Navigation Links
How chemo kills tumors: research to reduce side effects
Date:8/6/2008

University of Manchester researchers are investigating exactly how chemotherapy drugs kill cancerous tumours in a bid to reduce side effects and test the effectiveness of safer new agents.

Dr Stephen Taylor and Karen Gascoigne at the University of Manchester's Faculty of Life Sciences have taken a new systematic approach to studying anti-mitotic drugs, which are used extensively for breast or ovarian cancer in the UK.

This class of drugs, which includes the agent taxol, has been used clinically for many years because they are highly effective. However, as in all chemotherapy, there are side effects. In the case of taxol these include peripheral neuropathies which can lead to permanent nerve damage and loss of sensation in fingers.

In addition little is known about how anti-mitotic drugs work, despite a lot of research on them, because many studies were population-based approaches that were indirect and led to vague and confusing interpretations.

Dr Taylor said: "To bypass the neurotoxicity, new anti-mitotics are being generated. Early clinical studies show that these drugs do not result in significant neurotoxicity. The big question now is whether they will have anti-tumour effects.

"To help determine this, we need to know which types of tumours are likely to be sensitive to these new agents, and which ones are likely to be resistant. This would allow clinicians to better design the clinical trials, i.e. you only recruit patients who are likely to respond. In addition, if the drugs show promise, then it would pave the way for patient stratification in the future, again allowing oncologists to identify which patients are likely to benefit from these drugs in advance of treatment.

"To predict which types of tumours are likely to respond, we first need to know how anti-mitotic drugs work, both the classical drugs and these new agents."

He and Ms Gascoigne, whose findings are published in the journal Canc
'/>"/>

Contact: Mikaela Sitford
Mikaela.Sitford@manchester.ac.uk
01-612-752-111
University of Manchester
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. TG2 identified as potential therapeutic target in chemo-resistant ovarian cancer
2. Mitochondrial cholesterol makes response to chemotherapy difficult in hepatic cancer
3. Herceptin and chemo improves response rates without major adverse effects in HER2 breast cancer
4. New chemotherapy combo produces side effects, but no extra efficacy, in early breast cancer patients
5. Standard chemo works better against metastatic BRCA1/2 breast cancer than against sporadic tumors
6. A search for protection against chemotherapy cardiotoxicity
7. UC health news: molecular pathway may predict chemotherapy effectiveness
8. Food scientists confirm commercial product effectively kills bacteria in vegetable washwater
9. New UGA invention effectively kills foodborne pathogens in minutes
10. Mounting evidence shows red wine antioxidant kills cancer
11. New decontamination system kills anthrax rapidly without lingering effects
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/5/2014)... of biology in the UTSA College of Sciences, ... selected to receive a two-year $300,00 National Science ... (EAGER). The funding supports President Obama,s BRAIN Initiative, ... new technology that will demystify complex brain processes. ... neuroscience are broken into the interactions of multiple ...
(Date:11/5/2014)... Brazil -Individuals show great diversity in their ability to ... females greatly differ in their perceptual evaluation of odors, ... tests. , Sex differences in olfactory detection ... may be connected to one,s perception of smell, which ... women,s olfactory superiority has been suggested to be cognitive ...
(Date:11/4/2014)... death at the right time might actually help boost ... could help in understanding animal populations, pest control and ... in the journal Trends in Ecology and Evolution ... that the kind of positive population effect an overall ... depends on the size and developmental stage of the ...
Breaking Biology News(10 mins):UTSA biology professor awarded $300,000 NSF grant for brain research 2UTSA biology professor awarded $300,000 NSF grant for brain research 3The female nose always knows: Do women have more olfactory neurons? 2When less is more: Death in moderation boosts population density in nature 2
... July 11, 2012 Researchers at the Translational Genomics ... that could lead to a less costly, less invasive and ... CKD is a major complication of diabetes, high blood ... which is characterized by a progressive deterioration of the kidney,s ...
... scientists and research collaborators will present their work to ... of human animal interaction (HAI) at the ISAZ 2012 ... ISAZ 2012, a cross-disciplinary conference hosted by the International ... range of topics central to the field of human ...
... to impact the mating choices of fish, a new ... oestrogen-like properties, was found to alter an individual,s appearance ... in Evolutionary Applications , reveals the threat to ... The research, led by Dr Jessica Ward from ...
Cached Biology News:TGen method isolates biospecimens for treatment of kidney disease 2WALTHAM® demonstrates commitment to scientific dialogue and exchange at international human animal interaction conference 2Hormone-mimicking chemicals cause inter-species mating 2
(Date:11/24/2014)... One of the most extensive, widely cited ... is now available to high school and junior college students ... the international society for optics and photonics , announced today ... Digital Library available to high schools for free and ... integral to all areas of life in today’s world,” said ...
(Date:11/24/2014)... (PRWEB) November 24, 2014 Continental ... patient populations into clinical trials at its mid-Atlantic ... , “Continental was created with the idea of ... a fundamental role in medical advances," said Continental's ... syphilis experiment to the immortal cell line of ...
(Date:11/24/2014)... 2014 Deep Research Report on ... professional and in-depth research report on the Adipic ... its definition, classification, application, and industry chain structure ... the international market analysis, including China’s domestic market ... Europe, Asia, China, Japan etc. regions) industry analysis ...
(Date:11/24/2014)... 2014 The new video, “ ... TOLEDO demonstrates how to reduce the number of ... sample panel design can be complicated, requiring multiple ... against corrosion and deposition. Dedicated single and dual ... of panel space. Additionally, installing and maintaining each ...
Breaking Biology Technology:SPIE Digital Library Now Available to High Schools, Two-Year Colleges at No or Low Cost 2At Continental Clinical Solutions, CEO Saleh Stevens Focuses on Diversity in Clinical Trial Recruitment at Maryland Site 2At Continental Clinical Solutions, CEO Saleh Stevens Focuses on Diversity in Clinical Trial Recruitment at Maryland Site 3Adipic Dihydrazide Industry 2019 Research Forecasts on Worldwide, China Regions Now Available at ReportsnReports.com 2Adipic Dihydrazide Industry 2019 Research Forecasts on Worldwide, China Regions Now Available at ReportsnReports.com 3New Video Shows How to Simplify Cycle Chemistry Sample Panels to Save Time and Costs 2
... 1 Anesiva,Inc. (Nasdaq: ANSV ) will announce ... markets close on Thursday, May 8, 2008 and will ... Members of Anesiva,s,management team will discuss financial results from ... company,s product pipeline, recent events,and milestones., Interested parties ...
... -- Pharmaxis,(AXS: PSX; Nasdaq: PXSL) today announced that ... and Drug Administration (FDA) on the design of ... clearing agent, Bronchitol, in,patients with bronchiectasis., The ... daily in approximately 300 adults with bronchiectasis. Participants,will ...
... - Oncothyreon Inc. (Nasdaq:,ONTY) (TSX:ONY) today announced ... (IND) application with the U.S. Food and ... (PI-3-kinase),inhibitor for the treatment of advanced cancers. ... Phase 1 clinical trial of PX-866., ...
Cached Biology Technology:Anesiva Announces First Quarter 2008 Financial Results Conference Call and Webcast 2Regulatory Path for Bronchitol in Bronchiectasis 2Regulatory Path for Bronchitol in Bronchiectasis 3Oncothyreon files investigational new drug application for PX-866 oncology compound 2Oncothyreon files investigational new drug application for PX-866 oncology compound 3
... suitable for use in the Microsart e.motion are ... filter, in a specially designed individual package on ... the band of membrane filter units ensures that ... of the sealed band guarantees uniform dispensing of ...
...
... Variable Speed Rocker, with 12" x 14" table; ... x 14" table; 220V. The VSR-50 Variable ... for any lab. The VSR-50 provides a rhythmic ... a gentle to vigourous movement. This makes it ...
...
Biology Products: