Navigation Links
How proteins read meta DNA code
Date:3/19/2013

Three-quarters of the DNA in evolved organisms is wrapped around proteins, forming the basic unit of DNA packaging called nucleosomes, like a thread around a spool. The problem lies in understanding how DNA can then be read by such proteins. Now, Arman Fathizadeh, a physicist at Sharif University of Technology in Tehran, Iran, and colleagues have created a model showing how proteins move along DNA, in a paper just published in EPJ E.

The problem is that until now, we did not clearly understand the physical mechanisms of how to "open the book" to read the genetic text contained in DNA. Studying the dynamics of the nucleosome over reasonable time scales by means of molecular dynamics simulations is out of the question, as it would be too complex. Instead, the authors developed a basic computer model of the nucleosome in which DNA is described by a sequence of rigid blocks representing the base pairs. By introducing flexible binding sites of the DNA to the protein core, it provides a more physical representation of the system. It also makes it possible to identify the sliding mechanism of nucleosomes along the DNA.

The idea is that a small defect in the form of a missing or extra base pair enters the DNA section wrapped around a nucleosome. This defect can then diffuse through the wrapped DNA and once it leaves the other end of the wrapped section, the nucleosome moves by the extra or missing length that the defect carried with it. This model supports the idea of a second genetic code, previously suggested in 2006. This would consist of a mechanical code written down within the base pair sequence and multiplexed with the traditional genetic code.


'/>"/>

Contact: Sophia Grein
sophia.grein@springer.com
49-622-148-78414
Springer
Source:Eurekalert

Page: 1

Related biology news :

1. New monoclonal antibody developed that can target proteins inside cancer cells
2. Age-related dementia may begin with neurons inability to dispose of unwanted proteins
3. Stressed proteins can cause blood clots for hours
4. Adding to the list of disease-causing proteins in brain disorders
5. Nano-machines for bionic proteins
6. Discovering cell surface proteins behavior
7. FASEB SRC announces conference registration open for: Arf and Rab Family G Proteins
8. FASEB SRC announces conference: Matricellular Proteins in Development, Health, and Disease
9. First special edition updating progress on efforts to map human proteins
10. NYU biologists identify proteins vital to chromosome segregation
11. Cholesterol helps regulate key signaling proteins in the cell
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/14/2016)... 14, 2016  xG Technology, Inc. ("xG" or the ... wireless communications for use in challenging operating environments, announced ... 2016. Management will hold a conference call to discuss ... Eastern Time (details below). Key Recent Accomplishments ... million binding agreement to acquire Vislink Communication Systems. The ...
(Date:6/27/2016)... Research and Markets has announced the addition of the "Biometrics ... The report forecasts the biometrics market ... CAGR of 12.28% during the period 2016-2020. The ... inputs from industry experts. The report covers the market landscape and ... a discussion of the key vendors operating in this market. ...
(Date:6/22/2016)... 2016   Acuant , the leading ... has partnered with RightCrowd ® to ... Management, Self-Service Kiosks and Continuous Workforce Assurance. ... functional enhancements to existing physical access control ... with an automated ID verification and authentication ...
Breaking Biology News(10 mins):
(Date:12/2/2016)... ... December 01, 2016 , ... ... systems for North American hospitals, will present its chain-of-custody solution for tracking and ... in Las Vegas, Nev., Dec. 4-8, 2016. , Aerocom has a proven solution ...
(Date:12/2/2016)... ... December 01, 2016 , ... The Conference Forum has ... three days and will take place on February 1-3, 2017 at the Roosevelt Hotel ... Gulley (NCI), the program provides a unique 360-degree approach, which addresses the most up-to-date ...
(Date:12/2/2016)... ... 01, 2016 , ... Orthogonal, a Chicago-based medical device software ... II 510(k) clearance for their flagship medical device, SimplECG. , With this FDA ... that rely on cloth-based nanosensors. While other companies have attempted to focus on ...
(Date:12/2/2016)... ... 2016 , ... Robots will storm the Prudential Center in Boston, MA during ... which is held on the United Nations International Day of Persons with Disabilities, will ... workplace. Suitable Technologies is partnering with NTI to showcase how technology can help individuals ...
Breaking Biology Technology: