Navigation Links
Harvard scientists find cell fate switch that decides liver, or pancreas?
Date:2/13/2014

experiments showed that prostaglandin E2 could also enhance liver growth and regeneration of liver cells.

Goessling and his research partner North, a Harvard Medical School Assistant Professor of Pathology at Beth Israel Deaconess Hospital, first became intrigued by prostaglandin E2 in 2005, as postdoctoral fellows in the lab of HSCI Executive Committee Chair Leonard Zon, MD. It caught their attention during a chemical screen exposing 2,500 known drugs to zebrafish embryos to find any that could amplify blood stem cell populations. Prostaglandin E2 was the most successful hit the first molecule discovered in any system to have such an effectand recently successfully completed Phase 1b clinical trials as a therapeutic to improve cord blood transplants.

"Prostaglandin might be a master regulator of cell growth in different organs," Goessling said. "It's used in cord blood, as we have shown, it works in the liver, and who knows what other organs might be affected by it."

With evidence of how prostaglandin E2 works in the liver, the researchers next want to calibrate how it can be used in the laboratory to instruct induced pluripotent stem cellsmature cells that have been reprogrammed into a stem-like stateto become liver or pancreas cells. The scientists predict that such a protocol could benefit patients who need liver cells for transplantation or who have had organ injury.


