Navigation Links
IRICoR and Université de Montréal license a novel program for early-onset morbid obesity to Pfizer
Date:10/2/2013

This news release is available in French.

The Institute for Research in Immunology and Cancer Commercialization of Research (IRICoR) and its host institution, the Universit de Montral (UdM) today announced the licensing to Pfizer Inc. of a novel early-onset morbid obesity pre-clinical program developed at the Institute for Research in Immunology and Cancer (IRIC).

Under the terms of the global license, Pfizer will fund pre-clinical research activities at IRIC and will be fully responsible for the clinical development and marketing of any resulting products. Pfizer will make an upfront payment to IRICoR, and IRICoR will be eligible to receive development and commercial milestone payments, as well as a tiered royalty on any product sales.

In certain people, genetic defects in the cellular trafficking of the melanocortin receptor type 4 (MC4R) lead to an early-onset morbid obesity, resulting in multiple life-threatening problems, for example, an increased risk of cancer.

Dr. Michel Bouvier, world-renowned expert in the field of G-protein coupled receptor signaling, has developed a new therapeutic approach to this disease based on small molecule called "pharmacological chaperones" that selectively bind to MC4R and correct its folding, trafficking and function. Cell-based assays and pre-clinical studies using a new proprietary animal model for MC4R-promoted obesity indicate that this is a potentially promising approach for treating familial early-onset morbid obesity resulting from MC4R mutations.

"We are very pleased to partner with Pfizer for the development of this promising scientific breakthrough," commented Johane Boucher-Champagne, Chairperson of IRICoR's Board of Directors. "The ability of IRICoR to identify and incubate innovative projects which appeal to industry leaders such as Pfizer further validates our business model of forging collaborations between academia and industry for drug discovery and development. We look forward to working closely with Pfizer to potentially develop new treatment options for this indication."

"Dr. Bouvier's team brings leading expertise in GPCR pharmacological chaperones that will enrich Pfizer's already strong chaperone program targeting genetic diseases characterized by protein misfolding. The collaboration is designed to combine our capabilities and resources with the goal of expediting potential new therapies for early-onset morbid obesity patients with MCR4 mutations" said Kevin Lee, Chief Scientific Officer, Pfizer's Rare Disease Research Unit.


'/>"/>

Contact: William Raillant-Clark
w.raillant-clark@umontreal.ca
514-343-7593
University of Montreal
Source:Eurekalert

Related biology news :

1. UdeMs IRIC and IRICoR achieve important milestone in their collaboration with Bristol-Myers Squibb
2. Ultracold matter technology from CU and SRI International licensed to Boulders ColdQuanta
3. Ben-Gurion U. licenses drug delivery platform for central nervous system diseases to NY biotech firm
4. ORNLs newly licensed neutron detector will advance human disease research
5. Research spinoff ReXceptor gets license for Alzheimers treatment
6. Scripps Research announces research & license agreement with Janssen Pharmaceuticals
7. Inflection Biosciences licenses preclinical oncology programs from the CNIO
8. Local Pearle Vision Licensee Adds Second Center In Canton, Ohio
9. Researchers discover novel therapy for Crohns disease
10. New clinical trial explores novel noninvasive colon cancer screening test
11. Notre Dame researchers using novel method to combat malaria drug resistance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/12/2016)... WearablesResearch.com , a brand of Troubadour Research & ... Q1 wave of its quarterly wearables survey. A particular ... a program where they would receive discounts for sharing ... "We were surprised to see that so many ... CEO of Troubadour Research, "primarily because there are segments ...
(Date:4/28/2016)... 28, 2016 First quarter 2016:   ... compared with the first quarter of 2015 The gross ... M (loss: 18.8) and the operating margin was 40% (-13) ... Cash flow from operations was SEK 249.9 M (21.2) , ... is unchanged, SEK 7,000-8,500 M. The operating margin for ...
(Date:4/15/2016)... CHICAGO , April 15, 2016  A ... companies make more accurate underwriting decisions in a ... offering timely, competitively priced and high-value life insurance ... health screenings. With Force Diagnostics, rapid ... and lifestyle data readings (blood pressure, weight, pulse, ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... (PRWEB) , ... June 27, 2016 , ... Parallel ... clinical trials, announced today the Clinical Reach Virtual Patient Encounter CONSULT module ... circle with the physician and clinical trial team. , Using the CONSULT module, patients ...
(Date:6/24/2016)... -- Regular discussions on a range of subjects including policies, debt ... said Poloz. Speaking at a lecture to the ... pointed to the country,s inflation target, which is set by ... "In certain areas there needs to ... goals, why not sit down and address strategy together?" ...
(Date:6/23/2016)... ... 23, 2016 , ... UAS LifeSciences, one of the leading ... UP4™ Probiotics, into Target stores nationwide. The company, which has been manufacturing high ... its list of well-respected retailers. This list includes such fine stores as Whole ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... YM (Yeast and Mold) microbial test has received AOAC Research Institute approval 061601. ... microbial tests introduced last year,” stated Bob Salter, Vice President of Regulatory and ...
Breaking Biology Technology: