Navigation Links
High-resolution 3-D imaging draws new picture of Golgi's whereabouts during cell division
Date:12/15/2013

Resolving a fundamental question in cell biology and showing off the powers of new high-resolution 3-D imaging, NIH scientists have discovered where the Golgi apparatus, which sorts newly synthesized proteins for transport inside and outside the cell, goes when it disassembles during cell division, according to research to be presented on Sunday, Dec. 15, at the American Association for Cell Biology (ASCB) annual meeting in New Orleans.

With conventional microscopy techniques, the scientists said they could only watch as the Golgi dissolved into tiny "puncta" and an unresolvable haze. But powerful new imaging techniques allowed the researchers to follow the Golgi through its "choreographed disassembly process," which now appears tightly linked to the endoplasmic reticulum (ER) during cell division, said Dylan Burnette, Ph.D., and Prabuddha Sengupta, Ph.D., and Jennifer Lippincott-Schwartz, Ph.D., of the Eunice Shriver National Institute of Child Health and Human Development (NICHD) in Bethesda, MD.

Cell division by mitosis is the complicated yet critical process by which a mother cell divides into two daughter cells. But first, the mother cell has to pack up her cellular household contents, disassembling and dividing up everything for her soon-to-be-formed daughters.

How cells manage division has been exhaustively studied for over a century and yet basic mysteries remained. Scientists knew that some organelles such as the ER are pulled apart before division but keep their tubular membrane structure intact. Other organelles such as the Golgi, go to pieces after the prophase of mitosis through choreographed disassembly.

But where does the Golgi go once it is in pieces? To answer the question, the NIH researchers started with two plausible theories: In the endoplasmic reticulum (ER)-linked hypothesis, the Golgi puncta and enzyme haze are closely held by the ER; in the non-ER-linked model, the puncta and haze float about on thei
'/>"/>

Contact: Cathy Yarbrough
cyarbrough@ascb.org
858-243-1814

John Fleischman
jfleischman@ascb.org

American Society for Cell Biology
Source:Eurekalert


Page: 1 2

Related biology news :

1. A high-resolution endoscope as thin as a human hair
2. Citizen scientists to document biodiversity with high-resolution imagery during summer solstice
3. High-resolution atomic imaging of specimens in liquid by TEM using graphene liquid cell
4. High-tech X-ray imaging technique to offer detailed look at engineered tissue
5. Radiographic imaging exposes relationship between obesity and cancer
6. Visualizing the past: Nondestructive imaging of ancient fossils
7. Kessler Foundation neuroimaging study sheds light on mechanisms of cognitive fatigue in MS
8. Cancer imaging centers get £35 million boost
9. Organic electronics: Imaging defects in solar cells
10. Molecular Imaging Agents: Targets, Technology, Markets, and Commercial Opportunities
11. Texas A&M research contributes to improved ultrasound imaging
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/16/2015)... , June 16, 2015 Fingerprint ... previously communicated that it will amount to at least 340 ... Due to the rapid increase in market growth and orders ... previously communicated guidance that revenue for 2015 will exceed 1,500 ... amount to approximately 2,200 MSEK. Due to receipt ...
(Date:6/11/2015)... June 11, 2015 Daon, a global ... that its IdentityX Mobile Authentication Platform v4.0 has ... Alliance is an industry consortium launched in 2013 ... simpler, stronger authentication.  In order to receive certification, ... rigorous series of tests that measure compliance and ...
(Date:6/8/2015)...  The Secure Identity & Biometrics Association ... Troy Potter of L-3 National Security Solutions ... non-profit association that was established in February 2014 ... of solutions that protect and secure identity across ... Photo - ...
Breaking Biology News(10 mins):Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 2Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 3Daon's IdentityX Mobile Authentication Platform One of First Products to be Certified by FIDO Alliance 2Secure Identity & Biometrics Association (SIBA) Names Troy Potter of L-3 National Security Solutions as Chairman 2Secure Identity & Biometrics Association (SIBA) Names Troy Potter of L-3 National Security Solutions as Chairman 3Secure Identity & Biometrics Association (SIBA) Names Troy Potter of L-3 National Security Solutions as Chairman 4Secure Identity & Biometrics Association (SIBA) Names Troy Potter of L-3 National Security Solutions as Chairman 5
... of our daily vocabulary. We all know they,re part of ... We know they have something to do with starches and ... a lot for science to learn about them. ... Nikki Pohl, an Iowa State University associate professor of chemistry. ...
... UC Davis Cancer Center shows that a protein called Muc4 ... spread to other organs and resist therapeutic treatment. The study, ... Research , is one of the first to characterize the ... author of the study, knew that Muc4 was not always ...
... worldwide trade organisation bringing together users and manufacturers of ... Cavimeter was judged by the panel to be "more ... culmination of a period of research, development and exploitation ... Acoustic cavitation is the inception, growth and eventual collapse ...
Cached Biology News:Iowa State chemist synthesizes carbohydrates, launches startup company 2UC Davis researchers identify a protein that may help breast cancer spread, beat cancer drugs 2NPL Cavimeter receives 2009 UIA Outstanding Product Award 2
(Date:6/26/2015)... California (PRWEB) , ... June 26, 2015 , ... ... devices, today announced that its SimplePrep™ technologies have been integrated into a sample ... International Space Station (ISS) as a part of the NASA’s WetLab-2 Project. , ...
(Date:6/26/2015)... ... June 26, 2015 , ... DNA Genotek, a leading ... Technologies, Inc. (Nasdaq: OSUR) today announced that it has awarded grants to three ... Grant Program. The company has awarded its OMNIgene®•GUT fecal/stool collection kits ...
(Date:6/26/2015)... (PRWEB) , ... June 26, 2015 , ... ReliantHeart, ... that indicates that from the first implant of the HeartAssist5® LVAD (HA5) to the ... the HA5. , Thrombus that originates in an LVAD is referred to as ...
(Date:6/25/2015)... 25, 2015 ... announced the addition of the  "2015 ... Cancer Diagnostics Industry: Oncogenes, Biochemical Markers, ... Commercial Labs, POC Locations"  report ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , A ...
Breaking Biology Technology:Claremont BioSolutions’ SimplePrep™ Products Deployed in NASA Wetlab-2 Project Slated for June 28th Flight to International Space Station aboard SpaceX CRS-7 2Claremont BioSolutions’ SimplePrep™ Products Deployed in NASA Wetlab-2 Project Slated for June 28th Flight to International Space Station aboard SpaceX CRS-7 3DNA Genotek Inc. Announces Recipients of Gut Microbiome Grant Program 2DNA Genotek Inc. Announces Recipients of Gut Microbiome Grant Program 3HeartAssist5® Remote Monitoring has alerted no patterns of de novo thrombus in 68 consecutive implants 2HeartAssist5® Remote Monitoring has alerted no patterns of de novo thrombus in 68 consecutive implants 3Analysis of the Global Cancer Diagnostics Industry 2015-2020: Oncogenes, Biochemical Markers, Lymphokines, GFs, CSFs, Hormones, Immunohistochemical Stains 2Analysis of the Global Cancer Diagnostics Industry 2015-2020: Oncogenes, Biochemical Markers, Lymphokines, GFs, CSFs, Hormones, Immunohistochemical Stains 3
... trees pull vast amounts of water from their roots up ... capillary action, but now scientists at the University of Rochester ... using the same principlebut does so at a speed that ... upcoming issue of Applied Physics Letters , may prove ...
... (Nasdaq: VPHM ) today announced that Colin Broom, ... present at the 30th Annual Goldman Sachs Global Healthcare Conference ... The conference is being held at the Grand Hyatt in ... William Roberts, vice president, corporate communications will present at the ...
... BASKING RIDGE, N.J., June 2 Regado Biosciences, Inc., ... therapeutic aptamers with active control agents, today announced the ... MAB is comprised of leaders in the fields of ... highly regarded leaders will advise the Company on its ...
Cached Biology Technology:Scientists create metal that pumps liquid uphill 2Scientists create metal that pumps liquid uphill 3ViroPharma to Present at Two June Healthcare Conferences 2Regado Biosciences Establishes Medical Advisory Board 2Regado Biosciences Establishes Medical Advisory Board 3
...
... 500 optimization kit is for fine-tuning the ... The kit is recommended when you are ... The kit includes 0.25 g each of ... diameter gold microcarriers, 100 each of 9 ...
... is specifically designed for two-dimensional electrophoresis ... four proteins in this marker have ... pattern across a 2D gel. The ... Mol wt: 17,000-89,000 ...
... Blocker Arrays can be used to test ... proteins and sera that are commonly used ... array contains spots for 21 different protein ... of antibody crossreactivity and species specificity, QC ...
Biology Products: