Navigation Links
Immunotherapy in high-risk pediatric sarcomas shows promising response
Date:7/31/2008

PHILADELPHIA Based on a pilot study in children with sarcoma, researchers at the National Institutes of Health (NIH) believe that immunotherapy could prove beneficial in treating high-risk forms of this cancer.

The researchers tested a novel dendritic vaccine as well as a standard flu vaccine to potentially strengthen the immune system post chemotherapy. Their findings, published in the August 1 issue of Clinical Cancer Research, a journal of the American Association for Cancer Research, show that although the dendritic vaccine they tested did not perform as well as hoped, children participating in the study responded well to the standard flu vaccine suggesting that a strategy to bolster immune function in these patients holds promise for fighting their cancer.

Researchers also found that survival in these patients was at the higher end of what is generally seen with recurrent and/or metastatic Ewing's sarcoma (ESFT) or alveolar rhabdomyosarcoma (AR) the two sarcomas tested in this single arm study. The 22 enrolled patients who did not receive immunotherapy had a 31 percent five-year overall survival, compared to 43 percent five-year survival in 30 patients who ultimately received the novel immunotherapy.

Although the study is small, these early findings are promising, says the study's senior investigator, Crystal Mackall, M.D., of the National Cancer Institute's (NCI) Pediatric Oncology Branch. "We need new therapies. While outcomes overall for these tumors have improved during the past 40 years, there has not been substantial improvement for patients with metastatic or recurrent disease. This study shows that immunotherapy is safe and well tolerated, and could ultimately be beneficial for this high risk population. Mackall calls the study a rational approach to improving treatment of ESFT and AR. "We now know that the immune system of patients recovering from chemotherapy is malleable, so we just need to find the best
'/>"/>

Contact: Jeremy Moore
Jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Cancer immunotherapy shows long-term promise in lung cancer
2. Leading pediatrician addresses the future of childrens health
3. Pediatricians alerted to the developmental nature of underage drinking in special journal supplement
4. Research shows skeleton to be endocrine organ
5. Clones on task serve greater good, evolutionary study shows
6. Study shows link between alcohol consumption and hiv disease progression
7. Novel 3-D cell culture model shows selective tumor uptake of nanoparticles
8. New study shows greenback cutthroat trout involved in recovery effort misidentified
9. DNA analysis shows true dispersal of protozoa
10. New genetic research into nicotine addiction shows promise for personalized treatment
11. International team shows mercury concentrations in fish respond quickly to increased deposition
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2014)... , Dec. 12, 2014 Research and Markets ... "Global Facial Recognition Market 2015-2019" report to ... Facial recognition is a technology used for ... overall facial feature of a person such as nose, ...
(Date:12/11/2014)... ST. PAUL, Minn. , Dec. 10, 2014 ... wireless physiologic monitoring, has released a new series ... needs of preclinical toxicology researchers. M series, part ... help toxicologists collect the best possible physiologic data ...
(Date:12/10/2014)... CIE San Diego has launched an innovative trust network ... care coordination among social service and care providers by enabling ... million grant from the Alliance Healthcare Foundation to expand to ... as a "Live Well San Diego" partner on December 11 ...
Breaking Biology News(10 mins):Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3New telemetry implants expected to change how large animal toxicology studies are conducted 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4
... Survey is partnering with the Chilean government to develop a ... after the historic eruption of Chaitn Volcano on May 2. ... install monitoring networks at Chaitn to transmit data in real ... June 13, the USGS signed a letter of intent with ...
... Northwestern University biomedical engineer who has developed optical technology ... colon cancer has received a $7.5 million grant over ... study an instrument that potentially could become a routine ... trials. Colon cancer is the second-leading cause of ...
... release is available in German . , ... or dissolved metallic salts in high concentrations are detrimental to ... Such conditions destroy proteins, ensuring that all biological functions in ... find at the limits of hostile conditions where we still ...
Cached Biology News:USGS to help Chile develop volcano early warning system 2NCI grant launches clinical trials for colon cancer screening 2NCI grant launches clinical trials for colon cancer screening 3Purple extremist thrives under inhospitable conditions 2Purple extremist thrives under inhospitable conditions 3
(Date:1/22/2015)... 2015 Shimadzu Scientific Instruments today ... UV-visible spectrophotometer. Offering wavelength scanning from 190 to ... for applications in a variety of industries, including ... user-friendly UV-1280 enables intuitive operation, while the enhanced ...
(Date:1/22/2015)... 2015 Cambridge Semantics, the leading provider of ... that 2014 was a record-breaking year across the board for ... Anzo Smart Data Platform and our Smart Data solutions, our ... diverse data which led to record growth for the company ...
(Date:1/22/2015)... Diego, California (PRWEB) January 22, 2015 ... Promotional Offer to their comprehensive portfolio of Eppendorf ... allows customers to purchase a Centrifuge 5424/5424 R and ... Bundle of either Eppendorf Research plus or Eppendorf Reference ...
(Date:1/22/2015)... 2015 Selexis SA, a serial innovation ... Banks (RCBs) used for drug discovery to commercial manufacturing, ... include Next-Generation Sequencing (NGS) data packages. The ... manufacturing by ensuring the integrity of the gene, validation ...
Breaking Biology Technology:Shimadzu’s New Monitored Single-Beam UV-Vis Spectrophotometer Offers Comprehensive Measurement Options in a Compact Body 2Cambridge Semantics Announces Record Results for 2014 2Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2
... July 11 Sigma-Aldrich Corporation,(Nasdaq: SIAL ), ... second,quarter results on Wednesday, July 23, 2008, at ... This call is being webcast by Thomson/CCBN and ... http://www.sigma-aldrich.com ., The webcast is also ...
... Research Inc., (TSX:,ARI), a biotechnology company discovering ... today announced its financial and operational,results for ... May 31st, 2008., "Throughout the second ... anti-cancer antibodies towards human clinical trial. Most ...
... newly developed nano-sized electronic device is an important step ... creation of the universe. This invisible light makes up ... and may provide insights into the earliest stages of ... , The tiny, new circuit, developed by physicsts at ...
Cached Biology Technology:Sigma-Aldrich Corporation's 2nd Quarter 2008 Earnings Conference Call 2ARIUS announces second quarter fiscal 2008 financial results 2ARIUS announces second quarter fiscal 2008 financial results 3ARIUS announces second quarter fiscal 2008 financial results 4ARIUS announces second quarter fiscal 2008 financial results 5ARIUS announces second quarter fiscal 2008 financial results 6ARIUS announces second quarter fiscal 2008 financial results 7ARIUS announces second quarter fiscal 2008 financial results 8ARIUS announces second quarter fiscal 2008 financial results 9ARIUS announces second quarter fiscal 2008 financial results 10ARIUS announces second quarter fiscal 2008 financial results 11ARIUS announces second quarter fiscal 2008 financial results 12ARIUS announces second quarter fiscal 2008 financial results 13ARIUS announces second quarter fiscal 2008 financial results 14ARIUS announces second quarter fiscal 2008 financial results 15Nano-sized electronic circuit promises bright view of early universe 2Nano-sized electronic circuit promises bright view of early universe 3
... reagent (F-2902) was developed in collaboration with ... measurement of the kinetics of Fc receptor ... directly in the phagovacuole.2 The Fc OxyBURST ... albumin (BSA) that has been covalently linked ...
Because it is manufactured at our ISO 9001–certified facilities in Eugene, Oregon, we can guarantee that FluoroPure grade propidium iodide is greater than or equal to 98% pure by HPLC....
MOUSE ANTI RABBIT T LYMPHOCTYES Immunogen: Rabbit Thymocytes...
TACS Apoptotic DNA Laddering Kits are used to assay cells and tissues for apoptosis by...
Biology Products: