Navigation Links
Hop, skip or jump? Study says no to all of the above
Date:4/17/2013

CAMBRIDGE, MA -- Osteoarthritis, which affects at least 20 percent of adults in the United States, leads to deterioration of cartilage, the rubbery tissue that prevents bones from rubbing together. By studying the molecular properties of cartilage, MIT engineers have now discovered how the earliest stages of arthritis make the tissue more susceptible to damage from physical activities such as running or jumping.

The findings could help researchers develop tests to diagnose arthritis earlier in patients at high risk for the disease and also guide engineers in designing replacement cartilage. The results also suggest that athletes who suffer traumatic knee injuries, such as a torn anterior cruciate ligament (ACL) which gives them a greater chance of developing arthritis later in life should be cautious when returning to their sport following surgery.

"It's a clear signal to be careful of going right back out," says Alan Grodzinsky, an MIT professor of biological, electrical and mechanical engineering and senior author of a paper describing the findings in a recent issue of the Biophysical Journal. "Even though your knee may be stabilized, there's the possibility that deformation of cartilage at a high loading rate is still going to put it at risk."

Cartilage is packed with protein-sugar complexes known as aggrecans, each made of about 100 highly charged molecules called glycosaminoglycans (GAGs). Those molecules protect joints by absorbing water and causing the tissue to stiffen as pressure is applied.

"The cartilage is a stiff sponge, filled with fluid, and as we compress it, fluid has to percolate through these closely spaced GAG chains," Grodzinsky says. "The GAG chains provide resistance to flow, so the water can't get out of our cartilage instantly when we compress it. That pressurization at the nanoscale increases the stiffness of our cartilage to high-loading-rate activities."

The MIT team set out to in
'/>"/>

Contact: Sarah McDonnell
s_mcd@mit.edu
617-253-8923
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Federal Government Organization achieves cleaner and faster Clinical Study Data using Tablet PCs from TabletKiosk
2. Half of Tamiflu prescriptions went unused during 2009 H1N1 swine flu pandemic, UK sewage study
3. CU-Boulder study looks at microbial differences between parents, kids and dogs
4. TGen-led study discovers dramatic changes in bacteria following male circumcision
5. Mount Sinai study identifies new gene variations associated with heart rate
6. Study proposes alternative way to explain lifes complexity
7. Exercise or make dinner? Study finds adults trade one healthy act for another
8. BUSM researchers identify novel approach to study COPD and treatment efficacy
9. Sustainable fishing certification too lenient and discretionary, study finds
10. Methane emissions from natural gas local distribution focus of new study
11. Short daily walk might help teen smokers cut down or quit, new study says
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... As our ability to assess the pandemic risk from ... developments, we must not allow ourselves to become complacent ... an international consortium of scientists. , Influenza pandemics arise ... have yet to develop widespread immunity – spreads in ... in the past 100 years, the worst of which ...
(Date:10/15/2014)... resistance to bacterial pneumonia in female mice to an ... Females are naturally more resistant to respiratory infections than ... that increased resistance to bacterial pneumonia in female mice ... (NOS3). They also show that this enzyme is ultimately ... estrogen. , The team, lead by Professor Lester Kobzik ...
(Date:10/14/2014)... DURHAM, N.C. – Like discriminating thieves, prostate cancer tumors ... in the body. But such avarice may be a ... found a way to kill prostate cancer cells by ... that selectively destroys the diseased cells brimming with the ... which uses two drugs already commercially available for other ...
Breaking Biology News(10 mins):Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2Prostate cancer's penchant for copper may be a fatal flaw 2
... of the travels of the malaria parasite Plasmodium through ... found the parasites developing in an unexpected place: the ... nodes almost certainly has implications for the mammalian immune ... (HHMI) international research scholar who led the study. ...
... A new experiment has shed more light on the multi-decade debate ... them. , You don't have to watch your legs and feet ... scientists have debated two options for how the brain achieves this: ... it sends to the muscles telling them how strongly to contract, ...
... bone-marrow derived stem cells can regenerate damaged renal cells ... potential new strategy for managing this inherited kidney disease ... may be useful in repairing basement membrane matrix defects ... at Beth Israel Deaconess Medical Center (BIDMC), the findings ...
Cached Biology News:Malaria parasites develop in lymph nodes 2Malaria parasites develop in lymph nodes 3How does the brain know what the right hand is doing? 2New research demonstrates bone-marrow derived stem cells can reverse genetic kidney disease 2
(Date:10/19/2014)... October 19, 2014 According to ... (Access Points; WLAN Controllers; Wireless gateways)]- Global Advancements, ... segments the global Outdoor Wi-Fi market with analysis ... report MarketsandMarkets also identifies the drivers and the ... the trends, opportunities and challenges. , Browse 65 ...
(Date:10/18/2014)... October 18, 2014 The Asia-Pacific hardware ... market in Asia-Pacific with analysis and forecast of revenue. ... is expected to reach $51,362.6 million by 2018, at ... Browse through the TOC of the Asia-Pacific hardware encryption ... analysis provided. This also provides a glimpse of the ...
(Date:10/18/2014)... The report " Cloud Analytics Market ... Speech; Machine; Video; Predictive Analytics: Global Advancements, Delivery ... Analysis (2013 - 2018) ", defines and segments ... segments with an in-depth analysis and forecasting of ... driving this market, various restraints, and opportunities impacting ...
(Date:10/17/2014)... DE (PRWEB) October 17, 2014 ... among top employers, as published in today’s print ... Science Careers’ annual Top Employers Survey polled employees ... determine the 20 best employers. Rankings were ... were asked to rate their companies on 23 ...
Breaking Biology Technology:Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 2Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 3Outdoor Wi-Fi Market (by Access Points, WLAN Controllers, Wireless gateways) Expected to Cross $37.2 Billion by 2018 - New Report by MarketsandMarkets 4The Asia-Pacific hardware encryption display market is expected to reach $51,362.6 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific hardware encryption display market is expected to reach $51,362.6 million by 2018 - New Report by MicroMarket Monitor 3Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 2Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 3Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 4Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 5DuPont Named Top Employer by Science Magazine 2DuPont Named Top Employer by Science Magazine 3
... doubt, let me assure you that DEMOletter blog readers are ... space to any reader who had a perspective, opinion, or wild-eyed ... responded. And it seems even Jim prefers the safety of ... edited by me. , ,Most of you, I suppose, were clever ...
... With the support of a local equity investor, an early-stage ... and it is intent on marketing its games to major ... Nintnedo . , ,Selling its products to the "big ... Codebase Productions, LLC and its president, Ben Geisler, but ...
... Waukesha, Wis. - GE Healthcare , the ... will provide the Translational Genomics Research Institute ... with advanced imaging equipment for drug discovery and development. ... genomics technologies to accelerate research in translational genomics, a ...
Cached Biology Technology:The DEMO Summer Reading List 2The DEMO Summer Reading List 3Emerging game developer begins work on prototypes 2GE Healthcare partners with genomics institute 2