Navigation Links
Identification of stem cells raises possibility of new therapies
Date:4/30/2013

WINSTON-SALEM, N.C., April 30, 2013 Many diseases obesity, Type 2 diabetes, muscular dystrophy are associated with fat accumulation in muscle. In essence, fat replacement causes the muscles to weaken and degenerate.

Scientists at Wake Forest Baptist Medical Center have discovered the biological mechanism involved in this process, which could point the way to potential therapies. The findings are published in the April 27 online edition of Stem Cells and Development.

The Wake Forest Baptist researchers proved that pericytes, stem cells associated with blood vessels, contain two sub-types with completely different roles: Type 1, which forms only fat cells, and Type 2, which forms only muscle cells.

"We found that Type 1 contributes to fat accumulation in the skeletal muscle under pathogenic conditions, while Type 2 helps in forming muscle," said Osvaldo Delbono, M.D., Ph.D., professor of internal medicine at Wake Forest Baptist and senior author of the study.

"This is important because now we have the potential to develop therapies that can block the activity of Type 1 pericytes to form fat or activate Type 2 pericytes to regenerate muscle."

In the study, the researchers were able to identify the subtypes through genetic and molecular labeling methods. Using an in vitro model, they showed that Type 1 pericytes form fat while Type 2 pericytes form muscle.

To test their theory in an animal model, first they injected Type 2 cells into injured muscle in healthy young mice to determine if the muscle would regenerate to repair the damage; it did. When Type 1 cells were injected, they did not form muscle.

Next, to simulate what happens in diseases such as diabetes and muscular dystropy, the researchers injected glycerol into healthy mice to induce fat accumulation in the muscle. When Type 1 pericytes were injected into the disease model, they formed fat, not muscle. When Type 2 pericytes were injected into the disease model, nothing happened.

"Our results indicate that Type 1 and Type 2 pericytes may play a critical role in successful muscle regeneration, which results from a balance between different cells in the skeletal muscle," said Alexander Birbrair, a doctoral student in Delbono's lab and first author of the study. "This study proves that each type of pericyte has a completely different role in the body. We suggest that Type 1 pericytes could be used as a cellular target for therapy to diminish fat accumulation in the muscle."

Based on these findings, Delbono's team is planning to conduct a new study using biopsied human tissue to determine if the same mechanism holds true in people.


'/>"/>

Contact: Marguerite Beck
marbeck@wakehealth.edu
336-716-2415
Wake Forest Baptist Medical Center
Source:Eurekalert

Related biology news :

1. Source identification of H7N9 influenza virus causing human infections
2. More accurate, sensitive DNA test allows early identification of fungus causing WNS
3. University of Illinois researchers develop AFM-IR for nanometer scale chemical identification
4. Neurotechnology Launches SkyBiometry Spin-off Company to Deliver SaaS Biometric Identification and Feature Analysis
5. After 121 years, identification of grave robber fossil solves a paleontological enigma
6. Scientists discover new method of gene identification
7. IdentiSys acquires the Identification, Security and Presentation Divisions of Mountainland Business Systems, a Utah based reseller
8. Digicel Launches Worlds First Biometric Identification System For International Money Transfers
9. Identification of differential proteins in maternal serum with Down syndrome
10. SRI Sarnoffs Iris on the Move® N-Glance™ Identification System Receives Lenel Factory Certification
11. APS issues new policy requiring identification of sex or gender in reporting scientific research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/3/2017)... 2017  Data captured by IsoCode, IsoPlexis ... a statistically significant association between the potency ... and objective response of cancer patients post-treatment. ... whether cancer patients will respond to CAR-T ... as to improve both pre-infusion potency testing and ...
(Date:3/30/2017)... 2017 The research team of The Hong ... fingerprint identification by adopting ground breaking 3D fingerprint minutiae recovery and ... speed and accuracy for use in identification, crime investigation, immigration control, ... ... A research team led ...
(Date:3/29/2017)... -- higi, the health IT company that operates the largest ... , today announced a Series B investment from BlueCross ... new investment and acquisition accelerates higi,s strategy to create ... health activities through the collection and workflow integration of ... and secures data today on behalf of over 36 ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... for two-dimensional representations of a complex biological network, a depiction of a system ... big mess,” said Dmitry Korkin, PhD, associate professor of computer science at Worcester ...
(Date:10/12/2017)... ... October 12, 2017 , ... AMRI, a global ... industries to improve patient outcomes and quality of life, will now be offering ... being attributed to new regulatory requirements for all new drug products, including the ...
(Date:10/11/2017)... ... 11, 2017 , ... ComplianceOnline’s Medical Device Summit is back for its 4th ... in San Francisco, CA. The Summit brings together current and former FDA office bearers, ... and government officials from around the world to address key issues in device compliance, ...
(Date:10/11/2017)... ... October 11, 2017 , ... A new study published in ... and fresh in vitro fertilization (IVF) transfer cycles. The multi-center matched ... , After comparing the results from the fresh and frozen transfer cohorts, the ...
Breaking Biology Technology: