Navigation Links
Hepatitis C virus faces new weapon from Florida State scientists
Date:9/29/2010

In recent human trials for a promising new class of drug designed to target the hepatitis C virus (HCV) without shutting down the immune system, some of the HCV strains being treated exhibited signs of drug resistance.

In response, an interdisciplinary team of Florida State University biologists, chemists and biomedical researchers devised a novel genetic screening method that can identify the drug-resistant HCV strains and the molecular-level mechanisms that make them that way helping drug developers to tailor specific therapies to circumvent them.

The potentially life-saving technology also works when screening other viruses with drug-resistance issues, notably human immunodeficiency virus (HIV) and influenza.

More than 170 million people worldwide are infected with HCV, which leads to both acute and chronic liver diseases.

"In collaboration with pharmaceutical firm Gilead Sciences and researchers from the University of Heidelberg (Germany), what our research team discovered was how the latest drug for HCV works and what changes in the virus that makes it resistant to this unique therapy," said Hengli Tang, a Florida State University molecular biologist.

"This is knowledge that is essential to drug developers focused on HCV," said Tang, "but equally important is that our method, which we call 'CoFIM' (Cofactor-independent mutant) screening, can also be applied to other drug targets and other viruses.

"And, since we now understand how this latest class of drug works and what causes resistance to it, we can better select other classes of drugs with distinct mechanisms in other words, those that target other parts of the virus in order to craft a combination therapy, which is the future of HCV therapy and the key to overcoming drug resistance."

The groundbreaking research is described in a paper published online in the September 2010 issue of the journal PLoS Pathogens.


'/>"/>

Contact: Hengli Tang
tang@bio.fsu.edu
850-645-2402
Florida State University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Discovery of a hepatitis C-related virus in bats may reduce outbreaks in humans
2. Small genetic variant can predict response to hepatitis C treatment
3. New insights into treatment options for patients suffering from severe alcoholic hepatitis
4. Enzyme deficiency protects hepatitis C patients from treatment-related anemia
5. Natural compound blocks hepatitis C infection
6. Toward explaining why hepatitis B hits men harder than women
7. Largest-ever database for liver proteins may lead to treatments for hepatitis
8. The hepatitis healing power of blueberry leaves
9. First human gets new antibody aimed at hepatitis C virus
10. Novel antibody prevents infection by hepatitis C virus
11. Biolex presents Locteron US Phase 2a hepatitis C data at EASL
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Hepatitis C virus faces new weapon from Florida State scientists
(Date:3/23/2015)... SoundView Technology Group issues a new research update following the ... wallet. SoundView was one of the selected user groups to provide ... in multiple scenarios and outlets. Soundview shares ... both debit and credit card payments.  Soundview ... meets their plans in 2015, it would push our IV ...
(Date:3/20/2015)... Mar. 20, 2015 Research and Markets ... of the "India Sensors Market Forecast and ... The sensor market is projected to grow ... Consumer electronics, automotive, industrial and healthcare sectors ... the country. In addition, adoption of MEMS technology ...
(Date:3/19/2015)... 2015  NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... growing mobile commerce market, announces its biometric payment technology, the ... aired this week on Washington DC,s ... a segment "The Next Great Thing", host Laura Evans ... pay, and ,a really big breakthrough in mobile payment.,  ...
Breaking Biology News(10 mins):Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 2NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 3
... and fungi, such as white rot, are particularly harmful ... Soil samples are investigated to detect this; a labour-intensive ... (University of Wageningen) the company Blgg has developed a ... rot in soil samples. , Agricultural laboratory Blgg ...
... active antiretroviral therapy (HAART) for HIV infection remain susceptible ... HIV-infected patients not on HAART, according to an article ... now available online. , Opportunistic infections such as ... not only reduces the viral load of HIV, but ...
... body's defense against a wide variety of infectious agents and ... result of a new study by researchers at Washington University ... found a way to grease the gears that drive the ... Herman Seldin Professor of Medicine and director of the Division ...
Cached Biology News:DNA technique measures suitability of soil for onion crops 2Tuberculosis still a risk for patients receiving HIV drugs 2Greasing interferon's gears may pave way to greater therapeutic benefits, fewer side effects 2
(Date:4/1/2015)... , April 1, 2015 Synthetic ... pathogen-specific therapies for serious infections and diseases, with ... that clinical data supporting the development of SYN-004, ... beta-lactam intravenous (IV) antibiotics within the gastrointestinal (GI) ... gut microbiome for the prevention of C. ...
(Date:4/1/2015)... and NEW YORK CITY ... -- As a leading provider of market research reports and ... Worldwide, LLC, indicating that 2015 will be a year of ... For executives operating a stem cell company or cord ... difficult task. You must analyze market conditions, predict industry trends, ...
(Date:4/1/2015)... National recruitment firm Slone Partners is pleased ... of Sales at Optimal Medicine, an international digital health ... brings over 20 years experience in healthcare information technology ... including Dell Services Healthcare, Medsphere Systems and McKesson. ... for accomplishing the goals Optimal Medicine had for this ...
(Date:3/31/2015)... RATON, Fla. , March 31, 2015  Biotest ... products, is pleased to announce the addition of its ... Drive, Suite 205 Conway, Arkansas . ... its doors for business on March 26 th ... collection centers to eighteen. "This facility ...
Breaking Biology Technology:Synthetic Biologics' SYN-004 Clinical Data for Protection of Microbiome Selected for Poster Presentation at American Society of Microbiology 2015 2Synthetic Biologics' SYN-004 Clinical Data for Protection of Microbiome Selected for Poster Presentation at American Society of Microbiology 2015 3Synthetic Biologics' SYN-004 Clinical Data for Protection of Microbiome Selected for Poster Presentation at American Society of Microbiology 2015 4MarketResearch.com: "Blockbuster" Year for Stem Cells Creates Market Opportunities, Says BioInformant Worldwide Report 2MarketResearch.com: "Blockbuster" Year for Stem Cells Creates Market Opportunities, Says BioInformant Worldwide Report 3MarketResearch.com: "Blockbuster" Year for Stem Cells Creates Market Opportunities, Says BioInformant Worldwide Report 4Slone Partners Fills Head of Sales at Optimal Medicine 2Biotest Pharmaceuticals Corporation Announces the Opening of its Newest Plasma Collection Facility in Conway, Arkansas 2
... 31 March 2010 A quantum computer could provide an ... as yet they only exist in the laboratory in the ... bits. They can now be explored in more detail, at ... the largest quantum computer system in the world with 42 ...
... ... program. , ... SAN DIEGO, CA (Vocus) March 30, 2010 -- The Adventus Group, an ... Foundation (AEHS Foundation) to recognize talented, emerging environmental scientists during the “20th Annual ...
... learning how our immune system senses and tracks down infection ... bacteria. Studying how immune cells manipulate their movement in response ... our immune system functions but also how cancer cells spread ... Speaking at the Society for General Microbiology,s spring meeting ...
Cached Biology Technology:World record: Julich supercomputer simulates quantum computer 2Association for Environmental Health & Sciences Foundation and Adventus Group Recognize Future Environmental Science Leaders 2Association for Environmental Health & Sciences Foundation and Adventus Group Recognize Future Environmental Science Leaders 3Association for Environmental Health & Sciences Foundation and Adventus Group Recognize Future Environmental Science Leaders 4How immune cells 'sniff out' bacteria 2
... The DNAclear cDNA Purification Kit is designed ... reactions such as cDNA synthesis and PCR. The ... from 1 ng to 3 g can be ... of three steps: 1) DNA is bound to ...
GOAT ANTI PPP2R5B...
acridine orange 10-nonyl bromide (nonyl acridine orange)...
Because it is manufactured at our ISO 9001–certified facilities in Eugene, Oregon, we can guarantee that FluoroPure grade propidium iodide is greater than or equal to 98% pure by HPLC....
Biology Products: