Navigation Links
How bacteria integrate autotransporters into their outer membrane
Date:9/23/2013

The bacterial outer envelope is densely packed with proteins that form small pores and facilitate the passage of nutrients, toxins and signaling molecules. Professors Timm Maier and Sebastian Hiller from the Biozentrum of the University of Basel now demonstrate how these transporter proteins are integrated into the outer membrane. Using x-ray structural analysis they reveal the structure-function relationship of the protein TamA, which plays an important role in the assembly of transport proteins in the bacterial outer membrane. Their findings have been published recently in the renowned scientific journal Nature Structural and Molecular Biology.

Shuttling proteins from inside the cell to the outside environment is a complex task for Gram-negative bacteria, which are not only surrounded by an inner membrane, but also by an outer membrane barrier for protection against adverse environmental conditions. The bacteria however, can overcome this additional barrier by inserting special transport proteins into the protective outer membrane. In a joint project, Maier and Hiller, both Professors of Structural Biology at the Biozentrum of the University of Basel, provide mechanistic insights into this key process.

The structure of the assembly protein TamA explains its function

An important option for channeling protein domains across the outer membrane are so-called autotransporters. These membrane proteins form a barrel-like structure with a central pore, but they cannot autonomously transport their "passenger domain" across the outer membrane. Specific assembly proteins are required for the folding and integration of autotransporters into the outer membrane. Employing x-ray crystallography, the authors of the study decoded the atomic structure of the autotransporter assembly protein TamA of the intestinal bacterium Escherichia Coli.

"The protein TamA", explains Fabian Gruss, first author and recipient of a Werner-Siemen
'/>"/>

Contact: Olivia Poisson
olivia.poisson@unibas.ch
University of Basel
Source:Eurekalert

Page: 1 2

Related biology news :

1. Leading evolutionary scientist to discuss how genome of bacteria has evolved
2. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
3. Team discovers how bacteria resist a Trojan horse antibiotic
4. From scourge to saint: E. coli bacteria becomes a factory - to make cheaper, faster pharmaceuticals
5. Bacterial shock to recapture essential phosphate
6. Disarming disease-causing bacteria
7. Study shows unified process of evolution in bacteria and sexual eukaryotes
8. Invisible helpers: How probiotic bacteria protect against inflammatory bowel diseases
9. Researchers develop rapid test strips for bacterial contamination in swimming water
10. Bacteria discovery could lead to antibiotics alternatives
11. Agricultural bacteria: Blowing in the wind
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... Ravi Birla, associate professor of biomedical engineering at ... textbook on tissue engineering and artificial organ development., ... a comprehensive guide to entering into the field ... and professor of biomedical engineering at UH, served ... said that while there are other published books ...
(Date:7/25/2014)... a complex congenital central nervous system disease that ... neural tubes during the embryonic phase. Many patients ... incontinence and neurocognitive retardation. Such problems decrease the ... Researchers at Ankara Physical Medicine and Rehabilitation Education ... in children with SB, using the Pediatric Evaluation ...
(Date:7/25/2014)... The routine use of a molecular testing panel ... performing the correct initial surgery for patients with ... University of Pittsburgh Cancer Institute (UPCI), partner with ... Multidisciplinary Thyroid Center and other diagnostic testing agencies, ... initial surgery by 30 percent, according to the ...
Breaking Biology News(10 mins):University of Houston researcher publishes textbook on tissue engineering 2Test increases odds of correct surgery for thyroid cancer patients 2Test increases odds of correct surgery for thyroid cancer patients 3
... Researchers at Albert Einstein College of Medicine of Yeshiva ... single gene in living cells. In an unprecedented study, published in ... were able to follow, in real time, the process of gene ... molecules of messenger RNA (mRNA) that go on to ...
... A study of DNA rearrangements in roundworm chromosomes may offer ... tumors. A report of the research led by University ... was published in the April 22 online edition of the ... region of repetitive DNA sequence that protects the ends of ...
... Infection Research (HZI) in Braunschweig, Germany have discovered a new, ... cells: In this entry mode, the bacteria exploit the muscle ... cytoplasm. Thus, the strategies Salmonella use to infect ... World Health Organization, the number of Salmonella infections ...
Cached Biology News:Scientists observe single gene activity in living cells 2Study in roundworm chromosomes may offer new clues to tumor genome development 2Salmonella utilize multiple modes of infection 2
(Date:7/24/2014)... -- Keryx Biopharmaceuticals, Inc. (Nasdaq:KERX) (the "Company") announced the ... Phase 3 study of Zerenex (ferric citrate), the Company,s ... of hyperphosphatemia in patients with end-stage renal disease (ESRD) ... delivery with FErric CiTrate in EsrD) was published online ... of Nephrology ( JASN ). , ...
(Date:7/24/2014)... Gain recognition for leadership and ... the biotech industry. Nominations are now being accepted ... you by the Bio Supply Management Alliance ... management professionals for the past 7 years. , ... Biotech industry – Manufacturers, Service Providers, Material Suppliers, ...
(Date:7/24/2014)... , July 24, 2014  Asterias Biotherapeutics, Inc. ... emerging field of regenerative medicine, announced today that ... presentation to investors on Tuesday, July 29, 2014, ... presentation will include an overview of Asterias, business ... webcast, visit http://www.ustream.tv/channel/asterias-biotherapeutics at least 15 ...
(Date:7/24/2014)... rely on sophisticated equipment, trained personnel, and detection ... against terrorist attacks. A revolutionary new electronic chip ... their job much easier. , The groundbreaking nanotechnology-inspired ... Aviv University ,s School of Chemistry and Center ... Herzliya company Tracense, picks up the scent of ...
Breaking Biology Technology:Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 2Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 3Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 4Call for Submission: BSMA’s Supply Chain Management Innovation Awards 2Call for Submission: BSMA’s Supply Chain Management Innovation Awards 3Asterias Biotherapeutics Announces Live Investor Webcast 2Asterias Biotherapeutics Announces Live Investor Webcast 3Asterias Biotherapeutics Announces Live Investor Webcast 4Nano-sized chip 'sniffs out' explosives far better than trained dogs 2
... Jessica N Ebright 1 and Catherine Bowes Rickman 1, 2, ... Biology, Duke University Medical Center, Durham, , NC 27710 ... , Duke University Medical Center, Box 3802, Durham, NC ... bowes007@duke.edu , , ...
... Julio E Celis 1 , Morten stergaard 1 , Pamela Celis 1 , Hanne ... 2 , 1 Department of Medical Biochemistry ... University of Aarhus, Aarhus, Denmark , 2 Department ... Bladder cancer comprises a broad spectrum of tumors that includes ...
... Diana Davis, Aiguo Zhang, Jim Torrence, and Emily Dale, Bio-Rad Laboratories,Inc., 2000 Alfred Nobel ... Introduction , ... The concentrations of analytes in these assays ... standard curve. A regression analysis is performed to derive , ...
Cached Biology Technology:Rapid, Reproducible Real-Time Quantitative RT-PCR Using the iCycler iQ Real-Time PCR Detection System and iQ Supermix, Rev A 2Rapid, Reproducible Real-Time Quantitative RT-PCR Using the iCycler iQ Real-Time PCR Detection System and iQ Supermix, Rev A 3Rapid, Reproducible Real-Time Quantitative RT-PCR Using the iCycler iQ Real-Time PCR Detection System and iQ Supermix, Rev A 4Rapid, Reproducible Real-Time Quantitative RT-PCR Using the iCycler iQ Real-Time PCR Detection System and iQ Supermix, Rev A 5Rapid, Reproducible Real-Time Quantitative RT-PCR Using the iCycler iQ Real-Time PCR Detection System and iQ Supermix, Rev A 6Rapid, Reproducible Real-Time Quantitative RT-PCR Using the iCycler iQ Real-Time PCR Detection System and iQ Supermix, Rev A 7Rapid, Reproducible Real-Time Quantitative RT-PCR Using the iCycler iQ Real-Time PCR Detection System and iQ Supermix, Rev A 8Proteomics in Bladder Cancer Research: Protein Profiling of Bladder Squamous Cell Carcinomas, Rev C 2Proteomics in Bladder Cancer Research: Protein Profiling of Bladder Squamous Cell Carcinomas, Rev C 3Proteomics in Bladder Cancer Research: Protein Profiling of Bladder Squamous Cell Carcinomas, Rev C 4Proteomics in Bladder Cancer Research: Protein Profiling of Bladder Squamous Cell Carcinomas, Rev C 5Proteomics in Bladder Cancer Research: Protein Profiling of Bladder Squamous Cell Carcinomas, Rev C 6Proteomics in Bladder Cancer Research: Protein Profiling of Bladder Squamous Cell Carcinomas, Rev C 7Proteomics in Bladder Cancer Research: Protein Profiling of Bladder Squamous Cell Carcinomas, Rev C 8Proteomics in Bladder Cancer Research: Protein Profiling of Bladder Squamous Cell Carcinomas, Rev C 9Proteomics in Bladder Cancer Research: Protein Profiling of Bladder Squamous Cell Carcinomas, Rev C 10Proteomics in Bladder Cancer Research: Protein Profiling of Bladder Squamous Cell Carcinomas, Rev C 11Selection of Standards for Bio-Plex Cytokine Assays, Rev A 2Selection of Standards for Bio-Plex Cytokine Assays, Rev A 3Selection of Standards for Bio-Plex Cytokine Assays, Rev A 4Selection of Standards for Bio-Plex Cytokine Assays, Rev A 5Selection of Standards for Bio-Plex Cytokine Assays, Rev A 6Selection of Standards for Bio-Plex Cytokine Assays, Rev A 7Selection of Standards for Bio-Plex Cytokine Assays, Rev A 8
ERalpha (Ser 104/106)...
... while maintaining high cell viability , ... , Fast: less than one ... , Highly reproducible results from ... with the Bio-Rad Gene Pulser Xcell System ...
Agarose, pulse field, 250 g. Nuclease-free.Gel point (1.5%): 36 1.5 C, EEO (-mr): 1800 g/cm2. Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
Mouse CXCR3 Allophycocyanin MAb (Clone 220803)...
Biology Products: