Navigation Links
Hepatitis C virus faces new weapon from Florida State scientists
Date:9/29/2010

In recent human trials for a promising new class of drug designed to target the hepatitis C virus (HCV) without shutting down the immune system, some of the HCV strains being treated exhibited signs of drug resistance.

In response, an interdisciplinary team of Florida State University biologists, chemists and biomedical researchers devised a novel genetic screening method that can identify the drug-resistant HCV strains and the molecular-level mechanisms that make them that way helping drug developers to tailor specific therapies to circumvent them.

The potentially life-saving technology also works when screening other viruses with drug-resistance issues, notably human immunodeficiency virus (HIV) and influenza.

More than 170 million people worldwide are infected with HCV, which leads to both acute and chronic liver diseases.

"In collaboration with pharmaceutical firm Gilead Sciences and researchers from the University of Heidelberg (Germany), what our research team discovered was how the latest drug for HCV works and what changes in the virus that makes it resistant to this unique therapy," said Hengli Tang, a Florida State University molecular biologist.

"This is knowledge that is essential to drug developers focused on HCV," said Tang, "but equally important is that our method, which we call 'CoFIM' (Cofactor-independent mutant) screening, can also be applied to other drug targets and other viruses.

"And, since we now understand how this latest class of drug works and what causes resistance to it, we can better select other classes of drugs with distinct mechanisms in other words, those that target other parts of the virus in order to craft a combination therapy, which is the future of HCV therapy and the key to overcoming drug resistance."

The groundbreaking research is described in a paper published online in the September 2010 issue of the journal PLoS Pathogens.


'/>"/>

Contact: Hengli Tang
tang@bio.fsu.edu
850-645-2402
Florida State University
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Discovery of a hepatitis C-related virus in bats may reduce outbreaks in humans
2. Small genetic variant can predict response to hepatitis C treatment
3. New insights into treatment options for patients suffering from severe alcoholic hepatitis
4. Enzyme deficiency protects hepatitis C patients from treatment-related anemia
5. Natural compound blocks hepatitis C infection
6. Toward explaining why hepatitis B hits men harder than women
7. Largest-ever database for liver proteins may lead to treatments for hepatitis
8. The hepatitis healing power of blueberry leaves
9. First human gets new antibody aimed at hepatitis C virus
10. Novel antibody prevents infection by hepatitis C virus
11. Biolex presents Locteron US Phase 2a hepatitis C data at EASL
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Hepatitis C virus faces new weapon from Florida State scientists
(Date:10/15/2014)... As our ability to assess the pandemic risk from ... developments, we must not allow ourselves to become complacent ... an international consortium of scientists. , Influenza pandemics arise ... have yet to develop widespread immunity – spreads in ... in the past 100 years, the worst of which ...
(Date:10/15/2014)... Inc. (NASDAQ: NXTD and NXTDW) ("NXT-ID" or the ... market releases photos and video of the recent opening bell at ... . Gino Pereira , CEO of NXT-ID ... Chad A. Verdi rang the bell.  ... employees "for their work and dedication in bringing the world,s next ...
(Date:10/14/2014)... years since T. rex took its last ... is breathing life back into dinosaurs using high-powered computer ... has important implications for how dinosaurs used their noses ... of smell and cool their brains. , "Dinosaurs ... Jason Bourke, lead author of the new study published ...
Breaking Biology News(10 mins):Scientists 'must not become complacent' when assessing pandemic threat from flu viruses 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 3Dinosaur breathing study shows that noses enhanced smelling and cooled brain 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 3
... Biometric Time Clock Security and ... ATLANTA, Nov. 27 M2SYS Technology, ... that Software,Techniques Inc. has enhanced their TimeKRON ... Bio-SnapON(TM) solution., Bio-SnapON(TM) allows companies to ...
... for High-Performance Notebook Computers ... and Consumer Electronic Applications, SUNNYVALE, ... a leading supplier of innovative computer products including,hard disk ... of its MHZ2 BH series mobile hard disk drive ...
... has both UCLA and a team of enterprising UCLA scientists ... In 1996, a unique collaboration of leading ... company Agensys Inc. and the company now stands to ... making it one of the largest Los Angeles-based private biotech ...
Cached Biology News:Software Techniques Inc. Selects M2SYS Fingerprint Software to Meet Continuous Growth and Demand for Desktop Biometric Time & Attendance Solutions 2Fujitsu Announces Industry Highest Capacity 2.5 Inch SATA Hard Disk Drive at 320GB(1) 2Fujitsu Announces Industry Highest Capacity 2.5 Inch SATA Hard Disk Drive at 320GB(1) 3Biotech Co. founded by UCLA Scientists to be acquired by Astellas, Pharma Inc. 2Biotech Co. founded by UCLA Scientists to be acquired by Astellas, Pharma Inc. 3
(Date:10/22/2014)... , Oct. 22, 2014 /PRNewswire/ - iCo Therapeutics ... today announced next steps for its Oral Amphotericin ... from its in vitro work involving ... iCo now plans to complete pre clinical studies ... initial Phase 1A clinical trial, utilizing approximately $700,000 ...
(Date:10/22/2014)... Research and Markets  has announced the ... by Application, Geography - Global Analysis and Forecast (2014 ... Organic electronics, also called as polymer electronics or ... deals with small conductive molecules and electrically conductive polymers. ... polymers are carbon based, made using synthetic strategies developed ...
(Date:10/20/2014)... 20, 2014 The report “Pharmacy ... Systems, Packaging and Labeling Systems, Table-top Counters) by ... Global Forecasts & Trends to 2019” analyzes and ... in North America, Europe, Asia-Pacific, and the Rest ... tables and 30 figures spread through 300 pages ...
(Date:10/20/2014)... 2014 Convey Computer , the ... from Iowa State University won first place in the ... Convey HC-2ex, the team’s solution achieved the highest overall ... the second place finisher. , Experts from all segments ... month long challenge, using a variety of design tools, ...
Breaking Biology Technology:iCo Therapeutics Announces Advancement of Oral Amphotericin B Program 2iCo Therapeutics Announces Advancement of Oral Amphotericin B Program 3Global Organic Electronics (Semiconductor, Conductive, Dielectric and Substrate) Market - Analysis and Forecast (2014 - 2020) 2Global Organic Electronics (Semiconductor, Conductive, Dielectric and Substrate) Market - Analysis and Forecast (2014 - 2020) 3Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 2Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 3Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 4Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 2Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 3
... ChemAxon, a software,solutions provider for cheminformatics, today announced ... for working with chemical and,other data on local ... and form building, relational data support, advanced query ... the vast,majority of functionality and is free for ...
... CITY, Calif., Aug. 21 Codexis, Inc., a private,biotechnology ... the new position of Vice President and Managing Director ... first,facility in Asia. Dr. Daussmann will report to Alan ... to name Dr. Daussmann to this important new,position on ...
... to Increase Efficiency, MINNEAPOLIS, Aug. 21 ... a leading provider of enterprise-wide advanced,visualization and ... its,next generation enterprise-wide advanced visualization and analysis ... and ViTALConnect(R) 4.1. This,comprehensive package offers powerful ...
Cached Biology Technology:Instant JChem 2.0 Released: Instant JChem Personal Free for All Users 2Codexis Appoints Singapore Laboratories Managing Director 2Vital Images Releases Next Generation Enterprise-Wide Solutions Featuring Vitrea(R) 4.0 and ViTALConnect(R) 4.1 2Vital Images Releases Next Generation Enterprise-Wide Solutions Featuring Vitrea(R) 4.0 and ViTALConnect(R) 4.1 3Vital Images Releases Next Generation Enterprise-Wide Solutions Featuring Vitrea(R) 4.0 and ViTALConnect(R) 4.1 4
The 12-Tube Magnetic Separation Rack is designed to be used for small-scale separations using magnetic particles. ,Capacity: 12 microcentrifuge tubes. ,Magnets: Neodymium rare earth permanent ma...
DONOR BOVINE SERUM AND PLASMA...
12(S)-HETE-d8 is used as an internal standard for the quantification of 12(S)-HETE by stable isotope dilution mass spectrometry....
...
Biology Products: