Navigation Links
How bacteria integrate autotransporters into their outer membrane
Date:9/23/2013

s PhD fellowship, "also forms a barrel with a pore. The pore is closed to the outside by a lid but a particular kink in the barrel wall provides a gate for autotransporter substrates." When an unfolded autotransporter is delivered, TamA hooks onto one end of the substrate polypeptide chain and integrates it step by step via the gate into its own barrel structure. The TamA barrel is thus expanded; the pore widens and opens such that passenger substrates traverse to the exterior. The assembly process ends when TamA releases the autotransporter into the surrounding membrane. "The autotransporter insertion mechanism was previously completely enigmatic for the first time, knowing the structure of TamA, we can now picture how assembly and translocation could function."

Assembly process important for infections

Many pathogens, such as the diarrhea causing Yersinia, Salmonella or the Cholera pathogen, belong to the group of Gram-negative bacteria. With the help of the autotransporter, they release toxins or adhesive proteins to infect their host cells. In their study, Maier and Hiller provide completely new findings about membrane insertion of autotransporters as well as the translocation of their cargo.


'/>"/>

Contact: Olivia Poisson
olivia.poisson@unibas.ch
University of Basel
Source:Eurekalert

Page: 1 2

Related biology news :

1. Leading evolutionary scientist to discuss how genome of bacteria has evolved
2. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
3. Team discovers how bacteria resist a Trojan horse antibiotic
4. From scourge to saint: E. coli bacteria becomes a factory - to make cheaper, faster pharmaceuticals
5. Bacterial shock to recapture essential phosphate
6. Disarming disease-causing bacteria
7. Study shows unified process of evolution in bacteria and sexual eukaryotes
8. Invisible helpers: How probiotic bacteria protect against inflammatory bowel diseases
9. Researchers develop rapid test strips for bacterial contamination in swimming water
10. Bacteria discovery could lead to antibiotics alternatives
11. Agricultural bacteria: Blowing in the wind
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/16/2014)... Calif. (October 16, 2014) – Post-menopausal women experienced ... on hormone levels or genital bleeding, after 12 ... an investigational fermented soy germ-based nutritional supplement previously ... to a new peer-reviewed pilot study reported in ... (NAMS) annual scientific meeting. , "These data ...
(Date:10/15/2014)... risk from strains of influenza virus increases with the ... become complacent that the most substantial threats have been ... pandemics arise when a new virus strain – against ... spreads in the human population. There have been five ... of which – the 1918 Spanish Flu – cost ...
(Date:10/15/2014)... virus is spreading rapidly and to an unexpected extent. ... the past and the virus shows a new disease ... before. For this reason, the German National Academy of ... and Engineering, and the Union of the German Academies ... the Ebola epidemic today. , In the statement the ...
Breaking Biology News(10 mins):S-equol supplements associated with improved measures of reproductive health in postmenopausal women 2Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2Academies call for consequences from the Ebola virus epidemic 2Academies call for consequences from the Ebola virus epidemic 3Academies call for consequences from the Ebola virus epidemic 4Academies call for consequences from the Ebola virus epidemic 5
... seen amongst individual species within the animal kingdom evolved ... effectively serve as medical research models because humans and ... key to morphological and behavioral complexity, a growing body ... expression by a family of DNA-binding proteins called "transcription ...
... AUSTIN, Texas Researchers at The University of Texas at ... in the folic acid metabolic pathway leads to neural tube ... known for several decades that folic acid supplementation dramatically reduces ... and anencephaly, which are among the most common birth defects. ...
... press release is available in German . ... at the Max Planck Institute for Developmental Biology in ... to identify neuronal correlates of behaviour by comparing maps ... different behaviour. They compared the pharyngeal nervous systems of ...
Cached Biology News:New key to organism complexity identified 2New key to organism complexity identified 3New key to organism complexity identified 4Lack of key enzyme in the metabolism of folic acid leads to birth defects 2The neurobiological consequence of predating or grazing 2The neurobiological consequence of predating or grazing 3
(Date:10/18/2014)... The report "1,6-Hexanediol Market by Application and By ... the global market on the basis of its ... such as the key drivers, current trends and ... 81 Market Data Tables and 29 Figures spread ... Market by Application and by Geography - Trends ...
(Date:10/18/2014)... October 18, 2014 The Asian Electronic Medical ... in Asian with analysis and forecast of revenue. The electronic ... grow to $2,328.0 million by 2018, at a CAGR of ... of the Asian Electronic Medical Record (EMR) market, to get ... a glimpse of the segmentation of the market in the ...
(Date:10/18/2014)... The “Global Diagnostic Electrocardiograph (ECG) Market ... (Hospitals, Home/Ambulatory, Research Center, Physician Office, Nursing Homes), ... to 2020” provides a detailed overview of the ... and strategies impacting the global diagnostic ECG market ... revenue and share analysis. , The global diagnostic ...
(Date:10/17/2014)... DE (PRWEB) October 17, 2014 ... among top employers, as published in today’s print ... Science Careers’ annual Top Employers Survey polled employees ... determine the 20 best employers. Rankings were ... were asked to rate their companies on 23 ...
Breaking Biology Technology:1,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 21,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 31,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 41,6-Hexanediol Market Projected to Reach $916.1 Million at a CAGR of 8.3% by 2019 – Report by MarketsandMarkets 5The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 2The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 3The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 4The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 5The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 2The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 3The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 4The Electrocardiograph (ECG) Market Is Expected to Reach $5,435 Million By 2020 - New Research Report by MarketsandMarkets 5DuPont Named Top Employer by Science Magazine 2DuPont Named Top Employer by Science Magazine 3
... and has been hailed as ushering in the Next ... field, it has made its way into products all ... medications without much fanfare, while popular media entertain ... Somewhere in between are social scientists, ethicists and ...
... RI An injury to the anterior cruciate ligament ... it can often be corrected through surgery, the injury ... diseases, including osteoarthritis (OA). The problem is that fluid ... impacted by the trauma of the injury and begins ...
... MALVERN, Pa. , Aug. 5 Vicept Therapeutics, Inc., ... a pharmacodynamic and pharmacokinetic clinical trial of the Company,s lead product ... in patients with rosacea. , ... The double-blinded, placebo-controlled, crossover clinical trial of ...
Cached Biology Technology:New resource examines questions about the role of nanoscience 2Lubricating the knee cartilage after ACL injury may prevent osteoarthritis 2Lubricating the knee cartilage after ACL injury may prevent osteoarthritis 3Vicept Therapeutics Announces Positive Clinical Study Results of V-101 for the Treatment of the Erythema of Rosacea 2Vicept Therapeutics Announces Positive Clinical Study Results of V-101 for the Treatment of the Erythema of Rosacea 3
... PureLink PCR Purification Kits provide rapid ... enzymes, short-failed PCR products, and salts from ... bind/wash/elute procedure:, provides two Binding Buffer ... bp* , can be performed in either ...
... Zero Blunt TOPO PCR ... fastest and easiest method ... or equal to95%) cloning ... amplified with proofreading thermostable ...
Quartz-Halogen, 100 W, High Intensity...
... System with Gateway™ Technology is designed ... the polyhedrin promoter. The expression cassette ... (bacmid DNA) by site-specific transposition (Tn7) ... recombinant bacmid DNA is then used ...
Biology Products: