Navigation Links
How proteins read meta DNA code
Date:3/19/2013

Three-quarters of the DNA in evolved organisms is wrapped around proteins, forming the basic unit of DNA packaging called nucleosomes, like a thread around a spool. The problem lies in understanding how DNA can then be read by such proteins. Now, Arman Fathizadeh, a physicist at Sharif University of Technology in Tehran, Iran, and colleagues have created a model showing how proteins move along DNA, in a paper just published in EPJ E.

The problem is that until now, we did not clearly understand the physical mechanisms of how to "open the book" to read the genetic text contained in DNA. Studying the dynamics of the nucleosome over reasonable time scales by means of molecular dynamics simulations is out of the question, as it would be too complex. Instead, the authors developed a basic computer model of the nucleosome in which DNA is described by a sequence of rigid blocks representing the base pairs. By introducing flexible binding sites of the DNA to the protein core, it provides a more physical representation of the system. It also makes it possible to identify the sliding mechanism of nucleosomes along the DNA.

The idea is that a small defect in the form of a missing or extra base pair enters the DNA section wrapped around a nucleosome. This defect can then diffuse through the wrapped DNA and once it leaves the other end of the wrapped section, the nucleosome moves by the extra or missing length that the defect carried with it. This model supports the idea of a second genetic code, previously suggested in 2006. This would consist of a mechanical code written down within the base pair sequence and multiplexed with the traditional genetic code.


'/>"/>

Contact: Sophia Grein
sophia.grein@springer.com
49-622-148-78414
Springer
Source:Eurekalert

Page: 1

Related biology news :

1. New monoclonal antibody developed that can target proteins inside cancer cells
2. Age-related dementia may begin with neurons inability to dispose of unwanted proteins
3. Stressed proteins can cause blood clots for hours
4. Adding to the list of disease-causing proteins in brain disorders
5. Nano-machines for bionic proteins
6. Discovering cell surface proteins behavior
7. FASEB SRC announces conference registration open for: Arf and Rab Family G Proteins
8. FASEB SRC announces conference: Matricellular Proteins in Development, Health, and Disease
9. First special edition updating progress on efforts to map human proteins
10. NYU biologists identify proteins vital to chromosome segregation
11. Cholesterol helps regulate key signaling proteins in the cell
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/16/2014)... constantly wages war on the human body. Battles ... stalemate. In pancreatic cancer, this stalemate—known as tumor ... aggressively malignant, a phenomena that is poorly understood. ... the laboratory of Salvatore Torquato, a Professor of ... conditions surrounding tumor dormancy and the switch to ...
(Date:10/16/2014)... how the bowel lining develops and, in the process, ... , The researchers produced evidence that stem cells are ... a feature of the bowel lining, and believe these ... controversial finding as scientists are still divided on the ... Chin Wee Tan and Professor Tony Burgess from the ...
(Date:10/16/2014)... – Post-menopausal women experienced improvements in vaginal atrophy, ... genital bleeding, after 12 weeks of daily 10 ... germ-based nutritional supplement previously shown to help relieve ... pilot study reported in a poster at the ... , "These data documented improved vaginal epithelium, ...
Breaking Biology News(10 mins):Modeling tumor dormancy 2Cryptic clues drive new theory of bowel cancer development 2S-equol supplements associated with improved measures of reproductive health in postmenopausal women 2
... made concerning the possible inventory of molecules available ... Pizzarello, a research professor at Arizona State University, ... in a blazing fireball over California last year, ... meteorites. These findings suggest a far greater availability ...
... R.I. [Brown University] Although preeclampsia occurs in about ... cases. A report of new research, now in press ... how two distinct risk factors combine to affect the ... life-threatening pregnancy complication. The findings suggest there could be ...
... engineering capabilities that underpin the nuclear weapons stockpile stewardship ... laboratories are "healthy and vibrant," says a new report ... wrote the report found no problems with the quality ... the stockpile. However, the report identifies several issues that, ...
Cached Biology News:ASU scientists strike scientific gold with meteorite 2Study details paired risk factors in preeclampsia 2Study details paired risk factors in preeclampsia 3New report reviews science and engineering quality at national security laboratories 2
(Date:10/20/2014)... Texas (PRWEB) October 20, 2014 ... announced that a team from Iowa State University won ... design contest. Using a Convey HC-2ex, the team’s solution ... 14 times faster than the second place finisher. , ... world embarked upon the month long challenge, using a ...
(Date:10/20/2014)... BIOREM Inc. (TSXV: BRM) ("Biorem" or "the Company") today announced four ... million and provides a good start to Q4.  The orders are ... and one in the Middle East . ... said Peter Bruijns , President & CEO. "Total bidding activity ... they have been for any complete year since the company has ...
(Date:10/20/2014)... GAITHERSBURG, Md. , Oct. 20, 2014  GenVec, Inc. ... Zola P. Horovitz , Ph.D., from its board of ... GenVec board in August 2003, and served as its chairman ... also served on the Nominating and Corporate Governance and Audit ... Zola for more than a decade of dedicated service to ...
(Date:10/20/2014)... October 20, 2014 OncLive® ... Kimmel Cancer Center at Thomas Jefferson University has ... Through the Strategic Alliance Partnership program, the Sidney ... collaborate to raise awareness of the Center’s cutting-edge ... other projects. Clinicians and other health care professionals ...
Breaking Biology Technology:Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 2Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 3Zola P. Horovitz To Retire From GenVec Board 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 3
... entity to deal with for regulators. , ,In an editorial ... it, I observed that consolidation just like in the ... evolution and is critical for survival: , As a country, ... "revestiture". Revestiture is the industry's modern attempt to circle the ...
... LLC , a software company in Waukesha that sells home ... programs, said on Thursday it has been acquired by a ... it would expand its offerings to manufacturers and retailers by ... and product pictures. Big Hammer operates one of 11 authorized ...
... water main break Thursday at the Milwaukee County Grounds ... 37 companies in the Milwaukee County Research Parks Technology ... businesses in the incubator building were functioning despite the ... in the 137,000-square-foot Technology Innovation Center, said the center ...
Cached Biology Technology:Old bell system merging back together, but it's not the same 2Old bell system merging back together, but it's not the same 3Old bell system merging back together, but it's not the same 4
QPRT Immunogen: QPRT (NP_055113, 198 a.a. ~ 298 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Rabbit polyclonal to XTP4 ( Abpromise for all tested applications). entrezGeneID: 84299 SwissProtID: Q9BRT3...
...
Antibody Diluent for IHC 125 ml...
Biology Products: