Navigation Links
High-resolution 3-D imaging draws new picture of Golgi's whereabouts during cell division
Date:12/15/2013

Resolving a fundamental question in cell biology and showing off the powers of new high-resolution 3-D imaging, NIH scientists have discovered where the Golgi apparatus, which sorts newly synthesized proteins for transport inside and outside the cell, goes when it disassembles during cell division, according to research to be presented on Sunday, Dec. 15, at the American Association for Cell Biology (ASCB) annual meeting in New Orleans.

With conventional microscopy techniques, the scientists said they could only watch as the Golgi dissolved into tiny "puncta" and an unresolvable haze. But powerful new imaging techniques allowed the researchers to follow the Golgi through its "choreographed disassembly process," which now appears tightly linked to the endoplasmic reticulum (ER) during cell division, said Dylan Burnette, Ph.D., and Prabuddha Sengupta, Ph.D., and Jennifer Lippincott-Schwartz, Ph.D., of the Eunice Shriver National Institute of Child Health and Human Development (NICHD) in Bethesda, MD.

Cell division by mitosis is the complicated yet critical process by which a mother cell divides into two daughter cells. But first, the mother cell has to pack up her cellular household contents, disassembling and dividing up everything for her soon-to-be-formed daughters.

How cells manage division has been exhaustively studied for over a century and yet basic mysteries remained. Scientists knew that some organelles such as the ER are pulled apart before division but keep their tubular membrane structure intact. Other organelles such as the Golgi, go to pieces after the prophase of mitosis through choreographed disassembly.

But where does the Golgi go once it is in pieces? To answer the question, the NIH researchers started with two plausible theories: In the endoplasmic reticulum (ER)-linked hypothesis, the Golgi puncta and enzyme haze are closely held by the ER; in the non-ER-linked model, the puncta and haze float about on thei
'/>"/>

Contact: Cathy Yarbrough
cyarbrough@ascb.org
858-243-1814

John Fleischman
jfleischman@ascb.org

American Society for Cell Biology
Source:Eurekalert


Page: 1 2

Related biology news :

1. A high-resolution endoscope as thin as a human hair
2. Citizen scientists to document biodiversity with high-resolution imagery during summer solstice
3. High-resolution atomic imaging of specimens in liquid by TEM using graphene liquid cell
4. High-tech X-ray imaging technique to offer detailed look at engineered tissue
5. Radiographic imaging exposes relationship between obesity and cancer
6. Visualizing the past: Nondestructive imaging of ancient fossils
7. Kessler Foundation neuroimaging study sheds light on mechanisms of cognitive fatigue in MS
8. Cancer imaging centers get £35 million boost
9. Organic electronics: Imaging defects in solar cells
10. Molecular Imaging Agents: Targets, Technology, Markets, and Commercial Opportunities
11. Texas A&M research contributes to improved ultrasound imaging
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... is available in German . ... between organisms is considered the oldest form of communication. ... conspecifics, for example, the sexual attraction between males and ... and to coordinate reproductive behavior in males and females. ... of the Algarve in Faro, Portugal, and at the ...
(Date:8/29/2014)... Tibetan plateau -- the largest topographic anomaly above sea ... profound effect on climate and its reflection of continental ... , Katharine Huntington and colleagues employ a cutting-edge geochemical ... fossil snail shells to investigate the uplift history of ... range widely on the timing of surface uplift of ...
(Date:8/28/2014)... study reports that an expansion of marine protected areas ... ecological functions. According to investigators from the Wildlife ... fish have focused on saving the largest numbers of ... provide key and difficult-to-replace ecological functions. , ... by fish species that also are food for millions ...
Breaking Biology News(10 mins):Ready for mating at the right time 2Ready for mating at the right time 3Snails tell of the rise and fall of the Tibetan Plateau 2Snails tell of the rise and fall of the Tibetan Plateau 3Snails tell of the rise and fall of the Tibetan Plateau 4Snails tell of the rise and fall of the Tibetan Plateau 5Snails tell of the rise and fall of the Tibetan Plateau 6Snails tell of the rise and fall of the Tibetan Plateau 7Study finds marine protected areas inadequate for protecting fish and ocean ecology 2
... vaccine has successfully protected mice and ferrets against a ... who led the study at St. Jude Children's Research ... San Diego, California. , This finding, coupled with results ... influenza strains, suggests that such a vaccine would protect ...
... the bacteria which survive in extreme cold, scientists no ... Antarctic lakes and glaciers. Bacteria previously isolated from polar ... in extreme cold, have been isolated from soil in ... at Queen's University, Canada, have developed a technique to ...
... combining the four bacterial surface proteins that generate ... the University of Chicago have created a vaccine ... drug-resistant strains of Staphylococcus aureus, the most common ... source of community-associated illness. , The vaccine ...
Cached Biology News:St. Jude test of bird flu vaccine proves successful 2MRSA vaccine shows promise in mouse study 2MRSA vaccine shows promise in mouse study 3
(Date:8/28/2014)... A new research platform uses a ... tiny structures undergoing stress and heating, an ... designs for microelectronics and batteries., This new ... about how heating and the surface stress ... Researchers have discussed the merits of surface-stress ...
(Date:8/28/2014)... 2014  Next month, executives from clinical trial marketing firm ... beginning with Patient-Centered Clinical Trials 2014 , to be ... , September 4-5. Patient recruitment experts Bonnie A. ... will share insights on the benefits of employing an ... – from media to mobile apps – can be used ...
(Date:8/28/2014)... work by a Florida State University research team has ... your temperature, emit white light, and convert photon energy ... like a butterfly. , Biwu Ma, associate professor in ... FAMU-FSU College of Engineering, created the molecule in a ... discover that his creation has many other unique capabilities. ...
(Date:8/28/2014)... Boston, MA (PRWEB) August 28, 2014 ... of wholesale construction materials, selected SoundConnect ... of their cloud based audio and web conferencing ... configured to support PrimeSource’s employees’ needs. SoundConnect ... technologies. , PrimeSource Building Products will be ...
Breaking Biology Technology:New analytical technology reveals 'nanomechanical' surface traits 2New analytical technology reveals 'nanomechanical' surface traits 3BBK Worldwide Leads Sessions at Key September Events 2Novel 'butterfly' molecule could build new sensors, photoenergy conversion devices 2PrimeSource Chooses SoundConnect as Collaboration Provider 2
... PHILADELPHIA and LONDON, June 9 /PRNewswire/ -- ... today that, despite difficult economic times, renewals of ... existing customers have even added new content to their ... the world,s largest citation database, providing researchers, administrators, faculty ...
... Personalized Medicine Company in Next Phase of Growth , , ... personalized medicine company, announced today that James S. ... CEO. , , Burns comes to AssureRx with more ... science and technology for pharmaceutical, diagnostic, and biotech companies. Most recently, ...
... MARINO, Calif., June 9 Epeius Biotechnologies, Rexin-G is the ... you will, a tiny particle that can travel freely within ... that have spread far and wide. Imagine an entire ... high concentrations within the flagrant, otherwise intractable tumors with one ...
Cached Biology Technology:Web of Science(R) Renewals Remain Strong Despite Tough Economic Climate 2AssureRx Adds New CEO 2The World's Smallest Hero! Rexin-G, Targeted Therapy for Metastatic Cancers 2
Mouse monoclonal [6C3] to JAB1 ( Abpromise for all tested applications). entrezGeneID: 10987 SwissProtID: O15386...
Human TGF-beta RIIb Affinity Purified Polyclonal Ab...
Human FGF R2 (alpha isoforms) MAb (Clone 98706)...
dithiothreitol, sulfhydryl reducing agent, C4H10O2S2; MW: 154.24, 97% pure (minimum), CAS No: 27565-41-9, store at -20 C ...
Biology Products: