Navigation Links
How chemo kills tumors: research to reduce side effects
Date:8/6/2008

University of Manchester researchers are investigating exactly how chemotherapy drugs kill cancerous tumours in a bid to reduce side effects and test the effectiveness of safer new agents.

Dr Stephen Taylor and Karen Gascoigne at the University of Manchester's Faculty of Life Sciences have taken a new systematic approach to studying anti-mitotic drugs, which are used extensively for breast or ovarian cancer in the UK.

This class of drugs, which includes the agent taxol, has been used clinically for many years because they are highly effective. However, as in all chemotherapy, there are side effects. In the case of taxol these include peripheral neuropathies which can lead to permanent nerve damage and loss of sensation in fingers.

In addition little is known about how anti-mitotic drugs work, despite a lot of research on them, because many studies were population-based approaches that were indirect and led to vague and confusing interpretations.

Dr Taylor said: "To bypass the neurotoxicity, new anti-mitotics are being generated. Early clinical studies show that these drugs do not result in significant neurotoxicity. The big question now is whether they will have anti-tumour effects.

"To help determine this, we need to know which types of tumours are likely to be sensitive to these new agents, and which ones are likely to be resistant. This would allow clinicians to better design the clinical trials, i.e. you only recruit patients who are likely to respond. In addition, if the drugs show promise, then it would pave the way for patient stratification in the future, again allowing oncologists to identify which patients are likely to benefit from these drugs in advance of treatment.

"To predict which types of tumours are likely to respond, we first need to know how anti-mitotic drugs work, both the classical drugs and these new agents."

He and Ms Gascoigne, whose findings are published in the journal Canc
'/>"/>

Contact: Mikaela Sitford
Mikaela.Sitford@manchester.ac.uk
01-612-752-111
University of Manchester
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. TG2 identified as potential therapeutic target in chemo-resistant ovarian cancer
2. Mitochondrial cholesterol makes response to chemotherapy difficult in hepatic cancer
3. Herceptin and chemo improves response rates without major adverse effects in HER2 breast cancer
4. New chemotherapy combo produces side effects, but no extra efficacy, in early breast cancer patients
5. Standard chemo works better against metastatic BRCA1/2 breast cancer than against sporadic tumors
6. A search for protection against chemotherapy cardiotoxicity
7. UC health news: molecular pathway may predict chemotherapy effectiveness
8. Food scientists confirm commercial product effectively kills bacteria in vegetable washwater
9. New UGA invention effectively kills foodborne pathogens in minutes
10. Mounting evidence shows red wine antioxidant kills cancer
11. New decontamination system kills anthrax rapidly without lingering effects
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... -- The routine use of a molecular testing ... of performing the correct initial surgery for patients ... the University of Pittsburgh Cancer Institute (UPCI), partner ... UPMC/UPCI Multidisciplinary Thyroid Center and other diagnostic testing ... correct initial surgery by 30 percent, according to ...
(Date:7/25/2014)... 2014 Biometrics industry expands and ... digital technology for online & commerce payments while seeking ... GOOG ), LifeLock Inc. (NYSE: ... Apple Inc. (NASDAQ: AAPL ) and Fortinet ... a biometric authentication company focused on the growing m-commerce ...
(Date:7/24/2014)... leads to conflict among people around the world, a ... Health & Ecosystems: Analysis of Linkages (HEAL) Program Director ... tackle global biodiversity decline. , The harvest of wild ... and provides protein for more than a billion of ... that today,s unprecedented loss of wildlife, is bringing with ...
Breaking Biology News(10 mins):Test increases odds of correct surgery for thyroid cancer patients 2Test increases odds of correct surgery for thyroid cancer patients 3Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 2Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 3Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 4Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 5Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 6New study draws links between wildlife loss and social conflicts 2
... CORVALLIS, Ore. Researchers at Oregon State University for the ... overfishing and nitrate pollution can help destroy coral reefs ... bring with it unwanted pathogens, choke off oxygen and disrupt ... big enough to essentially smother corals. They can get out ...
... who take the time to read food labels are ... from a recently released study authored by Steven T. ... of Agriculture,s Department of Agricultural and Resource Economics, in ... Compostela in Spain, the University of Arkansas and the ...
... press release is available in Spanish . ... Development, NEIKER-Tecnalia, and the National Institute of Agricultural Research in ... of ,black dead arm, (BDA) on grapevine leaves are, in ... and BDA are diseases that affect the trunk of ...
Cached Biology News:The 'slippery slope to slime': Overgrown algae causing coral reef declines 2NEIKER and INRA discover that BDA symptoms in grapevine leaves are a sign of esca 2
(Date:7/25/2014)... , July 25, 2014 /PRNewswire-iReach/ -- Xybion ... consulting for global corporations operating in highly regulated ... its first annual Global User Group Conference, Xybion ... Philadelphia, Pennsylvania at the ... http://photos.prnewswire.com/prnh/20140724/130263 This year,s ...
(Date:7/24/2014)... Gain recognition for leadership and ... the biotech industry. Nominations are now being accepted ... you by the Bio Supply Management Alliance ... management professionals for the past 7 years. , ... Biotech industry – Manufacturers, Service Providers, Material Suppliers, ...
(Date:7/24/2014)... A research team led by group leader Yung-Eun ... technology to synthesize sulfur-doped and nitrogen-doped graphenes which ... secondary batteries and fuel cells. Yung-Eun Sung is ... Nanoparticle Research at Institute for Basic Science* (IBS) ... , This achievement has great significance with regards ...
(Date:7/24/2014)... July 24, 2014 Research and Markets ... Genomics and Proteomics Analytical Instruments Market 2014-2018" report ... Genomics is the study of the ... of the structure and functions of proteomes or sets ... and technology. Genomics involves the mapping of genes and ...
Breaking Biology Technology:Xybion Announces It Will Host International User Conference in Philadelphia 2Xybion Announces It Will Host International User Conference in Philadelphia 3Call for Submission: BSMA’s Supply Chain Management Innovation Awards 2Call for Submission: BSMA’s Supply Chain Management Innovation Awards 3Global Genomics and Proteomics Analytical Instruments Market 2014-2018: Key Vendors are Agilent, Bio-Rad , F. Hoffmann, La Roche, Illumina, PerkinElmer and Thermo Fisher Scientific 2
... 4, 2011   Creabilis SA, ... in dermatology, inflammation and pain, announces today that Dr David ... Roblin has gained extensive experience in the pharmaceutical industry in ... seen him deliver several drugs to the market. He has ...
... a molecule famous for storing the genetic blueprints for ... In a new paper,* researchers at the National Institute ... strands of DNA can be used to purify the ... wall carbon nanotubes are needed to make "quantum wires" ...
... 3, 2011 Dr. David Samadi, Vice Chairman, Department ... Surgery at The Mount Sinai Medical Center, welcomed 130 ... robotic prostatectomy procedure. National Youth Leadership ... be part of their ten-day residential program for exceptional ...
Cached Biology Technology:Creabilis Appoints Dr David Roblin as Chief Medical Officer 2Creabilis Appoints Dr David Roblin as Chief Medical Officer 3Armchair science: DNA strands that select nanotubes are first step to a practical 'quantum wire' 2Live Robotic Prostate Surgery Performed for Nation's Youth 2Live Robotic Prostate Surgery Performed for Nation's Youth 3
Rabbit polyclonal to ErbB 2 (phospho Y1248) ( Abpromise for all tested applications). entrezGeneID: 2064 SwissProtID: P04626...
The Microseal 384 plate positioner ensures precise positioning of Microseal 384-well plates in the x-, y-, and z-dimensions, for accurate automated liquid handling....
... This thin foil heat sealing material ... pressure from a screw down heated ... is a useful method for sample ... over the existing seal. Ideal for ...
... DS-U2 camera controller is the successor to the ... interface any of the cameras in the Nikon ... a USB2.0 interface. The DS-U2 transmits information at ... by equipping both hub and mass storage USB ...
Biology Products: