Navigation Links
Harvard Stem Cell researchers create cells that line blood vessels
Date:8/22/2013

In a scientific first, Harvard Stem Cell Institute scientists have successfully grown the cells that line the blood vesselscalled vascular endothelial cellsfrom human induced pluripotent stem cells (iPSCs), revealing new details about how these cells function. Using a unique approach, the researchers induced the differentiation of specific cell types by generating mechanical forces on the surface of the iPSC-derived endothelium mimicking the flow of blood. For example, cells that felt a stronger "flow" became artery cells, while those that felt a weaker "flow" became vein cells.

"It was especially exciting to us to discover that these cells are basically responding to biomechanical cues," research leader Guillermo Garca-Cardena, PhD, an HSCI Affiliated Faculty member, said. "By exposing cells to 'atheroprone flow,' we can direct differentiation of these cells into cells that are present in areas of the circulatory system that we know are affected by diseases like atherosclerosis." Garca-Cardena is now working on modeling the formation of arterial plaques using human iPSC-derived vascular endothelial cells and identifying potential drugs that might prevent plaque formation.

Garca-Cardena's team, which included Harvard School of Engineering and Applied Sciences graduate student William Adams, found that the iPS-derived human endothelial cells display three critical functions carried out by mature endothelium in the body: mounting inflammatory responses, keeping blood from leaking out of the blood vessel, and preventing blood clots.

Based on this information, Garca-Cardena's work, published this month in the journal Stem Cell Reports, has another exciting implicationit could potentially reduce, or even eliminate the need for heparin use during kidney dialysis and lung failure treatmentmaking both markedly safer.

Traditionally, patients undergoing dialysis are treated with heparin, a powerful drug, which prevents the blo
'/>"/>

Contact: B. D. Colen
bd_colen@harvard.edu
617-413-1224
Harvard University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Harvard and USC scientists show how DHA resolves inflammation
2. Harvards Wyss Institute and Sony DADC announce collaboration on Organs-on-Chips
3. Renewed Harvard-BASF initiative to advance functional materials
4. Got to go? Harvard scientists figure out how you know
5. Harvards Wyss Institute to develop smart suit that improves soldiers physical endurance
6. Researchers figure out why gold nanoparticles can penetrate cell walls
7. Finnish researchers develop quick test kit for detecting phenolic compounds in drinking water
8. BIDMC cardiovascular institute researchers will lead $4 million NIH grant to study micrornas
9. UC Davis researchers discover molecular target for the bacterial infection brucellosis
10. Researchers report a critical role for the complement system in early macular degeneration
11. Researchers study seleniums effects on horses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... State University researcher found that bacteria in the Gulf ... the oil released during the Deepwater Horizon spill in ... toxic contaminants. , In two new studies conducted in ... a species of bacteria called Colwellia likely ... xylene compounds that were released as part of the ...
(Date:7/31/2014)... 2014 NXT-ID, Inc., (NXTD: OTCQB) a biometric authentication ... investors and consumers wanting to learn more about ... be on-air today, July 31 st . ... be featured in a segment of NewsWatch, a ... on the History Channel, FYI Network today. ...
(Date:7/30/2014)... the way for a breakthrough that may prevent ... to poisonous chemicalsparticularly those in pesticides and chemical ... issue of the journal ChemBioChem outlines ... commonly used in pesticides and warfare agents. The ... Engineering Associate Professor of Chemical and Biological Engineering ...
Breaking Biology News(10 mins):NXT-ID's Next Generation Biometric Smart Wallet Featured on NewsWatch Consumer Show on the History Channel and FYI Network Today, July 31st 2NXT-ID's Next Generation Biometric Smart Wallet Featured on NewsWatch Consumer Show on the History Channel and FYI Network Today, July 31st 3Engineering a protein to prevent brain damage from toxic agents 2
... ARBORWorking beneath the towering oaks and maples on the ... their faculty adviser helped explain an observation that had ... caterpillars. The caterpillars, which defoliate and sometimes kill ... Northeast, are especially fond of oaks, but sugar maple ...
... Escocia, 30 de enero de 2013 Life ... anunció que proveerá una solución de laboratorio íntegra para ... comunes en Libia a raíz de la insurrección de ... durante el régimen de 42 años de Muammar Gaddafi. Se ...
... U.S. Antarctic Program (USAP) and Antarctica New Zealand have jointly ... Antarctic aircraft crash after examination of the plane indicated that ... the wreckage that is largely embedded in snow and ice ... able to recover some equipment from the exposed tail of ...
Cached Biology News:Campus as laboratory: U-M student biologists use Diag trees to help solve gypsy moth mystery 2Campus as laboratory: U-M student biologists use Diag trees to help solve gypsy moth mystery 3Life Technologies ayudará a identificar 20.000 restos humanos encontrados en fosas comunes en Libia 2Life Technologies ayudará a identificar 20.000 restos humanos encontrados en fosas comunes en Libia 3Life Technologies ayudará a identificar 20.000 restos humanos encontrados en fosas comunes en Libia 4US, New Zealand search-and-rescue teams recalled from Antarctic plane crash site 2
(Date:7/31/2014)... Calif. , July 31, 2014 Rogne ... San Francisco Bay Area , has acquired a ... of Oxford,s commercialisation company. The potent anti-inflammatory activity of ... at the University of Oxford,s Sir William ... company, which has raised over $1.5 million in seed ...
(Date:7/31/2014)... July 31, 2014 Research and Markets ... Genomics Market 2014-2018" report to their offering. ... is the study of the genetic material or genomes ... strong basis for the discovery and development of diagnostic ... or health conditions. Genomics is supported by three major ...
(Date:7/31/2014)... China , July 31, 2014 ... Irys™System by BGI , the world,s ... comprehensive exploration of human structural variation (SV) and to ... including those where no reference exists. In addition, BioNano ... for multiplexing on the Irys System, enabling significantly higher ...
(Date:7/31/2014)... 31, 2014 Although RNA-Sequencing is ... first transcriptome-wide analyses appearing around 2008, RNA-Sequencing has ... RNA measurement. In the last several years, assays ... work with smaller input amounts, process degraded RNA, ... samples). On the bioinformatics side, there have been ...
Breaking Biology Technology:Oxford licenses anti-inflammatory peptides to San Francisco Bay Area start-up 2Oxford licenses anti-inflammatory peptides to San Francisco Bay Area start-up 3Global Genomics Market 2014-2018: Key Vendors are F. Hoffmann-La Roche, Life Technologies, Qiagen and Illumina 2BioNano Genomics Announces the Purchase of the Irys System by BGI 2BioNano Genomics Announces the Purchase of the Irys System by BGI 3BioNano Genomics Announces the Purchase of the Irys System by BGI 4The Evolution of RNA-Sequencing, Upcoming Live Webinar August 22 hosted by Xtalks 2
... Stephen Simes, chief executive,officer of BioSante Pharmaceuticals, ... be featured in an exclusive interview with, http://www.wallst.net ... EDT. The interview,will be posted on http://www.wallst.net ... The interview will cover topics including BioSante,s ...
... MONTEREY, Calif., Sept. 24 Today, the ... that utilize PARI,s,eFlow electronic nebulizer for aerosol ... acquisition of Corus Pharma in,August 2006, this ... a,licensed eFlow is featured prominently in the ...
... WEST BRIDGEWATER, Mass., Sept. 24 Pressure,BioSciences, Inc. ... update on,various corporate activities, including the expansion of ... stock on the Frankfurt Stock Exchange, and,reaffirmation of ... Barocycler instruments. 1) Domestic Sales Force: the ...
Cached Biology Technology:WallSt.net Announces Upcoming Interview with CEO of BioSante Pharmaceuticals 2Pediatric Asthma Programs Featuring PARI Pharma's eFlow Acquired by AstraZeneca 2Pressure BioSciences, Inc. Provides Corporate Update 2Pressure BioSciences, Inc. Provides Corporate Update 3
Anti-Digoxigenin-AP, Fab fragments; from sheep...
...
... Immunogen: Partially purified chicken ... detects vitamin D receptor (VDR) from ... and fish tissues. This antibody ... glucocorticoid receptors. MA1-710 detects both ...
... AccuPrime™ Pfx DNA Polymerase is ideal ... for downstream applications such as cloning ... provided by a proprietary enzyme preparation ... sp. with proofreading (3'Cut Site5' exonuclease) ...
Biology Products: