Navigation Links
Immunotherapy in high-risk pediatric sarcomas shows promising response
Date:7/31/2008

PHILADELPHIA Based on a pilot study in children with sarcoma, researchers at the National Institutes of Health (NIH) believe that immunotherapy could prove beneficial in treating high-risk forms of this cancer.

The researchers tested a novel dendritic vaccine as well as a standard flu vaccine to potentially strengthen the immune system post chemotherapy. Their findings, published in the August 1 issue of Clinical Cancer Research, a journal of the American Association for Cancer Research, show that although the dendritic vaccine they tested did not perform as well as hoped, children participating in the study responded well to the standard flu vaccine suggesting that a strategy to bolster immune function in these patients holds promise for fighting their cancer.

Researchers also found that survival in these patients was at the higher end of what is generally seen with recurrent and/or metastatic Ewing's sarcoma (ESFT) or alveolar rhabdomyosarcoma (AR) the two sarcomas tested in this single arm study. The 22 enrolled patients who did not receive immunotherapy had a 31 percent five-year overall survival, compared to 43 percent five-year survival in 30 patients who ultimately received the novel immunotherapy.

Although the study is small, these early findings are promising, says the study's senior investigator, Crystal Mackall, M.D., of the National Cancer Institute's (NCI) Pediatric Oncology Branch. "We need new therapies. While outcomes overall for these tumors have improved during the past 40 years, there has not been substantial improvement for patients with metastatic or recurrent disease. This study shows that immunotherapy is safe and well tolerated, and could ultimately be beneficial for this high risk population. Mackall calls the study a rational approach to improving treatment of ESFT and AR. "We now know that the immune system of patients recovering from chemotherapy is malleable, so we just need to find the best
'/>"/>

Contact: Jeremy Moore
Jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Cancer immunotherapy shows long-term promise in lung cancer
2. Leading pediatrician addresses the future of childrens health
3. Pediatricians alerted to the developmental nature of underage drinking in special journal supplement
4. Research shows skeleton to be endocrine organ
5. Clones on task serve greater good, evolutionary study shows
6. Study shows link between alcohol consumption and hiv disease progression
7. Novel 3-D cell culture model shows selective tumor uptake of nanoparticles
8. New study shows greenback cutthroat trout involved in recovery effort misidentified
9. DNA analysis shows true dispersal of protozoa
10. New genetic research into nicotine addiction shows promise for personalized treatment
11. International team shows mercury concentrations in fish respond quickly to increased deposition
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/10/2015)... , April 10, 2015 ... addition of the "Security Competitive Profiles - NEC" ... http://photos.prnewswire.com/prnh/20130307/600769) , NEC will continue to supply ... to the market, with a company focus on the ... anticipated. Winning opportunities in the ...
(Date:4/8/2015)... 8, 2015  Infinisource, a leading provider of SaaS-based ... Morpho, a leading supplier of biometric identification and ... market,s most advanced biometrically-enabled time clock, the companies ... clock is setting a bold, new standard for ... the small and mid-size employer. When connected to ...
(Date:4/2/2015)... In the current eight ... the strongest competitors, showing outstanding performance in recognition ... is capable of a throughput of 5.000.000 fingerprints ... be ten times faster than most competitors and ...      (Photo: http://photos.prnewswire.com/prnh/20150402/738673-a ) , ...
Breaking Biology News(10 mins):NEC Security Competitive Profile 2015 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3
... A new study by researchers at the University of ... finds that promoting cleaner, more efficient technologies for producing ... have significant climate change and development benefits. , The ... Asia and Latin America, is dependent on both wood ...
... a common chemotherapy agent, researchers at UCLA's Jonsson Cancer ... found a way to move an important biomarker expressed ... in a cell ?where it could not be accessed ... The discovery, outlined in the cover article of May ...
... available yet, but there's a recent wiki article with more ... a squirrel? A rat? A Guinea pig? Try none of the ... discovered a long-whiskered rodent with stubby legs and a tail covered ... rat. Because it's actually more like a guinea pig or chinchilla. ...
Cached Biology News:Study of energy and health in Africa focuses spotlight on charcoal and forest management 2Study of energy and health in Africa focuses spotlight on charcoal and forest management 3UCLA cancer researchers shake loose hidden biomarker 2Scientists discover odd-ball rodent 2
(Date:5/21/2015)... 21, 2015 /PRNewswire/ - SQI Diagnostics Inc. ("SQI" or ... that develops and commercializes proprietary technologies and products for ... results for the second fiscal quarter ended March 31, ... continued to advance business with our existing customers and ... President and CEO of SQI. "The delivery of a ...
(Date:5/21/2015)... , May 21, 2015  Susan Hedstrom, Executive ... a nonprofit organization dedicated to supporting research to ... (PWS), announced today that FPWR has received the ... Irina Shaulov contributed $1 million in support ... "Our gift ...
(Date:5/21/2015)... Calif. , May 21, 2015  The ... Orrin Hatch (R-UT) and Amy Klobuchar ... Extensions Now Accelerating Cures & Treatments, or OPEN ... rare disease patient advocacy organizations, this bipartisan legislation ... and affordable medicines to rare disease patients by ...
(Date:5/21/2015)... 21, 2015 Patent Offering, The patent’s ... diagnostic or therapeutic imaging within a body lumen (open ... endoscope having a low cost, single-use disposable illumination and ... was October 18, 2013 and the patent approval was ... the physician to customize the lighting and magnification of ...
Breaking Biology Technology:SQI Diagnostics Reports Second Quarter Financial Results 2SQI Diagnostics Reports Second Quarter Financial Results 3SQI Diagnostics Reports Second Quarter Financial Results 4SQI Diagnostics Reports Second Quarter Financial Results 5SQI Diagnostics Reports Second Quarter Financial Results 6SQI Diagnostics Reports Second Quarter Financial Results 7SQI Diagnostics Reports Second Quarter Financial Results 8The Foundation for Prader-Willi Research Receives $1M Contribution in Support of Clinical Initiatives 2Advocates Cheer Senate Leaders for Introducing Bipartisan Bill to Increase Number of Rare Disease Treatments 2IpAuctions™ Presents The Worlds Smallest Disposable Illuminated Endoscope For Auction 2IpAuctions™ Presents The Worlds Smallest Disposable Illuminated Endoscope For Auction 3
... SAN DIEGO, June 16 3M and,Gen-Probe ... that 3M has,discontinued the companies, collaboration to ... The companies, which are exploring the ... area, said the collaboration was,discontinued due to ...
... Alternatives to Protect Privacy and Advance,Healthcare, WASHINGTON, ... Insurance Portability and Accountability Act (HIPAA) is having ... and the search for,treatments that benefit society, says ... Centers (AAHC). HIPAA Creating Barriers to,Research and Discovery ...
... an,international association focused on endocrinological research and,practice, today hosted ... 08, the annual conference of the Society, which is ... 14,000 members from 80,countries, many of whom attend the ... and clinical care., The purpose of today,s call ...
Cached Biology Technology:3M Discontinues Collaboration with Gen-Probe to Develop Molecular Tests for Healthcare-Associated Infections 23M Discontinues Collaboration with Gen-Probe to Develop Molecular Tests for Healthcare-Associated Infections 3HIPAA Privacy Rule Impedes Biomedical Research 2'Breakthroughs Ahead,' Endocrine Society Tells Security Analysts 2
Request Info...
Request Info...
... Ambion's custom siRNA service provides the ... gene silencing research. Custom siRNAs can be ... 19-21 base target sequence, or by providing ... check out Ambion's Silencer Validated and Silencer ...
... Ambion's custom siRNA service provides the ... gene silencing research. Custom siRNAs can be ... 19-21 base target sequence, or by providing ... check out Ambion's Silencer Validated and Silencer ...
Biology Products: