Navigation Links
Herpes infections: Natural killer cells activate hematopoiesis
Date:5/16/2013

Infections can trigger hematopoiesis at sites outside the bone marrow in the liver, the spleen or the skin.Researchers of Ludwig-Maximilians-Universitaet (LMU) in Munich now show that a specific type of immune cell facilitates such "extra medullary" formation of blood cells.

Balanced hematopoiesis is essential for the function of the immune system. During fetal development, hematopoiesis takes place mainly in the liver and the spleen. Later the process is delegated to the bone marrow, and this tissue normally serves as the sole source of blood cells for the rest of one's lifetime. However, certain infections can reactivate hematopoiesis at sites other than the bone marrow, a process which is referred to as "extramedullary" hematopoiesis. One of the best known inducers is the so-called cytomegalovirus (CMV), a member of the herpesvirus family, which is widespread in human populations worldwide, and can lead to serious illness in individuals with immature or otherwise compromised immune systems.

An international team led by Professor Ulrich Koszinowski at LMU's Max von Pettenkofer-Institute has now examined how this virus activates hematopoiesis in tissues other than the bone marrow. "Herpesviruses are highly species-specific," explains Dr. Stefan Jordan, the lead author on the new paper. "So, in order to study the phenomenon of extramedullary hematopoiesis in an animal model, we were forced to turn to the mouse virus." The murine CMV induces extramedullary hematopoiesis principally in the spleen.

Killing of infected cells paves the way

The new findings reveal a hitherto unsuspected link between natural killer (NK) cells and hematopoiesis. NK cells play an important role in combating CMV infections, because they are the immune system's first line of defense against the virus. In the first place, they are able to recognize and eliminate CMV-infected cells and, secondly, they synthesize and secrete signal molecules that mobili
'/>"/>

Contact: Luise Dirscherl
dirscherl@lmu.de
49-892-180-2706
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Page: 1 2

Related biology news :

1. How and why herpes viruses reactivate to cause disease
2. Princeton researchers identify unexpected bottleneck in the spread of herpes simplex virus
3. Novel treatment approach for bladder pain using a herpes simplex virus vector reported
4. Einstein study reveals new approach for stopping herpes infections
5. How herpesvirus invades nervous system
6. Biology professor secures grant to save West Virginias primary natural history collection
7. Validity CTO to Present Natural ID Solutions for Improving Mobile Risk Management and User Experience at NFC Solutions Summit 2012
8. Honoring the fundamental role of microbes in the natural history of our planet
9. Resveratrol may be a natural exercise performance enhancer: U of A medical research
10. Naturally adhesive
11. No matter the drilling method, natural gas is a much-needed tool to battle global warming
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/29/2014)... world,s needs to make cheaper and more effective ... efficient catalytic materials and processes must be developed. ... State University, is tackling this problem with the ... Science Foundation. , The nearly $1.5 million project, ... Cascade Reactions," was to Eranda Nikolla, Ph.D., assistant ...
(Date:9/29/2014)... a five-year, $6 million grant for clinical research ... development of safe and effective treatments for cocaine ... National Institutes of Health, National Institute on Drug ... Development for Cocaine Use Disorder to oversee preclinical ... on moving forward with more expensive large-scale clinical ...
(Date:9/29/2014)... published online in Behavioral Brain Research provides ... as a result of chronic alcohol exposure that can ... Clinical assessments and research indicate that individuals with alcohol ... can occur when people are actively drinking, when they ... , "Sleep-wake disturbances can last for months, or ...
Breaking Biology News(10 mins):Wayne State research aims to develop new, more efficient catalytic materials 2New VCU center to target cocaine addiction 2
... Feb. 5, 2010 In a landmark study in children ... University of Cambridge showed that using a first-generation artificial pancreas ... emergencies while sleeping, and at the same time improve diabetes ... in the February 5, 2010 issue of The Lancet ...
... an elaborate sleuthing system they developed to probe how ... discovered that common but hard-to-see sugar switches are partly ... are so abundant and potential targets of manipulation by ... new treatments for a number of diseases, including cancer, ...
... REDWOOD CITY, Calif. , Jan. 26 The ... leader in fingerprint identity and authentication solutions, to help address the ... in Central Florida , The City of Winter Park ... The City chose DigitalPersona ® Pro and DigitalPersona® Privacy Manager ...
Cached Biology News:Early artificial pancreas trials show benefits for kids, teenagers with diabetes overnight 2Early artificial pancreas trials show benefits for kids, teenagers with diabetes overnight 3Early artificial pancreas trials show benefits for kids, teenagers with diabetes overnight 4Sweet! -- sugar plays key role in cell division 2City of Winter Park Looks to DigitalPersona Software for Stronger Security and CJIS Compliance 2City of Winter Park Looks to DigitalPersona Software for Stronger Security and CJIS Compliance 3City of Winter Park Looks to DigitalPersona Software for Stronger Security and CJIS Compliance 4
(Date:9/30/2014)... Boston, MA (PRWEB) September 30, 2014 ... communications (UC) and collaboration company is dedicated to ... data connectivity needs. Julie Power, a ... team to ensure collaboration solutions stays connected and ... response to the increased movement of businesses to ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 Whitehouse ... been chosen by the Parenteral Drug Association (PDA) ... and 19, 2014) on container closure integrity testing. This ... integrity test methods and philosophies detailed in the recently ... Evaluation. The course will span container closure ...
(Date:9/29/2014)... imaging is at the forefront of diagnostics today, ... CT (computerized tomography), scanning, and NMR (nuclear magnetic ... However, persisting problems of image resolution and quality ... of living tissue. A solution is hyperpolarization, which ... increase imaging quality by following the distribution and ...
(Date:9/29/2014)... Biotech Inc. ("Portage" or "the Company") (OTC: PTGEF, Canadian ... three Promissory Note holders, two of whom are the ... July 2014 for a total of $ 300,000 opted ... 3,500,001 restricted common shares. Notes were repayable within one ... the coupon were convertible into common shares to be ...
Breaking Biology Technology:SoundConnect Expands Carrier Services Division 2Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 2Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 3Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 4A safer approach for diagnostic medical imaging 2A safer approach for diagnostic medical imaging 3Portage announces conversion of its debt into equity 2Portage announces conversion of its debt into equity 3
... N.J., Nov. 10 Regado Biosciences, a privately held company leading ... Ellen McDonald, MBA, Senior Vice President and Chief Business Officer, will ... in Philadelphia, Pennsylvania. Ms. McDonald,s presentation ... Monday, November 16 and will ...
... ... announces winners of its annual Student Award Program , ... Boston, Mass. (Vocus) -- The Adventus ... again joined the University of Massachusetts Amherst to recognize emerging environmental scientists during the ...
... PLYMOUTH MEETING, Pa., Nov. 9 /PRNewswire-Asia-FirstCall/ -- BMP Sunstone,Corporation (Nasdaq: ... for the third quarter ended September 30, 2009. , , ... -- Revenue increased to $33.6 million from $30.5 million in the ... across all divisions, particularly in, ...
Cached Biology Technology:Regado Biosciences to Present at the Ninth Annual Joint Symposium of BioNJ and Pennsylvania Bio on November 16, 2009 2University of Massachusetts Amherst and ADVENTUS Recognize Future Environmental Science Leaders 2University of Massachusetts Amherst and ADVENTUS Recognize Future Environmental Science Leaders 3University of Massachusetts Amherst and ADVENTUS Recognize Future Environmental Science Leaders 4BMP Sunstone Reports Third Quarter 2009 Financial Results 2BMP Sunstone Reports Third Quarter 2009 Financial Results 3BMP Sunstone Reports Third Quarter 2009 Financial Results 4BMP Sunstone Reports Third Quarter 2009 Financial Results 5BMP Sunstone Reports Third Quarter 2009 Financial Results 6BMP Sunstone Reports Third Quarter 2009 Financial Results 7BMP Sunstone Reports Third Quarter 2009 Financial Results 8BMP Sunstone Reports Third Quarter 2009 Financial Results 9BMP Sunstone Reports Third Quarter 2009 Financial Results 10BMP Sunstone Reports Third Quarter 2009 Financial Results 11BMP Sunstone Reports Third Quarter 2009 Financial Results 12
... is a highly sensitive reagent for the ... a purified form of recombinant E. coli ... which is sensitive to changes in its ... Phosphate Sensor is rapid and tight (Kd ...
... This modular benchtop fume ... fumes, allowing safe indoor release ... remove most organic contaminants. Configurations ... horizontal flow; options include final ...
Sigmas E-TOXATE (Limulus Amebocyte Lysate) test kits are intended for the detection and semiquantitation,of endotoxins for research purposes....
... These versatile enclosures are ... nitrogen or other process ... low-humidity environment. HEPA filtration, ... ionization modules also available, ...
Biology Products: