Navigation Links
Immunity mechanism discovered
Date:6/18/2013

Scientists at the University of Calgary's Faculty of Medicine have discovered a mechanism that is used to protect the body from harmful bacteria. Platelets, a component of blood typically associated with clotting, were discovered to actively search for specific bacteria, and upon detection, seal it off from the rest of the body. The findings, which were published in Nature Immunology this week, provide the science community with a greater understanding of immunity.

"The science community has known that platelets do participate in immunity, but now it's been demonstrated that they have a way of actively searching for bacteria," says Craig Jenne, PhD, one of the authors of the study and a member of the university's Snyder Institute for Chronic Diseases.

The vast majority of bacteria in the blood stream is trapped by the liver in a network of specialized cells known as Kupffer cells. Once trapped, a series of immune processes take place to eradicate the bacteria; however, this can take several hours, lending time to harmful bacteria to multiply and release toxins into the neighboring cells, subsequently causing infection and cell damage and death.

"Upon entering the blood stream, bacteria can start to divide within several minutes," he says. "So if you're waiting for the immune system to deal with it, the bacteria could become an infection before it gets there."

Through imaging of the liver in animal models, scientists discovered that platelets are constantly interacting with the Kupffer cells by 'touching' them to search for captured bacteria. If nothing is detected, or if the bacteria isn't deemed particularly harmful, the platelets will move on; however, if harmful bacteria is detected, the platelets will bind to it, sealing it off from the body until the immune system can rid the bacteria altogether. This happens within seconds of cell capture and thus reduces the likelihood of infection.

"If this instantaneous response didn't exist, it could be a matter of life and death," he says.

Interestingly, it was observed that while this touch-and-go mechanism is happening continuously, platelets only appear to create this barrier around particularly harmful bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA). MRSA can lead to serious and potential fatal conditions such as sepsis, and is spread through skin to skin contact.

"We now have a completely different angle of how the immune system deals with specific types of bacteria," says study author Paul Kubes, PhD, who is also director of the Snyder Institute for Chronic Diseases. "Going forth we can begin to look at how we can help our own defenses deal with these types of bacteria."


'/>"/>

Contact: Kathryn Sloniowski
kjslonio@ucalgary.ca
403-220-2232
University of Calgary
Source:Eurekalert

Related biology news :

1. Flu immunity is affected by how many viruses actually cause the infection
2. Behind closed doors: Researchers show how probiotics boost plant immunity
3. UTSW researchers identify new enzyme that acts as innate immunity sensor
4. Circuitry of cells involved in immunity, autoimmune diseases exposed
5. Pitt team finds immunity protein that ramps up inflammation, and agents that can block it
6. Innate immunity system of sheep and goat herds against viral infections clarified
7. Innate immunity
8. NIH fellowship helps researcher fight malaria, understand mosquito immunity
9. Mechanism for Burgess Shale-type preservation
10. New insight into mechanisms behind autoimmune diseases suggests a potential therapy
11. Unexpected discovery reveals a new mechanism for how the cerebellum extracts signal from noise
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/21/2016)... , March 22, 2016 ... recognition with passcodes for superior security   ... a leading provider of secure digital communications services, today ... biometric technology and offer enterprise customers, particularly those in ... facial recognition and voice authentication within a mobile app, ...
(Date:3/15/2016)... March 15, 2016 --> ... by Transparency Market Research "Digital Door Lock Systems Market - ... - 2023," the global digital door lock systems market in ... 2014 and is forecast to grow at a CAGR of ... small and medium enterprises (MSMEs) across the world and high ...
(Date:3/14/2016)... March 14, 2016 http://www.apimages.com ... --> - Renvoi : image disponible via ... --> --> DERMALOG, le ... de nouveaux lecteurs d,empreintes digitales pour l,enregistrement des ... sera utilisé pour produire des cartes d,identité aux ...
Breaking Biology News(10 mins):
(Date:5/27/2016)... ... , ... PBI-Gordon Corporation is pleased to announce Dave Loecke has accepted the ... with PBI-Gordon, Dave has served in a wide variety of roles. His most recent ... launch of many of PBI-Gordon’s most successful products. , “Dave has been essential to ...
(Date:5/27/2016)... 2016 At present, the Biotech sphere ... space know that volatility is what makes this industry interesting ... Synta Pharmaceuticals Corp. (NASDAQ: SNTA ), CTI BioPharma ... LPTN ), and Heat Biologics Inc. (NASDAQ: ... technical alerts for these stocks at: http://www.activewallst.com/register/ ...
(Date:5/26/2016)... -- Q BioMed Inc. (OTCQB: QBIO), a biotechnology ... presenter at the 5th Annual Marcum MicroCap Conference on Thursday, ... at the Grand Hyatt Hotel. The Company,s ... is scheduled to begin at 11a.m ET in the Broadway ... developments and outline milestones for the balance of 2016 and ...
(Date:5/26/2016)... ... May 26, 2016 , ... Kinder Scientific (KinderScientific.com), ... developments that position the Company for the future. Kinder Scientific announces restructured ... Kinghorn has been appointed Chairman of the Board, Curtis D. Kinghorn has been ...
Breaking Biology Technology: