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Hope for the overweight
Date:7/31/2014

dual to individual, and until now it was not possible to determine its proportion reliably. Current methods are based on measuring this tissue's activity, which greatly depends on outside conditions, such as the temperature or diet. The newly discovered surface proteins now offer an activity independent approach. They additionally make it possible to selectively deliver substances to brown adipose tissue by targeting these proteins.

New hope to finally let fat melt away

Activation of the brown adipose tissue is currently one of the most promising approaches to battling adiposity,* opening up new avenues to reduce excess weight without reducing the calorie intake. This is why numerous publications from basic research describe new potential mechanisms to activate or propagate the human brown adipose tissue. "Translating these research results into practice often fails, however, because the identified mechanisms also have important functions in other organs, which can result in incalculable side effects," Dr. Ussar explains. "Our research represents a novel approach to this problem, because the surface markers that we have discovered are very specific for the individual fat types and independent of the metabolic activity."

The scientists hope that further development of their research results will allow to introduce active substances selectively into the brown adipose tissue and consequently reduce side effects. "We are already at work, partially in our own group and also in collaboration with other groups at the Helmholtz Zentrum Mnchen, to produce specific molecules that recognize these surface proteins to examine their efficacy," Dr. Ussar reports. "Our goal is to work with partners from industry to further develop these molecules for use in humans."


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Contact: Dr. Siegfried Ussar
siegfried.ussar@helmholtz-muenchen.de
49-893-187-2047
Helmholtz Zentrum Mnchen - German Research Center for Environmental Health
Source:Eurekalert

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