Navigation Links
Herpes infections: Natural killer cells activate hematopoiesis
Date:5/16/2013

Infections can trigger hematopoiesis at sites outside the bone marrow in the liver, the spleen or the skin.Researchers of Ludwig-Maximilians-Universitaet (LMU) in Munich now show that a specific type of immune cell facilitates such "extra medullary" formation of blood cells.

Balanced hematopoiesis is essential for the function of the immune system. During fetal development, hematopoiesis takes place mainly in the liver and the spleen. Later the process is delegated to the bone marrow, and this tissue normally serves as the sole source of blood cells for the rest of one's lifetime. However, certain infections can reactivate hematopoiesis at sites other than the bone marrow, a process which is referred to as "extramedullary" hematopoiesis. One of the best known inducers is the so-called cytomegalovirus (CMV), a member of the herpesvirus family, which is widespread in human populations worldwide, and can lead to serious illness in individuals with immature or otherwise compromised immune systems.

An international team led by Professor Ulrich Koszinowski at LMU's Max von Pettenkofer-Institute has now examined how this virus activates hematopoiesis in tissues other than the bone marrow. "Herpesviruses are highly species-specific," explains Dr. Stefan Jordan, the lead author on the new paper. "So, in order to study the phenomenon of extramedullary hematopoiesis in an animal model, we were forced to turn to the mouse virus." The murine CMV induces extramedullary hematopoiesis principally in the spleen.

Killing of infected cells paves the way

The new findings reveal a hitherto unsuspected link between natural killer (NK) cells and hematopoiesis. NK cells play an important role in combating CMV infections, because they are the immune system's first line of defense against the virus. In the first place, they are able to recognize and eliminate CMV-infected cells and, secondly, they synthesize and secrete signal molecules that mobili
'/>"/>

Contact: Luise Dirscherl
dirscherl@lmu.de
49-892-180-2706
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Page: 1 2

Related biology news :

1. How and why herpes viruses reactivate to cause disease
2. Princeton researchers identify unexpected bottleneck in the spread of herpes simplex virus
3. Novel treatment approach for bladder pain using a herpes simplex virus vector reported
4. Einstein study reveals new approach for stopping herpes infections
5. How herpesvirus invades nervous system
6. Biology professor secures grant to save West Virginias primary natural history collection
7. Validity CTO to Present Natural ID Solutions for Improving Mobile Risk Management and User Experience at NFC Solutions Summit 2012
8. Honoring the fundamental role of microbes in the natural history of our planet
9. Resveratrol may be a natural exercise performance enhancer: U of A medical research
10. Naturally adhesive
11. No matter the drilling method, natural gas is a much-needed tool to battle global warming
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... and POINT ROBERTS, Washington , ... Play a Key Role in Addressing Security Concerns in the ... a global news source covering leading sectors including biometrics, issues ... market. Jason Peaslee , Managing Partner at ... and Gino Pereira , CEO of NXT-ID, Inc. (OTCBB: ...
(Date:8/19/2014)... used in supermarkets to encourage healthier spending habits? A ... that very question by tracking the purchasing records in ... to rate the nutritional value of foods for sale. ... David Just, PhD, and Brian Wansink PhD, author of ... over 150 Hannaford Supermarkets in the Northeastern United States ...
(Date:8/19/2014)... In many parts of the world, leprosy and ... new cases of leprosy per year, with nearly ... The currently available century-old vaccine Bacille Calmette-Guerin, or ... and leprosy, so a more potent vaccine is ... have found a stronger weapon against both diseases., ...
Breaking Biology News(10 mins):Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 2Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 3Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 4Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 5Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 6Digital Wallets for a Digital World - the Players and the Concerns for Consumer Adoption 7New vaccine shows promise as stronger weapon against both tuberculosis and leprosy 2
... French . , Quebec City, August 25, 2011A diet rich ... according to a study conducted by Universit Laval researchers. The team, ... extent of brain damage following a stroke was reduced by 25% ... study can be found on the website of the journal ...
... DURHAM, N.C. Aerobic exercise is your best bet when ... study finds. When Duke University Medical Center researchers conducted ... combination of the two, they found aerobic exercise to be ... belly fat that,s most damaging to your health. This ...
... have developed the first practical method to create a compound ... naturally in a species of moss found in China, is ... disease in China since the late 1990s and is sold ... memory. Scientists believe it could also potentially combat the effects ...
Cached Biology News:Omega-3s reduce stroke severity 2Aerobic exercise bests resistance training at burning belly fat 2Scientists create natural Alzheimer's-fighting compound in lab 2
(Date:8/20/2014)... university inventions licensed to biotechnology firms has revealed ... open these roadblocks, the researchers suggest that better ... stage could lead to faster commercialization down the ... discoveries made in university laboratories and licensed to ... trials, which have a high failure rate. But ...
(Date:8/20/2014)... Aug. 20, 2014 Neurotrope, Inc. (OTCQB: ... conference call to provide an update on Company ... daylight timeDial-in numbers:(888) 505-4369 (U.S. and Canada) or ... cast: www.neurotropebioscience.com , under "Investor Relations"The teleconference replay ... through September 2, 2014 at (888) 203-1112 (U.S. ...
(Date:8/20/2014)... Aug. 20, 2014  PAREXEL International Corporation (NASDAQ: ... presenting at the Baird Healthcare Conference in New York.  ... Financial Officer, will be making a presentation on PAREXEL ... Wednesday, Sept. 3, 2014. A live webcast ... section of PAREXEL,s website at www.PAREXEL.com in ...
(Date:8/20/2014)... , Aug. 20, 2014 /PRNewswire-iReach/ -- A ... transformative collaboration between the school,s bioengineering department and ... of the Intel® Software Academic Program, UCSD,s research ... and the human body.  Photo ... study exhibits the work of Dr. Todd ...
Breaking Biology Technology:Early bottlenecks in developing biopharmaceutical products delay commercialization 2Early bottlenecks in developing biopharmaceutical products delay commercialization 3Neurotrope To Host Conference Call 2PAREXEL International To Present At Baird Healthcare Conference 2Intel and University of San Diego Bioengineering Department Release Case Study on Health Sciences Research 2
... Crystal Research Associates, LLC announced today that it ... Inc. (NYSE Amex: CUR ). The full ... .Neuralstem, Inc. ("Neuralstem" or "the Company") is a ... stem cells to treat central nervous system (CNS) diseases. ...
... /PRNewswire-Asia/ -- Pharmaxis Ltd (AXS: PXS;,Nasdaq: PXSL ) ... afternoon of Wednesday 8th April 2009. Dr Alan Robertson ... quarter and answer,investor questions. , The ... 8th April at 6.00pm U.S. East Coast, 3.00pm U.S. West ...
... April 6 Cell Therapeutics, Inc. (CTI) (Nasdaq and ... from Spectrum Pharmaceuticals, Inc. (Spectrum) in connection with the ... venture to Spectrum for approximately $16.5 million that closed ... on March 2, 2009, related to this transaction, and ...
Cached Biology Technology:Crystal Research Associates, LLC Issues Executive Informational Overview(R) (EIO(R)) on Neuralstem, Inc. 2Crystal Research Associates, LLC Issues Executive Informational Overview(R) (EIO(R)) on Neuralstem, Inc. 3CTI Receives the Second Payment of $6.5 million Associated with the Sale of Interest in Zevalin Joint Venture 2CTI Receives the Second Payment of $6.5 million Associated with the Sale of Interest in Zevalin Joint Venture 3
... isolated fromStreptomyces griseolusthat inhibits protein synthesis. ... in eukaryote ribosomes. Reported to induce ... including promyelocytic leukemia cells, Jurkat cells, ... Initiates intracellular signals and immediate early ...
... RC DC protein assay kit I provides reagents ... in the presence of reducing agents and detergents. ... assay. The kit includes reagents and standards sufficient ... I, 250 ml RC reagent II, 250 ml ...
Recommended for use as a cell culture substratum at 0.1-0.2 mg/cm 2 or 5-10 μl/cm 2 . Optimal concentration depends on cell type as well as the application or research objectives. Type B...
... state-of-the-art separation system using the asymmetric flow ... integrates easily with Wyatts multi-angle light scattering ... as the Optilab DSP. The combined system ... of the particles/molecules separated by the AFFF ...
Biology Products: