Navigation Links
IU role in Human Microbiome Project exposes battle history between bacteria, viruses in human body
Date:6/13/2012

An Indiana University team of researchers has conducted the most in-depth and diverse genetic analysis of the defense systems that trillions of micro-organisms in the human body use to fend off viruses. The work is among a collection of 16 research papers released today by the Human Microbiome Project Consortium, a National Institutes of Health-led effort to map the normal microbial make-up of healthy humans.

Led by IU Bloomington assistant professor of informatics and computing Yuzhen Ye, the team of bioinformaticists and biologists reconstructed arrays of clusters of regularly interspaced short palindromic repeats -- CRISPRs -- which function as immune systems to the bacteria that play a vital role in human health. Between genomic repeats, CRISPR locations carry short strands of foreign DNA called spacers, which provide a history of past exposures to outside invaders like plasmids and bacteriophages (viruses that infect bacteria), and allow the bacteria to fight off viruses they have already encountered.

"By studying CRISPRs and their sequences, we ask the same types of questions we ask about viral infections in humans and other animals: Do individuals make antibodies to a particular virus? If they do, we then know they have been exposed to that virus," Ye said. "By examining CRISPR sequences, we learn about what viruses there have been infecting different species of bacteria in a particular environment."

Bacteriophages are the most abundant life form on the planet and are in a constant arms race with bacteria, which in the human body outnumber human cells by 10 to 1. Scientists want to better understand how microbes -- a group that contributes more genes responsible for human survival than humans themselves do -- battle the viruses that seek to infect them.

Using a targeted assembly strategy to reconstruct CRISPR arrays that otherwise are impossible to identify from whole metagenome assemblies, the team identified the
'/>"/>

Contact: Steve Chaplin
stjchap@iu.edu
812-856-1896
Indiana University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Loss of biodiversity increasingly threatens human well-being: UBC, University of Michigan research
2. Worlds largest release of comprehensive human cancer genome data helps speed discoveries
3. Engineered microvessels provide a 3-D test bed for human diseases
4. CSHL researchers solve structure of human protein critical for silencing genes
5. Human-like spine morphology found in aquatic eel fossil
6. Healing Method from Australia Addresses the Human Genome
7. European Society of Human Reproduction and Embryology 28th Annual Meeting -- Istanbul
8. New York Stem Cell Foundation scientist grows bone from human embryonic stem cells
9. Study sheds new light on importance of human breast milk ingredient
10. Navigating the IP Minefield of Human Embryonic Stem Cell Development
11. Sloppy shipping of human retina leads IU researchers to discover new treatment path for eye disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
IU role in Human Microbiome Project exposes battle history between bacteria, viruses in human body
(Date:1/22/2015)... , Jan. 21, 2015  Analyst Report Issued by Small ... Brands report showed that planet-wide, transactions at merchants on the ... the total number of credit, debit, and prepaid cards reached ... were victims of fraudulent card usage in 2012, and credit ...
(Date:12/24/2014)... 2014  Since its launch in December 2014, the 1U™ ... pain of trying to remember their usernames and passwords through ... their smartphones. To assist people who have struggled to remember ... created 1U and focuses on redefining identity, announced today that ...
(Date:12/19/2014)... 18, 2014 Research and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ) ... North America Perimeter Security Systems Market" report to their ... The North American perimeter security market is estimated to grow ... the U.S. market holds a larger share in this market, ...
Breaking Biology News(10 mins):$4.80 Near Term Price Target with "Buy" given by CapRock Research for NXT-ID, Inc. (NASDAQ: NXTD) issued by Small Cap IR 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3
... to know if your child had a fever or ... thoroughly cooked, you would, of course, use a thermometer ... temperature within its range. However, it isn,t that simple ... systemstiny, channel-lined devices used in medical diagnostics, DNA forensics ...
... Since most parents in the US are employed, there ... choices for themselves and their children. How parents cope with ... choice coping strategies are the subjects of a study in ... and Behavior . Findings suggest that better work conditions may ...
... What about tree power? It turns out that it,s ... in trees for University of Washington researchers to run ... in an upcoming issue of the Institute of ... "As far as we know this is the first ...
Cached Biology News:NIST calculations may improve temperature measures for microfluidics 2Work conditions impact parents' food choices 2Electrical circuit runs entirely off power in trees 2Electrical circuit runs entirely off power in trees 3
(Date:1/22/2015)... 22, 2015 Pipette.com has added the ... their comprehensive portfolio of Eppendorf products. , The Eppendorf ... a Centrifuge 5424/5424 R and receive the following:, ... Research plus or Eppendorf Reference 2 , ...
(Date:1/22/2015)... 2015 Diagenode, Inc., a leading ... Bioruptor® and complete solutions for epigenetics research, recently ... alleviating the need for manual processing. The new ... ChIP of histones or transcription factors and a ...
(Date:1/22/2015)... 22, 2015  Derma Sciences, Inc. (Nasdaq: ... advanced wound care, announces that AMNIOEXCEL® and AMNIOMATRIX®, ... added to the Premier, Inc. Regenerative Skin Grafting ... the AMNIOEXCEL® and AMNIOMATRIX® product lines, which continue ...
(Date:12/24/2014)... Wash. , Dec. 24, 2014   BioLife Solutions , ... and marketer of proprietary clinical grade hypothermic storage ... shipping products for cells and tissues  ("BioLife" or the ... Meeting of Stockholders on May 4, 2015 (the "Annual Meeting"). ...
Breaking Biology Technology:Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5BioLife Solutions Sets Date for Annual Meeting of Stockholders 2
... Inc. (OTC Bulletin Board Symbol: CCEL) (the "Company"), ... cord blood banks, today,announced results for fiscal 2007., ... November 30, 2007 were,approximately $17.5 million, up 2% ... November 30, 2006. The Company reported a net ...
... 11 AGA Medical Corporation ("AGA"),announced today it received ... ("ADO II"). AGA also announced the immediate availability,and launch ... the AGA family of,occlusion devices designed to occlude or ... heart defect that occurs when a blood vessel,called the ...
... Feb. 11 Genta,Incorporated (Nasdaq: GNTA ) ... with institutional investors to sell 6 million shares,of ... proceeds totaling,approximately $3.1 million before fees and expenses. ... about February 13, 2008, subject to the,satisfaction of ...
Cached Biology Technology:Cryo-Cell International, Inc. Reports Results for Fiscal 2007 2Cryo-Cell International, Inc. Reports Results for Fiscal 2007 3Cryo-Cell International, Inc. Reports Results for Fiscal 2007 4Cryo-Cell International, Inc. Reports Results for Fiscal 2007 5Cryo-Cell International, Inc. Reports Results for Fiscal 2007 6AGA Medical Corporation Receives European CE Mark Approval for the AMPLATZER(R) Duct Occluder II 2Genta Announces Common Stock Offering of Approximately $3.1 Million 2Genta Announces Common Stock Offering of Approximately $3.1 Million 3