Navigation Links
Hopkins researchers use light to move molecules
Date:3/16/2011

Using a light-triggered chemical tool, Johns Hopkins scientists report that they have refined a means of moving individual molecules around inside living cells and sending them to exact locations at precise times.

This new tool, they say, gives scientists greater command than ever in manipulating single molecules, allowing them to see how molecules in certain cell locations can influence cell behavior and to determine whether cells will grow, die, move or divide. A report on the work was published online December 13 in the Journal of the American Chemical Society.

Studying how just one signaling molecule communicates in various parts of a living cell has posed a challenge for scientists investigating how different interactions influence cell behavior, such as the decision to move, change shape or divide.

"By using one magical chemical set off by light, we modified our previous technique for moving molecules around and gained much more control," says Takanari Inoue, Ph.D., assistant professor of cell biology and member of the Center for Cell Dynamics in the Institute for Basic Biomedical Sciences. "The advantage of using light is that it is very controllable, and by confining the light, we can manipulate communication of molecules in only a tiny region of the cell," he says.

Specifically, the Hopkins team designed a way to initiate and spatially restrict the molecular interactions to a small portion of the cell by attaching a light-triggered chemical to a bulky molecule, the bond between which would break when researchers shined a defined beam of ultraviolet light on it. This enabled the chemical to enter the cell and force two different and specific proteins in that cell to mingle when they otherwise wouldn't. Normally, these proteins would have nothing to do with each other without the presence of the light-triggered chemical, but researchers decided to take advantage of this mingling to explore how certain proteins
'/>"/>

Contact: Vanessa McMains
vmcmain1@jhmi.edu
410-502-9410
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2

Related biology news :

1. Johns Hopkins researchers capture jumping genes
2. Johns Hopkins researchers reshape basic understanding of cell division
3. Hopkins team discovers sweet way to detect prediabetes
4. 2 Hopkins scientists awarded European honorary doctorates
5. Hopkins researchers put proteins right where they want them
6. Pancreatic Cancer Action Network-AACR Pathway to Leadership Grant awarded to Johns Hopkins Early Career investigator
7. Johns Hopkins scientists discover a controller of brain circuitry
8. Hopkins scientists ID 10 genes associated with a risk factor for sudden cardiac death
9. Johns Hopkins scientists pull proteins tail to curtail cancer
10. Johns Hopkins researchers detect sweet cacophony while listening to cellular cross-talk
11. Zoo researchers provide African sanctuaries road map
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2015)... Mass , March 23, 2015 SoundView Technology ... of NXT-ID,s (NASDAQ: NXTD ) Wocket smart wallet. SoundView was ... user feedback on their experience with the Wocket in multiple ... at CVS, Whole Foods and other retailers, making both debit ... Kris Tuttle also says, "If the company meets their ...
(Date:3/23/2015)... ANGELES , March 23, 2015  In the ... Federal fraud case conviction losses. This figure accounts for ... which, according to The Nilson Report, exceeds $11 billion ... investigative tool after a crime has occurred. Investor ... and polygraph expert Joe Paolella partnered to ...
(Date:3/20/2015)... , Mar. 20, 2015 Research and ... the addition of the "India Sensors Market ... offering. The sensor market is projected ... 2020 Consumer electronics, automotive, industrial and ... sensors in the country. In addition, adoption of ...
Breaking Biology News(10 mins):Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3
... recently discovered form of the protein that triggers blood ... of metastatic pancreatic cancer and primary breast cancer, according ... published online ahead of print in the International ... Proceedings of the National Academy of Sciences ). ...
... and hope to be a father, here,s another reason ... your waistline or metabolic disorders. That,s because scientists have ... did not show any signs of diabetes, passed this ... Sons don,t entirely dodge this genetic bullet eitherboth sons ...
... and the National Institutes of Health have obtained ground-breaking new ... play a role in the development of cancer cells. The ... and have just been published in Journal of Biological ... of proteases to force their way into the body., In ...
Cached Biology News:Metastatic pancreatic, primary breast cancer have common growth mechanisms, study suggests 2Obese dads pass on predisposition to obesity and metabolic disorders to their kids 2Molecular discovery puts cancer treatment in a new perspective 2Molecular discovery puts cancer treatment in a new perspective 3
(Date:4/1/2015)... Angeles, CA (PRWEB) April 01, 2015 The ... fat loss, a multi-billion dollar industry. Founder of Fasciology, Ashley ... target an area of fat, instead of having to wait ... fiction. Black claims that “ prior to fat cooling procedures, ... called sculpting or contouring, was liposuction, which is a highly ...
(Date:4/1/2015)... recruitment firm Slone Partners is pleased to ... Sales at Optimal Medicine, an international digital health group ... over 20 years experience in healthcare information technology client ... Dell Services Healthcare, Medsphere Systems and McKesson. , ... accomplishing the goals Optimal Medicine had for this role,” ...
(Date:3/31/2015)... JUNCTION, N.J., March 31, 2015 CytoSorbents ... company using blood purification to treat critically-ill and ... an operational summary and reports financial results for ... 2014 CytoSorb® product revenues were a ... compared to 2013 CytoSorb® revenues of $0.8M Highlights ...
(Date:3/31/2015)... and VANCOUVER , March 31, ... (TSX-V: EPI) announced today that it has filed with ... an Investigation New Drug ("IND") application related to the ... patients.  Approval of the IND application is required in ... in the US.  The IND application ...
Breaking Biology Technology:Hybrid Health Guru, Ashley Black, announces that her invention The FasciaBlaster™ rivals the “fat cooling” procedures that reduce exercise and diet resistant fat pockets. 2Hybrid Health Guru, Ashley Black, announces that her invention The FasciaBlaster™ rivals the “fat cooling” procedures that reduce exercise and diet resistant fat pockets. 3Slone Partners Fills Head of Sales at Optimal Medicine 2CytoSorbents Reports Record 2014 Revenue 2CytoSorbents Reports Record 2014 Revenue 3CytoSorbents Reports Record 2014 Revenue 4CytoSorbents Reports Record 2014 Revenue 5CytoSorbents Reports Record 2014 Revenue 6CytoSorbents Reports Record 2014 Revenue 7CytoSorbents Reports Record 2014 Revenue 8CytoSorbents Reports Record 2014 Revenue 9CytoSorbents Reports Record 2014 Revenue 10CytoSorbents Reports Record 2014 Revenue 11ESSA Pharma Inc. Announces Filing of Investigational New Drug Application for EPI-506 2ESSA Pharma Inc. Announces Filing of Investigational New Drug Application for EPI-506 3ESSA Pharma Inc. Announces Filing of Investigational New Drug Application for EPI-506 4
... operating income of $856,000, IRVINE, Calif., March ... developer of surgical products,and accessories used in angina-relieving ... and fiscal year ended December 31,2007., Sales ... a 24% decrease,from the prior year fourth quarter ...
... FRANCISCO, March 25 Medivation, Inc.,(Nasdaq: MDVN ... Bronson, Ph.D.,to vice president, regulatory and quality, Mohammad ... Mordenti, Ph.D., to vice,president, translational medicine., "As ... product candidate, we are,strengthening the team to lead ...
... MARINO, Calif., March 25 Epeius Biotechnologies,Corporation ... No. 7,347,998 for,Targeted Gene Delivery in vivo. ... the platform of highly advanced,biotechnologies embodied in ... by simple intravenous infusion, the Epeius,tumor-targeted gene ...
Cached Biology Technology:Cardiogenesis Reports Fourth Quarter and Full Year 2007 Results 2Cardiogenesis Reports Fourth Quarter and Full Year 2007 Results 3Cardiogenesis Reports Fourth Quarter and Full Year 2007 Results 4Cardiogenesis Reports Fourth Quarter and Full Year 2007 Results 5Cardiogenesis Reports Fourth Quarter and Full Year 2007 Results 6Cardiogenesis Reports Fourth Quarter and Full Year 2007 Results 7Medivation Announces Senior Management Promotions 2Medivation Announces Senior Management Promotions 3Epeius Biotechnologies Awarded U.S. Patent for Targeted Injectable Gene Delivery In Vivo 2
Natural Mouse Laminin is purified from the Engelbreth-Holm-Swarm (EHS) sarcoma and is provided in Tris-buffered saline....
EPH electrode, cathode, 1. Category: Electrophoresis Systems & Standards & Reagents, IEF & SDS-PAGE & 2-D Electrophoresis, Multiphor II Kits & Components and Accessories....
... Rat adult normal paraffin tissue array ... or proteins of interest in extensive ... Rat brain, heart, kidney, liver, ... are arrayed on positively charged glass ...
Rat Normal Multiple Tissue Array 1 slide...
Biology Products: