Navigation Links
Hopkins researchers use light to move molecules
Date:3/16/2011

Using a light-triggered chemical tool, Johns Hopkins scientists report that they have refined a means of moving individual molecules around inside living cells and sending them to exact locations at precise times.

This new tool, they say, gives scientists greater command than ever in manipulating single molecules, allowing them to see how molecules in certain cell locations can influence cell behavior and to determine whether cells will grow, die, move or divide. A report on the work was published online December 13 in the Journal of the American Chemical Society.

Studying how just one signaling molecule communicates in various parts of a living cell has posed a challenge for scientists investigating how different interactions influence cell behavior, such as the decision to move, change shape or divide.

"By using one magical chemical set off by light, we modified our previous technique for moving molecules around and gained much more control," says Takanari Inoue, Ph.D., assistant professor of cell biology and member of the Center for Cell Dynamics in the Institute for Basic Biomedical Sciences. "The advantage of using light is that it is very controllable, and by confining the light, we can manipulate communication of molecules in only a tiny region of the cell," he says.

Specifically, the Hopkins team designed a way to initiate and spatially restrict the molecular interactions to a small portion of the cell by attaching a light-triggered chemical to a bulky molecule, the bond between which would break when researchers shined a defined beam of ultraviolet light on it. This enabled the chemical to enter the cell and force two different and specific proteins in that cell to mingle when they otherwise wouldn't. Normally, these proteins would have nothing to do with each other without the presence of the light-triggered chemical, but researchers decided to take advantage of this mingling to explore how certain proteins
'/>"/>

Contact: Vanessa McMains
vmcmain1@jhmi.edu
410-502-9410
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related biology news :

1. Johns Hopkins researchers capture jumping genes
2. Johns Hopkins researchers reshape basic understanding of cell division
3. Hopkins team discovers sweet way to detect prediabetes
4. 2 Hopkins scientists awarded European honorary doctorates
5. Hopkins researchers put proteins right where they want them
6. Pancreatic Cancer Action Network-AACR Pathway to Leadership Grant awarded to Johns Hopkins Early Career investigator
7. Johns Hopkins scientists discover a controller of brain circuitry
8. Hopkins scientists ID 10 genes associated with a risk factor for sudden cardiac death
9. Johns Hopkins scientists pull proteins tail to curtail cancer
10. Johns Hopkins researchers detect sweet cacophony while listening to cellular cross-talk
11. Zoo researchers provide African sanctuaries road map
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... 2014   LaunchKey , the first decentralized mobile authentication ... of Things era, today announced the close of $3 ... led by Metamorphic Ventures with participation from ENIAC Ventures, ... others.  LaunchKey has raised $4 million to date, and ...
(Date:12/17/2014)... N.C. , Dec. 16, 2014 Valencell, a ... its PerformTek biometric technology to industry leaders such as ... accurate, clinically validated, biometric wearable products. These products will ... in Las Vegas . ...
(Date:12/11/2014)... , Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced the addition of ...  report to their offering. One major ... With continuous advances in technology, it is important to ...
Breaking Biology News(10 mins):LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... Institutes of Health have identified a gene associated with ... attacks, irresistible bouts of sleep that can strike at ... has a known role in the immune system, which ... turns against the body,s own tissues, plays an important ...
... May 3, 2009 Ben W. Strowbridge, Ph.D, associate professor ... student in the neurosciences program at Case Western Reserve ... a form of synaptic memory in the olfactory bulb, ... of smell. Their study, entitled "Long-term plasticity of ...
... 2009 Two scientists whose work has led to new ... have been chosen to receive the 2009 March of Dimes ... and Louis M. Kunkel, Ph.D., will share the 2009 March ... and proteins that cause muscular dystrophy, a disorder in which ...
Cached Biology News:Genetic study confirms the immune system's role in narcolepsy 2Genetic study confirms the immune system's role in narcolepsy 3Neuroscientists discover long-term potentiation in the olfactory bulb 2Neuroscientists discover long-term potentiation in the olfactory bulb 3March of Dimes awards $250,000 prize to scientists unraveling the causes of muscular dystrophy 2
(Date:1/22/2015)... 2015 Eckert & Ziegler Vitalea Science ... services to the pharmaceutical and biotech industry, has announced ... in the position of Director of Science & Technology. ... valuable experience in drug metabolism and bioanalysis to EZVS ...
(Date:1/22/2015)... , Jan. 22, 2015  Transwestern | RBJ today announces ... of office space for Shire a leading biopharmaceutical company, at ... Transwestern | RBJ,s Robert Richards , president, and ... lease for the entire five-floor building at 95 Hayden Ave. ...
(Date:1/22/2015)... 2015  Transwestern | RBJ today announces the firm brokered a ... Shire a leading biopharmaceutical company, at Two Ledgemont Center in ... Robert Richards , president, and Brian Cohen , senior ... five-floor building at 95 Hayden Ave. Photo - ...
(Date:1/22/2015)... The laboratory information management systems market is a rapidly ... advancements due to factors such as rising pressure to ... systems, and increasing government support for adoption of HCIT ... in the market focus on technological advancements to further ...
Breaking Biology Technology:Eckert & Ziegler Vitalea Science appoints Mark Seymour, PhD as Director of Science & Technology 2Eckert & Ziegler Vitalea Science appoints Mark Seymour, PhD as Director of Science & Technology 3Transwestern | RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Transwestern?RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 2Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 3Laboratory Information Management Systems Market is Expected to Reach $1,323.6 Million by 2019 - New Research Report by MarketsandMarkets 4
... For the second month in a row,the capital markets succumbed ... day of the month the Dow dropped over 300 points ... time. Amid these,fears, biotech was dragged down with the Burrill ... and the Dow, which closed down,3%., "The biotech sector ...
... BEACH, Va., March 3 LifeNet Health,a leading ... This product has been engineered for anterior,cervical fusion ... The new VG1(R) Cervical Bio-implant was co-developed ... represented in the U.S. by DePuy,Spine., "VG1(R) ...
... Calif., March 3 ROBODOC, a Curexo,Technology Company, ... into a,major patent Cross licensing agreement. The terms ... In addition to its current surgical robotics ... 40,000 patents in IBM,S Global Portfolio,and particularly, IBM,s ...
Cached Biology Technology:Biotech Drops Amid Tough Markets in February 2Biotech Drops Amid Tough Markets in February 3LifeNet Health(R) Unveils New Biomedical Spine Implant 2ROBODOC(R) Announces Patent Cross Licensing Agreement With IBM 2
With L-glutamine and potassium bicarbonate. Sterile, Insect cell culture tested...
... This CLS number ... number, created to easily ... If showing no availability ... the old Sigma-Aldrich number ...
... Ek Adaptor encodes a T7 promoter, ... ATG translation initation codon, and an N-terminal ... 109 aa sequence that encodes thioredoxin. Fusion ... enhance solubility of many proteins that are ...
...
Biology Products: