & Sullivan will host its 20 ... Executive MindXchange , March 8 to 10, at the Hilton ... Calif. This event is a platform ... leaders to discuss industry disruptions and how to succeed in ...
(Date:2/26/2015)... 26, 2015 The Pittcon 2015 ... the Ernest N. Morial Convention Center in New ... of February 19, 2015) displaying products and services ... and government labs. The Exposition will offer the ... limited to, analytical chemistry; drug discovery; nanotechnology; life ...
(Date:2/26/2015)... (PRWEB) February 26, 2015 Innovation ... are emerging from unexpected parts of the world ... From agriculture to manufacturing to health care, ... and environmental realities and socio-political trends shake the ... the key ingredient for CEOs to survive the ...
Breaking Biology Technology:Wilentz Client GenScript Awarded $10 Million in Trade Secrets Case Against Genewiz 2Wilentz Client GenScript Awarded $10 Million in Trade Secrets Case Against Genewiz 3Embrace the Future of Medical Technologies with Frost & Sullivan 2Embrace the Future of Medical Technologies with Frost & Sullivan 3Pittcon 2015 Announces Exposition Highlights 2One Million Acts of Innovation Canada Creates Partnership with The Economist Events’ Innovation Forum 2
... 4 Biotest Pharmaceuticals,Corporation, a leading developer ... new management team as part of the ... Pharmaceuticals (Nasdaq:,NABI) and the creation of Biotest ... Pharmaceuticals Corporation Completes Acquisition,of Nabi Biologics Business ...
... Dec. 4 Biotest Pharmaceuticals,Corporation, a leading ... it has completed the acquisition of the ... unit for $185 million,in cash. Biotest Pharmaceuticals ... announced the acquisition of the Nabi Biologics ...
... Genetics to Provide Testing for Important Cancer and Leukemia Group ... ... Genzyme Genetics,a business unit of Genzyme Corporation (Nasdaq: GENZ ), ... sponsored by,the National Cancer Institute. The multi-center study will include 1,700,newly diagnosed ...
Cached Biology Technology:Biotest Pharmaceuticals Corporation Announces Management Team 2Biotest Pharmaceuticals Corporation Announces Management Team 3Biotest Pharmaceuticals Corporation Completes Acquisition of Nabi Biologics Business Unit 2Biotest Pharmaceuticals Corporation Completes Acquisition of Nabi Biologics Business Unit 3National Cancer Institute Study to Determine the Optimal Time for CLL Patients to Begin Treatment 2National Cancer Institute Study to Determine the Optimal Time for CLL Patients to Begin Treatment 3National Cancer Institute Study to Determine the Optimal Time for CLL Patients to Begin Treatment 4