Navigation Links
Immune system protein accurate predictor of survival in pediatric septic shock
Date:8/1/2008

CINCINNATI About 4,000 children in the United States die every year from uncontrolled infections of the body known as septic shock, and researchers are pushing the boundaries of molecular science to find new therapies that can stem the condition. But a simple measure of an immune system protein within 24 hours of being admitted to the hospital for septic shock can predict survival in children, yielding a powerful tool for diagnostics and clinical trials of new septic shock therapies, according to a research team led by Cincinnati Children's Hospital Medical Center in the Aug. 1 American Journal of Respiratory and Critical Care Medicine.

The protein, interleukin-8 (IL-8), is secreted into the blood as part of the body's immune system response, the chief defense mechanism against infection-related conditions like septic shock. Previous research by the authors showed that higher blood levels of IL-8 are associated with more severe cases of pediatric septic shock and a greater chance of death. That research also pointed to the potential value of IL-8 as an early diagnostic marker of systemic bacterial infections.

The new study reports an IL-8 blood level at or below 220 pg/ml (picograms per milliliter) should allow doctors to predict with 95 percent accuracy which children with septic shock can survive through conventional antibiotics and therapies for at least 28 days following admission. Additionally, measuring IL-8 levels would make it possible to screen lower risk patients out of interventional clinical trials of experimental therapies, said Hector Wong, M.D., a physician and researcher of Critical Care Medicine at Cincinnati Children's and the study's lead author.

"Using IL-8 as a biomarker to screen low-risk septic shock patients from clinical trials of experimental or potentially high-risk therapies is an effective strategy to improve the risk-to-benefit ratio of a given intervention," said Dr. Wong, who also is professor
'/>"/>

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Bursts of waves drive immune system soldiers toward invaders
2. Key to out-of-control immune response in lung injury found
3. Flies can turn off their immune response
4. How the plant immune system can drive the formation of new species
5. Auto immune response creates barrier to fertility; could be a step in speciation
6. Immune police recognize good and bad guys in the body
7. Agent that triggers immune response in plants is uncovered
8. Immune cells promote blood vessel formation in mouse endometriosis
9. Influenza vaccine causes weaker immune response for children of rural Gabon than in semi-urban areas
10. The PIN codes of the immune system can be hacked
11. Pathogens use previously undescribed mechanism to sabotage host immune system
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2015)... 2015  Synaptics Inc. (NASDAQ: SYNA ), ... announced that Huawei has selected the Synaptics ® ... stylish smartwatch. Huawei chose the state-of-the-art ClearPad capacitive ... and highly responsive human interface qualities such as ... required a classic round watch face and Synaptics ...
(Date:7/27/2015)... 2015   Zynx Health ™, the market ... solutions, today announced that its ZynxCarebook ™ ... Android smartphones and tablets. With this expansion, care ... use ZynxCarebook to securely exchange messages and share ... transitions to other care settings, and improve clinical ...
(Date:7/23/2015)... -- Aware, Inc. (NASDAQ: AWRE ), a leading supplier ... its second quarter ended June 30, 2015.  ... a decrease of 33% compared to $6.8 million in the ... of 2015 was $0.3 million, or $0.01 per diluted share, ... in the same period a year ago.  ...
Breaking Biology News(10 mins):Synaptics Touchscreen Solution Powers New Huawei Watch 2Synaptics Touchscreen Solution Powers New Huawei Watch 3Zynx Health Adds Android Device Support to ZynxCarebook Solution 2Zynx Health Adds Android Device Support to ZynxCarebook Solution 3Aware, Inc. Reports Second Quarter 2015 Financial Results 2Aware, Inc. Reports Second Quarter 2015 Financial Results 3Aware, Inc. Reports Second Quarter 2015 Financial Results 4Aware, Inc. Reports Second Quarter 2015 Financial Results 5Aware, Inc. Reports Second Quarter 2015 Financial Results 6
... of the past decade such as the 2003 SARS ... deaths, and the 2009 H1N1 flu pandemic that killed about ... or bacteria could spread quickly across the globe, aided by ... complex network systems such as contagion patterns and information ...
... 16, 2012, Chikyu, operations in the second part of ... Drilling Project (JFAST), achieved another objective by installing temperature ... infers the fault slipped during the 2011 Tohoku Earthquake. ... scientific drilling vessel Chikyu to meet the challenge of ...
... Using recent advances in marine biomechanics, materials science, and ... and the California Institute of Technology (Caltech) have turned ... freely swimming "jellyfish." The finding serves as a ... muscular organs and simple life forms. It also suggests ...
Cached Biology News:New model of disease contagion ranks US airports in terms of their spreading influence 2New model of disease contagion ranks US airports in terms of their spreading influence 3Return to the Japan Trench 2Return to the Japan Trench 3Artificial jellyfish swims in a heartbeat 2Artificial jellyfish swims in a heartbeat 3Artificial jellyfish swims in a heartbeat 4
(Date:7/27/2015)... THOUSAND OAKS, Calif. , July 27, 2015 /PRNewswire/ ... will report its second quarter financial results on Thursday, ... financial markets. The announcement will be followed by a ... PT. Participating in the call from Amgen will be ... officer, and other members of Amgen,s senior management team. ...
(Date:7/27/2015)... FRANKLIN, Tenn. , July 27, 2015 /PRNewswire/ ... health care services and one of the largest ... that its parent company and sole stockholder, Capella ... Medical Properties Trust, Inc. ("MPT") (NYSE: MPW ... cash.  The transaction is expected to be finalized ...
(Date:7/27/2015)... Quest PharmaTech Inc. (TSX-V: QPT) ("Quest" or the "Company"), ... treatment of cancer, today provides the following financial update. ... $1,000,000 unit offering private placement.  This financing is a ... at a price of $0.06 per unit.  Each unit ... share purchase warrant.  Each whole warrant is exercisable into ...
(Date:7/27/2015)... ... July 27, 2015 , ... ... the Biophotonics industry.The report provides a basic overview of the industry including definitions, ... the international markets including development trends, competitive landscape analysis, and key regions development ...
Breaking Biology Technology:Amgen Announces Webcast of 2015 Second Quarter Financial Results 2Capella Healthcare Announces Agreement With Medical Properties Trust, Inc. 2Capella Healthcare Announces Agreement With Medical Properties Trust, Inc. 3Capella Healthcare Announces Agreement With Medical Properties Trust, Inc. 4Capella Healthcare Announces Agreement With Medical Properties Trust, Inc. 5Quest PharmaTech Closes $1,000,000 Private Placement 22015 Biophotonics Market Global Research 22015 Biophotonics Market Global Research 3
... disease detection facility, developed by the University of Leicester, ... in Leicester Royal Infirmary,s A&E department. It is ... disease without the use of invasive probes, blood tests, ... three different types of cutting-edge technology in combination under ...
... Researchers at Duke University Medical Center, Beth Israel Deaconess Medical ... HIV vaccine design that uses an altered form of HIV,s ... showed that they could design HIV envelopes that could bind ... immune response in an animal model. Immature B cells are ...
... , Porphyrins are organic molecules that appear in the ... and have a metal atom ,at their center that ... ,in the field of molecular electronics lies in their ... explains the responsible of the work at the Nanomaterials ...
Cached Biology Technology:Leicester scientists deploy space-age technologies at science-fiction style 'sick bay' 2Leicester scientists deploy space-age technologies at science-fiction style 'sick bay' 3Leicester scientists deploy space-age technologies at science-fiction style 'sick bay' 4New HIV vaccine approach targets desirable immune cells 2New HIV vaccine approach targets desirable immune cells 3The quantum tunneling effect leads electron transport in porphyrins 2
Economical and manually filled LN2 vacuum insulated storage container offers high capacity and low nitrogen consumption while offering convenient storage of samples....
... DNase I Amplification ... double-stranded DNA to oligodeoxyribonucleotides. ... >10000 units/mg. DNAse I ... purified and tested for ...
... Collection of Cell Cultures (ECACC) in conjunction ... the West of England, Bristol, UK, have ... control of HER2, oestrogen and progresterone receptor ... sections of formalin fixed, breast cancer cell ...
... protease from human rhinovirus (HRV 3C) is ... line of restriction grade proteases. The recombinant ... protein, which recognizes the same cleavage site ... 22 KDa size of the protease, optimal ...
Biology Products: