Navigation Links
Immune system important in fight against stomach cancer
Date:6/28/2010

Researchers have identified cells in the immune system that react to the stomach ulcer bacterium Helicobacter pylori, one of the risk factors for the development of stomach cancer. This discovery could lead to faster diagnosis and treatment as well as a better prognosis for patients with stomach cancer, reveals a thesis from the University of Gothenburg, Sweden.

Helicobacter pylori is one of the most common bacterial infections in the world, and leads to chronic inflammation of the stomach. While carriers are generally symptom-free, the bacterium can cause stomach ulcers and, sometimes, the development of stomach cancer. As the symptoms of stomach cancer are varied, it is often discovered at a late stage and has a very poor prognosis.

"We don't know how the chronic inflammation caused by Helicobacter pylori affects the development of stomach cancer," says sa Lindgren, a researcher from the Department of Microbiology and Immunology. "So it was interesting to study how the immune system behaves towards Helicobacter pylori in the stomach."

The team looked at how NK cells (natural killer cells a type of immune cell) reacted to Helicobacter pylori. These cells are an important part of the immune system as they can both recognise and kill cells that are infected by viruses and bacteria as well as tumour cells.

"We found that a special type of NK cells was active against the stomach ulcer bacterium," says sa Lindgren. "These NK cells produced cytokines, which are the immune system's signal substances and act as a defence against the intruder."

The researchers' results suggest that NK cells can play an important role in the immune defence against Helicobacter pylori. Previous research has also shown that a high proportion of NK cells in tumour tissue has contributed to a better prognosis and longer survival for patients with stomach cancer, as these cells help to eliminate the tumour cells.

The researchers therefore believe that activation of the NK cells can play a key role in stopping tumours from developing, and that reduced NK-cell activity can increase the risk of cancer developing. sa Lindgren hopes that these findings can be used to develop new ways of diagnosing and treating stomach cancer.

"This would make it possible to diagnose stomach cancer at an early stage, which, in turn, could mean a better prognosis for the patients."


'/>"/>

Contact: Asa Lindgren
asa.lindgren@microbio.gu.se
46-702-255-953
University of Gothenburg
Source:Eurekalert

Related biology news :

1. Bursts of waves drive immune system soldiers toward invaders
2. Key to out-of-control immune response in lung injury found
3. Flies can turn off their immune response
4. How the plant immune system can drive the formation of new species
5. Auto immune response creates barrier to fertility; could be a step in speciation
6. Immune police recognize good and bad guys in the body
7. Agent that triggers immune response in plants is uncovered
8. Immune cells promote blood vessel formation in mouse endometriosis
9. Influenza vaccine causes weaker immune response for children of rural Gabon than in semi-urban areas
10. The PIN codes of the immune system can be hacked
11. Pathogens use previously undescribed mechanism to sabotage host immune system
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/26/2017)... DALLAS , Feb. 25, 2017  Securus ... justice technology solutions for public safety, investigation, corrections ... of Recidivism and Reentry. "Too often, ... State prisons and county jails are trying to ... of inmates and friends and family members. While significant ...
(Date:2/22/2017)... , Feb. 22, 2017 With ... 2021, ABI Research identifies four technologies that innovative ... to secure significant share in the changing competitive ... and passive authentication.   "Companies can ... comes to security," says Dimitrios Pavlakis , ...
(Date:2/21/2017)... , February 21, 2017 Der ... US-Dollar wachsen. Nach einem Gespräch mit mehr als 50 Vertretern ... Hindernisse zu überwinden gilt, um diese Prognose zu realisieren. ... ... die Mobilisierung der finanziellen Mittel für die Biobank, die ...
Breaking Biology News(10 mins):
(Date:3/29/2017)... ... March 29, 2017 , ... Bactana Animal Health, a company developing natural ... supply through enhancement of the gut microbiota, today announced the closing of its first ... New York-based Sustainable Income Capital Management, LLC and a number of private investors. The ...
(Date:3/29/2017)... March 29, 2017 /PRNewswire/ -  GeneNews Limited (TSX:GEN) ("GeneNews" ... , a new risk stratification test for breast cancer, via ... Diagnostics Laboratory ("IDL"). BreastSentry incorporates a blood-based biomarker test with ... risk for developing breast cancer.   ... BreastSentry measures the fasting plasma ...
(Date:3/28/2017)... ... March 28, 2017 , ... ... replace paper-based processes and enhance training plan management for consistent implementation of standards ... partner with the SHL Group to help improve and streamline their training and ...
(Date:3/28/2017)... ... March 28, 2017 , ... Ecovia Renewables, Inc. ... Research (SBIR) grant from the National Science Foundation (NSF). Under the award ... a suite of BioGel™ biopolymer materials for hygiene applications, particularly for use in ...
Breaking Biology Technology: