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Hop, skip or jump? Study says no to all of the above
Date:4/17/2013

e working to further improve magnetic resonance imaging (MRI) to test for loss of aggrecan, while others are looking for blood or urine markers. If such a test existed, it would be especially useful for monitoring patients who have experienced an acute knee injury. It is estimated that at least 12 percent of all osteoarthritis cases originated with a traumatic joint injury, Grodzinsky says.

Researchers in Grodzinsky's lab are now working to identify possible drugs that might halt the loss of aggrecan, as well as designing tissue scaffolds that could be implanted into patients who need cartilage-replacement surgery. The new AFM system should be useful for testing these scaffolds, to see if cells grown on the scaffold can produce the necessary tissue stiffening at high loading rates.

"These two aspects are really important: preventing cartilage degradation after injury and, if the cartilage is already damaged beyond its ability to be repaired, replacing it," Grodzinsky says.

Other authors of the paper are Yang Li, a graduate student in biological engineering; Lin Han, a former MIT postdoc; Han-Hwa Hung, a research specialist in biological engineering; Eliot Frank, a principal research engineer in biological engineering; Kamal Youcef-Toumi, a professor of mechanical engineering; and Christine Ortiz, a professor of materials science and engineering and MIT's dean for graduate education.


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Contact: Sarah McDonnell
s_mcd@mit.edu
617-253-8923
Massachusetts Institute of Technology
Source:Eurekalert

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