'/>"/>

Contact: Joseph Caputo
joseph_caputo@harvard.edu
617-496-1491
Harvard University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Harvard scientists control cells following transplantation, from the inside out
2. Harvard study shows sprawl threatens water quality, climate protection, and land conservation gains
3. Wyss Institute at Harvard University announces election of 2 faculty to Natl Academy of Inventors
4. "GenoVive is changing the face of personalized health by continuing research efforts with Harvard."
5. Harvard Stem Cell researchers create cells that line blood vessels
6. Harvard and USC scientists show how DHA resolves inflammation
7. Harvards Wyss Institute and Sony DADC announce collaboration on Organs-on-Chips
8. Renewed Harvard-BASF initiative to advance functional materials
9. Got to go? Harvard scientists figure out how you know
10. Harvards Wyss Institute to develop smart suit that improves soldiers physical endurance
11. U-M scientists & colleagues investigate the fiber of our being
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/14/2014)... A new study published in Cancer Research ... liver and colon cancers—can promote the development of skin ... proliferation and survival of sun-damaged skin cells. , Previously ... seven proteins called sirtuins that help regulate genomic stability ... aging. SIRT6 helps repair DNA damage, which can lead ...
(Date:10/14/2014)... planet,s leading questions is how to produce enough food ... The Food and Agriculture Organization of the United Nations ... next 40 years to feed a growing global population, ... rise in food production. Plants—grains, cereals, fruits, vegetables, ... Current research must tap into our knowledge of ...
(Date:10/14/2014)... 14, 2014 – Scientists from The Scripps Research Institute ... Institutes of Health (NIH) to lead an investigation of ... disease in Africa. The study aims to understand how ... die, while others survive the inflection. , "The ... mechanism of how Lassa fever virus causes disease and ...
Breaking Biology News(10 mins):Two-faced gene: SIRT6 prevents some cancers but promotes sun-induced skin cancer 2Building a bridge from basic botany to applied agriculture 2Building a bridge from basic botany to applied agriculture 3Scripps Research Institute team receives $6.6 million to investigate deadly Lassa virus 2
... October 23, 2008 -- Are green schools acoustically sound? How ... manatees from getting hit by ships? What secrets will comparing ... hidden cars in forests and buried mines underwater? What is ... brain deal with sound? These are a few of ...
... explains the impact,of negative campaigning tactics and the ... conscientiousness are best predictors of,candidate preference and other ... SP Labs - the,research arm of Signal Patterns, ... connect people in meaningful ways -,today released its ...
... on low calorie diets. But now researchers at Washington University ... can extend the life spans of roundworms even when the ... that blocks their sense of smell. Three years ago, ... found that a class of anticonvulsant medications made the roundworm ...
Cached Biology News:156th Acoustical Society of America Meeting, Nov. 10-14, 2008 in Miami 2156th Acoustical Society of America Meeting, Nov. 10-14, 2008 in Miami 3156th Acoustical Society of America Meeting, Nov. 10-14, 2008 in Miami 4156th Acoustical Society of America Meeting, Nov. 10-14, 2008 in Miami 5156th Acoustical Society of America Meeting, Nov. 10-14, 2008 in Miami 6156th Acoustical Society of America Meeting, Nov. 10-14, 2008 in Miami 7New Study Reveals the Emotional Impact and Effectiveness of Negative Campaigning 2New Study Reveals the Emotional Impact and Effectiveness of Negative Campaigning 3New Study Reveals the Emotional Impact and Effectiveness of Negative Campaigning 4Deprived of a sense of smell, worms live longer 2
(Date:10/22/2014)... Cranford, NJ (PRWEB) October 22, 2014 ... technologies and services – has been working with a ... Health and New Haven Farms Community Farming Collaborative to ... iPad-based ePRO solution. The study, which started in ... Wellness program that provides participants weekly exposure to and ...
(Date:10/22/2014)... Oct. 22, 2014   Synthetic Biologics, Inc. ... therapies for serious infections and diseases, announced today that ... Notice of Allowance for a composition of matter patent ... difficile program, SYN-004. This is Synthetic Biologics, first ... U.S. and adds to the Company,s extensive C. ...
(Date:10/20/2014)... 20, 2014 The report “Pharmacy ... Systems, Packaging and Labeling Systems, Table-top Counters) by ... Global Forecasts & Trends to 2019” analyzes and ... in North America, Europe, Asia-Pacific, and the Rest ... tables and 30 figures spread through 300 pages ...
(Date:10/20/2014)... , October 20, 2014 ... gastrointestinal (GI) disorders and the delivery of care has ... diseases and worrying inequalities in the provision of healthcare ... which was commissioned by United European Gastroenterology (UEG), have ... political and public awareness of the burden of GI ...
Breaking Biology Technology:myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 2myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 3Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 2Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 3Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 4Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 2Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 3Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 4Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 2Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 3Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 4Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 5
... Received a New Patent for a Non-statistical Approach... -- ST. PAUL, Minnesota and PARIS, October 6, 2010 ... ... if (typeof(lpUnit)==,undefined,) var lpUnit=,PRN,; --> ... = function(data) { var s = ,; var first_result; // Results are keyed by longUrl, so we ...
... anklets are treasures but these gemstones inside the body ... researchers are building implants made of diamond and flexible ... changes in the brain of patients suffering from neural ... the paralyzed. The work of Heidi Martin, a ...
... sensors, are widely used as a navigational tool in ... of a vehicle on three axes to evaluate its ... Aviv University,s School of Physical Engineering is now scaling ... medical equipment and more futuristic technologies. Working in ...
Cached Biology Technology:INTERCIM Received a New Patent for a Non-statistical Approach for "Design of Experiments" and the Iterative Discovery of an Explanatory Model 2INTERCIM Received a New Patent for a Non-statistical Approach for "Design of Experiments" and the Iterative Discovery of an Explanatory Model 3INTERCIM Received a New Patent for a Non-statistical Approach for "Design of Experiments" and the Iterative Discovery of an Explanatory Model 4INTERCIM Received a New Patent for a Non-statistical Approach for "Design of Experiments" and the Iterative Discovery of an Explanatory Model 5INTERCIM Received a New Patent for a Non-statistical Approach for "Design of Experiments" and the Iterative Discovery of an Explanatory Model 6INTERCIM Received a New Patent for a Non-statistical Approach for "Design of Experiments" and the Iterative Discovery of an Explanatory Model 7Gem of an idea: A flexible diamond-studded electrode implanted for life 2Gem of an idea: A flexible diamond-studded electrode implanted for life 3A tracking device that fits on the head of a pin 2
... The Agilent One-Color RNA Spike-In Kit ... specifically anneal only to complementary control probes ... cross-hybridization. The spike-ins serve as a positive ... NOTE: This kit is a ...
... spatulas have been designed to save time ... those interested in eliminating the recycling and ... is individually packaged, RNase/DNase free, non-pyrogenic and ... new product number, created to easily match ...
... use spatulas have been designed to save ... for those interested in eliminating the recycling ... spatula is individually packaged, RNase/DNase free, non-pyrogenic ... a new product number, created to easily ...
... CHEMICONs Alkaline Phosphatase Detection Kit (Catalog ... tool for the phenotypic assessment of ES ... activity. Available separately from CHEMICON are ... and TRA-2-54 (Catalog Number MAB4354), which permit ...
Biology Products: