Navigation Links
Harvard Stem Cell researchers create cells that line blood vessels
Date:8/22/2013

In a scientific first, Harvard Stem Cell Institute scientists have successfully grown the cells that line the blood vesselscalled vascular endothelial cellsfrom human induced pluripotent stem cells (iPSCs), revealing new details about how these cells function. Using a unique approach, the researchers induced the differentiation of specific cell types by generating mechanical forces on the surface of the iPSC-derived endothelium mimicking the flow of blood. For example, cells that felt a stronger "flow" became artery cells, while those that felt a weaker "flow" became vein cells.

"It was especially exciting to us to discover that these cells are basically responding to biomechanical cues," research leader Guillermo Garca-Cardena, PhD, an HSCI Affiliated Faculty member, said. "By exposing cells to 'atheroprone flow,' we can direct differentiation of these cells into cells that are present in areas of the circulatory system that we know are affected by diseases like atherosclerosis." Garca-Cardena is now working on modeling the formation of arterial plaques using human iPSC-derived vascular endothelial cells and identifying potential drugs that might prevent plaque formation.

Garca-Cardena's team, which included Harvard School of Engineering and Applied Sciences graduate student William Adams, found that the iPS-derived human endothelial cells display three critical functions carried out by mature endothelium in the body: mounting inflammatory responses, keeping blood from leaking out of the blood vessel, and preventing blood clots.

Based on this information, Garca-Cardena's work, published this month in the journal Stem Cell Reports, has another exciting implicationit could potentially reduce, or even eliminate the need for heparin use during kidney dialysis and lung failure treatmentmaking both markedly safer.

Traditionally, patients undergoing dialysis are treated with heparin, a powerful drug, which prevents the blo
'/>"/>

Contact: B. D. Colen
bd_colen@harvard.edu
617-413-1224
Harvard University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Harvard and USC scientists show how DHA resolves inflammation
2. Harvards Wyss Institute and Sony DADC announce collaboration on Organs-on-Chips
3. Renewed Harvard-BASF initiative to advance functional materials
4. Got to go? Harvard scientists figure out how you know
5. Harvards Wyss Institute to develop smart suit that improves soldiers physical endurance
6. Researchers figure out why gold nanoparticles can penetrate cell walls
7. Finnish researchers develop quick test kit for detecting phenolic compounds in drinking water
8. BIDMC cardiovascular institute researchers will lead $4 million NIH grant to study micrornas
9. UC Davis researchers discover molecular target for the bacterial infection brucellosis
10. Researchers report a critical role for the complement system in early macular degeneration
11. Researchers study seleniums effects on horses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/5/2014)... Santamaria, associate professor of biology in the UTSA ... in the nation selected to receive a two-year ... for Exploratory Research (EAGER). The funding supports President ... researchers to create new technology that will demystify ... complex behaviors in neuroscience are broken into the ...
(Date:11/4/2014)... at the right time might actually help boost a ... help in understanding animal populations, pest control and managing ... the journal Trends in Ecology and Evolution , ... the kind of positive population effect an overall species ... on the size and developmental stage of the creatures ...
(Date:11/4/2014)...   3D scanner ... Fuel3D , a developer of 3D scanning solutions, ... $6.4 million (£4 million). This funding builds on the company,s ... and paves the way for the commercial launch of the ... round was led by Chimera Partners and will be used ...
Breaking Biology News(10 mins):UTSA biology professor awarded $300,000 NSF grant for brain research 2UTSA biology professor awarded $300,000 NSF grant for brain research 3When less is more: Death in moderation boosts population density in nature 2Fuel3D Secures $6.4 Million in Expansion Funding 2Fuel3D Secures $6.4 Million in Expansion Funding 3
... "mother of thousands" (Kalanchoe diagremontiana) makes the tiny plantlets that ... ability to make viable seeds, the plant has shifted some ... Neelima Sinha, professor of plant biology at UC Davis. ... that can grow into new plants. But mother of thousands ...
... Integrating silicon microchip technology with a network of tiny ... at The Johns Hopkins University have developed a thumb-size ... In a recent edition of the journal IEEE Transactions ... reported that they had successfully used the micro-incubator to ...
... to be penetrated by metastasizing cancer cells, so a ... block cancers spread, according to researchers at the ANZAC ... of breast cancer metastasis, the researchers found that a ... cancer to target bone. Dietary calcium, they reason, might ...
Cached Biology News:Thumb-size microsystem enables cell culture and incubation 2Thumb-size microsystem enables cell culture and incubation 3Dietary calcium could possibly prevent the spread of breast cancer to bone 2
(Date:11/22/2014)... Audubon, PA and London (PRWEB) November 21, 2014 ... in December will explore what comes next for ALS research ... clinical sites. , After the Ice Bucket Challenge: Where ... Merit Cudkowicz, Date: Tuesday, 2 December 2014, Time: ... complimentary , Join expert speaker Dr. Merit Cudkowicz, Julianne ...
(Date:11/22/2014)... During his lifetime Richard L. Sharp was ... himself with great people and take risks to achieve ... marveled at his extraordinarily courageous attitude when taking on ... even with his death impending—that’s how he continued looking ... ultimately take his life. , Carrying on Sharp’s relentless ...
(Date:11/22/2014)... MA (PRWEB) November 21, 2014 ... key investors will gather on December 3rd at ... Biotech Conferences series. GeneticRx will take place at ... Medical School and will discuss the present and ... therapy, exon skipping, and gene editing—as well as ...
(Date:11/22/2014)... CannLabs, Inc. (OTCQB: CANL), the leading ... methodologies relating to cannabis, today announced that it has ... from an existing stockholder of the Company. , ... from one of our existing stockholders,” stated Mark ... help accelerate our planned expansions into the Connecticut and ...
Breaking Biology Technology:DrugDev Webinars in December to Explore What Comes Next for ALS Research and How We Can Make Life Easier for Clinical Sites 2Sherry Sharp, Wife of CarMax Founder, Richard Sharp, Accepts Seat on Board of Cure Alzheimer’s Fund 2Sherry Sharp, Wife of CarMax Founder, Richard Sharp, Accepts Seat on Board of Cure Alzheimer’s Fund 3Pioneering Academics and Key Industry Leaders to Discuss Rare Diseases and the Emergence of New Genetic Medicines at Genetic Rx on December 3rd 2CannLabs Secures $750,000 Line Of Credit 2
... Obstructive ... Sleep Apnea, Advanced ... Employee Productivity; Minimize Litigation Risks, CARLSBAD, Calif., Sept. 5 ... manage was the number,of hours a driver spent behind the wheel. ...
... WEST BRIDGEWATER, Mass., Sept. 5 Pressure,BioSciences, Inc. ... has received,approval to CE Mark the Barocycler NEP2320, ... (PCT) instrument. The,Company also announced that it has ... indicating that the Barocycler NEP2320 has been found ...
... a Proven Leader at Driving Growth, SAN FRANCISCO, ... equity firm that focuses on investments in selected segments,of ... software, today announced the appointment of Michael L. Hurt,to ... Mr. Hurt, CEO,of Altra Industrial Motion (Nasdaq: AIMC ...
Cached Biology Technology:Time For the Trucking and Heavy Machinery Industries to Wake Up! 2Time For the Trucking and Heavy Machinery Industries to Wake Up! 3Time For the Trucking and Heavy Machinery Industries to Wake Up! 4Time For the Trucking and Heavy Machinery Industries to Wake Up! 5Pressure BioSciences, Inc. Announces CE Mark Approval and Compliance with the IEC 61010-1 Standard for a Second PCT-based Instrument, the Barocycler NEP2320 2Pressure BioSciences, Inc. Announces CE Mark Approval and Compliance with the IEC 61010-1 Standard for a Second PCT-based Instrument, the Barocycler NEP2320 3Pressure BioSciences, Inc. Announces CE Mark Approval and Compliance with the IEC 61010-1 Standard for a Second PCT-based Instrument, the Barocycler NEP2320 4Genstar Names Michael Hurt to Its Strategic Advisory Board 2