Navigation Links
IU role in Human Microbiome Project exposes battle history between bacteria, viruses in human body
Date:6/13/2012

An Indiana University team of researchers has conducted the most in-depth and diverse genetic analysis of the defense systems that trillions of micro-organisms in the human body use to fend off viruses. The work is among a collection of 16 research papers released today by the Human Microbiome Project Consortium, a National Institutes of Health-led effort to map the normal microbial make-up of healthy humans.

Led by IU Bloomington assistant professor of informatics and computing Yuzhen Ye, the team of bioinformaticists and biologists reconstructed arrays of clusters of regularly interspaced short palindromic repeats -- CRISPRs -- which function as immune systems to the bacteria that play a vital role in human health. Between genomic repeats, CRISPR locations carry short strands of foreign DNA called spacers, which provide a history of past exposures to outside invaders like plasmids and bacteriophages (viruses that infect bacteria), and allow the bacteria to fight off viruses they have already encountered.

"By studying CRISPRs and their sequences, we ask the same types of questions we ask about viral infections in humans and other animals: Do individuals make antibodies to a particular virus? If they do, we then know they have been exposed to that virus," Ye said. "By examining CRISPR sequences, we learn about what viruses there have been infecting different species of bacteria in a particular environment."

Bacteriophages are the most abundant life form on the planet and are in a constant arms race with bacteria, which in the human body outnumber human cells by 10 to 1. Scientists want to better understand how microbes -- a group that contributes more genes responsible for human survival than humans themselves do -- battle the viruses that seek to infect them.

Using a targeted assembly strategy to reconstruct CRISPR arrays that otherwise are impossible to identify from whole metagenome assemblies, the team identified the
'/>"/>

Contact: Steve Chaplin
stjchap@iu.edu
812-856-1896
Indiana University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Loss of biodiversity increasingly threatens human well-being: UBC, University of Michigan research
2. Worlds largest release of comprehensive human cancer genome data helps speed discoveries
3. Engineered microvessels provide a 3-D test bed for human diseases
4. CSHL researchers solve structure of human protein critical for silencing genes
5. Human-like spine morphology found in aquatic eel fossil
6. Healing Method from Australia Addresses the Human Genome
7. European Society of Human Reproduction and Embryology 28th Annual Meeting -- Istanbul
8. New York Stem Cell Foundation scientist grows bone from human embryonic stem cells
9. Study sheds new light on importance of human breast milk ingredient
10. Navigating the IP Minefield of Human Embryonic Stem Cell Development
11. Sloppy shipping of human retina leads IU researchers to discover new treatment path for eye disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
IU role in Human Microbiome Project exposes battle history between bacteria, viruses in human body
(Date:9/30/2014)... 30, 2014) People who suffer from asthma may ... control their asthma besides properly taking medications and avoiding ... in the Annals of Allergy, Asthma and Immunology ... Allergy, Asthma and Immunology (ACAAI), asthma sufferers can learn ... The woman described in the Annals article improved her ...
(Date:9/29/2014)... ramosum , coupled with a high-fat diet, may cause animals ... mBio , the online open-access journal of the American ... German Institute of Human Nutrition Potsdam-Rehbruecke in Nuthetal observed that ... gained weight when fed a high-fat diet. Mice that did ... when consuming a high-fat diet, and mice that had ...
(Date:9/29/2014)... 29, 2014 -- Plants have a symbiotic relationship ... pants extract nutrients and defend against invaders ... fruits and vegetables. Now, scientist have discovered that ... seeds; thus ensuring that sprouting plants are colonized ... of Notre Dame, presented their findings today at ...
Breaking Biology News(10 mins):Asthma symptoms kicking up? Check your exposure to air pollution 2Gut bacteria promote obesity in mice 2Plants prepackage beneficial microbes in their seeds 2
... volume transmitted every second with every quick eye movement ... Ruhr-Universitt Bochum (RUB) and the University of Osnabrck describe ... visual cortex, the entry point for the visual information ... ". Deploying novel optical imaging methods, they demonstrated that ...
... University researchers have shown natural radioactivity within DNA can ... mutation. The research, recently published in Biochimica ... looked at natural radioactivity within human DNA on the ... bodies as well as in every living organism across ...
... explanation for how the most common strain of methicillin-resistant ... prominence. Research published in mBio , the online ... that the strain recently acquired a number of genes ... and thrive on the skin where other strains of ...
Cached Biology News:Neurons subtract images and use the differences 2Neurons subtract images and use the differences 3Radioactivity muddles the alphabet of DNA 2MRSA strain gained dominance with help from skin bacteria 2
(Date:9/30/2014)... (PRWEB) September 30, 2014 OriginOil Inc. ... high-speed, chemical-free process to clean up large quantities of ... CEO Riggs Eckelberry reported on the launch of the ... a site provided by partner STW Resources . ... 1000 barrels per day (bpd) and achieved a 99.8% ...
(Date:9/30/2014)... BioHealth Innovation, Inc. (BHI), a ... and increasing access to early-stage funding in ... Tania Fernandez , Ph.D., has joined the BHI ... a member of the management team for a new ... million in seed and early-stage equity investments to therapeutics, ...
(Date:9/30/2014)... September 30, 2014 iLab Solutions announced ... Benchmarking study which focuses on core facility operations, ... core managers face today. , In its 4th year ... of note is the year-over-year decrease in the percentage ... appear to be feeling the constraints of this trend. ...
(Date:9/30/2014)... The custom stainless steel fabrication company HOLLOWAY AMERICA ... Boston Area Chapter of ISPE (International Society for Pharmaceutical ... Wed., Oct. 1 at Gillette Stadium Clubhouse in Foxborough, ... ISPE Boston’s long history, with more than 375 exhibitors ... , HOLLOWAY AMERICA President David Simpson is looking forward ...
Breaking Biology Technology:OriginOil, Inc. Report to Shareholders: Blue Gold in West Texas 2Seasoned Life Sciences Venture Capitalist Tania Fernandez Joins BHI to Help Manage New BioHealth Gap Fund 2iLab Solutions Announces the Results of the 2014 Core Facility Benchmarking Study 2iLab Solutions Announces the Results of the 2014 Core Facility Benchmarking Study 3HOLLOWAY AMERICA to Exhibit at ISPE Boston Product Show 2014 2HOLLOWAY AMERICA to Exhibit at ISPE Boston Product Show 2014 3
... Oncolytics Biotech Inc.,("Oncolytics") (TSX:ONC, NASDAQ:ONCY) announced today ... of its manufacturing process for,REOLYSIN(R) to commercial ... production and downstream processing,development was undertaken by ... located in Montreal, Canada., "Our existing ...
... Industry Expertise to Pathwork Following FDA ... Clearance and $20M Fundraising Round, SUNNYVALE, ... on oncology, announced today the,appointment of two key positions within ... Mark McDonough as Vice,President of US Sales. These professionals bring ...
... CJPS Enterprises, LLC, (http://www.CJPS-Enterprises.com ), the operator ... ) is announcing a new service available,to ... business, or looking to,invest in Michigan companies ... existing resources available on the Michigan Life ...
Cached Biology Technology:Oncolytics Biotech Inc. Completes Initial Scale Up of Manufacturing Process for REOLYSIN(R) to Commercial Scale 2Pathwork Diagnostics Announces Key Additions to Management Team 2The Michigan Life Sciences Pipeline Announces 'The Funding Place(TM)' and Other Resources to Connect Investors and Startups 2
Shake 'n' Stack Oven - New Model (includes 10 bottle capacity rotisserie, adjustable feet, drip tray, manual PLUS Shaker Platform)...
... DNA Polymerase I from ... DNA polymerase. The enzyme also ... activities.1 The 5'?3' exonuclease activity ... nicks and gaps in the ...
DNase I (Deoxyribonuclease I) digests single- and double-stranded DNA to oligodeoxyribonucleotides. Ribonuclease activity has been reduced to non-detectable levels....
... thymus Description: Topoisomerase I relaxes both ... breakage and rejoining of phosphodiester bonds (1,2) . ... to be differentiated by a single nucleotide pair ... active in the absence of Mn 2+ ...
Biology Products: