Navigation Links
Hitting target in cancer fight now easier with new nanoparticle platform, UCLA scientists say
Date:5/4/2011

The ability to use nanoparticles to deliver payloads of cancer-fighting drugs to tumors in the body could herald a fundamental change in chemotherapy treatment. But scientists are still at a relatively early stage in the implementation of this technology.

Although developing nanoparticles that work as "magic bullets" selectively targeting tumors while sparing normal, healthy tissues is still the goal, the reality is that most of these nanocarriers are removed through the liver and spleen before ever reaching their intended target. And many of the encapsulated drugs can be lost while the carriers circulate in the blood or degraded on the way to tumors.

In a study recently published in the journal ACS Nano, UCLA scientists report that by using engineered mesoporous silica nanoparticles (MSNPs) as delivery vehicles, they were able to achieve significant increases in the percentage of drug-carrying nanoparticles that reach and are retained at tumor sites.

The MSNP platform allows for the introduction of multiple and customized design features that can help optimize the delivery of chemotherapeutic drugs to a variety of cancer types, said the researchers, led by Dr. Andre Nel, a professor of medicine, pediatrics and public health and chief of the nanomedicine division in the UCLA Department of Medicine, and Jeffrey Zink, a professor in the UCLA Department of Chemistry and Biochemistry. Nel and Zink are also members of the California NanoSystems Institute at UCLA.

A key challenge in enhancing drug delivery has been improving nanocarriers' access to tumors by capitalizing on features like the leakiness of abnormal tumor blood vessels, which allows nanoparticles to slip through and be retained at tumor sites. To achieve that, particles must be designed to be the ideal size, to remain in the blood stream long enough by temporarily evading the liver and spleen, and to stably bind the drug.

The dynamic design
'/>"/>

Contact: Jennifer Marcus
jmarcus@cnsi.ucla.edu
310-267-4839
University of California - Los Angeles
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study shows hunger hitting closer to home
2. Chances of hurricane hitting Texas discussed at UH conference
3. How your body clock avoids hitting the snooze button
4. Why the swamp sparrow is hitting the high notes
5. MIT: Removable cloak for nanoparticles helps them target tumors
6. System in brain -- target of class of diabetes drugs -- linked to weight gain
7. La Jolla Institute identifies new therapeutic target for asthma, COPD and other lung disorders
8. Lesser-known Escherichia coli types targeted in food safety research
9. Target for lung cancer chemoprevention identified
10. Short rotation energy crops could help meet UKs renewable energy targets
11. Study identifies promising target for AIDS vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... from Spain, France, and the U.S. has discovered ... oldest definitive member of the tribe Omaliini that ... and description were made possible through the use ... which allows the detailed study of otherwise invisible ... described in the journal Annals of the ...
(Date:7/31/2014)... the photovoltaic effect in 1839, humankind has sought to ... its own purposes. In a new research report published ... FASEB Journal , scientists may have uncovered a ... focusing on a naturally occurring combination of lipids that ... over time and across speciessuggests that this specific natural ...
(Date:7/31/2014)... they are an iconic symbol of tropical resorts ... landscape. Some, like Hawaii,s State Flower- Hibiscus ... relatively few botanists and Hawaiian conservation workers, however, ... related group of plants known as Hibiscadelphus ... Hibiscus species are in fact highly endangered. Until ...
Breaking Biology News(10 mins):Scientists shine bright new light on how living things capture energy from the sun 2Brother of Hibiscus is found alive and well on Maui 2
... WASHINGTON, DC (February 18, 2014)The George Washington (GW) University ... hold a public forum on February 25 that will ... on college campuses. The event will feature a keynote ... and author of the best-selling book "Obsessed: America,s Food ...
... Ill. The Cache River Basin, which once ... counties, has changed substantively since the ancient Ohio River ... soils and productive farmlands; deep sand and gravel deposits; ... and diverse natural habitats in Illinois and the nation. ...
... correctly, baby hearts need rhythm...even before they have blood ... are important when making baby hearts," said Mary Kathryn ... of Vanderbilt engineers, scientists and clinicians attempting to grow ... In an article published last month in the journal ...
Cached Biology News:Mika Brzezinski, co-host of MSNBC's 'Morning Joe,' to give keynote at GW event on eating disorders 2Agricultural productivity loss as a result of soil and crop damage from flooding 2Agricultural productivity loss as a result of soil and crop damage from flooding 3Baby hearts need rhythm to develop correctly 2Baby hearts need rhythm to develop correctly 3Baby hearts need rhythm to develop correctly 4
(Date:7/31/2014)... Held at the Stanford Cancer Center, the ... the disease and its treatment. Survivors will find information ... as updates on the state-of-the-art with respect to newer ... organizing this educational opportunity,” says KCA CEO Bill Bro, ... colleagues have put together a program that balances the ...
(Date:7/31/2014)... IL (PRWEB) July 31, 2014 ... of automation across the U.S., increasing unemployment, depressing ... class. It is a Catch 22—we need ... but this means fewer jobs,” says economist and ... just-released Pollina Corporate Top 10 Pro-Business States for ...
(Date:7/31/2014)... Boston, MA (PRWEB) July 31, 2014 ... ) finds itself flush with innovative adult stem cell ... patents and has three additional patent applications ... Office. , The patented inventions address two of the ... and regenerative medicine. Adult stem cells are difficult ...
(Date:7/30/2014)... July 30, 2014 W. R. ... release of the REVELERIS® Prep purification system ... preparative chromatographers, and other researchers to perform both ... single unit. , With the REVELERIS® Prep purification ... preparative chromatography modes with a simple touch of ...
Breaking Biology Technology:ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 2ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 3ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 4The Adult Stem Cell Technology Center, LLC Launches A Marketing Campaign To License Adult Stem Cell Biotechnologies 2The Adult Stem Cell Technology Center, LLC Launches A Marketing Campaign To License Adult Stem Cell Biotechnologies 3Grace Launches New REVELERIS® Prep Purification System 2
... in a world where most ideas actually rise or fall on ... how government works. The debate over the $57.7 billion Wisconsin state ... Gov. Jim Doyle , the two-year budget contains some good ideas ... credits for investors in qualified start-up companies would be expanded; money ...
... past year, MedTech Futures has concerned itself mostly with ... turned and we will discuss - albeit only briefly ... , ,Following the lead of California and Massachusetts, Illinois ... a fundamental civil right and announced on Sunday an ...
... Wis. - GE Healthcare has signed ... Excellence in Breast Cancer Imaging within the University ... ,With funding from GE Healthcare, a $17 billion unit ... designed to advance and commercialize research and technology to ...
Cached Biology Technology:Tech ideas in state budget will need help from entrepreneurs 2Tech ideas in state budget will need help from entrepreneurs 3Tech ideas in state budget will need help from entrepreneurs 4Healthcare of business: Universal coverage plan includes new business taxes 2Healthcare of business: Universal coverage plan includes new business taxes 3Healthcare of business: Universal coverage plan includes new business taxes 4Healthcare of business: Universal coverage plan includes new business taxes 5Healthcare of business: Universal coverage plan includes new business taxes 6
Tissue culture grade....
The DNA DipStick Kit is ideal for estimating nucleic acid concentrations and approximate yields. Works with ss- and ds-DNA, RNA, and oligonucleotides at concentrations as low as 0.1 ng/l....
IHC detection kit for PCNA in cells and tissues...
Request Info...
Biology Products: