Navigation Links
Human stem cells converted to functional lung cells
Date:12/1/2013

NEW YORK, NY For the first time, scientists have succeeded in transforming human stem cells into functional lung and airway cells. The advance, reported by Columbia University Medical Center (CUMC) researchers, has significant potential for modeling lung disease, screening drugs, studying human lung development, and, ultimately, generating lung tissue for transplantation. The study was published today in the journal Nature Biotechnology.

"Researchers have had relative success in turning human stem cells into heart cells, pancreatic beta cells, intestinal cells, liver cells, and nerve cells, raising all sorts of possibilities for regenerative medicine," said study leader Hans-Willem Snoeck, MD, PhD, professor of medicine (in microbiology & immunology) and affiliated with the Columbia Center for Translational Immunology and the Columbia Stem Cell Initiative. "Now, we are finally able to make lung and airway cells. This is important because lung transplants have a particularly poor prognosis. Although any clinical application is still many years away, we can begin thinking about making autologous lung transplantsthat is, transplants that use a patient's own skin cells to generate functional lung tissue."

The research builds on Dr. Snoeck's 2011 discovery of a set of chemical factors that can turn human embryonic stem (ES) cells or human induced pluripotent stem (iPS) cells into anterior foregut endodermprecursors of lung and airway cells. (Human iPS cells closely resemble human ES cells but are generated from skin cells, by coaxing them into taking a developmental step backwards. Human iPS cells can then be stimulated to differentiate into specialized cellsoffering researchers an alternative to human ES cells.)

In the current study, Dr. Snoeck and his colleagues found new factors that can complete the transformation of human ES or iPS cells into functional lung epithelial cells (cells that cover the lung surface). The result
'/>"/>

Contact: Karin Eskenazi
ket2116@cumc.columbia.edu
212-342-0508
Columbia University Medical Center
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Course in human mate selection wins Science magazine prize
2. Study finds the forgotten ape threatened by human activity and forest loss
3. Study examines potential evolutionary role of sexual regret in human survival and reproduction
4. Clemson research finds chickens offer clues to human birth defects
5. Researchers describe 1 mechanism that favors rejection in transplantation of porcine cartilage in humans
6. Aging impacts epigenome in human skeletal muscle
7. Salk scientists for the first time generate mini-kidney structures from human stem cells
8. Human error most common cause of birth asphyxia
9. Ancient, modern DNA tell story of first humans in the Americas
10. Human stem cells used to elucidate mechanisms of beta-cell failure in diabetes
11. Fast-mutating DNA sequences shape early development; guided evolution of uniquely human traits
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Human stem cells converted to functional lung cells
(Date:10/15/2014)... risk from strains of influenza virus increases with the ... become complacent that the most substantial threats have been ... pandemics arise when a new virus strain – against ... spreads in the human population. There have been five ... of which – the 1918 Spanish Flu – cost ...
(Date:10/15/2014)... Johannes Gutenberg University Mainz (JGU) as a full ... to maintain a significant nationwide standing in the ... of Johannes Gutenberg University Mainz as a full ... the national and international competition for the best ... can be proud that Mainz University has been ...
(Date:10/15/2014)... increased resistance to bacterial pneumonia in female mice to ... , Females are naturally more resistant to respiratory infections ... shown that increased resistance to bacterial pneumonia in female ... 3 (NOS3). They also show that this enzyme is ... hormone estrogen. , The team, lead by Professor Lester ...
Breaking Biology News(10 mins):Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 3
... boards made from hemp and plant-based glues, computers with ... of toucan beaks, and stem cell control with nano-science ... research projects from every corner of the engineering world ... School of Engineering graduate students on Thursday 21 February ...
... temperate forests across the United States, choking out native ... of Illinois ecologist Adam Davis has created a computer ... believes will be able to predict the perfect predator ... forested area that will help reduce the garlic mustard ...
... February 13, 2008 Great Ape Trust of ... (MOU), a pact with Universitas Nasional in Jakarta, Indonesia, ... rapidly disappearing orangutans in the wild and bolster efforts ... research, signed the document on behalf of Great Ape ...
Cached Biology News:Predicting the perfect predator 2Predicting the perfect predator 3Great Ape Trust signs agreement with Universitas Nasional in Jakarta 2Great Ape Trust signs agreement with Universitas Nasional in Jakarta 3Great Ape Trust signs agreement with Universitas Nasional in Jakarta 4Great Ape Trust signs agreement with Universitas Nasional in Jakarta 5
(Date:10/18/2014)... 18, 2014 The Asian Electronic Medical Record ... Asian with analysis and forecast of revenue. The electronic medical ... to $2,328.0 million by 2018, at a CAGR of 9.4% ... the Asian Electronic Medical Record (EMR) market, to get an ... glimpse of the segmentation of the market in the same ...
(Date:10/18/2014)... The report " Cloud Analytics Market [Cloud ... Machine; Video; Predictive Analytics: Global Advancements, Delivery Models, ... (2013 - 2018) ", defines and segments the ... with an in-depth analysis and forecasting of market ... this market, various restraints, and opportunities impacting it ...
(Date:10/17/2014)... Oct. 16—As in Alice,s journey through the looking-glass to ... in surprising and unexpected ways, including a new class ... As reported today in The Optical Society,s (OSA) new ... demonstrated, for the first time, a new type of ... instead reflects infrared light by using an unusual magnetic ...
(Date:10/17/2014)... Bioquell, provider of germ-eliminating robots and ... around the world to decontaminate locations where Ebola-infected ... many places the hydrogen peroxide vapor technology is ... and at the National Institutes of Health (NIH) ... utilized to decontaminate patient rooms, equipment, and an ...
Breaking Biology Technology:The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 2The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 3The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 4The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 5Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 2Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 3Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 4Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 5Magnetic mirrors enable new technologies by reflecting light in uncanny ways 2Magnetic mirrors enable new technologies by reflecting light in uncanny ways 3Magnetic mirrors enable new technologies by reflecting light in uncanny ways 4Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 2Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 3Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 4Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 5Bioquell’s Vapor Producing Robots Selected to Combat Ebola in Hospitals Around the World 6
... 30 /Xinhua-PRNewswire-FirstCall/ -- American Oriental,Bioengineering, Inc. (NYSE: ... release,third quarter 2008 financial results on Monday, November ... will hold a conference call at 8:00 am ... quarter 2008 results. Listeners may access the,call by ...
... has potential to revolutionize,endoscopic surgery, LAS VEGAS, ... into the,future of women,s healthcare with the presentation ... time using "4K" technology, at the 37th,Global Congress ... AAGL,is the international professional society for specialists in ...
... Massachusetts, October 30 /PRNewswire-FirstCall/,-- Oridion Systems Ltd. ... with Kaiser Foundation Health Plan, Inc., America,s ... non-military medical,customer in the world. The agreement ... CO2 breath sampling consumables (FilterLine(R))., With ...
Cached Biology Technology:Women's Surgery Recorded for the First Time on '4K' Digital Cinema is Presented at the AAGL Congress 2Oridion Signs Agreement With Major US Health Plan Provider for Microstream(R) Capnography 2Oridion Signs Agreement With Major US Health Plan Provider for Microstream(R) Capnography 3
Trop-2 Purified Anti-Human clone 162-46, Isotype Mouse IgG 1 , 100 µg Consult technical datasheet for details....
... cloning of BAC (100+kb), fosmid (40kb), and ... stability than any othe BAC vector. On ... yields and easy recombinant DNA purification. Available ... (pSMART VC) vectors for the highest insert ...
... Error-free cloning of BAC (100+kb), fosmid (40kb), ... insert stability than any othe BAC vector. ... high yields and easy recombinant DNA purification. ... transcription-free (pSMART VC) vectors for the highest ...
Mouse Exodus 2 - 12kDa...
Biology Products: