Navigation Links
Herpes infections: Natural killer cells activate hematopoiesis
Date:5/16/2013

Infections can trigger hematopoiesis at sites outside the bone marrow in the liver, the spleen or the skin.Researchers of Ludwig-Maximilians-Universitaet (LMU) in Munich now show that a specific type of immune cell facilitates such "extra medullary" formation of blood cells.

Balanced hematopoiesis is essential for the function of the immune system. During fetal development, hematopoiesis takes place mainly in the liver and the spleen. Later the process is delegated to the bone marrow, and this tissue normally serves as the sole source of blood cells for the rest of one's lifetime. However, certain infections can reactivate hematopoiesis at sites other than the bone marrow, a process which is referred to as "extramedullary" hematopoiesis. One of the best known inducers is the so-called cytomegalovirus (CMV), a member of the herpesvirus family, which is widespread in human populations worldwide, and can lead to serious illness in individuals with immature or otherwise compromised immune systems.

An international team led by Professor Ulrich Koszinowski at LMU's Max von Pettenkofer-Institute has now examined how this virus activates hematopoiesis in tissues other than the bone marrow. "Herpesviruses are highly species-specific," explains Dr. Stefan Jordan, the lead author on the new paper. "So, in order to study the phenomenon of extramedullary hematopoiesis in an animal model, we were forced to turn to the mouse virus." The murine CMV induces extramedullary hematopoiesis principally in the spleen.

Killing of infected cells paves the way

The new findings reveal a hitherto unsuspected link between natural killer (NK) cells and hematopoiesis. NK cells play an important role in combating CMV infections, because they are the immune system's first line of defense against the virus. In the first place, they are able to recognize and eliminate CMV-infected cells and, secondly, they synthesize and secrete signal molecules that mobili
'/>"/>

Contact: Luise Dirscherl
dirscherl@lmu.de
49-892-180-2706
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Page: 1 2

Related biology news :

1. How and why herpes viruses reactivate to cause disease
2. Princeton researchers identify unexpected bottleneck in the spread of herpes simplex virus
3. Novel treatment approach for bladder pain using a herpes simplex virus vector reported
4. Einstein study reveals new approach for stopping herpes infections
5. How herpesvirus invades nervous system
6. Biology professor secures grant to save West Virginias primary natural history collection
7. Validity CTO to Present Natural ID Solutions for Improving Mobile Risk Management and User Experience at NFC Solutions Summit 2012
8. Honoring the fundamental role of microbes in the natural history of our planet
9. Resveratrol may be a natural exercise performance enhancer: U of A medical research
10. Naturally adhesive
11. No matter the drilling method, natural gas is a much-needed tool to battle global warming
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2015)... 13, 2015  higi, a leading cloud-based consumer engagement ... fully engage with their communities around health and wellness, ... and secure API.  ... accessible, affordable, and convenient vehicle to receive validated health ... The API will allow higi,s trusted partners, ...
(Date:4/6/2015)... Conn. , Apr. 6, 2015 NXT-ID, ... "Company"), a biometric authentication company focused on the ... has filed provisional patent 62/143028 for ... COMMUNICATIONS AND ENERGY TRANSFER  NXT-ID introduces a ... payments. This patent surrounds the use of miniature ...
(Date:4/2/2015)... Fingerprint Cards (FPC) has received ... the distributor World Peace Industrial Group (WPI), part of ... the major part of the shipments will take place ... smartphone manufacturers in China . The ... communicated revenue guidance of + 1 000 MSEK for 2015.  ...
Breaking Biology News(10 mins):higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2
... in collaboration with scientists at the University of California, San ... protein switch that plays a crucial role in the development ... 8 issue of the journal Molecular Cell, provide a template ... switch, a protein called Scp1, at will. , "Scp1 is ...
... the plague and some forms of food poisoning "paralyze" the ... to a new study in the September 8, 2006 issue ... researchers found that these bacteria, which belong to the genus ... enzyme. That copycat protein blocks host cells' capacity to change ...
... in the open access journal PLoS Biology, Sagiv Shifman, Jonathan ... the mouse genome--one of the most detailed genetic maps now ... this map, they used two groups of mice: one consisting ... inbred lines (RI). Using the single nucleotide polymorphism (SNP) data ...
Cached Biology News:Detailed 3-D image catches a key regulator of neural stem cell differentiation in action 2Detailed 3-D image catches a key regulator of neural stem cell differentiation in action 3Study illuminates how the plague bacteria causes disease 2Study illuminates how the plague bacteria causes disease 3Mapping the mouse genome 2
(Date:4/16/2015)... Ohio (PRWEB) April 16, 2015 ... Index, overexertion involving an outside source was ranked ... This includes injuries related to lifting, pushing, pulling, ... billion in direct costs. The David Round Company ... is committed to working hard to develop and ...
(Date:4/16/2015)... , April 16, 2015  RegeneRx Biopharmaceuticals, ... announced its U.S. joint venture with G-treeBNT (ReGenTree ... phase 3 clinical trial for the orphan disorder, ... trial for dry eye syndrome (DES) in the ... eye drops, RGN-259/GBT201, this year.  Each of these ...
(Date:4/16/2015)... , April 16, 2015  Scientists from Cleave Biosciences ... on the Horizon," at the American Association for Cancer ... on Sunday, April 19, 2015 from 3:15pm ... Director of Biology, will present new in vivo and ... oral inhibitor of p97, a critical enzyme that controls ...
(Date:4/16/2015)... Fairleigh Dickinson University ( FDU ) ... the Executive Director of the Rothman Institute of ... of the Initiative for Patient Centered Innovation (iPCI), ... the Rothman Institute of Innovation and Entrepreneurship (within ... with FDU’s School of Pharmacy’s Center for Healthcare ...
Breaking Biology Technology:The David Round Company Helps Companies Meet OSHA Standards by Combining Safety, Ergonomics, and Productivity 2RegeneRx JV Retains Ora, Inc. to Conduct Phase 3 Trial for NK and Phase 2b/3 Trial for Dry Eye Syndrome in U.S. 2RegeneRx JV Retains Ora, Inc. to Conduct Phase 3 Trial for NK and Phase 2b/3 Trial for Dry Eye Syndrome in U.S. 3RegeneRx JV Retains Ora, Inc. to Conduct Phase 3 Trial for NK and Phase 2b/3 Trial for Dry Eye Syndrome in U.S. 4RegeneRx JV Retains Ora, Inc. to Conduct Phase 3 Trial for NK and Phase 2b/3 Trial for Dry Eye Syndrome in U.S. 5Cleave Biosciences to Participate in Special Session "New Drugs on the Horizon" at AACR Annual Meeting 2015 2Cleave Biosciences to Participate in Special Session "New Drugs on the Horizon" at AACR Annual Meeting 2015 3Dr. Joseph V. Gulfo Named Executive Director of Fairleigh Dickinson University’s Rothman Institute to Spearhead New Initiative for Patient-Centered Innovation (iPCI) 2Dr. Joseph V. Gulfo Named Executive Director of Fairleigh Dickinson University’s Rothman Institute to Spearhead New Initiative for Patient-Centered Innovation (iPCI) 3
... the following Webcast:, What: Neurocrine Biosciences 3rd ... @ 5 p.m. Eastern 2 p.m. Pacific, Where: ... Internet -- Simply log on to the web at the address ... Claudia Woodworth, 858-617-7759 If you are unable to participate during the ...
... demand for health ... economics and market access support, BOSTON, Oct. 28 ... as Vice President., Mr. Barak brings 16 years of ... reimbursement strategies,for drugs, medical devices, and diagnostics in a wide ...
... Company Also Announces Completion of Enrollment in U.S. ... Chronic Hepatitis C,Genotype 1, TAMPA, Fla., Oct. ... today announced the presentation of studies,of nitazoxanide at ... for the Study of Liver Diseases (AASLD), also ...
Cached Biology Technology:Boston Healthcare Appoints Adam Barak as Vice President Enhancing Its International Pricing and Reimbursement Capability 2Romark Laboratories Announces Presentation of New Nitazoxanide Data at 59th Annual AASLD Meeting and 50th Anniversary IASL Meeting in San Francisco 2
Topoisomerase II...
BD BioCoat Fibronectin 150 mm Culture Dishes...
... General description: Dish uses include large-scale ... Compatible with PBA Flexys TM automated ... number is a new product number, created ... showing no availability yet, please order under ...
BD BioCoat Collagen IV 150 mm Culture Dishes...
Biology Products: