Navigation Links
High blood pressure, low energy -- a recipe for heart failure
Date:8/13/2007

Aug. 10, 2007 -- Many people with long-standing high blood pressure develop heart failure. But some don't. Daniel P. Kelly, M.D., and colleagues at Washington University School of Medicine in St. Louis and other institutions are trying to figure out what could explain that difference.

Their latest research reveals that impaired energy production in heart muscle may underlie heart failure in some hypertensive patients. The researchers assert that a molecular factor involved in maintaining the heart's energy supply could become a key to new approaches to prevent or treat heart failure.

The molecular factor, a protein called estrogen-related receptor alpha (ERR alpha), helps the heart keep up with energy-draining conditions like high blood pressure, which makes the heart work harder to pump blood. In the July issue of Cell Metabolism, Kelly and his colleagues report that mice born without any ERR alpha developed symptoms of heart failure when their hearts were forced to pump against high pressure. The hearts of normal mice took that pressure overload in stride and stayed healthy. Those contrasting outcomes suggest that heart health greatly depends on ERR alpha.

"The stress of a cardiac pressure overload asks heart muscle to manufacture more high energy compounds, and without ERR alpha, they can't do it," explains Kelly, the Tobias and Hortense Lewin Professor and Chief of the Cardiovascular Division. "You could say that in high blood pressure conditions, the heart fails because it becomes energy starved. And if you could feed the heart by using a drug that enhances ERR, for example you might enable the heart to better keep pace with its energy requirements."

Although preventions and treatments are now available for heart failure due to high blood pressure, almost all of those drugs act outside the heart by dilating blood vessels throughout the body to reduce resistance. In the future, doctors might look for diminished energy capacity in t
'/>"/>

Contact: Gwen Ericson
ericsong@wustl.edu
314-286-0141
Washington University School of Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Placenta Is A Rich Source Of Blood Stem Cells
2. White blood cell waste disposal system plays critical regulatory role
3. Epstein-Barr virus protein crucial to its role in blood cancers
4. New insight into regulation of blood stem cells
5. Infants With Rare Genetic Disease Saved by Cord Blood Stem Cells
6. White Blood Cell Waste Disposal System Plays Critical Regulatory Role
7. Mystery Blood Vessel Disorder Implicated In Mini Strokes
8. Nano-bumps could help repair clogged blood vessels
9. First technology to remove prions that cause vCJD from blood launched
10. Infants with Rare Genetic Disease Saved By Cord Blood Stem Cells
11. Breakthrough isolating embryo-quality stem cells from blood
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/16/2014)... , October 16, 2014 NXT-ID, Inc. (NASDAQ: ... "Company"), a biometric authentication company focused on the growing ... edge technologies including Wocket™, the Smart Wallet, at the ... FiRe is a leading global conference on the intersection ... by Mark Anderson , founder and publisher of ...
(Date:10/15/2014)... Johannes Gutenberg University Mainz (JGU) as a full ... to maintain a significant nationwide standing in the ... of Johannes Gutenberg University Mainz as a full ... the national and international competition for the best ... can be proud that Mainz University has been ...
(Date:10/15/2014)... awarded the 44th Rosenstiel Award for Distinguished Work in ... exploring the mechanisms of genomic instability and its implications ... the second alumnus to win the Rosenstiel Award; the ... , Alt is the Charles A. Janeway Professor of ... and an investigator at the Howard Hughes Medical Institute ...
Breaking Biology News(10 mins):NXT-ID Inc. to Present at 13th Annual FiRe Conference 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 3Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 3Brandeis awards 44th Rosenstiel Award to pioneering geneticist Fred Alt 2
... received an offer to establish its first foreign institute in ... proposed the sum of $86.9 million for the next 10 ... State of Florida will contribute funds to complete the financing, ... will take place. The County,s decision paved the ...
... out that older men chasing younger women contributes ... according to new findings by,researchers at Stanford and ... says that individuals should die of old age ... 55 in humans,according to demographer Cedric Puleston, a ...
... Calif., September 12, 2007 - UC Irvines Henry ... million gift from Edwards Lifesciences Corporation to establish ... next generation of cardiovascular devices. The Edwards ... interaction and collaboration among students, faculty members and ...
Cached Biology News:Palm Beach County wants to establish a Max Planck Institute in Florida 2Men shed light on the mystery of human longevity, study finds 2Men shed light on the mystery of human longevity, study finds 3Men shed light on the mystery of human longevity, study finds 4UCI receives $5M from Edwards Lifesciences 2
(Date:10/22/2014)... Diego, CA (PRWEB) October 22, 2014 ... balances from Sartorius, A & D Weighing, Rice ... Sartorius CPA Semi-Micro Balance . The Sartorius CPA ... for an affordable high-quality, precise, and user-friendly laboratory ... manufacturing of laboratory equipment, their laboratory balances are ...
(Date:10/22/2014)... VANCOUVER , Oct. 22, 2014 /PRNewswire/ - iCo ... ICOTF), today announced next steps for its Oral ... findings from its in vitro work ... therapy.  iCo now plans to complete pre clinical ... an initial Phase 1A clinical trial, utilizing approximately ...
(Date:10/20/2014)... 2014 Mapp Biopharmaceutical,s valiant effort to ... to fight the Ebola outbreak will make the ... production of pharmaceuticals can be, according to Kalorama ... while some may be taken aback by the ... industry knowledge are well aware of the complex ...
(Date:10/20/2014)... , Oct. 20, 2014  GenVec, Inc. (NASDAQ: ... P. Horovitz , Ph.D., from its board of directors effective ... in August 2003, and served as its chairman from June ... on the Nominating and Corporate Governance and Audit Committees of ... more than a decade of dedicated service to GenVec, and ...
Breaking Biology Technology:Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 2Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 3iCo Therapeutics Announces Advancement of Oral Amphotericin B Program 2iCo Therapeutics Announces Advancement of Oral Amphotericin B Program 3Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 2Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 3Zola P. Horovitz To Retire From GenVec Board 2
... LEIDEN, The Netherlands, and PARSIPPANY, N.J., Feb. 10 ... CRXL ; Swiss Exchange: CRX) announced today that they ... Utrecht, The Netherlands to join their Vendor Network. Under ... pre-approved cell line generation partner for licensees of the ...
... YORK, Feb. 9 5W Public Relations, a Top 25 ... Holtorf, founder of the Holtorf Medical Group and the Yan ... Trokel to its diverse roster of clientele. Both medical centers ... relations programs."We are delighted that Dr. Kent Holtorf and the ...
... Beckman Coulter, Inc. (NYSE: BEC ) ... a quarterly dividend payout of seventeen cents ($0.17) ... March 6, 2009 to all stockholders of record ... the 79th consecutive, quarterly payout of dividends.(Logo: ...
Cached Biology Technology:DSM and Crucell Sign Agreement with Bioceros to Serve as Pre-Approved Cell Line Generation Partner of PER.C6(R) Cell Line Proteins 2DSM and Crucell Sign Agreement with Bioceros to Serve as Pre-Approved Cell Line Generation Partner of PER.C6(R) Cell Line Proteins 3DSM and Crucell Sign Agreement with Bioceros to Serve as Pre-Approved Cell Line Generation Partner of PER.C6(R) Cell Line Proteins 4DSM and Crucell Sign Agreement with Bioceros to Serve as Pre-Approved Cell Line Generation Partner of PER.C6(R) Cell Line Proteins 5The Holtorf Medical Group and Yan Center for Corrective & Cosmetic Surgery Tap 5W Public Relations 2
... The Helios gene gun system, 220-240 V, ... biomaterials into cells. This handheld device employs ... RNA-, and other biomaterial-coated gold microcarriers from ... cartridge directly into target cells. This system ...
Mouse polyclonal antibody raised against a partial recombinant MHC2TA. NCBI Entrez Gene ID = 4261...
... Digital Sight DS-L2 imaging controller is a ... DS-L1, and allows users to comfortably observe, ... DS-L2 controller features an 8.4 inch LCD ... variety of Nikon cameras including the DS-Fi1 ...
Mouse monoclonal antibody to ST8SIA2 - ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2...
Biology Products: